| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margaret Czesak, Brice Le François, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Alber. Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22232550. |
in the dorsal raphe, deaf-1 knock-out mice displayed increased 5-ht1a mrna, protein, and 5-ht1a-positive cell counts but reduced 5-ht levels, whereas other serotonergic markers, such as tryptophan hydroxylase (tph)- or 5-ht-positive cells and tph2 rna levels, were unchanged. |
2012-04-25 |
2023-08-12 |
mouse |
| Margaret Czesak, Brice Le François, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Alber. Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22232550. |
the region-specific alterations of brain 5-ht1a gene expression and reduced raphe 5-ht content in deaf-1(-/-) mice indicate the importance of deaf-1 in regulation of 5-ht1a gene expression and provide insight into the role of the 5-ht1a g(-1019) allele in reducing serotonergic neurotransmission by derepression of 5-ht1a autoreceptors. |
2012-04-25 |
2023-08-12 |
mouse |
| Tomohiro Shirasaka, Wataru Ukai, Toshihiro Yoshinaga, Kimihiko Watanabe, Hiroo Kaneta, Yoshiyasu Kigawa, Takeshi Igarashi, Masaru Tateno, Eri Hashimoto, Toshikazu Sait. [Promising therapy of neural stem cell transplantation for FASD model--neural network reconstruction and behavior recovery]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 46. issue 6. 2012-04-19. PMID:22413566. |
it has also been reported that abnormal 5-ht neuron development can be reversed by treatment with a 5-ht1a agonist in a prenatal alcohol exposure model. |
2012-04-19 |
2023-08-12 |
rat |
| Subrata K Bose, Mitul A Mehta, Sudhakar Selvaraj, Oliver D Howes, Rainer Hinz, Eugenii A Rabiner, Paul M Grasby, Federico E Turkheimer, Venkatesha Murth. Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 11. 2012-03-20. PMID:21750580. |
physiological and pharmacological relationship between 5-ht1a receptors and serotonin transporter (5-htt) in the regulation of 5-ht neurotransmission has now been documented. |
2012-03-20 |
2023-08-12 |
human |
| Jiangnan Luo, Jaime Becnel, Charles D Nichols, Dick R Nässe. Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor. Cellular and molecular life sciences : CMLS. vol 69. issue 3. 2012-03-06. PMID:21818550. |
insulin-producing cells in the brain of adult drosophila are regulated by the serotonin 5-ht1a receptor. |
2012-03-06 |
2023-08-12 |
drosophila_melanogaster |
| Aram Rasul, Husameldin El-Nour, Randy D Blakely, Sol-Britt Lonne-Rahm, Johan Forsberg, Björn Johansson, Elvar Theodorsson, Klas Nordlin. Effect of chronic mild stress on serotonergic markers in the skin and brain of the NC/Nga atopic-like mouse strain. Archives of dermatological research. vol 303. issue 9. 2012-02-24. PMID:21400247. |
in chronic stress, there is a decrease of the 5-ht1a receptor (r)- and an increase in the 5-ht2ar-responsiveness to 5-ht. |
2012-02-24 |
2023-08-12 |
mouse |
| Aram Rasul, Husameldin El-Nour, Randy D Blakely, Sol-Britt Lonne-Rahm, Johan Forsberg, Björn Johansson, Elvar Theodorsson, Klas Nordlin. Effect of chronic mild stress on serotonergic markers in the skin and brain of the NC/Nga atopic-like mouse strain. Archives of dermatological research. vol 303. issue 9. 2012-02-24. PMID:21400247. |
in the present study, the impact of chronic mild stress on the expression of 5-ht1a and 5-ht2a receptors and serotonin transporter protein (sert) was investigated in eczematous skin and brain of atopic-like nc/nga mice. |
2012-02-24 |
2023-08-12 |
mouse |
| Abigail M Polter, Sufen Yang, Richard S Jope, Xiaohua L. Functional significance of glycogen synthase kinase-3 regulation by serotonin. Cellular signalling. vol 24. issue 1. 2012-02-23. PMID:21946431. |
using mutant gsk3 knock-in mice, we also tested the role of gsk3 in the behavioral effects of 5-ht1a receptors and the serotonin reuptake inhibitor fluoxetine. |
2012-02-23 |
2023-08-12 |
mouse |
| Mariano Soiza-Reilly, Kathryn G Common. Glutamatergic drive of the dorsal raphe nucleus. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21550397. |
moreover vglut3 is present, with or without 5-ht, in output pathways from the dr. 5-ht and non-5-ht neurons receive and integrate glutamatergic neurotransmission through multiple subtypes of glutamate receptors that have different patterns of expression within the dr. interestingly, excitatory drive provided by glutamatergic neurotransmission is closely opposed by feedback inhibition mediated by 5-ht1a receptors or local gabaergic circuits. |
2012-02-22 |
2023-08-12 |
Not clear |
| Cynthia L Bethea, Fernanda B Lima, Maria L Centeno, Karin V Weissheimer, Olga Senashova, Arubala P Reddy, Judy L Camero. Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21683135. |
examination of the serotonin system revealed that ss monkeys had significantly lower fev (fifth ewing variant, rodent pet1), tph2 (tryptophan hydroxylase 2), 5ht1a autoreceptor and sert (serotonin reuptake transporter) expression in the dorsal raphe than sr monkeys. |
2012-02-22 |
2023-08-12 |
monkey |
| Eduardo A Pineda, Julie G Hensler, Raman Sankar, Don Shin, Teresa F Burke, Andréy M Mazarat. Plasticity of presynaptic and postsynaptic serotonin 1A receptors in an animal model of epilepsy-associated depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 6. 2012-02-09. PMID:21346733. |
we examined possible involvement of presynaptic and postsynaptic serotonin 1a (5-ht1a) receptors in epilepsy-associated depression. |
2012-02-09 |
2023-08-12 |
human |
| Eduardo A Pineda, Julie G Hensler, Raman Sankar, Don Shin, Teresa F Burke, Andréy M Mazarat. Plasticity of presynaptic and postsynaptic serotonin 1A receptors in an animal model of epilepsy-associated depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 6. 2012-02-09. PMID:21346733. |
we suggest that under the conditions of chronic epilepsy, excessively hyperactive hpa axis activates presynaptic 5-ht1a receptors, thus shifting the regulation of serotonin release in favor of autoinhibition. |
2012-02-09 |
2023-08-12 |
human |
| C L Bethea, A W Smith, M L Centeno, A P Redd. Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques. Neuroscience. vol 192. 2012-01-18. PMID:21763405. |
in macaques, ovarian steroid administration to ovariectomized (ovx) individuals improves serotonin neural function through actions on pivotal serotonin-related genes and proteins, such as tph2 (tryptophan hydroxylase 2), sert (serotonin reuptake transporter), and the 5ht1a autoreceptor. |
2012-01-18 |
2023-08-12 |
Not clear |
| C L Bethea, A W Smith, M L Centeno, A P Redd. Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques. Neuroscience. vol 192. 2012-01-18. PMID:21763405. |
in summary, long-term ovarian steroid loss resulted in fewer serotonin neurons and overall lower fev, tph2, sert, and 5ht1a gene expression. |
2012-01-18 |
2023-08-12 |
Not clear |
| Christian Beste, Katharina Domschke, Britta Radenz, Michael Falkenstein, Carsten Konra. The functional 5-HT1A receptor polymorphism affects response inhibition processes in a context-dependent manner. Neuropsychologia. vol 49. issue 9. 2011-12-06. PMID:21645534. |
here, we examine context-dependent variations of response control processes using the ax-cpt task with respect to the relevance of the functional serotonin 1a receptor polymorphism (5-ht1a c(-1019)g) in a sample of healthy subjects (n=90) by means of event-related potentials (erps). |
2011-12-06 |
2023-08-12 |
human |
| Tamara B Franklin, Natacha Linder, Holger Russig, Beat Thöny, Isabelle M Mansu. Influence of early stress on social abilities and serotonergic functions across generations in mice. PloS one. vol 6. issue 7. 2011-12-06. PMID:21799751. |
the defects are associated with impaired serotonergic signaling, in particular, reduced 5ht1a receptor expression in the dorsal raphe nucleus, and increased serotonin level in a dorsal raphe projection area. |
2011-12-06 |
2023-08-12 |
mouse |
| Paul R Albert, Brice Le François, Anne M Milla. Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness. Molecular brain. vol 4. 2011-11-30. PMID:21619616. |
the serotonin-1a (5-ht1a) receptor is among the most abundant and widely distributed 5-ht receptors in the brain, but is also expressed on serotonin neurons as an autoreceptor where it plays a critical role in regulating the activity of the entire serotonin system. |
2011-11-30 |
2023-08-12 |
Not clear |
| Adrian Newman-Tancredi, Mark S Kleve. Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties. Psychopharmacology. vol 216. issue 4. 2011-11-22. PMID:21394633. |
comparative pharmacology of antipsychotics possessing combined dopamine d2 and serotonin 5-ht1a receptor properties. |
2011-11-22 |
2023-08-12 |
Not clear |
| M M Sidor, A Amath, G MacQueen, J A Foste. A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge. Neuroscience. vol 171. issue 3. 2011-10-31. PMID:20816924. |
here we examine both the spatial and temporal profile of 5-ht related gene expression, including 5ht1a, 2a, 2c receptors, the 5-ht transporter (5htt), and tryptophan hydroxylase 2 (tph2) during early development (postnatal day [p]14, p17, p21, p28) in mice challenged with lipopolysaccharide (lps) during the first postnatal week. |
2011-10-31 |
2023-08-12 |
mouse |
| M M Sidor, A Amath, G MacQueen, J A Foste. A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge. Neuroscience. vol 171. issue 3. 2011-10-31. PMID:20816924. |
increased tph2 and 5htt expression in the ventrolateral region of the dr of lps-mice accompanied decreased expression of ventral dr 5ht1a and dorsal dr 5htt. |
2011-10-31 |
2023-08-12 |
mouse |