| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Ricard Navin\\xc3\\xa9s, Roc\\xc3\\xado Mart\\xc3\\xadn-Santos, Esther G\\xc3\\xb3mez-Gil, Mar\\xc3\\xada J Mart\\xc3\\xadnez de Osaba, Crist\\xc3\\xb2bal Gast\\xc3\\xb. Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 8. 2009-04-15. PMID:18725263.' |
interaction between serotonin 5-ht1a receptors and beta-endorphins modulates antidepressant response. |
2009-04-15 |
2023-08-12 |
Not clear |
| b' Ricard Navin\\xc3\\xa9s, Roc\\xc3\\xado Mart\\xc3\\xadn-Santos, Esther G\\xc3\\xb3mez-Gil, Mar\\xc3\\xada J Mart\\xc3\\xadnez de Osaba, Crist\\xc3\\xb2bal Gast\\xc3\\xb. Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 8. 2009-04-15. PMID:18725263.' |
activation of serotonin 5-ht1a receptors has been shown to increase plasma beta-endorphin (beta-end) levels in animal studies and in healthy humans. |
2009-04-15 |
2023-08-12 |
Not clear |
| Chiung-Wen Chang, Ethan Poteet, John A Schetz, Zeynep H Gümüş, Harel Weinstei. Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18762202. |
to reveal the properties of the signaling pathways, and the way in which responses elicited through these receptors alone and in combination with other serotonin receptors' subtypes (the 5-ht1ar), we developed a detailed mathematical model of receptor-mediated erk1/2 activation in cells expressing the 5-ht1a and 5-ht2a subtypes individually, and together. |
2009-04-15 |
2023-08-12 |
Not clear |
| Elena Castro, Alvaro Díaz, Antonio Rodriguez-Gaztelumendi, Elena Del Olmo, Angel Pazo. WAY100635 prevents the changes induced by fluoxetine upon the 5-HT1A receptor functionality. Neuropharmacology. vol 55. issue 8. 2009-04-15. PMID:18809415. |
5-ht1a receptor-mediated signalling in rat brain was evaluated after chronic administration (14 days; s.c.) of the selective serotonin reuptake inhibitor (srri) fluoxetine (10 mg/kg/day) alone, or in combination with the 5-ht1a receptor antagonist way100635 (0.1 mg/kg/day). |
2009-04-15 |
2023-08-12 |
rat |
| Elena Castro, Alvaro Díaz, Antonio Rodriguez-Gaztelumendi, Elena Del Olmo, Angel Pazo. WAY100635 prevents the changes induced by fluoxetine upon the 5-HT1A receptor functionality. Neuropharmacology. vol 55. issue 8. 2009-04-15. PMID:18809415. |
chronic administration of way100635 alone did not affect the 5-ht1a receptor-induced stimulation of [35s]gtpgammas binding, nor the 8-oh-dpat-induced inhibition of 5-ht neuron firing. |
2009-04-15 |
2023-08-12 |
rat |
| Kristin B Dupre, Karen L Eskow, Christopher J Barnum, Christopher Bisho. Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat. Neuropharmacology. vol 55. issue 8. 2009-04-15. PMID:18824001. |
convergent evidence suggests that serotonin 5-ht1a receptor (5-ht1ar) agonists reduce l-dopa-induced dyskinesia by auto-regulating aberrant release of l-dopa-derived dopamine (da) from raphestriatal neurons. |
2009-04-15 |
2023-08-12 |
rat |
| E Engin, J Stellbrink, D Treit, C T Dickso. Anxiolytic and antidepressant effects of intracerebroventricularly administered somatostatin: behavioral and neurophysiological evidence. Neuroscience. vol 157. issue 3. 2009-04-14. PMID:18940236. |
benzodiazepines, selective 5-ht reuptake inhibitors, 5-ht1a agonists) provides strong converging evidence for the anxiolytic-like characteristics of sst. |
2009-04-14 |
2023-08-12 |
rat |
| Vanessa de Paula Soares, Hélio Zangross. Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats. Behavioural brain research. vol 197. issue 1. 2009-04-10. PMID:18801389. |
moreover, as shown by the results of antagonism studies, 5-ht2a receptors are recruited for the anxiolysis caused by serotonin and doi, while 5-ht1a receptors account for the effect of 8-oh-dpat. |
2009-04-10 |
2023-08-12 |
rat |
| Akira Asagarasu, Teruaki Matsui, Hiroyuki Hayashi, Satoru Tamaoki, Yukinao Yamauchi, Michitaka Sat. Design and synthesis of piperazinylpyridine derivatives as novel 5-HT1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS). Chemical & pharmaceutical bulletin. vol 57. issue 1. 2009-04-06. PMID:19122313. |
these compounds, which were designed by pharmacophore analysis, bind to both serotonin subtype 1a (5-ht1a) and subtype 3 (5-ht3) receptors. |
2009-04-06 |
2023-08-12 |
Not clear |
| M Shahid, G B Walker, S H Zorn, E H F Won. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18308814. |
in comparison with the antipsychotics, asenapine showed high affinity and a different rank order of binding affinities (pki) for serotonin receptors (5-ht1a [8.6], 5-ht1b [8.4], 5-ht2a [10.2], 5-ht2b [9.8], 5-ht2c [10.5], 5-ht5 [8.8], 5-ht6 [9.6] and 5-ht7 [9.9]), adrenoceptors (alpha1 [8.9], alpha2a [8.9], alpha2b [9.5] and alpha2c [8.9]), dopamine receptors (d1 [8.9], d2 [8.9], d3 [9.4] and d4 [9.0]) and histamine receptors (h1 [9.0] and h2 [8.2]). |
2009-04-03 |
2023-08-12 |
human |
| Esther Berrocoso, Juan A Mic. Role of serotonin 5-HT1A receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice. The international journal of neuropsychopharmacology. vol 12. issue 1. 2009-03-13. PMID:18405417. |
role of serotonin 5-ht1a receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice. |
2009-03-13 |
2023-08-12 |
mouse |
| Rainald Mössner, Anna Schuhmacher, Kai-Uwe Kühn, Gabriela Cvetanovska, Dan Rujescu, Peter Zill, Boris B Quednow, Marcella Rietschel, Wolfgang Wölwer, Wolfgang Gaebel, Michael Wagner, Wolfgang Maie. Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia. Pharmacogenetics and genomics. vol 19. issue 1. 2009-03-03. PMID:18849890. |
the serotonin (5-ht) 1a receptor has been found to be dysregulated in prefrontal cortex and other brain regions in schizophrenia, and 5-ht1a receptor levels in the amygdala have been related to negative schizophrenia symptoms. |
2009-03-03 |
2023-08-12 |
Not clear |
| Jhodie R Duncan, David S Paterson, Hannah C Kinne. The development of nicotinic receptors in the human medulla oblongata: inter-relationship with the serotonergic system. Autonomic neuroscience : basic & clinical. vol 144. issue 1-2. 2009-02-20. PMID:18986852. |
the distribution of different nachrs was determined from 39-82 postconceptional weeks (n=5) using tissue autoradiography for 3h-nicotine, 3h-epibatidine, 3h-cytisine, and 125i-bungarotoxin; the findings were compared to laboratory 5-ht1a and 5-ht transporter binding data, and 5-ht neuronal density. |
2009-02-20 |
2023-08-12 |
human |
| Andrew Holme. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18439676. |
serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c, 5-ht3a, 5-ht4, 5-ht5a, 5-ht6, 5-ht7), reuptake (serotonin transporter), and degradation (monoamine oxidase a). |
2009-02-19 |
2023-08-12 |
mouse |
| Judith R Homberg, Sietse F De Boer, Halfdan S Raasø, Jocelien D A Olivier, Mark Verheul, Eric Ronken, Alexander R Cools, Bart A Ellenbroek, Anton N M Schoffelmeer, Louk J M J Vanderschuren, Taco J De Vries, Edwin Cuppe. Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology. vol 200. issue 3. 2009-02-09. PMID:18581099. |
adaptations in pre- and postsynaptic 5-ht1a receptor function and cocaine supersensitivity in serotonin transporter knockout rats. |
2009-02-09 |
2023-08-12 |
rat |
| Stefania Butini, Sandra Gemma, Giuseppe Campiani, Silvia Franceschini, Francesco Trotta, Marianna Borriello, Nicoletta Ceres, Sindu Ros, Salvatore Sanna Coccone, Matteo Bernetti, Meri De Angelis, Margherita Brindisi, Vito Nacci, Isabella Fiorini, Ettore Novellino, Alfredo Cagnotto, Tiziana Mennini, Karin Sandager-Nielsen, Jesper Tobias Andreasen, Jorgen Scheel-Kruger, Jens D Mikkelsen, Caterina Fattoruss. Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior. Journal of medicinal chemistry. vol 52. issue 1. 2009-02-06. PMID:19072656. |
discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-ht1a and 5-ht2a receptors: design, synthesis, and effects on behavior. |
2009-02-06 |
2023-08-12 |
Not clear |
| Thibault Renoir, Eleni Païzanis, Malika El Yacoubi, Françoise Saurini, Naïma Hanoun, Maxette Melfort, Klaus Peter Lesch, Michel Hamon, Laurence Lanfume. Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice. The international journal of neuropsychopharmacology. vol 11. issue 8. 2009-01-26. PMID:18611291. |
four weeks after mdma administration (20 mg/kg b.i.d for 4 d), a 2-fold increase in the potency of the 5-ht1a receptor agonist ipsapirone to inhibit the discharge of drn 5-ht neurons and a larger hypothermic response to 8-oh-dpat were observed in mdma- compared to saline-treated mice. |
2009-01-26 |
2023-08-12 |
mouse |
| Thibault Renoir, Eleni Païzanis, Malika El Yacoubi, Françoise Saurini, Naïma Hanoun, Maxette Melfort, Klaus Peter Lesch, Michel Hamon, Laurence Lanfume. Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice. The international journal of neuropsychopharmacology. vol 11. issue 8. 2009-01-26. PMID:18611291. |
this adaptive 5-ht1a autoreceptor supersensitivity was associated with decreases in 5-ht levels but no changes of [3h]citalopram binding in brain. |
2009-01-26 |
2023-08-12 |
mouse |
| Mostafa El Mansari, Ramez Ghanbari, Shannon Janssen, Pierre Blie. Sustained administration of bupropion alters the neuronal activity of serotonin, norepinephrine but not dopamine neurons in the rat brain. Neuropharmacology. vol 55. issue 7. 2009-01-26. PMID:18708076. |
these results indicate that bupropion, unlike 5-ht reuptake inhibitors, promptly increased 5-ht neuronal activity, due to early desensitization of the 5-ht1a autoreceptor. |
2009-01-26 |
2023-08-12 |
rat |
| b' Sean P David, Elaine C Johnstone, Michael F G Murphy, Paul Aveyard, Boliang Guo, Caryn Lerman, Marcus R Munaf\\xc3\\xb. Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses. Drug and alcohol dependence. vol 98. issue 1-2. 2009-01-23. PMID:18562131.' |
therefore, 792 cigarette smokers from the patch in practice trial were genotyped for the tryptophan hydroxylase (tph1 a779c), serotonin transporter (slc6a45-httlpr), and 5-ht1a (htr1a c-1019g) polymorphisms. |
2009-01-23 |
2023-08-12 |
Not clear |