Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Sumitaka Inoue, Hiroki Shikanai, Machiko Matsumoto, Sachiko Hiraide, Yasuhiro Saito, Yoshiki Yanagawa, Mitsuhiro Yoshioka, Kei-ichi Shimamura, Hiroko Togash. Metaplastic regulation of the median raphe nucleus via serotonin 5-HT1A receptor on hippocampal synaptic plasticity is associated with gender-specific emotional expression in rats. Journal of pharmacological sciences. vol 124. issue 3. 2014-09-30. PMID:24599137. |
metaplastic regulation of the median raphe nucleus via serotonin 5-ht1a receptor on hippocampal synaptic plasticity is associated with gender-specific emotional expression in rats. |
2014-09-30 |
2023-08-12 |
rat |
Lea R Medeiros, Maria C Cartolano, M Danielle McDonal. Crowding stress inhibits serotonin 1A receptor-mediated increases in corticotropin-releasing factor mRNA expression and adrenocorticotropin hormone secretion in the Gulf toadfish. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 184. issue 2. 2014-09-29. PMID:24362954. |
stimulation of the serotonin 1a (5-ht1a) receptor subtype by 5-ht has been shown to result in an elevation in plasma corticosteroid levels in both mammals and several species of teleost fish, including the gulf toadfish (opsanus beta); however, in the case of teleost fish, it is not clearly known at which level of the hypothalamic-pituitary-interrenal axis the 5-ht1a receptor is stimulated. |
2014-09-29 |
2023-08-12 |
Not clear |
Kenji Maeda, Linda Lerdrup, Haruhiko Sugino, Hitomi Akazawa, Naoki Amada, Robert D McQuade, Tine Bryan Stensbøl, Christoffer Bundgaard, Jørn Arnt, Tetsuro Kikuch. Brexpiprazole II: antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator. The Journal of pharmacology and experimental therapeutics. vol 350. issue 3. 2014-09-29. PMID:24947464. |
brexpiprazole (opc-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1h)-one) is a novel serotonin-dopamine activity modulator with partial agonist activity at serotonin 1a (5-ht1a) and d2/3 receptors, combined with potent antagonist effects on 5-ht2a, α1b-, and α2c-adrenergic receptors. |
2014-09-29 |
2023-08-13 |
rat |
Ji-Young Kim, Ana Kim, Zhong-Qiu Zhao, Xian-Yu Liu, Zhou-Feng Che. Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem. Molecular brain. vol 7. 2014-09-29. PMID:24972638. |
despite the importance of 5-ht1a as a major target for the action of several anxiolytics/antidepressant drugs, little is known about its regulation in central serotonin (5-hydroxytryptamine, 5-ht) neurons. |
2014-09-29 |
2023-08-13 |
Not clear |
N Nevalainen, S Af Bjerkén, G A Gerhardt, I Strömber. Serotonergic nerve fibers in L-DOPA-derived dopamine release and dyskinesia. Neuroscience. vol 260. 2014-09-25. PMID:24361918. |
furthermore, fluoxetine-induced altered 5-ht transmission blocked dyskinetic behavior via action on 5-ht1a receptors. |
2014-09-25 |
2023-08-12 |
rat |
Mirjana Carli, Roberto W Invernizz. Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24966814. |
in this review, we focus on the 5-choice serial reaction time task which is able to provide various measures of attention and executive control over performance in rodents and the ability of prefrontocortical and striatal serotonin 5-ht1a, 5-ht2a, and 5-ht2c as well as dopamine d1- and d2-like receptors to modulate different aspects of executive and attention disturbances induced by nmda receptor hypofunction in the prefrontal cortex. |
2014-09-24 |
2023-08-13 |
Not clear |
Mirjana Carli, Roberto W Invernizz. Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24966814. |
these studies illustrate the control of attention selectivity by serotonin 5-ht1a, 5-ht2a, 5-ht2c, and dopamine d1- but not d2-like receptors and a distinct contribution of these cortical and striatal serotonin and dopamine receptors to the control of different aspects of executive control over performance such as impulsivity and compulsivity. |
2014-09-24 |
2023-08-13 |
Not clear |
Tonino Anelli, Silvia Cardarelli, Michela Ori, Irma Nardi, Stefano Biagioni, Giancarlo Poian. 5-Hydroxytryptamine 1A and 2B serotonin receptors in neurite outgrowth: involvement of early growth response protein 1. Developmental neuroscience. vol 35. issue 6. 2014-09-22. PMID:24158140. |
n18tg2 neuroblastoma cells (which do not produce neurotransmitters and constitutively express muscarinic acetylcholine receptors) were transfected with constructs containing the cdna for choline acetyltransferase, 5-hydroxytryptamine 1a (5-ht1a) and 5-ht2b serotonin receptors to study acetylcholine and serotonin interplay in neurite outgrowth. |
2014-09-22 |
2023-08-12 |
Not clear |
Tonino Anelli, Silvia Cardarelli, Michela Ori, Irma Nardi, Stefano Biagioni, Giancarlo Poian. 5-Hydroxytryptamine 1A and 2B serotonin receptors in neurite outgrowth: involvement of early growth response protein 1. Developmental neuroscience. vol 35. issue 6. 2014-09-22. PMID:24158140. |
when both cholinergic and 5-ht1a receptors are stimulated, fiber outgrowth is restored; therefore, acetylcholine counterbalances the inhibitory effect of serotonin on neurite outgrowth. |
2014-09-22 |
2023-08-12 |
Not clear |
Hernán Pessoa-Mahana, Christian González-Lira, Angélica Fierro, Gerald Zapata-Torres, C David Pessoa-Mahana, Javiera Ortiz-Severin, Patricio Iturriaga-Vásquez, Miguel Reyes-Parada, Paul Silva-Matus, Claudio Saitz-Barría, Ramiro Araya-Maturan. Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor. Bioorganic & medicinal chemistry. vol 21. issue 24. 2014-09-22. PMID:24262884. |
a series of 3-(3-(4-(3-(1h-indol-3-yl)propyl)piperazin-1-yl)propyl)-1h-indole derivatives (3a-d and 5a-f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter (sert) and the 5-ht1a receptor. |
2014-09-22 |
2023-08-12 |
Not clear |
Na Ye, Zilan Song, Ao Zhan. Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents. Current medicinal chemistry. vol 21. issue 4. 2014-09-17. PMID:24164194. |
dual ligands targeting dopamine d2 and serotonin 5-ht1a receptors as new antipsychotical or anti-parkinsonian agents. |
2014-09-17 |
2023-08-12 |
Not clear |
Na Ye, Zilan Song, Ao Zhan. Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents. Current medicinal chemistry. vol 21. issue 4. 2014-09-17. PMID:24164194. |
the present review discusses the advance of dual agents with mixed actions at the dopamine d2 and serotonin 5-ht1a receptors in the treatment of these diseases. |
2014-09-17 |
2023-08-12 |
Not clear |
Kristian Gaarn du Jardin, Jesper Bornø Jensen, Connie Sanchez, Alan L Pehrso. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:23916504. |
vortioxetine dose-dependently reverses 5-ht depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-ht1a receptor agonism and 5-ht3 receptor antagonism. |
2014-09-12 |
2023-08-12 |
rat |
Kristian Gaarn du Jardin, Jesper Bornø Jensen, Connie Sanchez, Alan L Pehrso. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:23916504. |
the present report studied the effects of vortioxetine and the potential impact of its 5-ht1a receptor agonist and 5-ht3 receptor antagonist properties on 5-ht depletion-induced memory deficits. |
2014-09-12 |
2023-08-12 |
rat |
Jesper Bornø Jensen, Kristian Gaarn du Jardin, Dekun Song, David Budac, Gennady Smagin, Connie Sanchez, Alan Lars Pehrso. Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:24284262. |
the investigational multimodal acting antidepressant vortioxetine is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and 5-ht transporter (sert) inhibitor that enhances memory in normal rats in novel object recognition (nor) and conditioned fear (mørk et al., 2013). |
2014-09-12 |
2023-08-12 |
rat |
Xiaosu Gu, Yong Zhou, Xiaomei Wu, Fen Wang, Cai-Yi Zhang, Chenchen Du, Lihua Shen, Xiang Chen, Jiansheng Shi, Chunfeng Liu, Kaifu K. Antidepressant-like effects of auraptenol in mice. Scientific reports. vol 4. 2014-09-02. PMID:24658501. |
in addition, the antidepressant-like effects of auraptenol was significantly averted by a selective serotonin 5-ht1a receptor antagonist way100635 (1 mg/kg). |
2014-09-02 |
2023-08-12 |
mouse |
María Eugenia Cornide-Petronio, Blanca Fernández-López, Antón Barreiro-Iglesias, María Celina Rodici. Traumatic injury induces changes in the expression of the serotonin 1A receptor in the spinal cord of lampreys. Neuropharmacology. vol 77. 2014-08-26. PMID:24490228. |
here, we showed that in lampreys there is an acute increase in the expression of the serotonin 1a receptor transcript (5-ht1a) after sci and a few weeks later expression levels go back to normal rostrally and caudally to the lesion. |
2014-08-26 |
2023-08-12 |
Not clear |
Tomohisa Mori, Naoki Uzawa, Haruyo Kazawa, Hirohiko Watanabe, Ayano Mochizuki, Masahiro Shibasaki, Kazumi Yoshizawa, Kimio Higashiyama, Tsutomu Suzuk. Differential substitution for the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine and methylphenidate in rats. The Journal of pharmacology and experimental therapeutics. vol 350. issue 2. 2014-08-26. PMID:24917544. |
on the other hand, serotonin (5-ht) receptor agonists 5-ht1a and 5-ht2 fully substituted for the discriminative stimulus effects of mdma. |
2014-08-26 |
2023-08-13 |
rat |
Zoe R Donaldson, David A Piel, Tabia L Santos, Jesse Richardson-Jones, E David Leonardo, Sheryl G Beck, Frances A Champagne, René He. Developmental effects of serotonin 1A autoreceptors on anxiety and social behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 2. 2014-08-21. PMID:23907404. |
the serotonin 1a receptor (5-ht1a) has a major role in modulating the effects of serotonin on mood and behavior. |
2014-08-21 |
2023-08-12 |
Not clear |
Francisco Espejo-Porras, Javier Fernández-Ruiz, Roger G Pertwee, Raphael Mechoulam, Concepción Garcí. Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors. Neuropharmacology. vol 75. 2014-08-19. PMID:23924692. |
however, recent evidence suggests that cbd may interact with the serotonin 5-ht1a receptor to produce some of its beneficial effects. |
2014-08-19 |
2023-08-12 |
rat |