| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideho Arit. [The neuroscience of suicide]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 8. 2012-10-18. PMID:22868884. |
reduced 5-ht1a feedback inhibition and increased tph may reflect compensatory changes in response to 5-ht hypofunction in depression-related suicide. |
2012-10-18 |
2023-08-12 |
Not clear |
| G T Shishkina, T S Kalinina, N N Dygal. Effects of swim stress and fluoxetine on 5-HT1A receptor gene expression and monoamine metabolism in the rat brain regions. Cellular and molecular neurobiology. vol 32. issue 5. 2012-10-17. PMID:22453856. |
metabolism of 5-ht (5-hiaa/5-ht) in the brainstem was significantly decreased by fluoxetine and further reduced by swim stress, showing a certain degree of independence of these changes on 5-ht1a receptor gene expression that was increased in this brain region only after the fst, but not after fluoxetine. |
2012-10-17 |
2023-08-12 |
rat |
| B T Carrol. The universal field hypothesis of catatonia and neuroleptic malignant syndrome. CNS spectrums. vol 5. issue 7. 2012-10-02. PMID:18197153. |
this hypothesis considers both disorders as a single entity that result from variable combinations of the following: 1) gamma-aminobutyric acid (gaba) hypoactivity at the gabaa receptor; 2) dopamine hypoactivity at the d2 receptor; 3) serotonin hyperactivity at the 5-ht1a receptor and hypoactivity at the 5-ht2a receptor; and 4) glutamate hypoactivity at the n-methyl-d-aspartate (ndma) receptor. |
2012-10-02 |
2023-08-12 |
human |
| P J Goodnic. Psychopharmacology of depression in the next millennium. CNS spectrums. vol 4. issue 7. 2012-10-02. PMID:18438295. |
this review will focus on information available for the following proposed antidepressants: 1) reboxetine, a norepinephrine selective reuptake inhibitor; 2) milnacipran, a combined serotonin/norepinephrine reuptake inhibitor; 3) a new enantiomer of fluoxetine, a selective serotonin reuptake inhibitor; 4) duloxetine, another combined serotonin/norepinephrine reuptake inhibitor; 5) sunepitron, a combined 5-ht1a agonist and a2 antagonist; and 6) mk-869, a substance p inhibitor. |
2012-10-02 |
2023-08-12 |
Not clear |
| D Weissmann-Nanopoulos, E Mach, J Magre, Y Demassey, J F Pujo. Evidence for the localization of 5HT1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain. Neurochemistry international. vol 7. issue 6. 2012-10-02. PMID:20493020. |
evidence for the localization of 5ht1a binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain. |
2012-10-02 |
2023-08-12 |
rat |
| D Weissmann-Nanopoulos, E Mach, J Magre, Y Demassey, J F Pujo. Evidence for the localization of 5HT1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain. Neurochemistry international. vol 7. issue 6. 2012-10-02. PMID:20493020. |
this pattern, more pronounced when 5ht1a sites were labelled, completely disappeared after lesioning by 5, 7dht indicating the presence of this subtype of 5ht1 binding sites on 5ht containing neurons. |
2012-10-02 |
2023-08-12 |
rat |
| D Weissmann-Nanopoulos, E Mach, J Magre, Y Demassey, J F Pujo. Evidence for the localization of 5HT1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain. Neurochemistry international. vol 7. issue 6. 2012-10-02. PMID:20493020. |
it is postulated that these 5ht1a sites correspond in these raphe nuclei to 5ht autoreceptors. |
2012-10-02 |
2023-08-12 |
rat |
| A K Tripathi, R H Sing. Experimental evaluation of antidepressant effect of Vacha (Acorus calamus) in animal models of depression. Ayu. vol 31. issue 2. 2012-10-02. PMID:22131703. |
while eliciting the 5-ht syndrome, only two components out of five were influenced by vacha, indicating that vacha does not sensitize postsynaptic 5-ht1a receptors, which explains the behavioral deficit prevention in stressed rat group. |
2012-10-02 |
2023-08-12 |
rat |
| S Antonato. [The role of serotonergic 2C receptors in neurobiology and treatment of eating disorders]. Psychiatrike = Psychiatriki. vol 18. issue 1. 2012-10-02. PMID:22466431. |
5-ht2c receptor blockade seems to be the most significant reason for increased carbohydrate consumption, rather than the inhibition of serotonin (5-ht) release through the 5-ht1a receptors. |
2012-10-02 |
2023-08-12 |
rat |
| S Antonato. [The role of serotonergic 2C receptors in neurobiology and treatment of eating disorders]. Psychiatrike = Psychiatriki. vol 18. issue 1. 2012-10-02. PMID:22466431. |
our results suggest that both 5-ht1a and 5-ht2c receptor subtypes are involved in the protein-sparing effect of 5-ht, while the 5-ht2c receptors may have the prominent role on 5-ht induced food and carbohydrate intake suppression. |
2012-10-02 |
2023-08-12 |
rat |
| Patrick M Fisher, Julie C Price, Carolyn C Meltzer, Eydie L Moses-Kolko, Carl Becker, Sarah L Berga, Ahmad R Harir. Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity. Biology of mood & anxiety disorders. vol 1. issue 1. 2012-10-02. PMID:22738071. |
the colocalization of 5-ht1a and 5-ht2a receptors on mpfc glutamatergic neurons suggests that their functional interactions may mediate 5-ht effects on this circuit through top-down regulation of amygdala reactivity. |
2012-10-02 |
2023-08-12 |
human |
| Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppe. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European journal of medicinal chemistry. vol 53. 2012-09-25. PMID:22520153. |
benzothiazoles as probes for the 5ht1a receptor and the serotonin transporter (sert): a search for new dual-acting agents as potential antidepressants. |
2012-09-25 |
2023-08-12 |
Not clear |
| T Watanabe, H Aonum. Identification and expression analyses of a novel serotonin receptor gene, 5-HT2β, in the field cricket, Gryllus bimaculatus. Acta biologica Hungarica. vol 63 Suppl 2. 2012-09-17. PMID:22776473. |
in our previous report, in order to elucidate the molecular basis of the cricket 5-ht system, we identified three genes involved in 5-ht biosynthesis, as well as four 5-ht receptor genes (5-ht1a, 5-ht1b, 5-ht2α, and 5-ht7) expressed in the brain of the field cricket gryllus bimaculatus degeer [7]. |
2012-09-17 |
2023-08-12 |
cricket |
| YeeWen Candace Wu, Rachel A Hill, Maren Klug, Maarten van den Buus. Sex-specific and region-specific changes in BDNF-TrkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice. Brain research. vol 1452. 2012-09-14. PMID:22464183. |
brain-derived neurotrophic factor (bdnf) and serotonin 5-ht1a receptors are implicated in the pathophysiology of depression and the mechanism of action of antidepressant drugs. |
2012-09-14 |
2023-08-12 |
mouse |
| Yoshihiro Tadori, Tetsuro Kikuch. [Pharmacology of antipsychotics at human dopamine D2 and D3 receptors]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 32. issue 1. 2012-09-13. PMID:22568121. |
aripiprazole is a dopamine d/d3 and serotonin 5-ht1a receptor partial agonist which is approved for treatment of schizophrenia. |
2012-09-13 |
2023-08-12 |
human |
| Enric Alvarez, Victor Perez, Marianne Dragheim, Henrik Loft, Francesc Artiga. A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder. The international journal of neuropsychopharmacology. vol 15. issue 5. 2012-09-06. PMID:21767441. |
lu aa21004 is a novel antidepressant that is a 5-ht3 and 5-ht7 receptor antagonist, 5-ht1a receptor agonist, 5-ht1b receptor partial agonist and inhibitor of the 5-ht transporter in recombinant cell lines. |
2012-09-06 |
2023-08-12 |
Not clear |
| Mark D Underwood, Suham A Kassir, Mihran J Bakalian, Hanga Galfalvy, J John Mann, Victoria Arang. Neuron density and serotonin receptor binding in prefrontal cortex in suicide. The international journal of neuropsychopharmacology. vol 15. issue 4. 2012-09-05. PMID:21733245. |
therefore, we measured neuron density and serotonin transporter (sert), 5-ht1a and 5-ht2a binding in matched suicides and controls. |
2012-09-05 |
2023-08-12 |
Not clear |
| Darakhshan Jabeen Halee. Raphe-Hippocampal Serotonin Neurotransmission In The Sex Related Differences of Adaptation to Stress: Focus on Serotonin-1A Receptor. Current neuropharmacology. vol 9. issue 3. 2012-08-23. PMID:22379463. |
pharmacological and neurochemical data are relevant that facilitation of serotonin neurotransmission via hippocampus due to desensitization of somatodendritic 5-ht1a receptors may lead to adaptation to stress. |
2012-08-23 |
2023-08-12 |
Not clear |
| Mandeep Singh, Thomas L Schwart. Clinical utility of vilazodone for the treatment of adults with major depressive disorder and theoretical implications for future clinical use. Neuropsychiatric disease and treatment. vol 8. 2012-08-23. PMID:22536068. |
its dual mechanism of action combines the inhibition of serotonin transporters while simultaneously partially agonizing serotonin-1a (5-ht1a) receptors. |
2012-08-23 |
2023-08-12 |
Not clear |
| Ferenc Kassai, István Gyertyá. Shock priming enhances the efficacy of SSRIs in the foot shock-induced ultrasonic vocalization test. Progress in neuro-psychopharmacology & biological psychiatry. vol 36. issue 1. 2012-08-20. PMID:22041499. |
the serotonin 5ht1a receptor antagonist 8-oh-dpat also showed linear dose-response relationship in all protocols, but this compound was less potent in the single shocking design (ed50 values were 0.27, 0.04 and 0.07 mg/kg i.p. |
2012-08-20 |
2023-08-12 |
rat |