| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antoni Nasal, Adam Bucinski, Tomasz Baczek, Anna Wojdelk. Prediction of the affinity of the newly synthesised azapirone derivatives for 5-HT1A receptors based on artificial neural network analysis of chromatographic retention data and calculation chemistry parameters. Combinatorial chemistry & high throughput screening. vol 7. issue 4. 2004-08-17. PMID:15200379. |
a high prediction performance of both ann models considered as regards the affinity of new azapirone derivatives for the serotonin 5-ht1a receptors was demonstrated. |
2004-08-17 |
2023-08-12 |
rat |
| Richard E Mewshaw, Dahui Zhou, Ping Zhou, Xiaojie Shi, Geoffrey Hornby, Taylor Spangler, Rosemary Scerni, Deborah Smith, Lee E Schechter, Terrance H Andre. Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines. Journal of medicinal chemistry. vol 47. issue 15. 2004-08-12. PMID:15239661. |
dual 5-ht1a and serotonin transporter affinity within a class of n-aryloxyethylindolylalkylamines. |
2004-08-12 |
2023-08-12 |
Not clear |
| Charles E Glatt, Maricel Tampilic, Carroll Christie, Joe DeYoung, Nelson B Freime. Re-screening serotonin receptors for genetic variants identifies population and molecular genetic complexity. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 124B. issue 1. 2004-07-28. PMID:14681923. |
we have re-screened the genes for the 5-ht1a, 5-ht2a, 5-ht2c, and 5-ht7 serotonin receptors for genetic variants in a large african-american and caucasian-american population sample. |
2004-07-28 |
2023-08-12 |
human |
| Kenneth N Sokolski, Janet C Conney, Brenda J Brown, Edward M DeMe. Once-daily high-dose pindolol for SSRI-refractory depression. Psychiatry research. vol 125. issue 2. 2004-07-22. PMID:15006431. |
selective serotonin reuptake inhibitor (ssri) augmentation with the 5-ht1a antagonist pindolol has met with mixed results. |
2004-07-22 |
2023-08-12 |
human |
| Joëlle Adrie. [Implication of serotonin in the control of vigilance states as revealed by knockout-mouse studies]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146953. |
homologous recombination knocking-out genes encoding various proteins involved in 5-ht neurotransmission in the mouse has recently allowed further assesment of the role of the serotonin transporter (5-htt), the monoamine oxidase a (mao-a), and the 5-ht1a, 5-ht1b and 5-ht2a receptors in the regulation of sleep. |
2004-07-19 |
2023-08-12 |
mouse |
| Joëlle Adrie. [Implication of serotonin in the control of vigilance states as revealed by knockout-mouse studies]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146953. |
in addition, 5-ht1a -/- and 5-ht1b -/- mutants were hypersensitive to 5-ht1b and 5-ht1a receptor agonists, respectively, which suggests that adaptive changes at 5-ht neurotransmission develop in knock-out animals. |
2004-07-19 |
2023-08-12 |
mouse |
| Claudia Regina Monassi, Leda Menescal-de-Oliveir. Serotonin 5-HT2 and 5-HT1A receptors in the periaqueductal gray matter differentially modulate tonic immobility in guinea pig. Brain research. vol 1009. issue 1-2. 2004-07-12. PMID:15120594. |
serotonin 5-ht2 and 5-ht1a receptors in the periaqueductal gray matter differentially modulate tonic immobility in guinea pig. |
2004-07-12 |
2023-08-12 |
Not clear |
| Patrick Osei-Owusu, Karie E Scrogi. Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage. The Journal of pharmacology and experimental therapeutics. vol 309. issue 3. 2004-07-01. PMID:14769835. |
5-hydroxytryptamine 1a (5-ht1a) receptor agonists reverse the hypotensive and sympathoinhibitory responses to severe hemorrhage in rats. |
2004-07-01 |
2023-08-12 |
rat |
| David S Paterson, Richard A Belliveau, Felicia Trachtenberg, Hannah C Kinne. Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medulla. The Journal of comparative neurology. vol 472. issue 2. 2004-07-01. PMID:15048689. |
tissue receptor autoradiography with 3h-lysergic acid diethylamide (3h-lsd), 3h-8-hydroxy-2-[di-n-propylamine] tetralin (3h-8-oh-dpat), and 125i-rti-55 was used to map the distribution and developmental profile of 5-ht(1a-1d) and 5-ht2 receptors, 5-ht1a receptors, and the serotonin (5-ht) transporter (sert), respectively, to nuclei with cardiorespiratory function in the human medulla from midgestation to maturity. |
2004-07-01 |
2023-08-12 |
human |
| David S Paterson, Richard A Belliveau, Felicia Trachtenberg, Hannah C Kinne. Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medulla. The Journal of comparative neurology. vol 472. issue 2. 2004-07-01. PMID:15048689. |
with the exception of the hypoglossal nucleus, where 5-ht1a receptor binding increases while sert binding remains stable, the medullary 5-ht markers analyzed in the study are essentially "in place" at birth. |
2004-07-01 |
2023-08-12 |
human |
| Philippe De Deurwaerdère, Sylvia Navailles, Kelly A Berg, William P Clarke, Umberto Spampinat. Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 13. 2004-06-18. PMID:15056702. |
furthermore, sb 206553-stimulated da release was insensitive to reduction of 5-ht neuronal function induced by the 5-ht1a agonist (+/-)-8-hydroxy-2-dipropylaminotetralin or intra-raphe injections of 5,7-dihydroxytryptamine neurotoxin. |
2004-06-18 |
2023-08-12 |
rat |
| Jaime M Monti, Héctor Janto. Differential effects of the 5-HT1A receptor agonist flesinoxan given locally or systemically on REM sleep in the rat. European journal of pharmacology. vol 478. issue 2-3. 2004-06-17. PMID:14575796. |
our results indicate that the 5-ht1a receptor is involved in the inhibitory effect of serotonin on brainstem structures that act to promote and to induce rem sleep. |
2004-06-17 |
2023-08-12 |
rat |
| Jan Boksa, Sijka Charakchieva-Minol, Beata Duszyńska, Ryszard Bugno, Aleksandra Kłodzińska, Ewa Tatarczyńska, Ewa Chojnacka-Wójcik, Andrzej J Bojarsk. Synthesis, in vitro and in vivo 5-HT1A/5-HT2A serotonin receptor activity of new hybrid 1,2,3,4-tetrahydro-gamma-carbolines with 1-(2-methoxyphenyl)piperazine moiety. Polish journal of pharmacology. vol 55. issue 6. 2004-06-15. PMID:14730096. |
a series of 15 new 2-h- and 2-substituted 5-[omega-[4-(2-methoxyphenyl)-piperazinyl]-alkyl]-1,2,3,4-tetrahydro-gamma-carboline derivatives were prepared, and their affinity for 5-ht1a and 5-ht2a serotonin receptors was determined. |
2004-06-15 |
2023-08-12 |
mouse |
| Mary M Niblock, Hannah C Kinney, Catherine J Luce, Richard A Belliveau, James J Filian. The development of the medullary serotonergic system in the piglet. Autonomic neuroscience : basic & clinical. vol 110. issue 2. 2004-06-08. PMID:15046730. |
tritiated (3h)-lysergic acid diethylamide (lsd) binding to 5-ht1a-d and 5-ht2 receptors and 3h-8-hydroxy-2-[di-n-propylamine]tetralin (8-oh-dpat) binding to 5-ht1a receptors were used to quantify and map the distribution of these serotonin receptors between 4 and 60 postnatal days. |
2004-06-08 |
2023-08-12 |
human |
| Clotilde Mannoury la Cour, Naïma Hanoun, Maxette Melfort, René Hen, Klaus-Peter Lesch, Michel Hamon, Laurence Lanfume. GABA(B) receptors in 5-HT transporter- and 5-HT1A receptor-knock-out mice: further evidence of a transduction pathway shared with 5-HT1A receptors. Journal of neurochemistry. vol 89. issue 4. 2004-06-04. PMID:15140188. |
gaba(b) receptors in 5-ht transporter- and 5-ht1a receptor-knock-out mice: further evidence of a transduction pathway shared with 5-ht1a receptors. |
2004-06-04 |
2023-08-12 |
mouse |
| Marcus H Andrews, Alice Kostaki, Elaine Setiawan, Lucy McCabe, Stephen G Matthew. Developmental regulation of 5-HT1A receptor mRNA in the fetal limbic system: response to antenatal glucocorticoid. Brain research. Developmental brain research. vol 149. issue 1. 2004-05-24. PMID:15013627. |
because fetal exposure to glucocorticoids programs hypothalamo-pituitary-adrenal (hpa) function, and hippocampal serotonin is known to influence glucocorticoid receptor (gr) expression, the glucocorticoid-mediated changes in 5-ht1a receptor mrna may play a role in the programming of hpa function. |
2004-05-24 |
2023-08-12 |
Not clear |
| Isabelle Merlet, Karine Ostrowsky, Nicolas Costes, Philippe Ryvlin, Jean Isnard, Isabelle Faillenot, Franck Lavenne, Damien Dufournel, Didier Le Bars, François Mauguièr. 5-HT1A receptor binding and intracerebral activity in temporal lobe epilepsy: an [18F]MPPF-PET study. Brain : a journal of neurology. vol 127. issue Pt 4. 2004-05-20. PMID:14985263. |
experimental data in animals show that 5-ht1a receptors are predominantly located in limbic areas, and that serotonin, via these receptors, mediates an antiepileptic and anticonvulsant effect. |
2004-05-20 |
2023-08-12 |
human |
| Koji Tada, Kimihiro Kasamo, Tadashi Suzuki, Yamato Matsuzaki, Takuya Kojim. Endogenous 5-HT inhibits firing activity of hippocampal CA1 pyramidal neurons during conditioned fear stress-induced freezing behavior through stimulating 5-HT1A receptors. Hippocampus. vol 14. issue 2. 2004-05-20. PMID:15098719. |
endogenous 5-ht inhibits firing activity of hippocampal ca1 pyramidal neurons during conditioned fear stress-induced freezing behavior through stimulating 5-ht1a receptors. |
2004-05-20 |
2023-08-12 |
rat |
| Koji Tada, Kimihiro Kasamo, Tadashi Suzuki, Yamato Matsuzaki, Takuya Kojim. Endogenous 5-HT inhibits firing activity of hippocampal CA1 pyramidal neurons during conditioned fear stress-induced freezing behavior through stimulating 5-HT1A receptors. Hippocampus. vol 14. issue 2. 2004-05-20. PMID:15098719. |
these results suggested that endogenous 5-ht inhibited the firing activity of hippocampal ca1 pyramidal neurons during cfs-induced freezing behavior mainly through stimulating 5-ht1a receptors. |
2004-05-20 |
2023-08-12 |
rat |
| G D Bartoszyk, C Van Amsterdam, H E Greiner, W Rautenberg, H Russ, C A Seyfrie. Sarizotan, a serotonin 5-HT1A receptor agonist and dopamine receptor ligand. 1. Neurochemical profile. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 2. 2004-05-19. PMID:14767715. |
sarizotan, a serotonin 5-ht1a receptor agonist and dopamine receptor ligand. |
2004-05-19 |
2023-08-12 |
rat |