All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
M Bourin, D J P David, P Jolliet, A Gardie. [Mechanism of action of antidepressants and therapeutic perspectives]. Therapie. vol 57. issue 4. 2002-12-10. PMID:12422559. developing drugs using innovative mechanisms such as directly acting on 5-ht receptors (5-ht1a agonists or 5-ht2 antagonists), would appear to be useful in the treatment of depression. 2002-12-10 2023-08-12 Not clear
Jan Sevcík, Vladimír Růicka, Josef Sláinský, Karel Mase. Muramyl dipeptide (MDP) and 5-HT receptors. Neuroimmunomodulatory effects of MDP are probably not mediated through 5-HT4 or 5-HT1A receptors. Immunopharmacology and immunotoxicology. vol 24. issue 1. 2002-12-04. PMID:12022444. selective 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat) decreased the height of twitches and this effect was significantly attenuated in the presence of 5-ht antagonist metergoline (1 microm). 2002-12-04 2023-08-12 Not clear
Elaine A Del-Bel, Sâmia Regiane Lourenço Joca, Cláudia Maria Padovan, Francisco S Guimarãe. Effects of isolation-rearing on serotonin-1A and M1-muscarinic receptor messenger RNA expression in the hipocampal formation of rats. Neuroscience letters. vol 332. issue 2. 2002-11-26. PMID:12384226. they showed a significant (p < 0.05, mann-whitney test) serotonin 1a (5-ht1a) mrna expression increase in the dentate gyrus and ca3 areas of isolated animals. 2002-11-26 2023-08-12 rat
Elaine A Del-Bel, Sâmia Regiane Lourenço Joca, Cláudia Maria Padovan, Francisco S Guimarãe. Effects of isolation-rearing on serotonin-1A and M1-muscarinic receptor messenger RNA expression in the hipocampal formation of rats. Neuroscience letters. vol 332. issue 2. 2002-11-26. PMID:12384226. these results may reflect up-regulation of 5-ht1a gene transcription in response to deficits in hippocampal serotonin neurotransmission induced by social isolation. 2002-11-26 2023-08-12 rat
Kotapola G Imendra, Takenori Miyamoto, Yukio Okada, Kazuo Tod. Serotonin differentially modulates the electrical properties of different subsets of taste receptor cells in bullfrog. The European journal of neuroscience. vol 16. issue 4. 2002-11-22. PMID:12270038. the 5-ht (0.1-1 micro m) and 5-ht1a receptor agonist (+/-)-8-oh-2-(d1-n-propyl-amino)tetralin (8-oh-dpat) (1-20 micro m) inhibited both voltage-gated sodium current (ina) and voltage-gated potassium current (ik) in 50% of trcs, but potentiated ik without any significant effect on ina in another subset of 18% of trcs. 2002-11-22 2023-08-12 Not clear
Y Ago, M Sakaue, A Baba, T Matsud. Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice. Journal of neurochemistry. vol 83. issue 2. 2002-11-20. PMID:12423245. the present study examined the effect of isolation rearing on the 5-ht1a receptor-mediated modulation of dopamine (da), 5-ht and noradrenaline (na) release in the frontal cortex of mice. 2002-11-20 2023-08-12 mouse
Y Ago, M Sakaue, A Baba, T Matsud. Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice. Journal of neurochemistry. vol 83. issue 2. 2002-11-20. PMID:12423245. the selective 5-ht1a receptor agonist (s)-5-[-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole hcl (mkc-242) increased the release of da and na and decreased the release of 5-ht in the frontal cortex of mice. 2002-11-20 2023-08-12 mouse
Y Ago, M Sakaue, A Baba, T Matsud. Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice. Journal of neurochemistry. vol 83. issue 2. 2002-11-20. PMID:12423245. the effect of the other 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin on cortical da release was also less in isolation-reared mice than in group-reared mice, and that of the drug on cortical 5-ht release did not differ between both groups. 2002-11-20 2023-08-12 mouse
Xiang Cai, Zhenglin Gu, Ping Zhong, Yong Ren, Zhen Ya. Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons. The Journal of biological chemistry. vol 277. issue 39. 2002-11-13. PMID:12149253. serotonin 5-ht1a receptors regulate ampa receptor channels through inhibiting ca2+/calmodulin-dependent kinase ii in prefrontal cortical pyramidal neurons. 2002-11-13 2023-08-12 mouse
G Roglic, D Andric, S Kostic-Rajacic, S Dukic, V Soski. Introduction of a methyl group in alpha- or beta-position of 1-heteroarylethyl-4-phenylpiperazines affects their dopaminergic/serotonergic properties. Archiv der Pharmazie. vol 334. issue 12. 2002-10-22. PMID:11852532. they were evaluated for in vitro binding affinity at the d1 and d2 dopamine and 5-ht1a serotonin receptors using synaptosomal membranes of the bovine caudate nucleus and hippocampus, respectively, as a source of the corresponding receptors. 2002-10-22 2023-08-12 cattle
Rosa M Tordera, Antonio Monge, Joaquín Del Río, Berta Lashera. Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. European journal of pharmacology. vol 442. issue 1-2. 2002-10-08. PMID:12020683. antidepressant-like activity of vn2222, a serotonin reuptake inhibitor with high affinity at 5-ht1a receptors. 2002-10-08 2023-08-12 mouse
Rosa M Tordera, Antonio Monge, Joaquín Del Río, Berta Lashera. Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. European journal of pharmacology. vol 442. issue 1-2. 2002-10-08. PMID:12020683. it has been suggested that drugs combining serotonin (5-hydroxytryptamine, 5-ht) transporter blockade and 5-ht1a autoreceptor antagonism could be a novel strategy for a shorter onset of action and higher therapeutic efficacy of antidepressants. 2002-10-08 2023-08-12 mouse
Rosa M Tordera, Antonio Monge, Joaquín Del Río, Berta Lashera. Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. European journal of pharmacology. vol 442. issue 1-2. 2002-10-08. PMID:12020683. the present study was aimed at characterizing the pharmacology of 1-(3-benzo[b]tiophenyl)-3-[4-(2-methoxyphenyl)-1-piperazinyl]-1-propanol (vn2222) a new synthetic compound with high affinity at both the 5-ht transporter and 5-ht1a receptors and devoid of high affinity at other receptors studied, with the only exception of alpha1-adrenoceptors. 2002-10-08 2023-08-12 mouse
Rosa M Tordera, Antonio Monge, Joaquín Del Río, Berta Lashera. Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. European journal of pharmacology. vol 442. issue 1-2. 2002-10-08. PMID:12020683. in body temperature studies, 5 mg/kg vn2222 produced a mild hypothermic effect in mice, suggesting a weak agonist activity at presynaptic 5-ht1a receptors; much lower doses (0.01-0.5 mg/kg) partially antagonized the hypothermia induced by 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) possibly through 5-ht transporter blockade. 2002-10-08 2023-08-12 mouse
Rosa M Tordera, Antonio Monge, Joaquín Del Río, Berta Lashera. Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. European journal of pharmacology. vol 442. issue 1-2. 2002-10-08. PMID:12020683. consequently, vn2222 is a new compound with a dual effect on the serotonergic system, as 5-ht uptake blocker and 5-ht1a receptor partial agonist, and with a remarkable activity in an animal model of depression with high predictive validity. 2002-10-08 2023-08-12 mouse
L Orús, J Martínez, S Pérez, A M Oficialdegui, J C del Castillo, M Mourelle, B Lasheras, J del Río, A Mong. New 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Die Pharmazie. vol 57. issue 8. 2002-10-08. PMID:12227188. new 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-ht1a serotonin receptors and serotonin transporter as a new class of antidepressants. 2002-10-08 2023-08-12 Not clear
L Orús, J Martínez, S Pérez, A M Oficialdegui, J C del Castillo, M Mourelle, B Lasheras, J del Río, A Mong. New 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Die Pharmazie. vol 57. issue 8. 2002-10-08. PMID:12227188. in this paper a series of new 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives is presented as a new class of antidepressant drugs with dual activity at 5-ht1a serotonin receptors and serotonin transporter. 2002-10-08 2023-08-12 Not clear
L Orús, J Martínez, S Pérez, A M Oficialdegui, J C del Castillo, M Mourelle, B Lasheras, J del Río, A Mong. New 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Die Pharmazie. vol 57. issue 8. 2002-10-08. PMID:12227188. the 5-ht1a receptor and 5-ht transporter binding affinities of hydroxylic compounds 4 a-e have been determined. 2002-10-08 2023-08-12 Not clear
L Orús, J Martínez, S Pérez, A M Oficialdegui, J C del Castillo, M Mourelle, B Lasheras, J del Río, A Mong. New 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Die Pharmazie. vol 57. issue 8. 2002-10-08. PMID:12227188. the new compounds present nanomolar affinity for both activities, and 1-(benzo[b]thiophen-3-yl)-3-[4-(3-methoxyphenyl)piperazin-1-yl]propan-1-ol (4d) shows values (nm) of ki = 86 for 5-ht1a receptors and ki = 76 for the serotonin transporter, respectively. 2002-10-08 2023-08-12 Not clear
A D Lê, S Harding, W Juzytsch, P J Fletcher, Y Shaha. The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 18. 2002-10-03. PMID:12223536. intra-mrn infusions of 8-oh-dpat [8-hydroxy-2-(di-n-propylamino)tetralin] (a 5-ht1a agonist that decreases 5-ht cell firing and release) reinstated alcohol seeking. 2002-10-03 2023-08-12 rat