| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Murck, R M Frieboes, I A Antonijevic, A Steige. Distinct temporal pattern of the effects of the combined serotonin-reuptake inhibitor and 5-HT1A agonist EMD 68843 on the sleep EEG in healthy men. Psychopharmacology. vol 155. issue 2. 2001-10-18. PMID:11401008. |
emd 68843 (emd) has properties of a serotonin (5-ht)-reuptake inhibitor and a partial 5-ht1a agonist in one molecule in order to combine antidepressive and anxiolytic properties. |
2001-10-18 |
2023-08-12 |
Not clear |
| J Passchier, A van Waarde, R M Pieterman, A T Willemsen, W Vaalbur. Quantifying drug-related 5-HT1A receptor occupancy with. Psychopharmacology. vol 155. issue 2. 2001-10-18. PMID:11401009. |
[18f]mppf (4-(2'-methoxyphenyl)-1-[2'-(n-2"-pyridinyl)-p-[18f]fluorobenzamido]ethylpiperazine) is a selective radioligand for serotonin 5-ht1a receptors. |
2001-10-18 |
2023-08-12 |
human |
| A Bronowska, A Leś, Z Chilmonczyk, S Filipek, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors. Bioorganic & medicinal chemistry. vol 9. issue 4. 2001-10-11. PMID:11354671. |
molecular dynamics of buspirone analogues interacting with the 5-ht1a and 5-ht2a serotonin receptors. |
2001-10-11 |
2023-08-12 |
human |
| A Bronowska, A Leś, Z Chilmonczyk, S Filipek, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors. Bioorganic & medicinal chemistry. vol 9. issue 4. 2001-10-11. PMID:11354671. |
three-dimensional (3-d) models of the human serotonin 5-ht1a and 5-ht2a receptors were constructed, energy refined, and used to study the interactions with a series of buspirone analogues. |
2001-10-11 |
2023-08-12 |
human |
| M He, E Sibille, D Benjamin, M Toth, T Shippenber. Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis. Brain research. vol 902. issue 1. 2001-09-20. PMID:11376590. |
differential effects of 5-ht1a receptor deletion upon basal and fluoxetine-evoked 5-ht concentrations as revealed by in vivo microdialysis. |
2001-09-20 |
2023-08-12 |
mouse |
| M He, E Sibille, D Benjamin, M Toth, T Shippenber. Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis. Brain research. vol 902. issue 1. 2001-09-20. PMID:11376590. |
basal and fluoxetine-evoked extracellular concentrations of 5-ht were quantified in the striatum, a projection area of dorsal raphe neurons (drn), of wild-type (wt) and 5-ht1a receptor knock out (ko) mice. |
2001-09-20 |
2023-08-12 |
mouse |
| M He, E Sibille, D Benjamin, M Toth, T Shippenber. Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis. Brain research. vol 902. issue 1. 2001-09-20. PMID:11376590. |
the enhanced response to fluoxetine in ko mice is consistent with pharmacological studies and suggests that adaptive mechanisms that occur in response to 5-ht1a receptor deletion are insufficient to oppose increases in 5-ht concentrations produced by acute inhibition of the 5-ht transporter. |
2001-09-20 |
2023-08-12 |
mouse |
| S J Oh, H J Ha, D Y Chi, H K Le. Serotonin receptor and transporter ligands - current status. Current medicinal chemistry. vol 8. issue 9. 2001-09-20. PMID:11472239. |
radioisotope-labeled ligands have also been developed, including [carbonyl-(11)c]way 100635 for 5-ht1a receptor, [(11c) or (18)f]ketanserine derivatives for 5-ht(2) receptor, [(125)i]daizac for 5-ht(3) receptor, and [123i]idam for 5-ht transporter, and these are accumulated in brain regions that are rich in the respective receptors. |
2001-09-20 |
2023-08-12 |
human |
| M G Frank, D R Johnson, S E Hendricks, J L Fran. Monocyte 5-HT1A receptors mediate pindobind suppression of natural killer cell activity: modulation by catalase. International immunopharmacology. vol 1. issue 2. 2001-09-13. PMID:11360926. |
nk cell activity (nkca) was measured after exposure of mononuclear cells to the 5-ht1a receptor antagonist pindobind and the 5-ht(1c/2) receptor antagonist ketanserin. |
2001-09-13 |
2023-08-12 |
Not clear |
| M G Frank, D R Johnson, S E Hendricks, J L Fran. Monocyte 5-HT1A receptors mediate pindobind suppression of natural killer cell activity: modulation by catalase. International immunopharmacology. vol 1. issue 2. 2001-09-13. PMID:11360926. |
these data are consistent with previous results that 5-ht modulates nkca via 5-ht1a receptors on monocytes and suggest that 5-ht may abrogate monocyte suppression of nkca by inhibiting monocyte signals such as h2o2. |
2001-09-13 |
2023-08-12 |
Not clear |
| Y Tohyama, F Yamane, M F Merid, M Diksi. Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 11. issue 3. 2001-08-30. PMID:11418278. |
effects of selective 5-ht1a receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14c]methyl-l-tryptophan. |
2001-08-30 |
2023-08-12 |
rat |
| A R Ase, T A Reader, R Hen, M Riad, L Descarrie. Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice, and of serotonin innervation in the 5-HT1B knockout. Journal of neurochemistry. vol 78. issue 3. 2001-08-30. PMID:11483665. |
regional changes in density of serotonin transporter in the brain of 5-ht1a and 5-ht1b knockout mice, and of serotonin innervation in the 5-ht1b knockout. |
2001-08-30 |
2023-08-12 |
mouse |
| A R Ase, T A Reader, R Hen, M Riad, L Descarrie. Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice, and of serotonin innervation in the 5-HT1B knockout. Journal of neurochemistry. vol 78. issue 3. 2001-08-30. PMID:11483665. |
to identify serotoninergic correlates of these altered behaviors, autoradiographic measurements of 5-ht1a and 5-ht1b serotonin (5-ht) receptors and transporter (5-htt) were obtained using the radioligands [3h]8-oh-dpat, [125i]cyanopindolol and [3h]citalopram, respectively. |
2001-08-30 |
2023-08-12 |
mouse |
| A R Ase, T A Reader, R Hen, M Riad, L Descarrie. Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice, and of serotonin innervation in the 5-HT1B knockout. Journal of neurochemistry. vol 78. issue 3. 2001-08-30. PMID:11483665. |
(iii) this down-regulation could contribute to the anxious-like phenotype of the 5-ht1a kos, by reducing 5-ht clearance in several territories of 5-ht innervation. |
2001-08-30 |
2023-08-12 |
mouse |
| A Newman-Tancredi, C Chaput, M Touzard, M J Milla. Pindolol antagonises G-protein activation at both pre- and postsynaptic serotonin 5-HT1A receptors: a. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330332. |
pindolol antagonises g-protein activation at both pre- and postsynaptic serotonin 5-ht1a receptors: a. |
2001-08-16 |
2023-08-12 |
Not clear |
| A Newman-Tancredi, C Chaput, M Touzard, M J Milla. Pindolol antagonises G-protein activation at both pre- and postsynaptic serotonin 5-HT1A receptors: a. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330332. |
both 8-oh-dpat (1 microm) and 5-ht (10 microm) elicited a pronounced increase in [35s]gtpys binding in the dorsal raphe nucleus, which contains serotonergic cell bodies bearing 5-ht1a autoreceptors. |
2001-08-16 |
2023-08-12 |
Not clear |
| A Newman-Tancredi, C Chaput, M Touzard, M J Milla. Pindolol antagonises G-protein activation at both pre- and postsynaptic serotonin 5-HT1A receptors: a. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330332. |
in the dentate gyrus, lateral septum and entorhinal cortex, structures enriched in postsynaptic 5-ht1a receptors, 8-oh-dpat (1 microm) and 5-ht (10 microm) also elicited a marked increase in [35s]gtpgammas binding which was likewise blocked by pindolol. |
2001-08-16 |
2023-08-12 |
Not clear |
| A Newman-Tancredi, C Chaput, M Touzard, M J Milla. Pindolol antagonises G-protein activation at both pre- and postsynaptic serotonin 5-HT1A receptors: a. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330332. |
in conclusion, these data suggest that, as characterised by [35s]gtpgammas autoradiography, and compared with 5-ht and 8-oh-dpat, pindolol possesses low efficacy at both pre- and postsynaptic 5-ht1a receptors. |
2001-08-16 |
2023-08-12 |
Not clear |
| A Dekeyne, J M Rivet, A Gobert, M J Milla. Generalization of serotonin (5-HT)1A agonists and the antipsychotics, clozapine, ziprasidone and S16924, but not haloperidol, to the discriminative stimuli elicited by PD128,907 and 7-OH-DPAT. Neuropharmacology. vol 40. issue 7. 2001-08-09. PMID:11378160. |
the selective 5-ht1a receptor agonists, 8-oh-dpat and flesinoxan, dose-dependently generalized to pd128,907 with effective dose(50)s (ed50s) of 0.08 and 1.5mg/kg, s.c., respectively, and inhibited the release and synthesis of 5-ht but not of da. |
2001-08-09 |
2023-08-12 |
rat |
| J Martínez-Esparza, A M Oficialdegui, S Pérez-Silanes, B Heras, L Orús, J A Palop, B Lasheras, J Roca, M Mourelle, A Bosch, J C Del Castillo, R Tordera, J Del Río, A Mong. New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. Journal of medicinal chemistry. vol 44. issue 3. 2001-08-02. PMID:11462981. |
new 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-ht1a serotonin receptors and serotonin transporter, as a new class of antidepressants. |
2001-08-02 |
2023-08-12 |
mouse |