| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A D Lê, S Harding, W Juzytsch, P J Fletcher, Y Shaha. The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 18. 2002-10-03. PMID:12223536. |
intra-mrn infusions of 8-oh-dpat [8-hydroxy-2-(di-n-propylamino)tetralin] (a 5-ht1a agonist that decreases 5-ht cell firing and release) reinstated alcohol seeking. |
2002-10-03 |
2023-08-12 |
rat |
| Naoki Nishiguchi, Osamu Shirakawa, Hisae Ono, Akiyoshi Nishimura, Hideyuki Nushida, Yasuhiro Ueno, Kiyoshi Maed. Lack of an association between 5-HT1A receptor gene structural polymorphisms and suicide victims. American journal of medical genetics. vol 114. issue 4. 2002-09-27. PMID:11992564. |
serotonin 1a (5-ht1a) receptors are known to be located on serotonergic nerve terminals and to be involved in the presynaptic regulation of serotonin release. |
2002-09-27 |
2023-08-12 |
Not clear |
| M Sasa, S Takeshita, T Amano, K Kuris. Primary neurotransmitters and regulatory substances onto vestibular nucleus neurons. Uchu Seibutsu Kagaku. vol 15. issue 4. 2002-09-27. PMID:12101361. |
furthermore, serotonin was found to inhibit the mvn neuronal activities via the 5-ht1a receptors. |
2002-09-27 |
2023-08-12 |
Not clear |
| Efrain C Azmiti. Cajal's hypotheses on neurobiones and neurotropic factor match properties of microtubules and S-100 beta. Progress in brain research. vol 136. 2002-09-19. PMID:12143407. |
serotonin, by acting on the astroglial 5-ht1a receptor, releases s-100 beta and regulates neuronal morphology and apoptosis. |
2002-09-19 |
2023-08-12 |
Not clear |
| Keiichiro Tsuj. [Effect of (+/-)-pindolol on the central 5-HT1A receptor by the use of in vivo microdialysis and hippocampal slice preparations]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 22. issue 3. 2002-09-12. PMID:12166089. |
although it is suggested that (+/-)-pindolol, a beta-adrenergic/5-ht1a receptor antagonist, may enhance the efficacy of selective serotonin reuptake inhibitors (ssri), the results of double-blind studies are contradictory and recent animal studies suggest that (+/-)-pindolol may act as a partial agonist to the 5-ht1a receptor. |
2002-09-12 |
2023-08-12 |
Not clear |
| Keiichiro Tsuj. [Effect of (+/-)-pindolol on the central 5-HT1A receptor by the use of in vivo microdialysis and hippocampal slice preparations]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 22. issue 3. 2002-09-12. PMID:12166089. |
(+/-)-pindolol and flesinoxan, a 5-ht1a receptor full agonist, significantly decreased the extracellular levels of 5-ht in the raphe and prefrontal cortex. |
2002-09-12 |
2023-08-12 |
Not clear |
| Keiichiro Tsuj. [Effect of (+/-)-pindolol on the central 5-HT1A receptor by the use of in vivo microdialysis and hippocampal slice preparations]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 22. issue 3. 2002-09-12. PMID:12166089. |
the 5-ht and other 5-ht1a receptor agonists, flesinoxan and 8-hydroxy-2- (di-n-propylamino)tetralon (8-oh-dpat), significantly decreased the population excitatory postsynaptic potential (epsp) in the ca3-ca1 excitatory synapse in a dose-dependent manner. |
2002-09-12 |
2023-08-12 |
Not clear |
| Keiichiro Tsuj. [Effect of (+/-)-pindolol on the central 5-HT1A receptor by the use of in vivo microdialysis and hippocampal slice preparations]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 22. issue 3. 2002-09-12. PMID:12166089. |
the effect of 5-ht and other 5-ht1a receptor agonists accompanied the increase in paired-pulse facilitation (ppf) induced by short-interval two stimuli and were reversed by the coadministration of the 5-ht1a receptor agonist, nan-190, but not by (+/-)-pindolol. |
2002-09-12 |
2023-08-12 |
Not clear |
| John J Sramek, Victoria Zarotsky, Neal R Cutle. Generalised anxiety disorder: treatment options. Drugs. vol 62. issue 11. 2002-09-11. PMID:12109925. |
there are a number of potentially new pharmacotherapies being investigated, including newer serotonin 5-ht1a receptor agonists, cholecystokinin receptor antagonists, neurokinin receptor antagonists, gabapentin and its analogues, and gamma-aminobutyric acid (gaba)a receptor modulators. |
2002-09-11 |
2023-08-12 |
Not clear |
| Markus Delling, Erhard Wischmeyer, Alexander Dityatev, Vladimir Sytnyk, Rüdiger W Veh, Andreas Karschin, Melitta Schachne. The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 16. 2002-09-04. PMID:12177211. |
mice deficient in the neural cell adhesion molecule (ncam) exhibit increased anxiety and anxiolytic sensitivity to serotonin 5-ht1a receptor agonists. |
2002-09-04 |
2023-08-12 |
mouse |
| Diana Kelder, Svante B Ros. Counteraction of the rapid tolerance to 8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia in rats by activation of the GABAA receptor-chloride channel complex. Pharmacology & toxicology. vol 90. issue 1. 2002-08-22. PMID:12005107. |
it is concluded that the results support the hypothesis that gaba neurones beyond the 5-ht neurones are involved in the mechanism causing tolerance to the 5-ht1a receptor-mediated hypothermia in rats. |
2002-08-22 |
2023-08-12 |
rat |
| I Muraki, T Inoue, S Hashimoto, T Izumi, K Ito, T Koyam. Effect of subchronic lithium treatment on citalopram-induced increases in extracellular concentrations of serotonin in the medial prefrontal cortex. Journal of neurochemistry. vol 76. issue 2. 2002-08-15. PMID:11208912. |
we investigated the effect of citalopram [a selective serotonin (5-ht) reuptake inhibitor; ssri] and mkc-242 (a selective 5-ht1a agonist), following treatment with subchronic lithium (p.o., 1 week) on extracellular 5-ht concentrations in the medial prefrontal cortex (mpfc). |
2002-08-15 |
2023-08-12 |
Not clear |
| I Muraki, T Inoue, S Hashimoto, T Izumi, K Ito, T Koyam. Effect of subchronic lithium treatment on citalopram-induced increases in extracellular concentrations of serotonin in the medial prefrontal cortex. Journal of neurochemistry. vol 76. issue 2. 2002-08-15. PMID:11208912. |
the addition of lithium did not change the effect of the 5-ht1a agonist on extracellular 5-ht concentrations. |
2002-08-15 |
2023-08-12 |
Not clear |
| L Orús, Y Sáinz, S Pérez, A M Oficialdegui, J Martinez, B Lasheras, J del Río, A Mong. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-2-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Die Pharmazie. vol 57. issue 6. 2002-08-09. PMID:12116869. |
new 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-2-yl)propane derivatives with dual action at 5-ht1a serotonin receptors and serotonin transporter as a new class of antidepressants. |
2002-08-09 |
2023-08-12 |
Not clear |
| L Orús, Y Sáinz, S Pérez, A M Oficialdegui, J Martinez, B Lasheras, J del Río, A Mong. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-2-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Die Pharmazie. vol 57. issue 6. 2002-08-09. PMID:12116869. |
compounds derived from 2-acetyl-3-methylbenzo[b]thiophene or 2-acetyl-3,5-dimethylbenzo[b]thiophene were prepared with two different phenylpiperazines (2-methoxy and 2-hydroxyphenylpiperazine) and evaluated for in vitro 5-ht1a receptor affinity and serotonin reuptake inhibition by radioligand assays. |
2002-08-09 |
2023-08-12 |
Not clear |
| L Orús, Y Sáinz, S Pérez, A M Oficialdegui, J Martinez, B Lasheras, J del Río, A Mong. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-2-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Die Pharmazie. vol 57. issue 6. 2002-08-09. PMID:12116869. |
compound 1-(3,5-dimethylbenzo[b]thiophen-2-yl)-3-[4-(2-methoxyphenyl)piperazin-1- yl]propan-1-ol (ii.2.a) shows good values (nm) for both activities: ki = 85 for 5-ht1a receptor and ki = 120 for serotonin transporter. |
2002-08-09 |
2023-08-12 |
Not clear |
| Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. |
the hypothermia produced by 5-ht1a agonists had initially been claimed to be caused by the activation of cell body 5-ht1a autoreceptors resulting in decreased 5-ht transmission in laboratory animals. |
2002-08-07 |
2023-08-12 |
human |
| Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. |
in order to address this issue in humans, 12 healthy volunteers underwent a dietary tryptophan depletion paradigm to decrease 5-ht availability, under double-blind conditions, during which body temperature was monitored following oral administration of the 5-ht1a agonist buspirone (30 mg). |
2002-08-07 |
2023-08-12 |
human |
| Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. |
the hypothesis was that if responses are mediated by decreased transmission at postsynaptic 5-ht1a receptors, resulting from dampened 5-ht release as a consequence of 5-ht1a autoreceptors activation, then responses to the exogenous 5-ht1a agonist should be attenuated when 5-ht availability has been markedly decreased beforehand. |
2002-08-07 |
2023-08-12 |
human |
| Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. |
in conclusion, these results strongly suggest that the hypothermia and the increases in prolactin and growth hormone produced by buspirone are attributable to the enhanced activation of postsynaptic 5-ht1a receptors, and not to a decrease in 5-ht transmission resulting from the activation of the 5-ht1a cell body autoreceptors on 5-ht neurons. |
2002-08-07 |
2023-08-12 |
human |