All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Dieter Scheller, Christoph Ullmer, Reinhard Berkels, Mirella Gwarek, Hermann Lübber. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology. vol 379. issue 1. 2009-07-14. PMID:18704368. significant affinities were also demonstrated at alpha-adrenergic (alpha2b, ki=27 nm) and serotonin receptors (5-ht1a ki=30 nm). 2009-07-14 2023-08-12 Not clear
Dieter Scheller, Christoph Ullmer, Reinhard Berkels, Mirella Gwarek, Hermann Lübber. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology. vol 379. issue 1. 2009-07-14. PMID:18704368. at serotonergic sites, rotigotine had a weak but significant agonistic activity at 5-ht1a receptors and a minor or nonexistent activity at other serotonin receptors. 2009-07-14 2023-08-12 Not clear
David Moranta, Susana Esteban, Jesús A García-Sevill. Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 379. issue 1. 2009-07-14. PMID:18709357. in win-dependent rats (chronic and withdrawal states), the effect of a low dose of (+/-)-8-hydroxy-2-(di-n-propylamino)-tetralin (5-ht1a agonist; 0.1 mg/kg) on the accumulation of precursor amino acids was markedly potentiated in cerebellum and striatum, indicating the induction of supersensitivity of 5-ht1a-autoreceptors and 5-ht1a-heteroreceptors that regulate the synthesis of 5-ht, noradrenaline, and dopamine in these brain regions. 2009-07-14 2023-08-12 rat
Li-Ming Zhang, You-Zhi Zhang, Yan-Qin Liu, Ze-Hui Gong, Yi-Min Zhao, Yun-Feng L. CTN-986, a compound extracted from cottonseeds, increases cell proliferation in hippocampus in vivo and in cultured neural progenitor cells in vitro. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19326568. this effect was significantly reversed by co-incubation with serotonin 1a (5-ht1a) receptor antagonist way100635. 2009-07-07 2023-08-12 mouse
Jonathan Shelton, Pascal Bonaventure, Xiaorong Li, Sujin Yun, Timothy Lovenberg, Christine Dugovi. 5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor. Neuropharmacology. vol 56. issue 2. 2009-07-01. PMID:18948124. 5-ht7 receptor deletion enhances rem sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-ht1a receptor. 2009-07-01 2023-08-12 mouse
Xavier López-Gil, Francesc Artigas, Albert Adel. Role of different monoamine receptors controlling MK-801-induced release of serotonin and glutamate in the medial prefrontal cortex: relevance for antipsychotic action. The international journal of neuropsychopharmacology. vol 12. issue 4. 2009-06-26. PMID:18752722. to study the contribution of different monoaminergic receptors (for which clozapine and haloperidol exhibit distinct affinities) to these effects, here we used in-vivo microdialysis to examine the role of local blockade of dopamine d2, 5-ht2a and alpha1-adrenergic receptors as well as agonism at dopamine d1 and 5-ht1a receptors in the mpfc on the increased efflux of glutamate and 5-ht elicited by mk-801. 2009-06-26 2023-08-12 Not clear
Xavier López-Gil, Francesc Artigas, Albert Adel. Role of different monoamine receptors controlling MK-801-induced release of serotonin and glutamate in the medial prefrontal cortex: relevance for antipsychotic action. The international journal of neuropsychopharmacology. vol 12. issue 4. 2009-06-26. PMID:18752722. the results show that m100907 (5-ht2a antagonist), bay x 3702 (5-ht1a agonist) and prazosin (alpha1-adrenergic antagonist) blocked the mk-801-induced increase of 5-ht and glutamate in the mpfc. 2009-06-26 2023-08-12 Not clear
Claudia Sorbi, Silvia Franchini, Annalisa Tait, Adolfo Prandi, Rossella Gallesi, Piero Angeli, Gabriella Marucci, Lorenza Pirona, Elena Poggesi, Livio Brasil. 1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors. ChemMedChem. vol 4. issue 3. 2009-06-19. PMID:19152363. conformational restriction of naftopidil proved to be compatible with binding at alpha(1) adrenoceptor subtypes and 5-ht receptor 1a (5-ht(1a)), and led to the discovery of a new class of ligands with a 1,3-dioxolane (1,3-oxathiolane, 1,3-dithiolane) structure. 2009-06-19 2023-08-12 Not clear
Alexander Bohorquez, Laura M Hurle. Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus. Hearing research. vol 251. issue 1-2. 2009-06-19. PMID:19236912. metabotropic serotonin receptors such as 5-ht1a and 5-ht1b receptors shape the level, selectivity, and timing of auditory responses in the inferior colliculus (ic). 2009-06-19 2023-08-12 mouse
M A Tikhonova, E L Al'perina, T G Tolstikova, D V Bazovkina, V Iu Di, G V Idova, A V Kulikov, N K Popov. [Effects of chronic fluoxetine treatment on catalepsy and immune response in mice genetically predisposed to freezing reaction: the role of 5-HT1A and 5-HT2A receptors and tph2 and SERT genes]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 59. issue 2. 2009-06-19. PMID:19445393. no effect on cortical 5-ht1a and 5-ht2a receptor mrna levels and on 5-ht1a receptor, tph2 (tryptophan hydroxylase-2) and sert (serotonin transporter) mesencephalic gene expression was observed in asc mice. 2009-06-19 2023-08-12 mouse
Alain M Gardier, Bruno P Guiard, Jean-Philippe Guilloux, Christelle Repérant, François Coudoré, Denis J Davi. Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review. Fundamental & clinical pharmacology. vol 23. issue 1. 2009-06-01. PMID:19267769. the present review will thus focus on ko mice lacking g protein-coupled monoaminergic receptors (e.g; 5-ht1b, 5-ht1a, and 5-ht4 receptors) and the 5-ht serotonin transporter, which is the main target of antidepressant drugs (or strategies). 2009-06-01 2023-08-12 mouse
S B Pinnock, S E Lazic, H T Wong, I H W Wong, J Herber. Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat. Neuroscience. vol 158. issue 4. 2009-05-20. PMID:19068226. this synergistic action does not appear to be mediated by alterations in brain-derived neurotrophic factor (bdnf) gene expression; or by trkb, mineralocorticoid, glucocorticoid, or 5-ht (5ht1a) receptor expression in the dentate gyrus; or by altered levels of plasma corticosterone. 2009-05-20 2023-08-12 rat
Francis Rodriguez Bambico, Nhu-Tram Nguyen, Gabriella Gobb. Decline in serotonergic firing activity and desensitization of 5-HT1A autoreceptors after chronic unpredictable stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 3. 2009-05-20. PMID:19147333. these were associated with a decrease in the spontaneous firing activity (35.4%) as well as in the number of spontaneously active 5-ht neurons, and a desensitization of somatodendritic 5-ht1a autoreceptors in the dorsal raphe. 2009-05-20 2023-08-12 rat
Francis Rodriguez Bambico, Nhu-Tram Nguyen, Gabriella Gobb. Decline in serotonergic firing activity and desensitization of 5-HT1A autoreceptors after chronic unpredictable stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 3. 2009-05-20. PMID:19147333. these results suggest that cus dramatically decreases 5-ht neural activity and 5-ht1a autoreceptor sensitivity, and may represent endophenotypic features of depressive-like states. 2009-05-20 2023-08-12 rat
John T Mondick, Charles Oo, Dimple Patel, Tomomichi Fujitani, Kahori Shimizu, Jeffrey S Barret. Population pharmacokinetics of the selective serotonin 5-HT1A receptor partial agonist piclozotan. American journal of therapeutics. vol 16. issue 2. 2009-05-15. PMID:19300037. population pharmacokinetics of the selective serotonin 5-ht1a receptor partial agonist piclozotan. 2009-05-15 2023-08-12 Not clear
Antonio Drago, Diana De Ronchi, Alessandro Serrett. Pharmacogenetics of antidepressant response: an update. Human genomics. vol 3. issue 3. 2009-05-14. PMID:19403460. some replicated findings in the literature have suggested the serotonin transporter promoter (5-httlpr), serotonin receptor 1a (htr1a), serotonin receptor 2a (htr2a), brain derived neurotrophic factor (bdnf), corticotropin releasing hormone receptor 1 (crhr1) and fk506 binding protein 5 (fkbp5) as putative regulators of the antidepressant response. 2009-05-14 2023-08-12 Not clear
Jian-song Zhou, Lingjiang Li, Xia Cao, Xiang-hui Zhang, Wei-hui Li, Ze-xuan L. [Effect of 5-HT and postsynaptic 5-HT1 A on the mood and recogniztion of the repeated restraint stress in rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 33. issue 4. 2009-05-07. PMID:18460773. to explore the role of 5-ht and postsynaptic 5-ht1a receptors in the stress adaptation. 2009-05-07 2023-08-12 rat
Su-xia Li, Yan Zou, Li-jing Liu, Ping Wu, Lin L. Aripiprazole blocks reinstatement but not expression of morphine conditioned place preference in rats. Pharmacology, biochemistry, and behavior. vol 92. issue 2. 2009-04-27. PMID:19353810. aripiprazole is an atypical antipsychotic drug primarily characterized by partial agonist activity at dopamine(da) d2 receptors and serotonin-1a (5-hydroxytryptamine, 5-ht1a) receptors and minimal side effects.based on its pharmacological profile, including stabilization of mesocorticolimbic da activity (a pathway implicated in drug addiction), we investigated the effects of aripiprazole on relapse to morphine seeking in rats. 2009-04-27 2023-08-12 rat
Maria Adrielle Vicente, Hélio Zangrossi, Lucinéia dos Santos, Carlos Eduardo de Macedo, Telma Gonçalves C S Andrad. Involvement of median raphe nucleus 5-HT1A receptors in the regulation of generalized anxiety-related defensive behaviours in rats. Neuroscience letters. vol 445. issue 3. 2009-04-16. PMID:18789373. overall, the current findings support the view that mrn 5-ht neurons, through the regulation of 5-ht1a somatodendritic autoreceptors, are implicated in the regulation of generalized anxiety-associated behaviours. 2009-04-16 2023-08-12 rat
b' Ricard Navin\\xc3\\xa9s, Roc\\xc3\\xado Mart\\xc3\\xadn-Santos, Esther G\\xc3\\xb3mez-Gil, Mar\\xc3\\xada J Mart\\xc3\\xadnez de Osaba, Crist\\xc3\\xb2bal Gast\\xc3\\xb. Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 8. 2009-04-15. PMID:18725263.' interaction between serotonin 5-ht1a receptors and beta-endorphins modulates antidepressant response. 2009-04-15 2023-08-12 Not clear