| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Wedzony, A Chocyk, W Kolasiewicz, M Maćkowia. Glutamatergic neurons of rat medial prefrontal cortex innervating the ventral tegmental area are positive for serotonin 5-HT1A receptor protein. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 58. issue 4. 2008-04-24. PMID:18195476. |
recent data stress the role of serotonin 5-ht1a receptors in the pathology of schizophrenia, and in the mechanism of action of novel antipsychotic drugs. |
2008-04-24 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, W Kolasiewicz, M Maćkowia. Glutamatergic neurons of rat medial prefrontal cortex innervating the ventral tegmental area are positive for serotonin 5-HT1A receptor protein. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 58. issue 4. 2008-04-24. PMID:18195476. |
it was found that approximately 52% of cells in layers ii/iii of the mpc whose axons initial segments were immunoreactive for serotonin 5ht1a receptor were also labeled with fluoro-gold (fg), a retrograde tracer injected into the vta, indicating that certain portion of neurons forming glutamatergic innervations of the vta may be controlled by serotonin 5-ht1a receptors. |
2008-04-24 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, W Kolasiewicz, M Maćkowia. Glutamatergic neurons of rat medial prefrontal cortex innervating the ventral tegmental area are positive for serotonin 5-HT1A receptor protein. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 58. issue 4. 2008-04-24. PMID:18195476. |
in deep cortical layers (v/vi) retrogradely labeled neurons never colocalized with serotonin 5-ht1a receptormmunoreactivity. |
2008-04-24 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, W Kolasiewicz, M Maćkowia. Glutamatergic neurons of rat medial prefrontal cortex innervating the ventral tegmental area are positive for serotonin 5-HT1A receptor protein. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 58. issue 4. 2008-04-24. PMID:18195476. |
these anatomical data indicate that serotonin 5-ht1a receptors might potentially control the excitability and propagation of information transmitted by the pyramidal cells to the vta. |
2008-04-24 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, W Kolasiewicz, M Maćkowia. Glutamatergic neurons of rat medial prefrontal cortex innervating the ventral tegmental area are positive for serotonin 5-HT1A receptor protein. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 58. issue 4. 2008-04-24. PMID:18195476. |
moreover, our results indicate that the drugs operating via serotonin 5-ht1a receptors in the mpc, might control from this level the release of glutamate in the vta and restore function of glutamate neurotransmission, whose dysfunction is observed for example in schizophrenia. |
2008-04-24 |
2023-08-12 |
rat |
| Lucinéia Dos Santos, Telma G C S de Andrade, Hélio Zangrossi Junio. 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 4. 2008-04-23. PMID:17728111. |
5-ht1a receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-ht neurons in the median raphe nucleus. |
2008-04-23 |
2023-08-12 |
rat |
| Lucinéia Dos Santos, Telma G C S de Andrade, Hélio Zangrossi Junio. 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 4. 2008-04-23. PMID:17728111. |
we evaluated the involvement of dorsal hippocampus (dh) 5-ht1a receptors in the mediation of the behavioral effects caused by the pharmacological manipulation of 5-ht neurons in the median raphe nucleus (mrn). |
2008-04-23 |
2023-08-12 |
rat |
| Lucinéia Dos Santos, Telma G C S de Andrade, Hélio Zangrossi Junio. 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 4. 2008-04-23. PMID:17728111. |
these results indicate that dh 5-ht1a receptors mediate the anxiogenic effect induced by the selective stimulation of 5-ht neurons in the mrn. |
2008-04-23 |
2023-08-12 |
rat |
| Christian Geretsegger, Waltraud Bitterlich, Renate Stelzig, Christoph Stuppaeck, Brigitta Bondy, Wolfgang Aichhor. Paroxetine with pindolol augmentation: a double-blind, randomized, placebo-controlled study in depressed in-patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 2. 2008-04-18. PMID:18054209. |
pindolol, a 5-ht1a autoreceptor antagonist, given in combination with selective serotonin reuptake inhibitors (ssris), may enhance and/or accelerate the therapeutic efficacy of ssris. |
2008-04-18 |
2023-08-12 |
Not clear |
| A Rex, J P Voigt, K M Wicke, H Fin. In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17888505. |
serotonin 5-ht1a and 5-ht1b/1d receptors control serotonin (5-ht) release and are targets for the pharmacological treatment of psychiatric disorders. |
2008-04-09 |
2023-08-12 |
Not clear |
| A Rex, J P Voigt, K M Wicke, H Fin. In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17888505. |
we investigated effects of the 5-ht1b/1d antagonist gr127935, the 5-ht1a antagonist way 100635 and a combination of both in guinea pigs on the behaviour in the forced swimming test and on extracellular 5-ht in the hippocampus and the prefrontal cortex using in vivo microdialysis. |
2008-04-09 |
2023-08-12 |
Not clear |
| William E Fantegrossi, Chad J Reissig, Elyse B Katz, Haley L Yarosh, Kenner C Rice, Jerrold C Winte. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17905422. |
hallucinogen-like effects of n,n-dipropyltryptamine (dpt): possible mediation by serotonin 5-ht1a and 5-ht2a receptors in rodents. |
2008-04-09 |
2023-08-12 |
mouse |
| William E Fantegrossi, Chad J Reissig, Elyse B Katz, Haley L Yarosh, Kenner C Rice, Jerrold C Winte. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17905422. |
a separate group of rats was also trained to recognize dpt itself as a discriminative stimulus, and in all cases, the behavioral effects of dpt were challenged with the selective serotonin (5-ht)2a antagonist m100907, the 5-ht1a selective antagonist way-100635, or their combination. |
2008-04-09 |
2023-08-12 |
mouse |
| C J Reissig, J R Eckler, R A Rabin, K C Rice, J C Winte. The stimulus effects of 8-OH-DPAT: evidence for a 5-HT2A receptor-mediated component. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17936346. |
also suggestive of behaviorally relevant interactions between 5-ht1a and 5-ht2a receptors are behavioral analyses of locomotor activity, head-twitch response, forepaw treading and production of the serotonin syndrome; in some instances effects are augmented, in other, diminished. |
2008-04-09 |
2023-08-12 |
rat |
| Gilda Neves, Michele Kliemann, Andresa H Betti, Daniela J Conrado, Leandro Tasso, Carlos A M Fraga, Eliezer J Barreiro, Teresa Dalla Costa, Stela M K Rate. Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581. Pharmacology, biochemistry, and behavior. vol 89. issue 1. 2008-04-09. PMID:18082872. |
the serotonin 5-ht1a antagonist way 100635 (0.05 mg/kg, s.c.) abolished the hypothermia induced by lassbio-579 and diminished the hypothermia induced by lassbio-581. |
2008-04-09 |
2023-08-12 |
mouse |
| Robert J Carey, Gail DePalma, Arielle Shanahan, Ernest N Damianopoulos, Christian P Müller, Joseph P Husto. Effects on spontaneous and cocaine-induced behavior of pharmacological inhibition of noradrenergic and serotonergic systems. Pharmacology, biochemistry, and behavior. vol 89. issue 1. 2008-04-09. PMID:18155756. |
in order to selectively block the increases in ne and 5-ht evoked by cocaine, autoreceptor preferring low doses (0.01, 0.025 and 0.05 mg/kg) of the a2 agonist, clonidine or the 5-ht1a agonist, 8-ohdpat were given as pretreatments 20 min prior to saline or cocaine (10.0 mg/kg) in separate groups of rats (n=10). |
2008-04-09 |
2023-08-12 |
rat |
| Anh Dzung Lê, Anh Lê Dzung, Douglas Funk, Stephen Harding, Walter Juzytsch, Zhaoxia Li, Paul J Fletche. Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward. Psychopharmacology. vol 195. issue 4. 2008-03-31. PMID:17891381. |
we previously found that the inhibition of median raphe nucleus (mrn) 5-ht transmission by local injections of a 5-ht1a agonist 8-oh-dpat or corticotrophin-releasing factor (crf) mimic the effect of foot shock stress to reinstate alcohol seeking. |
2008-03-31 |
2023-08-12 |
rat |
| James W Crane, Keiko Shimizu, Gonzalo A Carrasco, Francisca Garcia, Cuihong Jia, Nicole R Sullivan, Deborah N D'Souza, Yahong Zhang, Louis D Van de Kar, Nancy A Muma, George Battagli. 5-HT1A receptors mediate (+)8-OH-DPAT-stimulation of extracellular signal-regulated kinase (MAP kinase) in vivo in rat hypothalamus: time dependence and regional differences. Brain research. vol 1183. 2008-03-25. PMID:17976547. |
brain serotonin 1a (5-ht1a) receptors play an important role in mood disorders and can modulate various intracellular signaling mechanisms. |
2008-03-25 |
2023-08-12 |
rat |
| P Salazar-Colocho, J Del Río, D Frechill. Serotonin 5-hT1A receptor activation prevents phosphorylation of NMDA receptor NR1 subunit in cerebral ischemia. Journal of physiology and biochemistry. vol 63. issue 3. 2008-03-13. PMID:18309776. |
serotonin 5-ht1a receptor activation prevents phosphorylation of nmda receptor nr1 subunit in cerebral ischemia. |
2008-03-13 |
2023-08-12 |
Not clear |
| P Salazar-Colocho, J Del Río, D Frechill. Serotonin 5-hT1A receptor activation prevents phosphorylation of NMDA receptor NR1 subunit in cerebral ischemia. Journal of physiology and biochemistry. vol 63. issue 3. 2008-03-13. PMID:18309776. |
the mechanisms involved in the neuroprotective effect of serotonin 5-ht1a receptor agonists on brain damage induced by ischemia remain to be fully elucidated. |
2008-03-13 |
2023-08-12 |
Not clear |