Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
I Murak. [Behavioral and neurochemical study on the mechanism of the anxiolytic effect of a selective serotonin reuptake inhibitor, a selective serotonin1A agonist and lithium carbonate]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 76. issue 2. 2001-06-21. PMID:11344903. |
subchronic lithium did not cause decreases in extracellular 5-ht after presynaptic stimulation of 5-ht1a receptors by mkc-242. |
2001-06-21 |
2023-08-12 |
Not clear |
I Murak. [Behavioral and neurochemical study on the mechanism of the anxiolytic effect of a selective serotonin reuptake inhibitor, a selective serotonin1A agonist and lithium carbonate]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 76. issue 2. 2001-06-21. PMID:11344903. |
it is hypothesized that subchronic lithium treatment gives an additive effect to the treatment with citalopram (3 and 30 mg/kg) by increasing the extracellular 5-ht concentrations in the mpfc, and that subchronic lithium treatment enhances the anxiolytic effect of mkc-242 by increasing sensitivity of postsynaptic 5-ht1a receptors. |
2001-06-21 |
2023-08-12 |
Not clear |
X M Ou, J M Storring, N Kushwaha, P R Alber. Heterodimerization of mineralocorticoid and glucocorticoid receptors at a novel negative response element of the 5-HT1A receptor gene. The Journal of biological chemistry. vol 276. issue 17. 2001-06-14. PMID:11278286. |
negative regulation of neuronal serotonin (5-ht1a) receptor levels by glucocorticoids in vivo may contribute to depression. |
2001-06-14 |
2023-08-12 |
mouse |
A W Wilson, B Costall, J C Neil. Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system. Journal of psychopharmacology (Oxford, England). vol 14. issue 4. 2001-05-31. PMID:11198050. |
results showed that the 5-ht releaser d-fenfluramine, the selective serotonin reuptake inhibitor fluoxetine, the 5-ht1a receptor agonist 8-hydroxy-2[di-n-propylamino]tetralin, the partial 5-ht1a receptor agonist buspirone, and the 5-ht1b/5-ht2c receptor agonist 1-(3-trifluoromethylphenyl)piperazine, but not the 5-ht2a/5-ht2c receptor agonist 1-(2,5-dimethoxy-4-iodophenylaminopropane)-2, selectively reduced responding on a lever leading to presentation of an ethanol paired conditioned stimulus. |
2001-05-31 |
2023-08-12 |
rat |
A W Wilson, B Costall, J C Neil. Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system. Journal of psychopharmacology (Oxford, England). vol 14. issue 4. 2001-05-31. PMID:11198050. |
results are consistent with involvement of the dopaminergic and 5-ht systems, in particular activation of 5-ht1a and 5-ht1b receptor subtypes, in mediation of the conditioned or secondary reinforcing properties of ethanol. |
2001-05-31 |
2023-08-12 |
rat |
H J Bidmon, A Schleicher, K Wicke, G Gross, K Zille. Localisation of mRNA for h5-HT1B and h5-HT1D receptors in human dorsal raphe. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284452. |
pharmacological evidence obtained in rodents suggests that terminal and somatodendritic autoreceptors controlling serotonin (5-hydroxytryptamine, 5-ht) release belong to the 5-ht1b/d subtype of receptors, whereas somatodendritic autoreceptors controlling neuronal cell firing are predominantly of the 5-ht1a subtype. |
2001-05-24 |
2023-08-12 |
human |
A Scandroglio, E Monferini, F Borsin. Ex vivo binding of flibanserin to serotonin 5-HT1A and 5-HT2A receptors. Pharmacological research. vol 43. issue 2. 2001-05-17. PMID:11243720. |
ex vivo binding of flibanserin to serotonin 5-ht1a and 5-ht2a receptors. |
2001-05-17 |
2023-08-12 |
Not clear |
T Miyawaki, A K Goodchild, P M Pilowsk. Rostral ventral medulla 5-HT1A receptors selectively inhibit the somatosympathetic reflex. American journal of physiology. Regulatory, integrative and comparative physiology. vol 280. issue 5. 2001-05-17. PMID:11294742. |
the role of the 5-hydroxytryptamine (5-ht1a) receptors in the rostral ventrolateral medulla (rvlm) on somatosympathetic, baroreceptor, and chemoreceptor reflexes was examined in anesthetized rats. |
2001-05-17 |
2023-08-12 |
rat |
G Wegener, V Volke, Z Bandpey, R Rosenber. Nitric oxide modulates lithium-induced conditioned taste aversion. Behavioural brain research. vol 118. issue 2. 2001-05-10. PMID:11164517. |
furthermore, the results suggest that the 5-ht1a receptor plays an important role in the cta induced by mb and 7-ni, thus indicating a possible interaction between the 5-ht and no systems. |
2001-05-10 |
2023-08-12 |
Not clear |
C Roberts, G W Pric. Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study. Neuroscience letters. vol 300. issue 1. 2001-05-10. PMID:11172936. |
5-ht1a, 5-ht1b and 5-ht1d receptors are known to function as 5-ht autoreceptors in the rat dorsal raphe nucleus (drn), modulating local 5-ht efflux. |
2001-05-10 |
2023-08-12 |
rat |
C Roberts, G W Pric. Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study. Neuroscience letters. vol 300. issue 1. 2001-05-10. PMID:11172936. |
we investigated the effect of 5-ht1b and 5-ht1d receptor antagonists on 5-ht efflux in rat drn, alone and in the presence of 5-ht1a receptor antagonists, using the technique of fast cyclic voltammetry. |
2001-05-10 |
2023-08-12 |
rat |
C Roberts, G W Pric. Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study. Neuroscience letters. vol 300. issue 1. 2001-05-10. PMID:11172936. |
the 5-ht1a receptor antagonist, way 100635, and the 5-ht1b receptor antagonist, sb-224289, had no effect on 5-ht efflux while the 5-ht1b/1d receptor antagonist, gr 127935, produced a small decrease in 5-ht efflux. |
2001-05-10 |
2023-08-12 |
rat |
C Roberts, G W Pric. Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study. Neuroscience letters. vol 300. issue 1. 2001-05-10. PMID:11172936. |
these data confirm that 5-ht efflux within the drn is under the control of 5-ht1a, 5-ht1b and 5-ht1d autoreceptors and elevation of 5-ht efflux was greatest following antagonism of 5-ht1a and 5-ht1b receptors. |
2001-05-10 |
2023-08-12 |
rat |
K N Browning, R A Travagl. The peptide TRH uncovers the presence of presynaptic 5-HT1A receptors via activation of a second messenger pathway in the rat dorsal vagal complex. The Journal of physiology. vol 531. issue Pt 2. 2001-05-10. PMID:11230515. |
such trh-induced 5-ht responses were prevented by the 5-ht1a antagonist nan-190 (1 microm) and mimicked by the 5-ht1a agonist 8-oh-dpat (1 microm). |
2001-05-10 |
2023-08-12 |
rat |
J Martínez, S Pérez, A M Oficialdegui, B Heras, L Orús, H Villanueva, J A Palop, J Roca, M Mourelle, A Bosch, J C Del Castillo, B Lasheras, R Tordera, J del Río, A Mong. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. European journal of medicinal chemistry. vol 36. issue 1. 2001-05-10. PMID:11231049. |
new 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-ht1a serotonin receptors and serotonin transporter as a new class of antidepressants. |
2001-05-10 |
2023-08-12 |
Not clear |
J Martínez, S Pérez, A M Oficialdegui, B Heras, L Orús, H Villanueva, J A Palop, J Roca, M Mourelle, A Bosch, J C Del Castillo, B Lasheras, R Tordera, J del Río, A Mong. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. European journal of medicinal chemistry. vol 36. issue 1. 2001-05-10. PMID:11231049. |
a series of new 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives were synthesized in an attempt to find a new class of antidepressant drugs with dual activity at 5-ht1a serotonin receptors and serotonin transporter. |
2001-05-10 |
2023-08-12 |
Not clear |
J Martínez, S Pérez, A M Oficialdegui, B Heras, L Orús, H Villanueva, J A Palop, J Roca, M Mourelle, A Bosch, J C Del Castillo, B Lasheras, R Tordera, J del Río, A Mong. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. European journal of medicinal chemistry. vol 36. issue 1. 2001-05-10. PMID:11231049. |
title compounds were evaluated for in vitro activity on 5-ht1a receptor and 5-ht transporter. |
2001-05-10 |
2023-08-12 |
Not clear |
J Martínez, S Pérez, A M Oficialdegui, B Heras, L Orús, H Villanueva, J A Palop, J Roca, M Mourelle, A Bosch, J C Del Castillo, B Lasheras, R Tordera, J del Río, A Mong. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. European journal of medicinal chemistry. vol 36. issue 1. 2001-05-10. PMID:11231049. |
they show high nanomolar affinity for both activities, and in particular, compounds 1-(5-chlorobenzo[b]thiophen-3-yl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-ol (7) and 1-(5-fluorobenzo[b]thiophen-3-yl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-ol (8) show values (nm) of k(i)=30 and 2.3 for 5-ht1a receptors and k(i)=30 and 12 for serotonin transporters, respectively. |
2001-05-10 |
2023-08-12 |
Not clear |
Y J Karten, C M Stienstra, M Joël. Corticosteroid effects on serotonin responses in granule cells of the rat dentate gyrus. Journal of neuroendocrinology. vol 13. issue 3. 2001-05-03. PMID:11207937. |
these cells also express various receptor-subtypes for serotonin (5-ht), including the 5-ht1a receptor which mediates a membrane hyperpolarization accompanied by a decrease in membrane resistance. |
2001-05-03 |
2023-08-12 |
rat |
Y J Karten, C M Stienstra, M Joël. Corticosteroid effects on serotonin responses in granule cells of the rat dentate gyrus. Journal of neuroendocrinology. vol 13. issue 3. 2001-05-03. PMID:11207937. |
in the present, intracellular recording study in vitro, we examined if the altered levels of 5-ht1a receptor mrna and protein are associated with changes in the response to 5-ht. |
2001-05-03 |
2023-08-12 |
rat |