All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Murat Oz, Li Zhang, Alessandro Rotondo, Hui Sun, Marisela Morale. Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors. Synapse (New York, N.Y.). vol 50. issue 4. 2003-12-19. PMID:14556235. comparison of the potencies and efficacies of 5-ht and da indicated that the relative potency of da increased in the order of 5-ht3 > 5-ht1a > 5-ht2c, and relative efficacy increased in the order of 5-ht1a > 5-ht2c > 5-ht3. 2003-12-19 2023-08-12 human
Silvana Chiavegatto, Randy J Nelso. Interaction of nitric oxide and serotonin in aggressive behavior. Hormones and behavior. vol 44. issue 3. 2003-12-17. PMID:14609545. recently, the excessive aggressive and impulsive traits of neuronal no synthase knockout (nnos-/-) mice were shown to be caused by reductions in serotonin (5-ht) turnover and deficient 5-ht1a and 5-ht1b receptor function in brain regions regulating emotion. 2003-12-17 2023-08-12 mouse
Silvana Chiavegatto, Randy J Nelso. Interaction of nitric oxide and serotonin in aggressive behavior. Hormones and behavior. vol 44. issue 3. 2003-12-17. PMID:14609545. the consistently high levels of aggression observed in nnos-/- mice could be reversed by 5-ht precursors and by treatment with specific 5-ht1a and 5-ht1b receptor agonists. 2003-12-17 2023-08-12 mouse
Anna Czyrak, Klaudia Czepiel, Marzena Maćkowiak, Agnieszka Chocyk, Krzysztof Wedzon. Serotonin 5-HT1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex. Brain research. vol 989. issue 1. 2003-12-12. PMID:14519510. serotonin 5-ht1a receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex. 2003-12-12 2023-08-12 rat
Anna Czyrak, Klaudia Czepiel, Marzena Maćkowiak, Agnieszka Chocyk, Krzysztof Wedzon. Serotonin 5-HT1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex. Brain research. vol 989. issue 1. 2003-12-12. PMID:14519510. the present study was designed to investigate the distribution of serotonin 5-ht1a receptor protein (5-ht1a-immunoreactivity) and its localization within cortical pyramidal neurons of the rat cingulate cortex. 2003-12-12 2023-08-12 rat
Petrus J Pauwels, Francis C Colpaer. Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12970382. little experimental evidence has been reported for diverse signaling via 5-hydroxytryptamine (5-ht)1a receptors despite the fact that agonists seem to be more efficacious at dorsal raphe somatodendritic 5-ht1a autoreceptors than at postsynaptic 5-ht1a receptors. 2003-12-10 2023-08-12 human
Petrus J Pauwels, Francis C Colpaer. Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12970382. the present study investigated ca2+ responses in chinese hamster ovary (cho)-k1 cells expressing a human 5-ht1a receptor by 5-ht, prototypical 5-ht1a agonists, n-(3-chloro-4-fluorobenzoyl)-4-fluoro-4-[(5-methyl-6-; methylaminopyridin-2-yl)-methylaminomethyl]-piperidine (f 14679), and especially n-(3-chloro-4-fluorobenzoyl)-4-fluoro-4-[(5-methylpyridin-2-yl)-; methylaminomethyl]piperidine (f 13640) as representative ligands of a new chemical class (methylamino-pyridine) that combines both high efficacy and selectivity for 5-ht1a receptors. 2003-12-10 2023-08-12 human
Jean-François Perrier, Aidas Alaburda, Jørn Hounsgaar. 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. The Journal of physiology. vol 548. issue Pt 2. 2003-12-04. PMID:12626670. the modulatory effects of serotonin mediated by 5-ht1a receptors in adult spinal motoneurons were investigated by intracellular recordings in a slice preparation from the turtle. 2003-12-04 2023-08-12 Not clear
Jean-François Perrier, Aidas Alaburda, Jørn Hounsgaar. 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. The Journal of physiology. vol 548. issue Pt 2. 2003-12-04. PMID:12626670. our results show that activation of 5-ht1a receptors contributes to the excitatory effect of serotonin on spinal motoneurons by inhibition of a task-1 potassium channel leading to depolarization and increased input resistance. 2003-12-04 2023-08-12 Not clear
Donatella Marazziti, Lionella Palego, Annalisa Giromella, Maria Rosa Mazzoni, Franco Borsini, Norbert Mayer, Antonio Giuseppe Naccarato, Antonio Lucacchini, Giovanni Battista Cassan. Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain. The international journal of neuropsychopharmacology. vol 5. issue 2. 2003-11-21. PMID:12135537. the mode of action of antidepressant drugs may be related to mechanisms of receptor adaptation, involving overall the serotonin 1a (5-ht1a) receptor subtype. 2003-11-21 2023-08-12 human
N K Popova, A V Kulikov, D F Avgustinovich, N N Barykin. Involvement of striatum serotonergic system in the expression of genetically defined catalepsy. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 83. issue 5-6. 2003-11-07. PMID:13677667. the activity of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase, and specific binding of [3h]ketanserin to 5-ht2a receptors and [3h]8-oh-dpat to 5-ht1a receptors in the striatum of genetically predisposed to catalepsy rats and mice have been studied. 2003-11-07 2023-08-12 mouse
Luc Zimmer, Latifa Rbah, Fabrice Giacomelli, Didier Le Bars, Bernard Renau. A reduced extracellular serotonin level increases the 5-HT1A PET ligand 18F-MPPF binding in the rat hippocampus. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 44. issue 9. 2003-10-31. PMID:12960198. a reduced extracellular serotonin level increases the 5-ht1a pet ligand 18f-mppf binding in the rat hippocampus. 2003-10-31 2023-08-12 rat
S E Gartside, M M Leitch, A H Youn. Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 9. 2003-10-06. PMID:12784107. both glucocorticoids and selective serotonin reuptake inhibitors (ssris) alter aspects of 5-ht function including somatodendritic 5-ht1a autoreceptor sensitivity. 2003-10-06 2023-08-12 rat
S E Gartside, M M Leitch, A H Youn. Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 9. 2003-10-06. PMID:12784107. finally in fluoxetine, corticosterone, and corticosterone plus fluoxetine groups, there was marked 5-ht1a receptor desensitization, evidenced by attenuation of the decrease in 5-ht release following systemic fluoxetine injection. 2003-10-06 2023-08-12 rat
S E Gartside, M M Leitch, A H Youn. Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 9. 2003-10-06. PMID:12784107. the data indicate that, despite desensitization of 5-ht1a autoreceptors, concurrent flattened glucocorticoid rhythm compromises the ability of ssris to elevate forebrain 5-ht. 2003-10-06 2023-08-12 rat
M J Millan, A Gobert, F Lejeune, A Dekeyne, A Newman-Tancredi, V Pasteau, J-M Rivet, D Cussa. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12750432. it also interacted with h5-ht2b receptors (6.6), whereas it showed low affinity at native (rat)/cloned, human 5-ht2a (<5.0/5.3) and 5-ht1a (<5.0/5.2) receptors, and negligible (<5.0) affinity for other 5-ht receptors. 2003-10-03 2023-08-12 human
Steven G Potkin, Anutosh R Saha, Mary J Kujawa, William H Carson, Mirza Ali, Elyse Stock, Joseph Stringfellow, Gary Ingenito, Stephen R Marde. Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder. Archives of general psychiatry. vol 60. issue 7. 2003-09-16. PMID:12860772. aripiprazole is a dopamine d2 receptor partial agonist with partial agonist activity at serotonin 5ht1a receptors and antagonist activity at 5ht2a receptors. 2003-09-16 2023-08-12 Not clear
Rita J Valentino, Vincent Bey, Luise Pernar, Kathryn G Common. Substance P Acts through local circuits within the rat dorsal raphe nucleus to alter serotonergic neuronal activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 18. 2003-09-09. PMID:12904475. this results in 5-ht release throughout the dr, activation of 5-ht1a receptors, and subsequent inhibition. 2003-09-09 2023-08-12 rat
Ying-Chih Lin, Ming-Tsuen Hsieh, Chung-Fung Chen, Hao-Yuan Cheng, Wen-Huang Pen. Anxiolytic effect of ting-chih-wan in mouse behavior models of anxiety. The American journal of Chinese medicine. vol 31. issue 1. 2003-09-05. PMID:12723754. from these results, tcwa at 0.1 and 0.5 g/kg possessed an anxiolytic effect t heanxiolytic mechanisms of tcwa might be due to decreased catecholaminergic activity caused by the increase in the turnover rate of catecholamines in the brain and decreased concentrations of 5-ht in the brain stemvia activating somatodendritic 5-ht1a autoreceptors and inhibiting postsynaptic 5-ht receptors. 2003-09-05 2023-08-12 mouse
Peter F Buckle. Aripiprazole: efficacy and tolerability profile of a novel-acting atypical antipsychotic. Drugs of today (Barcelona, Spain : 1998). vol 39. issue 2. 2003-09-04. PMID:12698209. aripiprazole, the latest atypical antipsychotic to come to clinical practice, has a proposed mechanism of action different to other agents, most notably in its partial agonist action at dopamine (d2) receptors and at serotonin (5ht1a) receptors. 2003-09-04 2023-08-12 Not clear