| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nina K Popova, Vladimir S Naumenk. 5-HT1A receptor as a key player in the brain 5-HT system. Reviews in the neurosciences. vol 24. issue 2. 2013-08-21. PMID:23492554. |
specifically, it describes the (1) functional interactions between 5-ht1a, 5-ht2a, 5-ht3, and 5-ht7 receptors; (2) cross-talk between 5-ht1a receptor and genes encoding key members of the brain 5-ht system; (3) implication of the 5-ht1a receptor in natural hibernation and genetic predisposition to different kinds of defensive behavior; and (4) role of 5-ht1a autoreceptors and heteroreceptors in anxiety, depression, and suicide, and in the antidepressant effect of serotonin reuptake inhibitors. |
2013-08-21 |
2023-08-12 |
Not clear |
| Nina K Popova, Vladimir S Naumenk. 5-HT1A receptor as a key player in the brain 5-HT system. Reviews in the neurosciences. vol 24. issue 2. 2013-08-21. PMID:23492554. |
this review provides converging lines of evidence that the 5-ht1a receptor contributes to the action of other 5-ht receptors, modulating their effect on behavior, and describes new data on the unique role of the 5-ht1a receptor in the indirect regulation of gene expression and in the autoregulation of the brain 5-ht system. |
2013-08-21 |
2023-08-12 |
Not clear |
| Yin Chen, Songlin Wang, Xiangqing Xu, Xin Liu, Minquan Yu, Song Zhao, Shicheng Liu, Yinli Qiu, Tan Zhang, Bi-Feng Liu, Guisen Zhan. Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics. Journal of medicinal chemistry. vol 56. issue 11. 2013-08-20. PMID:23675993. |
the discovery and synthesis of potential and novel antipsychotic coumarin derivatives, associated with potent dopamine d2, d3, and serotonin 5-ht1a and 5-ht2a receptor properties, are the focus of the present article. |
2013-08-20 |
2023-08-12 |
Not clear |
| Yin Chen, Songlin Wang, Xiangqing Xu, Xin Liu, Minquan Yu, Song Zhao, Shicheng Liu, Yinli Qiu, Tan Zhang, Bi-Feng Liu, Guisen Zhan. Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics. Journal of medicinal chemistry. vol 56. issue 11. 2013-08-20. PMID:23675993. |
this derivative possesses unique pharmacological features, including high affinity for dopamine d2 and d3 and serotonin 5-ht1a and 5-ht2a receptors. |
2013-08-20 |
2023-08-12 |
Not clear |
| Rachel L Dennis, Alan G Fahey, Heng W Chen. Alterations to embryonic serotonin change aggression and fearfulness. Aggressive behavior. vol 39. issue 2. 2013-08-15. PMID:23386480. |
eggs were injected with 50 μl of excess 5-ht (10 μg/egg), 8-oh-dpat (a 5-ht1a receptor agonist; 16 μg/egg), or saline on day 0 prior to the 21 days incubation. |
2013-08-15 |
2023-08-12 |
chicken |
| Rachel L Dennis, Alan G Fahey, Heng W Chen. Alterations to embryonic serotonin change aggression and fearfulness. Aggressive behavior. vol 39. issue 2. 2013-08-15. PMID:23386480. |
hens treated with excess embryonic 5-ht exhibited significantly less aggressive behaviors at 9 weeks of age compared to both 5-ht1a agonist treated and saline hens (p < 0.05), and at 18 weeks of age compared to saline control birds only (p < 0.05). |
2013-08-15 |
2023-08-12 |
chicken |
| Ramesh Boinpally, Harry Alcorn, Marijke H Adams, James Longstreth, John Edward. Pharmacokinetics of vilazodone in patients with mild or moderate renal impairment. Clinical drug investigation. vol 33. issue 3. 2013-08-13. PMID:23417352. |
vilazodone is a selective serotonin reuptake inhibitor and 5-ht1a receptor partial agonist approved for the treatment of major depressive disorder. |
2013-08-13 |
2023-08-12 |
human |
| Da-Hui Wang, Kongfatt Wong-Li. Comodulation of dopamine and serotonin on prefrontal cortical rhythms: a theoretical study. Frontiers in integrative neuroscience. vol 7. 2013-08-12. PMID:23935568. |
single neuronal model shows pyramidal cells with 5-ht1a and 2a receptors can be non-monotonically modulated by 5-ht. |
2013-08-12 |
2023-08-12 |
Not clear |
| Naozumi Araragi, Boris Mlinar, Gilda Baccini, Lise Gutknecht, Klaus-Peter Lesch, Renato Corradett. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Frontiers in pharmacology. vol 4. 2013-08-12. PMID:23935583. |
conservation of 5-ht1a receptor-mediated autoinhibition of serotonin (5-ht) neurons in mice with altered 5-ht homeostasis. |
2013-08-12 |
2023-08-12 |
mouse |
| Naozumi Araragi, Boris Mlinar, Gilda Baccini, Lise Gutknecht, Klaus-Peter Lesch, Renato Corradett. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Frontiers in pharmacology. vol 4. 2013-08-12. PMID:23935583. |
firing activity of serotonin (5-ht) neurons in the dorsal raphe nucleus (drn) is controlled by inhibitory somatodendritic 5-ht1a autoreceptors. |
2013-08-12 |
2023-08-12 |
mouse |
| Naozumi Araragi, Boris Mlinar, Gilda Baccini, Lise Gutknecht, Klaus-Peter Lesch, Renato Corradett. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Frontiers in pharmacology. vol 4. 2013-08-12. PMID:23935583. |
while 5-ht neurons from tph2-/- mice did not display autoinhibition in response to l-tryptophan, autoinhibition of these neurons was unaltered in sert-/- mice despite marked desensitization of their 5-ht1a autoreceptors. |
2013-08-12 |
2023-08-12 |
mouse |
| Naozumi Araragi, Boris Mlinar, Gilda Baccini, Lise Gutknecht, Klaus-Peter Lesch, Renato Corradett. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Frontiers in pharmacology. vol 4. 2013-08-12. PMID:23935583. |
our findings demonstrate that, as opposed to the prevalent view, sensitivity of somatodendritic 5-ht1a receptors does not predict the magnitude of 5-ht neuron autoinhibition. |
2013-08-12 |
2023-08-12 |
mouse |
| Naozumi Araragi, Boris Mlinar, Gilda Baccini, Lise Gutknecht, Klaus-Peter Lesch, Renato Corradett. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Frontiers in pharmacology. vol 4. 2013-08-12. PMID:23935583. |
changes in 5-ht1a receptor sensitivity may rather be seen as an adaptive mechanism to keep autoinhibition functioning in response to extremely altered levels of extracellular 5-ht resulting from targeted inactivation of mediators of serotonergic signaling. |
2013-08-12 |
2023-08-12 |
mouse |
| John Edwards, Vasi Sperry, Marijke H Adams, Susan Gallipoli, Michael D Thorn, James Longstreth, Ramesh Boinpall. Vilazodone lacks proarrhythmogenic potential in healthy participants: a thorough ECG study. International journal of clinical pharmacology and therapeutics. vol 51. issue 6. 2013-08-06. PMID:23611569. |
vilazodone is a potent serotonin reuptake inhibitor and 5-ht1a receptor partial agonist approved for the treatment of major depressive disorder (mdd) in adults. |
2013-08-06 |
2023-08-12 |
human |
| Guo-Du Wang, Xi-Yu Wang, Fei Zou, Meihua Qu, Sumei Liu, Guijun Fei, Yun Xia, Bradley J Needleman, Dean J Mikami, Jackie D Woo. Mast cell expression of the serotonin1A receptor in guinea pig and human intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 304. issue 10. 2013-07-18. PMID:23518679. |
a selective 5-ht1a receptor antagonist, way-100135, suppressed stimulation of histamine release by 5-ht or 8-hydroxy-pipat. |
2013-07-18 |
2023-08-12 |
human |
| Guo-Du Wang, Xi-Yu Wang, Fei Zou, Meihua Qu, Sumei Liu, Guijun Fei, Yun Xia, Bradley J Needleman, Dean J Mikami, Jackie D Woo. Mast cell expression of the serotonin1A receptor in guinea pig and human intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 304. issue 10. 2013-07-18. PMID:23518679. |
association of 5-ht with the pathophysiology of functional gastrointestinal disorders (e.g., irritable bowel syndrome) underlies a question of whether selective 5-ht1a receptor antagonists might have therapeutic application in disorders of this nature. |
2013-07-18 |
2023-08-12 |
human |
| Xiaofeng Zhao, Yinglin Huang, Jingying Li, Hui Ma, Qiu Jin, Yuan Wang, Lijuan Wu, Gang Zh. Association between the 5-HT1A receptor gene polymorphism (rs6295) and antidepressants: a meta-analysis. International clinical psychopharmacology. vol 27. issue 6. 2013-07-10. PMID:22890315. |
previous studies have implicated 5-ht1a receptor gene (htr1a) polymorphisms in the therapeutic response to antidepressants, especially selective serotonin reuptake inhibitors. |
2013-07-10 |
2023-08-12 |
Not clear |
| H Gu, C Liu, C Liu, M Chen, Q Zhang, J Zhai, K Wang, F Ji, Z Xu, Q Shen, X Bao, X Chen, J Li, Q Dong, C Che. The combined effects of the 5- HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients. Genes, brain, and behavior. vol 12. issue 1. 2013-07-03. PMID:23036158. |
this study investigated how decision making was affected by the genetic variants in the serotonin transporter gene (triallelic 5- httlpr) and serotonin receptor 1a gene (rs6295) and their interaction in 465 schizophrenia patients and 448 healthy controls. |
2013-07-03 |
2023-08-12 |
Not clear |
| Vera Kiyasova, Patricia Bonnavion, Sophie Scotto-Lomassese, Véronique Fabre, Iman Sahly, François Tronche, Evan Deneris, Patricia Gaspar, Sebastian P Fernande. A subpopulation of serotonergic neurons that do not express the 5-HT1A autoreceptor. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336048. |
early studies suggested that the raphe 5-ht neurons were a homogeneous population showing similar electrical properties, and feedback inhibition mediated by 5-ht1a autoreceptors. |
2013-07-02 |
2023-08-12 |
mouse |
| Vera Kiyasova, Patricia Bonnavion, Sophie Scotto-Lomassese, Véronique Fabre, Iman Sahly, François Tronche, Evan Deneris, Patricia Gaspar, Sebastian P Fernande. A subpopulation of serotonergic neurons that do not express the 5-HT1A autoreceptor. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336048. |
we utilized histochemistry techniques in epet1-egfp and 5-ht1a-icre/r26r mice to show that a subpopulation of 5-ht neurons do not express the somatodendritic 5-ht1a autoreceptor mrna. |
2013-07-02 |
2023-08-12 |
mouse |