| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H G Kumperscak, V Dolzan, A Videtic, B K Plesnica. Polymorphisms in genes encoding the serotonin and dopamine pathways in two sisters with metachromatic leukodystrophy. The Journal of international medical research. vol 36. issue 5. 2008-10-27. PMID:18831910. |
the sisters shared dopamine receptor d(2) (drd(2)) c.1047gg (p.311ser/ser) and c.-141cins/ins polymorphisms, which are significantly associated with schizophrenia, but differed in the serotonin transporter gene-linked polymorphic region and serotonin receptor 1a (5-ht(1a)) c.-1019c to g polymorphisms, which may have increased the elder sister's susceptibility to depressive symptoms. |
2008-10-27 |
2023-08-12 |
Not clear |
| Marie-Bernadette Assié, Elisabeth Carilla-Durand, Laurent Bardin, Mireille Maraval, Monique Aliaga, Nathalie Malfètes, Michèle Barbara, Adrian Newman-Tancred. The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063. European journal of pharmacology. vol 592. issue 1-3. 2008-10-24. PMID:18640111. |
several novel antipsychotics activate serotonin 5-ht1a receptors as well as antagonising dopamine d2/3 receptors. |
2008-10-24 |
2023-08-12 |
rat |
| Nobuaki Egashira, Ryoko Okuno, Michihiko Matsushita, Moe Abe, Kenichi Mishima, Katsunori Iwasaki, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwar. Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms. European journal of pharmacology. vol 592. issue 1-3. 2008-10-24. PMID:18644366. |
aripiprazole is a first next-generation atypical antipsychotic drug with dopamine system stabilizing, serotonin (5-hydroxytryptamine, 5-ht) 5-ht1a receptor partial agonistic, and 5-ht2a receptor antagonistic properties. |
2008-10-24 |
2023-08-12 |
mouse |
| Ana Carolina Tramontina, Francine Tramontina, Larissa D Bobermin, Caroline Zanotto, Daniela F Souza, Marina C Leite, Patrícia Nardin, Carmem Gottfried, Carlos-Alberto Gonçalve. Secretion of S100B, an astrocyte-derived neurotrophic protein, is stimulated by fluoxetine via a mechanism independent of serotonin. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 6. 2008-10-22. PMID:18582527. |
moreover, we found that serotonin (possibly via the 5ht1a receptor) reduces s100b secretion and antagonizes the effect of fluoxetine on s100b secretion. |
2008-10-22 |
2023-08-12 |
Not clear |
| Kyu Seung Lee, Tae Hee Han, Ji Yoon Jo, Gun Kang, So Yeong Lee, Pan Dong Ryu, Jae Hyeng Im, Byeong Hwa Jeon, Jin Bong Par. Serotonin inhibits GABA synaptic transmission in presympathetic paraventricular nucleus neurons. Neuroscience letters. vol 439. issue 2. 2008-10-14. PMID:18524490. |
the sipsc inhibition of 5-ht was mimicked by 5-ht1a agonist, 8-oh-dpat (8-hydroxy-2(di-n-propylamino)tetralin, 10 microm), and blocked by 5-ht1a antagonist way-100635 but not by 5-ht1b antagonist sb224289. |
2008-10-14 |
2023-08-12 |
Not clear |
| Kyu Seung Lee, Tae Hee Han, Ji Yoon Jo, Gun Kang, So Yeong Lee, Pan Dong Ryu, Jae Hyeng Im, Byeong Hwa Jeon, Jin Bong Par. Serotonin inhibits GABA synaptic transmission in presympathetic paraventricular nucleus neurons. Neuroscience letters. vol 439. issue 2. 2008-10-14. PMID:18524490. |
all together, our results indicate that 5-ht can inhibit presynaptic gaba release via presynaptic 5-ht1a receptors in presympathetic pvn neurons projecting to spinal cord. |
2008-10-14 |
2023-08-12 |
Not clear |
| S O'Mahony, A S B Chua, E M M Quigley, G Clarke, F Shanahan, P W N Keeling, T G Dina. Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 6. 2008-10-13. PMID:18194152. |
serotonin metabolites were measured together with the expression of the 5ht1a and serotonin transporter (sert) gene. |
2008-10-13 |
2023-08-12 |
rat |
| Brian George Dias, David Crew. Regulation of pseudosexual behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens. Endocrinology. vol 149. issue 9. 2008-10-02. PMID:18483155. |
postovulatory and ovx plus t animals have lower intracellular serotonin (5-ht) levels, and greater abundance of inhibitory 5-ht1a receptor mrna in the poa compared with both preov and ovx plus e lizards. |
2008-10-02 |
2023-08-12 |
Not clear |
| Sigeng Chen, Geoffrey C Owens, David B Edelma. Dopamine inhibits mitochondrial motility in hippocampal neurons. PloS one. vol 3. issue 7. 2008-09-24. PMID:18665222. |
in an earlier study, we found that serotonin (5-ht), acting through the 5-ht1a receptor subtype, promotes axonal transport of mitochondria in cultured hippocampal neurons by increasing akt activity, and consequently decreasing glycogen synthase kinase (gsk3beta) activity. |
2008-09-24 |
2023-08-12 |
Not clear |
| Dahui Zhou, Ping Zhou, Deborah A Evrard, Kristin Meagher, Michael Webb, Boyd L Harrison, Donna M Huryn, Jeannette Golembieski, Geoffrey A Hornby, Lee E Schechter, Deborah L Smith, Terrance H Andree, Richard E Mewsha. Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives. Bioorganic & medicinal chemistry. vol 16. issue 14. 2008-09-11. PMID:18571421. |
part 6: dual 5-ht1a receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives. |
2008-09-11 |
2023-08-12 |
Not clear |
| Karl Ebner, Georg M Singewald, Nigel Whittle, Francesco Ferraguti, Nicolas Singewal. Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 8. 2008-09-02. PMID:17957216. |
this effect seems to be mediated by enhanced intraseptal serotonergic transmission via serotonin (5-ht)1a receptors since nk1r blockade reversed the swim stress-induced decrease to an increase in extracellular 5-ht efflux, and furthermore the behavioral effects of l-822429 were blocked by intraseptal 5-ht1a receptor antagonism. |
2008-09-02 |
2023-08-12 |
rat |
| Ihoko Muraki, Takeshi Inoue, Tsukasa Koyam. Effect of co-administration of the selective 5-HT1A receptor antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 on anxiolytic effect of citalopram in conditioned fear stress in the rat. European journal of pharmacology. vol 586. issue 1-3. 2008-09-02. PMID:18423441. |
this study investigated the effect of co-administration of the selective 5-ht1a receptor antagonist way 100,635 and selective 5-ht(1b/1d) receptor antagonist gr 127,935 with a subactive dose of citalopram [selective serotonin (5-ht) reuptake inhibitor (ssri)] on the expression of conditioned freezing, an index of fear. |
2008-09-02 |
2023-08-12 |
rat |
| Tetsuya Takahashi, Hironori Mitsuya, Tetsuhito Murata, Junichi Murayama, Yuji Wad. Opposite effects of SSRIs and tandospirone in the treatment of REM sleep behavior disorder. Sleep medicine. vol 9. issue 3. 2008-08-29. PMID:17644482. |
we encountered a patient with idiopathic rbd that dramatically improved with selective serotonin reuptake inhibitors (ssris) and deteriorated with a 5-ht1a partial agonist, tandospirone. |
2008-08-29 |
2023-08-12 |
Not clear |
| Hiroko Hagiwara, Yuko Fujita, Tamaki Ishima, Shinsui Kunitachi, Yukihiko Shirayama, Masaomi Iyo, Kenji Hashimot. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 6. 2008-08-13. PMID:18164909. |
phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-ht1a receptors. |
2008-08-13 |
2023-08-12 |
mouse |
| Jussi Hirvonen, Hasse Karlsson, Jaana Kajander, Antti Lepola, Juha Markkula, Helena Rasi-Hakala, Kjell Någren, Jouko K Salminen, Jarmo Hietal. Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635. The international journal of neuropsychopharmacology. vol 11. issue 4. 2008-08-08. PMID:17971260. |
decreased brain serotonin 5-ht1a receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using pet and [carbonyl-11c]way-100635. |
2008-08-08 |
2023-08-12 |
human |
| Jussi Hirvonen, Hasse Karlsson, Jaana Kajander, Antti Lepola, Juha Markkula, Helena Rasi-Hakala, Kjell Någren, Jouko K Salminen, Jarmo Hietal. Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635. The international journal of neuropsychopharmacology. vol 11. issue 4. 2008-08-08. PMID:17971260. |
this study demonstrated a widespread reduction in the availability of serotonin 5-ht1a receptors in a relatively large sample of drug-naive primary-care patients with mdd, suggesting the involvement of this receptor subtype in the pathophysiology of the illness. |
2008-08-08 |
2023-08-12 |
human |
| E Fiske, C M Portas, J Grønli, E Sørensen, B Bjorvatn, A A Bjørkum, R Ursi. Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats. Acta physiologica (Oxford, England). vol 193. issue 1. 2008-08-01. PMID:18081887. |
increased extracellular 5-ht but no change in sleep after perfusion of a 5-ht1a antagonist into the dorsal raphe nucleus of rats. |
2008-08-01 |
2023-08-12 |
rat |
| Fritz Kobe, Ute Renner, Andrew Woehler, Jakub Wlodarczyk, Ekaterina Papusheva, Guobin Bao, Andre Zeug, Diethelm W Richter, Erwin Neher, Evgeni Ponimaski. Stimulation- and palmitoylation-dependent changes in oligomeric conformation of serotonin 5-HT1A receptors. Biochimica et biophysica acta. vol 1783. issue 8. 2008-08-01. PMID:18381076. |
stimulation- and palmitoylation-dependent changes in oligomeric conformation of serotonin 5-ht1a receptors. |
2008-08-01 |
2023-08-12 |
Not clear |
| Fritz Kobe, Ute Renner, Andrew Woehler, Jakub Wlodarczyk, Ekaterina Papusheva, Guobin Bao, Andre Zeug, Diethelm W Richter, Erwin Neher, Evgeni Ponimaski. Stimulation- and palmitoylation-dependent changes in oligomeric conformation of serotonin 5-HT1A receptors. Biochimica et biophysica acta. vol 1783. issue 8. 2008-08-01. PMID:18381076. |
in the present study we analyzed the oligomerization state of the serotonin 5-ht1a receptor and studied oligomerization dynamics in living cells. |
2008-08-01 |
2023-08-12 |
Not clear |
| Chi-Un Pae, Alessandro Serretti, Ashwin A Patkar, Praksh S Masan. Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence. CNS drugs. vol 22. issue 5. 2008-08-01. PMID:18399707. |
such mechanisms include aripiprazole action at serotonin (5-ht) receptors as a 5-ht1a partial receptor agonist, a 5-ht2c partial receptor agonist and a 5-ht2a receptor antagonist. |
2008-08-01 |
2023-08-12 |
Not clear |