| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liesbeth A Bruins Slot, Luc De Vries, Adrian Newman-Tancredi, Didier Cussa. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. European journal of pharmacology. vol 534. issue 1-3. 2006-06-07. PMID:16497294. |
differential profile of antipsychotics at serotonin 5-ht1a and dopamine d2s receptors coupled to extracellular signal-regulated kinase. |
2006-06-07 |
2023-08-12 |
human |
| Liesbeth A Bruins Slot, Luc De Vries, Adrian Newman-Tancredi, Didier Cussa. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. European journal of pharmacology. vol 534. issue 1-3. 2006-06-07. PMID:16497294. |
the effects of antipsychotics targeting dopamine d2 and serotonin 5-ht1a receptors were compared with conventional antipsychotics on phosphorylation of extracellular signal-regulated kinase 1/2 (erk 1/2) in cho cell lines stably expressing either the human serotonin 5-ht1a or human dopamine d2s receptor. |
2006-06-07 |
2023-08-12 |
human |
| Liesbeth A Bruins Slot, Luc De Vries, Adrian Newman-Tancredi, Didier Cussa. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. European journal of pharmacology. vol 534. issue 1-3. 2006-06-07. PMID:16497294. |
all antipsychotics except haloperidol and olanzapine exhibited agonist properties at serotonin 5-ht1a receptors. |
2006-06-07 |
2023-08-12 |
human |
| Liesbeth A Bruins Slot, Luc De Vries, Adrian Newman-Tancredi, Didier Cussa. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. European journal of pharmacology. vol 534. issue 1-3. 2006-06-07. PMID:16497294. |
amongst the dopamine d2/serotonin 5-ht1a receptor compounds, aripiprazole acts as a partial dopamine d2s and serotonin 5-ht1a receptor agonist. |
2006-06-07 |
2023-08-12 |
human |
| Liesbeth A Bruins Slot, Luc De Vries, Adrian Newman-Tancredi, Didier Cussa. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. European journal of pharmacology. vol 534. issue 1-3. 2006-06-07. PMID:16497294. |
ssr181507 and bifeprunox possess a profile of action similar to each other, efficaciously stimulating both serotonin 5-ht1a and dopamine d2s receptors. |
2006-06-07 |
2023-08-12 |
human |
| Liesbeth A Bruins Slot, Luc De Vries, Adrian Newman-Tancredi, Didier Cussa. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. European journal of pharmacology. vol 534. issue 1-3. 2006-06-07. PMID:16497294. |
in contrast, slv313, also an efficacious serotonin 5-ht1a receptor agonist, acted as a high potency dopamine d2 receptor antagonist. |
2006-06-07 |
2023-08-12 |
human |
| Liesbeth A Bruins Slot, Luc De Vries, Adrian Newman-Tancredi, Didier Cussa. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. European journal of pharmacology. vol 534. issue 1-3. 2006-06-07. PMID:16497294. |
thus, antipsychotics display varying efficacies at serotonin 5-ht1a and dopamine d2s receptors which may play a major role in their differential functional profiles in blocking the diverse symptoms of schizophrenia. |
2006-06-07 |
2023-08-12 |
human |
| W Wolfgang Fleischhacke. Aripiprazole. Expert opinion on pharmacotherapy. vol 6. issue 12. 2006-06-01. PMID:16197361. |
partial agonism of the d2 dopamine and 5ht1a serotonin receptors, and antagonism of the 5ht2 serotonin receptor are believed to be the functional basis of its therapeutic efficacy. |
2006-06-01 |
2023-08-12 |
Not clear |
| Arata Watanabe, Shu Hasegawa, Kyoko Nishi, Khnah Q Nguyen, Mirko Diksi. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin. vol 69. issue 2. 2006-06-01. PMID:16533657. |
these results suggest that normalization (reduction to the level found in the shx-sal rats) of 5-ht synthesis in the obx requires a greater dose of buspirone (20 mg/(kg day)) than that needed to produce a desensitization of the 5-ht1a receptors in the sham operated rats (10 mg/(kg day)). |
2006-06-01 |
2023-08-12 |
rat |
| Arata Watanabe, Shu Hasegawa, Kyoko Nishi, Khnah Q Nguyen, Mirko Diksi. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin. vol 69. issue 2. 2006-06-01. PMID:16533657. |
furthermore, our results support the hypothesis that 5-ht1a receptors mediate the antidepressant-like effect of 5-ht1a agonists, as the chronic 5-ht1a agonist treatment in the depression model known to be sensitive to antidepressants resulted in the normalization of 5-ht synthesis. |
2006-06-01 |
2023-08-12 |
rat |
| Martijn Meeter, Lucia Talamini, Jeroen A J Schmitt, Wim J Riede. Effects of 5-HT on memory and the hippocampus: model and data. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 4. 2006-05-25. PMID:16132065. |
the results suggest that the memory impairments in depressed subjects may be related to 5-ht undertransmission, and support the notion that 5-ht1a agonists ameliorate memory deficits in depression. |
2006-05-25 |
2023-08-12 |
human |
| Sietse F de Boer, Jaap M Koolhaa. 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. European journal of pharmacology. vol 526. issue 1-3. 2006-05-25. PMID:16310183. |
5-ht1a and 5-ht1b receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. |
2006-05-25 |
2023-08-12 |
rat |
| Christopher Derry, Christopher Benjamin, Peter Bladin, Didier le Bars, Henri Tochon-Danguy, Samuel F Berkovic, Luc Zimmer, Nicolas Costes, Rachel Mulligan, David Reuten. Increased serotonin receptor availability in human sleep: evidence from an [18F]MPPF PET study in narcolepsy. NeuroImage. vol 30. issue 2. 2006-05-23. PMID:16275016. |
binding of the radioligand [18f]mppf to 5ht1a receptors is sensitive to levels of endogenous serotonin. |
2006-05-23 |
2023-08-12 |
human |
| K Asgari, S Body, Z Zhang, K C F Fone, C M Bradshaw, E Szabad. Effects of 5-HT1A and 5-HT2A receptor stimulation on temporal differentiation performance in the fixed-interval peak procedure. Behavioural processes. vol 71. issue 2-3. 2006-05-22. PMID:16098683. |
we examined the effects of the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and 5-ht(2a/2c) receptor agonist 2,5-dimethoxy-4-iodoamphetamine (doi) on performance on the fixed-interval peak procedure, and the sensitivity of these effects to 5-ht1a and 5-ht2a receptor antagonists (n-[2-(4-[2-methoxyphenyl]-1-piperazinyl]ethyl]-n-2-pyridinylcyclohexanecarboxamide [way-100635] and ketanserin). |
2006-05-22 |
2023-08-12 |
rat |
| Andre Rex, H Fin. Effects of 8-OH-DPAT on hippocampal NADH fluorescence in vivo in anaesthetized rats. Journal of neuroscience research. vol 83. issue 4. 2006-05-17. PMID:16435395. |
systemic administration of the 5-ht1a receptor agonist 8-oh-dpat modifies 5-ht neuronal transmission via stimulation of presynaptic and postsynaptic receptors. |
2006-05-17 |
2023-08-12 |
rat |
| José Rioja, Luis J Santín, Alicia Doña, Laura de Pablos, Francisco J Minano, Salvador Gonzalez-Baron, Jose A Aguirr. 5-HT1A receptor activation counteracts c-Fos immunoreactivity induced in serotonin neurons of the raphe nuclei after immobilization stress in the male rat. Neuroscience letters. vol 397. issue 3. 2006-05-04. PMID:16406667. |
5-ht1a receptor activation counteracts c-fos immunoreactivity induced in serotonin neurons of the raphe nuclei after immobilization stress in the male rat. |
2006-05-04 |
2023-08-12 |
rat |
| Lisa E Kalynchuk, John P J Pinel, Michael J Meane. Serotonin receptor binding and mRNA expression in the hippocampus of fearful amygdala-kindled rats. Neuroscience letters. vol 396. issue 1. 2006-04-28. PMID:16324784. |
then, the rats were sacrificed and 5-ht transporter binding, 5-ht1a and 5-ht2a receptor binding, and 5-ht1a mrna expression in several brain regions was assessed. |
2006-04-28 |
2023-08-12 |
rat |
| G Koller, B Bondy, U W Preuss, P Zill, M Soyk. The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients. Behavioral and brain functions : BBF. vol 2. 2006-04-26. PMID:16504134. |
the 5ht1a receptor is one of at least 14 different receptors for serotonin which has a role in moderating several brain functions and may be involved in the aetiology of several psychiatric disorders. |
2006-04-26 |
2023-08-12 |
Not clear |
| Sarah J Judge, Sarah E Gartsid. Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation. Neurochemistry international. vol 48. issue 2. 2006-04-24. PMID:16256247. |
firing of 5-ht neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-ht1a receptor modulation. |
2006-04-24 |
2023-08-12 |
rat |
| Valiya Veettil Mohanan, Reas Khan, C S Paulos. Hypothalamic 5-HT functional regulation through 5-HT1A and 5-HT2C receptors during pancreatic regeneration. Life sciences. vol 78. issue 14. 2006-04-14. PMID:16253282. |
hypothalamic 5-ht functional regulation through 5-ht1a and 5-ht2c receptors during pancreatic regeneration. |
2006-04-14 |
2023-08-12 |
rat |