| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E Marshall, T G Bird, K Hart, K I Wels. Unified approach to the analysis of genetic variation in serotonergic pathways. American journal of medical genetics. vol 88. issue 6. 2000-02-24. PMID:10581480. |
these genes include tryptophan hydroxylase, tryptophan dioxygenase, monoamine oxidase a, and the serotonin receptors 5ht1a, 5ht1d-alpha, 5ht1d-beta, 5ht2a, 5ht2c, and 5ht5a. |
2000-02-24 |
2023-08-12 |
Not clear |
| E Le Poul, C Boni, N Hanoun, A M Laporte, N Laaris, J Chauveau, M Hamon, L Lanfume. Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology. vol 39. issue 1. 2000-02-18. PMID:10665824. |
differential adaptation of brain 5-ht1a and 5-ht1b receptors and 5-ht transporter in rats treated chronically with fluoxetine. |
2000-02-18 |
2023-08-12 |
rat |
| K P Ittner, M Zimmermann, M Bucher, W Gessele, F Kees, B K Krämer, H F Grobecke. The effect of urapidil and ramipril on hyperglycemia in streptozotocin diabetic rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 1. 2000-02-17. PMID:10651153. |
we compared the effect of the antihypertensive hybrid drug urapidil [alpha1-adrenoceptor antagonist serotonin 1a (5-hydroxytryptamine 1a, 5-ht1a) receptor agonist] on hyperglycemia in streptozotocin diabetic rats with the angiotensin-converting enzyme inhibitor ramipril. |
2000-02-17 |
2023-08-12 |
rat |
| M Riad, S Garcia, K C Watkins, N Jodoin, E Doucet, X Langlois, S el Mestikawy, M Hamon, L Descarrie. Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain. The Journal of comparative neurology. vol 417. issue 2. 2000-02-17. PMID:10660896. |
somatodendritic localization of 5-ht1a and preterminal axonal localization of 5-ht1b serotonin receptors in adult rat brain. |
2000-02-17 |
2023-08-12 |
rat |
| M Riad, S Garcia, K C Watkins, N Jodoin, E Doucet, X Langlois, S el Mestikawy, M Hamon, L Descarrie. Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain. The Journal of comparative neurology. vol 417. issue 2. 2000-02-17. PMID:10660896. |
the 5-ht1a and 5-ht1b receptors of serotonin play important roles as auto- and heteroreceptors controlling the release of serotonin itself and of other neurotransmitters/modulators in the central nervous system (cns). |
2000-02-17 |
2023-08-12 |
rat |
| M Riad, S Garcia, K C Watkins, N Jodoin, E Doucet, X Langlois, S el Mestikawy, M Hamon, L Descarrie. Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain. The Journal of comparative neurology. vol 417. issue 2. 2000-02-17. PMID:10660896. |
because the 5-ht1a receptors are somatodendritic, they are ideally situated to mediate serotonin effects on neuronal firing, both as auto- and as heteroreceptors. |
2000-02-17 |
2023-08-12 |
rat |
| P A Sargent, K H Kjaer, C J Bench, E A Rabiner, C Messa, J Meyer, R N Gunn, P M Grasby, P J Cowe. Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Archives of general psychiatry. vol 57. issue 2. 2000-02-16. PMID:10665620. |
the aim of the present study was to use positron emission tomography with the selective 5-ht1a receptor antagonist [11c]way-100635 to measure 5-ht1a receptor binding in depressed patients before and during treatment with selective serotonin reuptake inhibitors. |
2000-02-16 |
2023-08-12 |
Not clear |
| M L López-Rodríguez, B Benhamú, A Viso, M J Morcillo, M Murcia, L Orensanz, M J Alfaro, M I Martí. Benzimidazole derivatives. Part 1: Synthesis and structure-activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists. Bioorganic & medicinal chemistry. vol 7. issue 11. 2000-02-14. PMID:10632037. |
amides 12-15 and esters 24 and 25 bound at central 5-ht4 sites with very high affinity (ki = 0.11-2.9 nm) and excellent selectivity over serotonin 5-ht3, 5-ht2a, and 5-ht1a receptors (ki > 1000-10,000 nm). |
2000-02-14 |
2023-08-12 |
Not clear |
| E J Homan, M T Tulp, J E Nilsson, H V Wikström, C J Gro. C5-substituted derivatives of 5-OMe-BPAT: synthesis and interactions with dopamine D2 and serotonin 5-HT1A receptors. Bioorganic & medicinal chemistry. vol 7. issue 11. 2000-02-14. PMID:10632064. |
c5-substituted derivatives of 5-ome-bpat: synthesis and interactions with dopamine d2 and serotonin 5-ht1a receptors. |
2000-02-14 |
2023-08-12 |
rat |
| E J Homan, M T Tulp, J E Nilsson, H V Wikström, C J Gro. C5-substituted derivatives of 5-OMe-BPAT: synthesis and interactions with dopamine D2 and serotonin 5-HT1A receptors. Bioorganic & medicinal chemistry. vol 7. issue 11. 2000-02-14. PMID:10632064. |
the 5-acetyl, 5-cyano, 5-methyl, 5-(2-furyl), 5-phenyl, methyl 5-carboxylate, and the 5-carboxamido analogues 5-11 thus obtained, the previously disclosed 5-methoxy, 5-hydroxy, and 5-unsubstituted analogues 1-3, and the 5-triflate analogue 4 were evaluated for their ability to compete for [3h]-spiperone binding to rat striatal membranes containing dopamine d2 receptors, and their ability to compete for [3h]-8-oh-dpat binding to rat frontal cortex membranes containing serotonin 5-ht1a receptors in vitro. |
2000-02-14 |
2023-08-12 |
rat |
| E J Homan, M T Tulp, J E Nilsson, H V Wikström, C J Gro. C5-substituted derivatives of 5-OMe-BPAT: synthesis and interactions with dopamine D2 and serotonin 5-HT1A receptors. Bioorganic & medicinal chemistry. vol 7. issue 11. 2000-02-14. PMID:10632064. |
the serotonin 5-ht1a receptor tolerated more structural diversity at the c5-position of 1, as revealed by the higher ki-values of 1-11, which ranged from 60 nm for the 5-carboxamido analogue to 1.0 nm for the 5-unsubstituted analogue. |
2000-02-14 |
2023-08-12 |
rat |
| E J Homan, M T Tulp, J E Nilsson, H V Wikström, C J Gro. C5-substituted derivatives of 5-OMe-BPAT: synthesis and interactions with dopamine D2 and serotonin 5-HT1A receptors. Bioorganic & medicinal chemistry. vol 7. issue 11. 2000-02-14. PMID:10632064. |
a pls model with moderate predictability (q2 = 0.49) could be derived for the serotonin 5-ht1a receptor affinities of 1-11. |
2000-02-14 |
2023-08-12 |
rat |
| I Misane, S O Ogre. Multiple 5-HT receptors in passive avoidance: comparative studies of p-chloroamphetamine and 8-OH-DPAT. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 2. 2000-02-14. PMID:10649830. |
the aim of this study was to examine the involvement of multiple 5-ht receptors in passive avoidance (pa) with a focus on 5-ht1a, 5-ht2a, and 5-ht2c receptors. |
2000-02-14 |
2023-08-12 |
rat |
| I Misane, S O Ogre. Multiple 5-HT receptors in passive avoidance: comparative studies of p-chloroamphetamine and 8-OH-DPAT. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 2. 2000-02-14. PMID:10649830. |
because increases in 5-ht transmission result in concomitant multiple 5-ht receptor activation, the effects of the 5-ht releasing compound p-chloroamphetamine (pca) were compared with those of the selective 5-ht1a receptor agonist 8-oh-dpat in the rat. |
2000-02-14 |
2023-08-12 |
rat |
| A Menese. 5-HT system and cognition. Neuroscience and biobehavioral reviews. vol 23. issue 8. 2000-02-11. PMID:10643820. |
likewise, the stimulation or blockade of presynaptic 5-ht1a, 5-ht1b, 5-ht(2a/2c) and 5-ht3 receptors, postsynaptic 5-ht(2b/2c) and 5-ht4 receptors and 5-ht uptake/transporter sites modulate these processes. |
2000-02-11 |
2023-08-12 |
Not clear |
| A Menese. 5-HT system and cognition. Neuroscience and biobehavioral reviews. vol 23. issue 8. 2000-02-11. PMID:10643820. |
in this regard, it is probable that selective drugs with agonists, neutral antagonist, agonists or inverse agonist properties for 5-ht1a, 5-ht(1b/1d), 5-ht(2a/2b/2c), 5-ht4 and 5-ht7 receptors could constitute a new therapeutic opportunity for learning and memory alterations. |
2000-02-11 |
2023-08-12 |
Not clear |
| S W Watts, G D Fink, P J Silver, D J Cushin. Interaction of the beta adrenergic receptor antagonist bucindolol with serotonergic receptors. Journal of cardiovascular pharmacology. vol 35. issue 1. 2000-02-10. PMID:10630730. |
both in vitro and in vivo methods were used to examine the interaction of bucindolol with 5-ht receptors relevant to the cardiovascular system-the 5-ht1a, 5-ht1d, 5-ht2a, and 5-ht2b receptors-and with alpha1-adrenergic receptors. |
2000-02-10 |
2023-08-12 |
rat |
| P W Burnet, T Sharp, S M LeCorre, P J Harriso. Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock. Neuroscience letters. vol 277. issue 2. 2000-02-08. PMID:10624814. |
we have measured the mrnas encoding 5-ht1a, 5-ht2a, 5-ht2c and 5-ht7 receptors, and the 5-ht transporter, in rat brain after single ecs, repeated ecs, and 3 weeks after repeated ecs. |
2000-02-08 |
2023-08-12 |
rat |
| J P Voigt, F Kienzle, R Sohr, A Rex, H Fin. Feeding and 8-OH-DPAT-related release of serotonin in the rat lateral hypothalamus. Pharmacology, biochemistry, and behavior. vol 65. issue 1. 2000-01-28. PMID:10638652. |
based on the different effects of somatodendritic 5-ht1a agonist 8-oh-dpat on food intake whether given to food-deprived rats or freely feeding rats, we hypothesized that the effects of 8-oh-dpat on extracellular serotonin (5-ht) in the lateral hypothalamus (lh) will interfere with different feeding states, eventually resulting in different patterns of 5-ht release. |
2000-01-28 |
2023-08-12 |
rat |
| D J McLoughlin, P G Strang. Mechanisms of agonism and inverse agonism at serotonin 5-HT1A receptors. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617139. |
mechanisms of agonism and inverse agonism at serotonin 5-ht1a receptors. |
2000-01-18 |
2023-08-12 |
Not clear |