All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Sumitaka Inoue, Hiroki Shikanai, Machiko Matsumoto, Sachiko Hiraide, Yasuhiro Saito, Yoshiki Yanagawa, Mitsuhiro Yoshioka, Kei-ichi Shimamura, Hiroko Togash. Metaplastic regulation of the median raphe nucleus via serotonin 5-HT1A receptor on hippocampal synaptic plasticity is associated with gender-specific emotional expression in rats. Journal of pharmacological sciences. vol 124. issue 3. 2014-09-30. PMID:24599137. metaplastic regulation of the median raphe nucleus via serotonin 5-ht1a receptor on hippocampal synaptic plasticity is associated with gender-specific emotional expression in rats. 2014-09-30 2023-08-12 rat
Lea R Medeiros, Maria C Cartolano, M Danielle McDonal. Crowding stress inhibits serotonin 1A receptor-mediated increases in corticotropin-releasing factor mRNA expression and adrenocorticotropin hormone secretion in the Gulf toadfish. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 184. issue 2. 2014-09-29. PMID:24362954. stimulation of the serotonin 1a (5-ht1a) receptor subtype by 5-ht has been shown to result in an elevation in plasma corticosteroid levels in both mammals and several species of teleost fish, including the gulf toadfish (opsanus beta); however, in the case of teleost fish, it is not clearly known at which level of the hypothalamic-pituitary-interrenal axis the 5-ht1a receptor is stimulated. 2014-09-29 2023-08-12 Not clear
Kenji Maeda, Linda Lerdrup, Haruhiko Sugino, Hitomi Akazawa, Naoki Amada, Robert D McQuade, Tine Bryan Stensbøl, Christoffer Bundgaard, Jørn Arnt, Tetsuro Kikuch. Brexpiprazole II: antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator. The Journal of pharmacology and experimental therapeutics. vol 350. issue 3. 2014-09-29. PMID:24947464. brexpiprazole (opc-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1h)-one) is a novel serotonin-dopamine activity modulator with partial agonist activity at serotonin 1a (5-ht1a) and d2/3 receptors, combined with potent antagonist effects on 5-ht2a, α1b-, and α2c-adrenergic receptors. 2014-09-29 2023-08-13 rat
Ji-Young Kim, Ana Kim, Zhong-Qiu Zhao, Xian-Yu Liu, Zhou-Feng Che. Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem. Molecular brain. vol 7. 2014-09-29. PMID:24972638. despite the importance of 5-ht1a as a major target for the action of several anxiolytics/antidepressant drugs, little is known about its regulation in central serotonin (5-hydroxytryptamine, 5-ht) neurons. 2014-09-29 2023-08-13 Not clear
N Nevalainen, S Af Bjerkén, G A Gerhardt, I Strömber. Serotonergic nerve fibers in L-DOPA-derived dopamine release and dyskinesia. Neuroscience. vol 260. 2014-09-25. PMID:24361918. furthermore, fluoxetine-induced altered 5-ht transmission blocked dyskinetic behavior via action on 5-ht1a receptors. 2014-09-25 2023-08-12 rat
Mirjana Carli, Roberto W Invernizz. Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24966814. in this review, we focus on the 5-choice serial reaction time task which is able to provide various measures of attention and executive control over performance in rodents and the ability of prefrontocortical and striatal serotonin 5-ht1a, 5-ht2a, and 5-ht2c as well as dopamine d1- and d2-like receptors to modulate different aspects of executive and attention disturbances induced by nmda receptor hypofunction in the prefrontal cortex. 2014-09-24 2023-08-13 Not clear
Mirjana Carli, Roberto W Invernizz. Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24966814. these studies illustrate the control of attention selectivity by serotonin 5-ht1a, 5-ht2a, 5-ht2c, and dopamine d1- but not d2-like receptors and a distinct contribution of these cortical and striatal serotonin and dopamine receptors to the control of different aspects of executive control over performance such as impulsivity and compulsivity. 2014-09-24 2023-08-13 Not clear
Tonino Anelli, Silvia Cardarelli, Michela Ori, Irma Nardi, Stefano Biagioni, Giancarlo Poian. 5-Hydroxytryptamine 1A and 2B serotonin receptors in neurite outgrowth: involvement of early growth response protein 1. Developmental neuroscience. vol 35. issue 6. 2014-09-22. PMID:24158140. n18tg2 neuroblastoma cells (which do not produce neurotransmitters and constitutively express muscarinic acetylcholine receptors) were transfected with constructs containing the cdna for choline acetyltransferase, 5-hydroxytryptamine 1a (5-ht1a) and 5-ht2b serotonin receptors to study acetylcholine and serotonin interplay in neurite outgrowth. 2014-09-22 2023-08-12 Not clear
Tonino Anelli, Silvia Cardarelli, Michela Ori, Irma Nardi, Stefano Biagioni, Giancarlo Poian. 5-Hydroxytryptamine 1A and 2B serotonin receptors in neurite outgrowth: involvement of early growth response protein 1. Developmental neuroscience. vol 35. issue 6. 2014-09-22. PMID:24158140. when both cholinergic and 5-ht1a receptors are stimulated, fiber outgrowth is restored; therefore, acetylcholine counterbalances the inhibitory effect of serotonin on neurite outgrowth. 2014-09-22 2023-08-12 Not clear
Hernán Pessoa-Mahana, Christian González-Lira, Angélica Fierro, Gerald Zapata-Torres, C David Pessoa-Mahana, Javiera Ortiz-Severin, Patricio Iturriaga-Vásquez, Miguel Reyes-Parada, Paul Silva-Matus, Claudio Saitz-Barría, Ramiro Araya-Maturan. Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor. Bioorganic & medicinal chemistry. vol 21. issue 24. 2014-09-22. PMID:24262884. a series of 3-(3-(4-(3-(1h-indol-3-yl)propyl)piperazin-1-yl)propyl)-1h-indole derivatives (3a-d and 5a-f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter (sert) and the 5-ht1a receptor. 2014-09-22 2023-08-12 Not clear
Na Ye, Zilan Song, Ao Zhan. Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents. Current medicinal chemistry. vol 21. issue 4. 2014-09-17. PMID:24164194. dual ligands targeting dopamine d2 and serotonin 5-ht1a receptors as new antipsychotical or anti-parkinsonian agents. 2014-09-17 2023-08-12 Not clear
Na Ye, Zilan Song, Ao Zhan. Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents. Current medicinal chemistry. vol 21. issue 4. 2014-09-17. PMID:24164194. the present review discusses the advance of dual agents with mixed actions at the dopamine d2 and serotonin 5-ht1a receptors in the treatment of these diseases. 2014-09-17 2023-08-12 Not clear
Kristian Gaarn du Jardin, Jesper Bornø Jensen, Connie Sanchez, Alan L Pehrso. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:23916504. vortioxetine dose-dependently reverses 5-ht depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-ht1a receptor agonism and 5-ht3 receptor antagonism. 2014-09-12 2023-08-12 rat
Kristian Gaarn du Jardin, Jesper Bornø Jensen, Connie Sanchez, Alan L Pehrso. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:23916504. the present report studied the effects of vortioxetine and the potential impact of its 5-ht1a receptor agonist and 5-ht3 receptor antagonist properties on 5-ht depletion-induced memory deficits. 2014-09-12 2023-08-12 rat
Jesper Bornø Jensen, Kristian Gaarn du Jardin, Dekun Song, David Budac, Gennady Smagin, Connie Sanchez, Alan Lars Pehrso. Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:24284262. the investigational multimodal acting antidepressant vortioxetine is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and 5-ht transporter (sert) inhibitor that enhances memory in normal rats in novel object recognition (nor) and conditioned fear (mørk et al., 2013). 2014-09-12 2023-08-12 rat
Xiaosu Gu, Yong Zhou, Xiaomei Wu, Fen Wang, Cai-Yi Zhang, Chenchen Du, Lihua Shen, Xiang Chen, Jiansheng Shi, Chunfeng Liu, Kaifu K. Antidepressant-like effects of auraptenol in mice. Scientific reports. vol 4. 2014-09-02. PMID:24658501. in addition, the antidepressant-like effects of auraptenol was significantly averted by a selective serotonin 5-ht1a receptor antagonist way100635 (1 mg/kg). 2014-09-02 2023-08-12 mouse
María Eugenia Cornide-Petronio, Blanca Fernández-López, Antón Barreiro-Iglesias, María Celina Rodici. Traumatic injury induces changes in the expression of the serotonin 1A receptor in the spinal cord of lampreys. Neuropharmacology. vol 77. 2014-08-26. PMID:24490228. here, we showed that in lampreys there is an acute increase in the expression of the serotonin 1a receptor transcript (5-ht1a) after sci and a few weeks later expression levels go back to normal rostrally and caudally to the lesion. 2014-08-26 2023-08-12 Not clear
Tomohisa Mori, Naoki Uzawa, Haruyo Kazawa, Hirohiko Watanabe, Ayano Mochizuki, Masahiro Shibasaki, Kazumi Yoshizawa, Kimio Higashiyama, Tsutomu Suzuk. Differential substitution for the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine and methylphenidate in rats. The Journal of pharmacology and experimental therapeutics. vol 350. issue 2. 2014-08-26. PMID:24917544. on the other hand, serotonin (5-ht) receptor agonists 5-ht1a and 5-ht2 fully substituted for the discriminative stimulus effects of mdma. 2014-08-26 2023-08-13 rat
Zoe R Donaldson, David A Piel, Tabia L Santos, Jesse Richardson-Jones, E David Leonardo, Sheryl G Beck, Frances A Champagne, René He. Developmental effects of serotonin 1A autoreceptors on anxiety and social behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 2. 2014-08-21. PMID:23907404. the serotonin 1a receptor (5-ht1a) has a major role in modulating the effects of serotonin on mood and behavior. 2014-08-21 2023-08-12 Not clear
Francisco Espejo-Porras, Javier Fernández-Ruiz, Roger G Pertwee, Raphael Mechoulam, Concepción Garcí. Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors. Neuropharmacology. vol 75. 2014-08-19. PMID:23924692. however, recent evidence suggests that cbd may interact with the serotonin 5-ht1a receptor to produce some of its beneficial effects. 2014-08-19 2023-08-12 rat