| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Popa, Julie Cerdan, Christelle Repérant, Bruno P Guiard, Jean-Philippe Guilloux, Denis J David, Alain M Gardie. A longitudinal study of 5-HT outflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19944680. |
our study suggests that the beneficial anxiolytic/antidepressant-like effects of chronic ssri treatment indeed depend on 5-ht1a autoreceptor internalization, but do not require a sustained increase in extracellular 5-ht levels in a territory of 5-ht projection such as hippocampus. |
2010-04-05 |
2023-08-12 |
mouse |
| L J Strug, R Suresh, A J Fyer, A Talati, P B Adams, W Li, S E Hodge, T C Gilliam, M M Weissma. Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Molecular psychiatry. vol 15. issue 2. 2010-03-30. PMID:18663369. |
we analyzed five genes, derived from pharmacological or translational mouse models, in a new case-control study of pd and sad in european americans: (1) the serotonin transporter (slc6a4), (2) the serotonin receptor 1a, (3) catechol-o-methyltransferase, (4) a regulator of g-protein signaling and (5) the gastrin-releasing peptide receptor. |
2010-03-30 |
2023-08-12 |
mouse |
| Sabina Cevoli, Nadia Marzocchi, Sabina Capellari, Chiara Scapoli, Giulia Pierangeli, Daniela Grimaldi, Federica Naldi, L Alberto Pini, Pasquale Montagna, Pietro Cortell. Lack of association between five serotonin metabolism-related genes and medication overuse headache. The journal of headache and pain. vol 11. issue 1. 2010-03-25. PMID:19936617. |
we performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (5htt), serotonin receptor 1a(5-ht1a), serotonin receptor 1b (5-ht1b), serotonin receptor 2a (5-ht2a) and serotonin receptor 6 (5ht6)genes. |
2010-03-25 |
2023-08-12 |
Not clear |
| Sabina Cevoli, Nadia Marzocchi, Sabina Capellari, Chiara Scapoli, Giulia Pierangeli, Daniela Grimaldi, Federica Naldi, L Alberto Pini, Pasquale Montagna, Pietro Cortell. Lack of association between five serotonin metabolism-related genes and medication overuse headache. The journal of headache and pain. vol 11. issue 1. 2010-03-25. PMID:19936617. |
in conclusion, our studydoes not provide evidence that the 5htt, 5-ht1a, 5ht1b,5ht2a and 5ht6 gene polymorphisms play a role in the genetic predisposition to moh. |
2010-03-25 |
2023-08-12 |
Not clear |
| Chen-Li Cheng, William C de Groa. Role of 5-HT1A receptors in control of lower urinary tract function in anesthetized rats. American journal of physiology. Renal physiology. vol 298. issue 3. 2010-03-19. PMID:20042459. |
the role of 5-hydroxytryptamine (5-ht) 1a (5-ht1a) receptors in lower urinary tract function was examined in urethane-anesthetized female sprague-dawley rats. |
2010-03-19 |
2023-08-12 |
rat |
| Chen-Li Cheng, William C de Groa. Role of 5-HT1A receptors in control of lower urinary tract function in anesthetized rats. American journal of physiology. Renal physiology. vol 298. issue 3. 2010-03-19. PMID:20042459. |
these results indicate that activation of 5-ht1a receptors by endogenous 5-ht lowers the threshold for initiating reflex voiding and promotes voiding function by enhancing the duration of eus relaxation, which should reduce urethral outlet resistance. |
2010-03-19 |
2023-08-12 |
rat |
| M Victoria Puig, Akiya Watakabe, Mika Ushimaru, Tetsuo Yamamori, Yasuo Kawaguch. Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147548. |
serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-ht1a and 5-ht2a receptors. |
2010-03-05 |
2023-08-12 |
rat |
| Chi-Un Pa. A review of the safety and tolerability of aripiprazole. Expert opinion on drug safety. vol 8. issue 3. 2010-03-02. PMID:19505266. |
it seems that the efficacy of aripiprazole for treating schizophrenia is mediated through a combination of partial agonism at dopamine d2 and serotonin 5-ht1a receptors and antagonism at serotonin 5-ht2a receptors. |
2010-03-02 |
2023-08-12 |
Not clear |
| Lee A Dawson, Jeannette M Watso. Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders. CNS neuroscience & therapeutics. vol 15. issue 2. 2010-03-01. PMID:19499624. |
vilazodone (emd 68843; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (ssri) and 5-ht1a receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
2010-03-01 |
2023-08-12 |
rat |
| Lee A Dawson, Jeannette M Watso. Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders. CNS neuroscience & therapeutics. vol 15. issue 2. 2010-03-01. PMID:19499624. |
preclinical in vitro evaluation has confirmed vilazodone's primary pharmacological profile both in clonal and native systems, that is, serotonin reuptake blockade and 5-ht1a partial agonism. |
2010-03-01 |
2023-08-12 |
rat |
| Norimasa Kanegawa, Chihiro Suzuki, Kousaku Ohinat. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS letters. vol 584. issue 3. 2010-02-18. PMID:20005875. |
dipeptide tyr-leu (yl) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-ht1a, dopamine d1 and gabaa receptors in mice. |
2010-02-18 |
2023-08-12 |
mouse |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
fev (fifth ewing variant) ets transcription factor, tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor were determined at 7-8 levels of the dorsal raphe nucleus with in situ hybridization (ish) using radiolabeled- and digoxygenin-incorporated riboprobes. |
2010-02-12 |
2023-08-12 |
monkey |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
these data suggest that ss monkeys have fewer serotonin (5-ht) neurons than hsr monkeys, and that they have deficient fev expression, which in turn, leads to deficient tph2, sert and 5ht1a expression. |
2010-02-12 |
2023-08-12 |
monkey |
| Christian la Fougère, Guido Böning, Hero Bartmann, Björn Wängler, Sebastian Nowak, Theresa Just, Erika Wagner, Petra Winter, Axel Rominger, Stefan Förster, Franz-Josef Gildehaus, Pedro Rosa-Neto, Luciano Minuzzi, Peter Bartenstein, Heidrun Potschka, Paul Cummin. Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar. NeuroImage. vol 49. issue 2. 2010-02-12. PMID:19796699. |
uptake and binding of the serotonin 5-ht1a antagonist [18f]-mppf in brain of rats: effects of the novel p-glycoprotein inhibitor tariquidar. |
2010-02-12 |
2023-08-12 |
rat |
| Takashi Ueda, Shinya Ugawa, Yusuke Ishida, Aki Hondoh, Shoichi Shimad. Development of generic calcium imaging assay for monitoring Gi-coupled receptors and G-protein interaction. Journal of biomolecular screening. vol 14. issue 7. 2010-02-03. PMID:19541673. |
the authors introduce a series of chimeras that combine both galpha16 and galpha(i/o) (galpha(16/o), galpha(16/i2), and galpha(16/i3)) into a well-established transient expression system to examine the ability of these chimeras to interact with d2 long-form (d2l) dopamine and 5-ht1a serotonin receptors. |
2010-02-03 |
2023-08-12 |
Not clear |
| Takashi Ueda, Shinya Ugawa, Yusuke Ishida, Aki Hondoh, Shoichi Shimad. Development of generic calcium imaging assay for monitoring Gi-coupled receptors and G-protein interaction. Journal of biomolecular screening. vol 14. issue 7. 2010-02-03. PMID:19541673. |
in contrast, the 5-ht1a receptor exhibited a significantly preferential coupling for galpha(16/i3) compared with galpha(16/i2) when serotonin was used as a ligand. |
2010-02-03 |
2023-08-12 |
Not clear |
| S Pasquier de Franclieu, C Germain, F Petitjea. [Aripiprazole induced Parkinsonism: A case report]. L'Encephale. vol 35. issue 5. 2010-02-01. PMID:19853725. |
it is a high-affinity partial agonist at the dopamine d2 and serotonin 5-ht1a receptors and an antagonist at serotonin 5-ht2 receptors. |
2010-02-01 |
2023-08-12 |
Not clear |
| A V Kulikov, V S Naumenko, D V Bazovkina, V Yu Dee, D V Osipova, N K Popov. Effect of mouse chromosome 13 terminal fragment on liability to catalepsy and expression of tryptophane hydroxylase-2, serotonin transporter, and 5-HT1A receptor genes in the brain. Bulletin of experimental biology and medicine. vol 147. issue 5. 2010-01-20. PMID:19907754. |
effect of mouse chromosome 13 terminal fragment on liability to catalepsy and expression of tryptophane hydroxylase-2, serotonin transporter, and 5-ht1a receptor genes in the brain. |
2010-01-20 |
2023-08-12 |
mouse |
| P E Harrison-Rea. Antimanic potency of typical neuroleptic drugs and affinity for dopamine D2 and serotonin 5-HT2A receptors--a new analysis of data from the archives and implications for improved antimanic treatments. Journal of psychopharmacology (Oxford, England). vol 23. issue 8. 2010-01-12. PMID:18635692. |
other considerations also suggest that combining drugs to achieve high affinity for and blockade of both dopamine d2 receptors and serotonin 5-ht2a receptors, possibly with additional direct or indirect stimulation of postsynaptic 5-ht1a receptors, might maximize antimanic efficacy. |
2010-01-12 |
2023-08-12 |
Not clear |
| Joanna Dabrowska, Przemyslaw Nowak, Ryszard Bru. Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion--implications for antidepressant-like action. Brain research. vol 1239. 2010-01-12. PMID:18789911. |
5-ht1a autoreceptor is involved in the regulation of 5-ht release as well as the pathogenesis of depression. |
2010-01-12 |
2023-08-12 |
rat |