All Relations between 5-ht receptor 1b and 5-ht receptor 1d

Reference Sentence Publish Date Extraction Date Species
C Davidson, J A Stamfor. Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus. Neurochemistry international vol 36 issue 2 2000 10676872 Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus. 2000-02-25 2022-01-08 rat
C Davidson, J A Stamfor. Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus. Neurochemistry international vol 36 issue 2 2000 10676872 This study reports the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on 5-HT1B and 5-HT1D autoreceptors controlling stimulated 5-HT efflux in slices of rat dorsal raphe nucleus. 2000-02-25 2022-01-08 rat
C Davidson, J A Stamfor. Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus. Neurochemistry international vol 36 issue 2 2000 10676872 5-HT efflux was inhibited by CP 93129 (10 nM-10 microM) and by sumatriptan (1 nM-1 microM) agonists at 5-HT1B and 5-HT1D receptors, respectively. 2000-02-25 2022-01-08 rat
T Nilsson, J Longmore, D Shaw, I J Olesen, L Edvinsso. Contractile 5-HT1B receptors in human cerebral arteries: pharmacological characterization and localization with immunocytochemistry. British journal of pharmacology vol 128 issue 6 2000 10578124 We have examined 5-HT receptor subtype distribution in cerebral blood vessels by immunocytochemistry with antibodies selective for human 5-HT1B and human 5-HT1D receptors and also studied the contractile effects of a range of 5-HT receptor agonists and antagonists in HCA. 2000-01-24 2022-01-08 Not clear
R J Hargreaves, S L Shephear. Pathophysiology of migraine--new insights. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques vol 26 Suppl 3 issue 1999 10563228 sumatriptan, rizatriptan, zolmitriptan naratriptan) are serotonergic agonists that have been shown to act selectively by causing vasoconstriction through 5-HT1B receptors that are expressed in human intracranial arteries and by inhibiting nociceptive transmission through an action at 5-HT1D receptors on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei. 1999-12-07 2022-01-08 Not clear
C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology vol 38 issue 9 1999 10471095 Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. 1999-10-25 2022-01-08 Not clear
C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology vol 38 issue 9 1999 10471095 These data demonstrate that to simultaneously increase extracellular 5-HT in both frontal cortex and dorsal hippocampus of the guinea-pig brain concurrent 5-HTA1A, 5-HT1B and 5-HT1D receptor blockade is required. 1999-10-25 2022-01-08 Not clear
P De Vries, E W Willems, J P Heiligers, C M Villal\\xc3\\xb3n, P R Saxen. Investigation of the role of 5-HT1B and 5-HT1D receptors in the sumatriptan-induced constriction of porcine carotid arteriovenous anastomoses. British journal of pharmacology vol 127 issue 2 1999 10385240 The results indicate that sumatriptan constricts porcine carotid arteriovenous anastomoses primarily via 5-HT1B, but not via 5-HT1D receptors. 1999-10-15 2022-01-08 Not clear
P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology vol 38 issue 8 1999 10462130 Consequently, the present study using in vivo microdialysis was undertaken to (i) characterize the effects of alpha2D, 5-HT1B and 5-HT1D receptor stimulation or blockade on 5-HT efflux in the FC given the purported regulatory role of these sites on 5-HT release, and (ii) to investigate the ability of risperidone to interfere with these receptors in order to examine their putative role in the facilitatory action or risperidone on cortical 5-HT output. 1999-10-12 2022-01-08 Not clear
P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology vol 38 issue 8 1999 10462130 The present in vivo biochemical data indicate that the output of 5-HT in the FC is negatively regulated via alpha2D, 5-HT1B and tentatively also via 5-HT1D receptors located in the nerve terminal area. 1999-10-12 2022-01-08 Not clear
D N Middlemiss, M G\\xc3\\xb6thert, E Schlicker, C M Scott, J V Selkirk, J Watson, L M Gaster, P Wyman, G Riley, G W Pric. SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor. European journal of pharmacology vol 375 issue 1-3 1999 10443589 A novel compound, SB-236057 (1'-ethyl-5-(2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl- 4-carbonyl)-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperid ine]) has been shown to have high affinity for human 5-hydroxytryptamine1B (5-HT1B) receptors (pKi = 8.2) and displays over 75 or more-fold selectivity for the human 5-HT1B receptor over other 5-HT receptors, including the human 5-HT1D receptor, and a range of other receptors, ion channels and enzymes. 1999-10-08 2022-01-08 Not clear
G W John, P J Pauwels, M Perez, S Halazy, B Le Grand, Y Verscheure, J P Valentin, C Palmier, T Wurch, P Chopin, M Marien, M S Kleven, W Koek, M B Assie, E Carilla-Durand, J P Tarayre, F C Colpaer. F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. The Journal of pharmacology and experimental therapeutics vol 290 issue 1 1999 10381763 F 11356 has subnanomolar affinity for cloned human and nonhuman 5-HT1B and 5-HT1D receptors, and its affinity for 5-HT1A and other 5-HT receptors, including the 5-ht1F subtype, is 50-fold lower and micromolar, respectively. 1999-07-26 2022-01-08 Not clear
G W John, P J Pauwels, M Perez, S Halazy, B Le Grand, Y Verscheure, J P Valentin, C Palmier, T Wurch, P Chopin, M Marien, M S Kleven, W Koek, M B Assie, E Carilla-Durand, J P Tarayre, F C Colpaer. F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. The Journal of pharmacology and experimental therapeutics vol 290 issue 1 1999 10381763 In C6 cells expressing human 5-HT1B or human 5-HT1D receptors, F 11356 was the most potent compound in inhibiting forskolin-induced cyclic AMP formation (pD2 = 8.9 and 9.6), and in contrast to tryptamine and derivatives, it produced maximal enhancement of [35S]guanosine-5'-O-(3-thio)triphosphate-specific binding equivalent to 5-HT. 1999-07-26 2022-01-08 Not clear
D D Mitsikostas, M Sanchez del Rio, M A Moskowitz, C Waebe. Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis. European journal of pharmacology vol 369 issue 3 1999 10225363 Sumatriptan's effects might be mediated by 5-HT1B, 5-HT1D or 5-HT1F receptors. 1999-06-29 2022-01-08 rat
W D Hirst, N Y Cheung, M Rattray, G W Price, G P Wilki. Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase. Brain research. Molecular brain research vol 61 issue 1-2 1999 9795156 The functional expression of 5-HT1 receptor subtypes was investigated by measuring the ability of 5-HT1 receptor agonists: 8-OH-DPAT (5-HT1A receptors), RU24969 (5-HT1A, 5-HT1B, 5-HT1D, and 5-HT1F receptors) or sumatriptan (5-HT1B, 5-HT1D, and 5-HT1F receptors) to modulate forskolin or isoproterenol stimulated cAMP production. 1999-06-10 2022-01-08 rat
C Napier, M Stewart, H Melrose, B Hopkins, A McHarg, R Walli. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. European journal of pharmacology vol 368 issue 2-3 1999 10193663 Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. 1999-06-01 2022-01-08 Not clear
C Napier, M Stewart, H Melrose, B Hopkins, A McHarg, R Walli. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. European journal of pharmacology vol 368 issue 2-3 1999 10193663 Eletriptan, like sumatriptan, zolmitriptan, naratriptan and rizatriptan had highest affinity for the human 5-HT1B, 5-HT1D and putative 5-ht1f receptor. 1999-06-01 2022-01-08 Not clear
C Napier, M Stewart, H Melrose, B Hopkins, A McHarg, R Walli. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. European journal of pharmacology vol 368 issue 2-3 1999 10193663 Kinetic studies comparing the binding of [3H]eletriptan and [3H]sumatriptan to the human recombinant 5-HT1B and 5-HT1D receptors expressed in HeLa cells revealed that both radioligands bound with high specificity (>90%) and reached equilibrium within 10-15 min. 1999-06-01 2022-01-08 Not clear
C Napier, M Stewart, H Melrose, B Hopkins, A McHarg, R Walli. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. European journal of pharmacology vol 368 issue 2-3 1999 10193663 However, [3H]eletriptan had over 6-fold higher affinity than [3H]sumatriptan at the 5-HT1D receptor (K(D)): 0.92 and 6.58 nM, respectively) and over 3-fold higher affinity than [3H]sumatriptan at the 5-HT1B receptor (K(D): 3.14 and 11.07 nM, respectively). 1999-06-01 2022-01-08 Not clear
C Napier, M Stewart, H Melrose, B Hopkins, A McHarg, R Walli. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. European journal of pharmacology vol 368 issue 2-3 1999 10193663 These data indicate that eletriptan is a potent ligand at the human 5-HT1B, 5-HT1D, and 5-ht1f receptors and are consistent with its potent vasoconstrictor activity and use as a drug for the acute treatment of migraine headache. 1999-06-01 2022-01-08 Not clear
A J Schee. [Pharmacy-clinic medication of the month. Naratriptan (naramig)]. Revue medicale de Liege vol 54 issue 3 1999 10321110 Naratriptan, launched by Glaxo Wellcome under the trade name Naramig, is a potent and selective agonist of 5-HT1B and 5-HT1D vascular receptors. 1999-05-28 2022-01-08 Not clear
D S Dupuis, M Perez, S Halazy, F C Colpaert, P J Pauwel. Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses. Brain research. Molecular brain research vol 67 issue 1 1999 10101238 Dimerization of sumatriptan increased the binding affinity for h 5-HT1B (pKi: 9.22 vs. 7.79 for sumatriptan), h 5-HT1D (9.07 vs. 8.08) and also h 5-HT1A receptors (7.80 vs. 6.40), while the binding affinity for h 5-ht1E (6.67 vs. 6.19) and h 5-ht1F (7.37 vs. 7.78) receptors was not affected. 1999-05-21 2022-01-08 Not clear
B Le Grand, A Panissi\\xc3\\xa9, P J Pauwels, G W Joh. Activation of recombinant h 5-HT1B and h 5-HT1D receptors stably expressed in C6 glioma cells produces increases in Ca2+-dependent K+ current. Naunyn-Schmiedeberg's archives of pharmacology vol 358 issue 6 1999 9879718 In C6 glioma cells expressing either recombinant h 5-HT1B or h 5-HT1D receptors, sumatriptan similarly increased IK in a concentration-dependent manner (maximum increase 19.4+/-7.2%, n=8, P<0.05 and 25.1+/-3.9%, n=6, P<0.001, respectively) with EC50 values (geometric mean with 95% confidence intervals in parentheses) of 56.3 nM (7.9-140 nM) and 68.7 nM (16-120 nM), respectively. 1999-04-29 2022-01-08 Not clear
B Le Grand, A Panissi\\xc3\\xa9, P J Pauwels, G W Joh. Activation of recombinant h 5-HT1B and h 5-HT1D receptors stably expressed in C6 glioma cells produces increases in Ca2+-dependent K+ current. Naunyn-Schmiedeberg's archives of pharmacology vol 358 issue 6 1999 9879718 Sumatriptan failed to elicit increases in IK in non-transfected cells, confirming a specific involvement of the respective membrane h 5-HT1B and h 5-HT1D receptors in transfected C6 cells. 1999-04-29 2022-01-08 Not clear
B Le Grand, A Panissi\\xc3\\xa9, P J Pauwels, G W Joh. Activation of recombinant h 5-HT1B and h 5-HT1D receptors stably expressed in C6 glioma cells produces increases in Ca2+-dependent K+ current. Naunyn-Schmiedeberg's archives of pharmacology vol 358 issue 6 1999 9879718 In the presence of the mixed 5-HT1B/D receptor antagonist GR 127935 (0.1 microM), sumatriptan (1 microM) failed to significantly increase IK in C6 cells expressing h 5-HT1B receptors (-7.5+/-3.5%, P=NS, n=6), although a higher concentration of GR 127935 (1 microM) was required to significantly inhibit sumatriptan-evoked increases in IK in C6 cells expressing h 5-HT1D receptors (-1.8+/-3.5%, P=NS, n=6), confirming that sumatriptan-evoked responses were indeed mediated by h 5-HT1B and h 5-HT1D receptors, respectively. 1999-04-29 2022-01-08 Not clear
P De Vries, A S\\xc3\\xa1nchez-L\\xc3\\xb3pez, D Centuri\\xc3\\xb3n, J P Heiligers, P R Saxena, C M Villal\\xc3\\xb3. The canine external carotid vasoconstrictor 5-HT1 receptor: blockade by 5-HT1B (SB224289), but not by 5-HT1D (BRL15572) receptor antagonists. European journal of pharmacology vol 362 issue 1 1999 9865532 It is concluded that mainly 5-HT1B, but not 5-HT1D receptors mediate the canine external carotid vasoconstriction by 5-HT and sumatriptan. 1999-04-13 2022-01-08 Not clear
M Perez, C Jorand-Lebrun, P J Pauwels, I Pallard, S Halaz. Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes. Bioorganic & medicinal chemistry letters vol 8 issue 11 1999 9871775 New dimers of known 5HT1 ligands (5HT, 1-NP or 8-OH-DPAT) have been prepared and evaluated at human cloned 5HT1B, 5HT1D and 5HT1A receptors. 1999-03-11 2022-01-08 Not clear
J Stanton, L Castro, A MacLeod, F Sternfeld, L Street, M Bee. [3H]5-HT binding to cloned human, dog, and rat 5-HT1D and 5-HT1B receptors. Annals of the New York Academy of Sciences vol 861 issue 1999 9928282 [3H]5-HT binding to cloned human, dog, and rat 5-HT1D and 5-HT1B receptors. 1999-02-25 2022-01-08 Not clear
K W Johnson, L A Phebus, M L Cohe. Serotonin in migraine: theories, animal models and emerging therapies. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques vol 51 issue 1999 9949863 Sumatriptan is an agonist at 5-HT1D and 5-HT1B receptor subtypes, and effective in treating migraine pain and associated symptoms. 1999-02-24 2022-01-08 Not clear
R Verheggen, A G Hundeshagen, A M Brown, M Schindler, A J Kauman. 5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression. British journal of pharmacology vol 124 issue 7 1998 9723944 In the human temporal artery both 5-HT1-like and 5-HT2A receptors mediate the contractile effects of 5-hydroxytryptamine (5-HT) and we have suggested that the 5-HT1-like receptors resemble more closely recombinant 5-HT1B than 5-HT1D receptors. 1998-11-13 2022-01-08 Not clear
R Verheggen, A G Hundeshagen, A M Brown, M Schindler, A J Kauman. 5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression. British journal of pharmacology vol 124 issue 7 1998 9723944 We also used RT-PCR to search for the mRNA of 5-HT1B, 5-HT1D and other 5-HT receptors. 1998-11-13 2022-01-08 Not clear
A J Ellwood, M J Curti. Involvement of 5-HT(1B/1D) and 5-HT2A receptors in 5-HT-induced contraction of endothelium-denuded rabbit epicardial coronary arteries. British journal of pharmacology vol 122 issue 5 1998 9384503 These data suggest a possible involvement of 5-HT2A and 5-HT1B or 5-HT1D receptors in the response to 5-HT. 1998-09-24 2022-01-08 Not clear
A J Ellwood, M J Curti. Involvement of 5-HT(1B/1D) and 5-HT2A receptors in 5-HT-induced contraction of endothelium-denuded rabbit epicardial coronary arteries. British journal of pharmacology vol 122 issue 5 1998 9384503 This reinforces the evidence that 5-HT1B and/or 5-HT1D receptors contribute to the effects of 5-HT in the tissue. 1998-09-24 2022-01-08 Not clear
A J Ellwood, M J Curti. Involvement of 5-HT(1B/1D) and 5-HT2A receptors in 5-HT-induced contraction of endothelium-denuded rabbit epicardial coronary arteries. British journal of pharmacology vol 122 issue 5 1998 9384503 In conclusion, in endothelium denuded rabbit epicardial coronary arteries, 5-HT activates 5-HT2A and 5-HT1D and/or 5-HT1B receptors to cause contraction. 1998-09-24 2022-01-08 Not clear
A S Lesage, R Wouters, P Van Gompel, L Heylen, P Vanhoenacker, G Haegeman, W H Luyten, J E Leyse. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. British journal of pharmacology vol 123 issue 8 1998 9605573 Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. 1998-07-07 2022-01-08 Not clear
A S Lesage, R Wouters, P Van Gompel, L Heylen, P Vanhoenacker, G Haegeman, W H Luyten, J E Leyse. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. British journal of pharmacology vol 123 issue 8 1998 9605573 We compared the agonistic properties of alniditan, sumatriptan and dihydroergotamine on the cloned human 5-HT1B receptor expressed at 200 fmol mg(-1) protein (Bmax) in non-induced L929sA cells, at 740 fmol mg(-1) protein in HEK 293 and at 2300 fmol mg(-1) protein in mIFNbeta-induced L929sA cells, and on the human cloned 5-HT1D receptor expressed in C6 glioma cells (Bmax 780 fmol mg(-1) protein). 1998-07-07 2022-01-08 Not clear
G Maura, M Marcoli, M Tortarolo, G C Andrioli, M Raiter. Glutamate release in human cerebral cortex and its modulation by 5-hydroxytryptamine acting at h 5-HT1D receptors. British journal of pharmacology vol 123 issue 1 1998 9484853 The effect of sumatriptan was prevented by ketanserin, a drug known to display much higher affinity for recombinant h 5-HT1D than for h 5-HT1B receptors. 1998-03-30 2022-01-08 Not clear
P Bonaventure, P Voorn, W H Luyten, M Jurzak, A Schotte, J E Leyse. Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function. Neuroscience vol 82 issue 2 1998 9466454 While 5-HT1B receptor messenger RNA was abundant throughout the brain (with highest levels in the striatum, nucleus accumbens, olfactory tubercle, cortex, hypothalamus, hippocampal formation, amygdala, thalamus, dorsal raphe and cerebellum), 5-HT1D receptor messenger RNA exhibited a more restricted pattern; it was found mainly in the olfactory tubercle, entorhinal cortex, dorsal raphe, cerebellum, mesencephalic trigeminal nucleus and in the trigeminal ganglion. 1998-03-11 2022-01-08 Not clear
L Monari, M Mochi, M L Valentino, C Arnaldi, P Cortelli, A De Monte, G Pierangeli, G Prologo, C Scapoli, S Soriani, P Montagn. Searching for migraine genes: exclusion of 290 cM out of the whole human genome. Italian journal of neurological sciences vol 18 issue 5 1998 9412851 We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (1p36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. 1998-01-30 2022-01-08 Not clear
J Pascual, M E Castro, A Pazo. Central sites of actions of zolmitriptan and sumatriptan: 5HT1B, 5HT1D and 5HT1F receptor distribution. Cephalalgia : an international journal of headache vol 17 issue 6 1997 9350394 Central sites of actions of zolmitriptan and sumatriptan: 5HT1B, 5HT1D and 5HT1F receptor distribution. 1997-12-09 2022-01-08 Not clear
H M Clawges, K M Depree, E M Parker, S G Grabe. Human 5-HT1 receptor subtypes exhibit distinct G protein coupling behaviors in membranes from Sf9 cells. Biochemistry vol 36 issue 42 1997 9335552 The G protein coupling behavior of four human 5-hydroxytryptamine receptor subtypes (5-HT1A, 5-HT1B, 5-HT1D, and 5-HT1E) has been studied in membranes from Sf9 cells expressing the individual receptors. 1997-11-20 2022-01-08 Not clear
A C Trillat, I Malagi\\xc3\\xa9, K Scearce, D Pons, M C Anmella, C Jacquot, R Hen, A M Gardie. Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies. Journal of neurochemistry vol 69 issue 5 1997 9349547 These data provide in vivo evidence that, in mice, 5-HT1B, but not 5-HT1D, autoreceptors inhibit 5-HT release at nerve terminals located in the frontal cortex and ventral hippocampus. 1997-11-20 2022-01-08 mouse
C Davidson, J A Stamfor. Chronic paroxetine desensitises 5-HT1D but not 5-HT1B autoreceptors in rat lateral geniculate nucleus. Brain research vol 760 issue 1-2 1997 9237540 The present study examined the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on the 5-HT1B and 5-HT1D autoreceptors controlling 5-HT efflux in slices of rat ventrolateral geniculate nucleus. 1997-10-28 2022-01-08 Not clear
C Davidson, J A Stamfor. Chronic paroxetine desensitises 5-HT1D but not 5-HT1B autoreceptors in rat lateral geniculate nucleus. Brain research vol 760 issue 1-2 1997 9237540 5-HT efflux was inhibited by CP 93129 (1 nM-10 microM) and sumatriptan (1 nM-1 microM), agonists at 5-HT1B and 5-HT1D receptors, respectively. 1997-10-28 2022-01-08 Not clear
J J Hagan, P D Slade, L Gaster, P Jeffrey, J P Hatcher, D N Middlemis. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. European journal of pharmacology vol 331 issue 2-3 1997 9274976 These data demonstrate that 5-HT1B (formerly 5-HT(1D beta)) and not 5-HT1D (formerly 5-HT(1D alpha)) receptors mediate the hypothermic response to SKF-99101H (30 mg/kg i.p.) 1997-10-27 2022-01-08 Not clear
K W Johnson, J M Schaus, M M Durkin, J E Audia, S W Kaldor, M E Flaugh, N Adham, J M Zgombick, M L Cohen, T A Branchek, L A Phebu. 5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs. Neuroreport vol 8 issue 9-10 1997 9243618 The serotonin (5-HT) receptor subtype mediating inhibition of neurogenic dural inflammation in guinea pigs was investigated using a series of serotonin agonists with differing affinities for the 5-HT1B, 5-HT1D and 5-HT1F receptors. 1997-10-07 2022-01-08 Not clear
C Davidson, M Ho, G W Price, B J Jones, J A Stamfor. (+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors. British journal of pharmacology vol 121 issue 4 1997 9208142 We have studied the effects of the purportedly selective 5-HT1A receptor antagonist (+)-WAY 100135 on electrically stimulated 5-hydroxytryptamine (5-HT) efflux in the ventrolateral geniculate nucleus (vLGN), and its affinity at human 5-HT1B and 5-HT1D receptors stably expressed in Chinese hamster ovary (CHO) cells. 1997-09-25 2022-01-08 Not clear
J M Zgombick, J A Bard, S A Kucharewicz, D A Urquhart, R L Weinshank, T A Branche. Molecular cloning and pharmacological characterization of guinea pig 5-HT1B and 5-HT1D receptors. Neuropharmacology vol 36 issue 4-5 1997 9225276 Human 5-HT1B and 5-HT1D receptors have been implicated as molecular targets for the treatment of acute migraine based upon the pharmacological actions and clinical efficacy of sumatriptan, an agonist for human 5-HT1B/1D receptors. 1997-09-15 2022-01-08 Not clear
J M Zgombick, J A Bard, S A Kucharewicz, D A Urquhart, R L Weinshank, T A Branche. Molecular cloning and pharmacological characterization of guinea pig 5-HT1B and 5-HT1D receptors. Neuropharmacology vol 36 issue 4-5 1997 9225276 Guinea pig 5-HT1B and 5-HT1D receptor genes were transiently expressed in Cos-7 cells and their binding properties were evaluated using [3H]5-HT. 1997-09-15 2022-01-08 Not clear
M E Castro, J Pascual, T Rom\\xc3\\xb3n, C del Arco, E del Olmo, A Pazo. Differential distribution of [3H]sumatriptan binding sites (5-HT1B, 5-HT1D and 5-HT1F receptors) in human brain: focus on brainstem and spinal cord. Neuropharmacology vol 36 issue 4-5 1997 9225278 Differential distribution of [3H]sumatriptan binding sites (5-HT1B, 5-HT1D and 5-HT1F receptors) in human brain: focus on brainstem and spinal cord. 1997-09-15 2022-01-08 Not clear
M E Castro, J Pascual, T Rom\\xc3\\xb3n, C del Arco, E del Olmo, A Pazo. Differential distribution of [3H]sumatriptan binding sites (5-HT1B, 5-HT1D and 5-HT1F receptors) in human brain: focus on brainstem and spinal cord. Neuropharmacology vol 36 issue 4-5 1997 9225278 We have used [3H]sumatriptan as a radioligand in the presence of suitable concentrations of 5-CT (5-carboxamidotryptamine) to define 5-HT1F receptors, and ketanserin, to discriminate between 5-HT1B and 5-HT1D receptors. 1997-09-15 2022-01-08 Not clear
X J Yu, F M Cutrer, M A Moskowitz, C Waebe. The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater. Neuropharmacology vol 36 issue 1 1997 9144644 These data suggest that sumatriptan inhibits neurogenic inflammation via 5-HT1D alpha receptors in guinea pigs and 5-HT1D beta (5-HT1B) receptors in rats. 1997-08-18 2022-01-08 rat
H E Connor, W Feniuk, D T Beattie, P C North, A W Oxford, D A Saynor, P P Humphre. Naratriptan: biological profile in animal models relevant to migraine. Cephalalgia : an international journal of headache vol 17 issue 3 1997 9170336 Naratriptan has high affinity for human recombinant 5HT1B and 5HT1D receptors (pKi = 8.7 +/- 0.03 and 8.3 +/- 0.1, respectively) and causes contractions of dog isolated basilar and middle cerebral artery (EC50 values of 0.11 and 0.07 microM, respectively). 1997-07-31 2022-01-08 rat
C Davidson, J A Stamfor. Serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-HT1B and 5-HT1D autoreceptors. Neuropharmacology vol 35 issue 11 1997 9025111 Furthermore, released 5-HT is taken up by the 5-HT transporter and may be under the influence of 5-HT1B and 5-HT1D autoreceptors. 1997-05-28 2022-01-07 Not clear
M D Ferrar. 311C90: increasing the options for therapy with effective acute antimigraine 5HT1B/1D receptor agonists. Neurology vol 48 issue 3 Suppl 3 1997 9071266 The novel antimigraine drug 311C90 (Zomig; zolmitriptan) has a high selectivity for serotonin (5HT)1 receptors, mainly 5HT1B and 5HT1D subtypes, and in preclinical studies it has been shown to act on four different sites within the trigemino-vascular system (blockade of neurogenic inflammation by inhibition of peptide release, vasoconstriction, inhibition of neuronal depolarization at peripheral sites, and effects at central sites). 1997-04-10 2022-01-07 Not clear
H Saito, M Matsumoto, H Togashi, M Yoshiok. Functional interaction between serotonin and other neuronal systems: focus on in vivo microdialysis studies. Japanese journal of pharmacology vol 70 issue 3 1997 8935715 5-HT release is negatively regulated not only by somatodendritic 5-HT1A and terminal 5-HT1B (5-HT1D) autoreceptors but also by alpha 2-adrenergic and mu-opioid heteroreceptors that are located on serotonergic nerve terminals. 1997-01-15 2022-01-07 rat
P J Pauwels, F C Colpaer. Selective antagonism of human 5-HT1D and 5-HT1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935. European journal of pharmacology vol 300 issue 1-2 1996 8741180 The differential antagonist effects of ketanserin and GR 127,935 on naratriptan responses elicited in C6-glial/5-HT1D and C6-glial/5-HT1B cells demonstrate these compounds do selectively block human 5-HT1D and 5-HT1B receptors, respectively. 1996-10-17 2022-01-07 Not clear
X J Yu, C Waeber, N Castanon, K Scearce, R Hen, J E Macor, J Chauveau, M A Moskowitz, J Chavea. 5-Carboxamido-tryptamine, CP-122,288 and dihydroergotamine but not sumatriptan, CP-93,129, and serotonin-5-O-carboxymethyl-glycyl -tyrosinamide block dural plasma protein extravasation in knockout mice that lack 5-hydroxytryptamine1B receptors. Molecular pharmacology vol 49 issue 5 1996 8622623 These results suggest that CP-93,129, sumatriptan, and GTI exert their effects via 5-HT1B (5-HT1D beta) receptors in mice. 1996-06-19 2022-01-07 mouse
P J Pauwels, T Wurch, M C Amoureux, C Palmier, F C Colpaer. Stimulation of cloned human serotonin 5-HT1D beta receptor sites in stably transfected C6 glial cells promotes cell growth. Journal of neurochemistry vol 66 issue 1 1996 8522991 The 5-HT receptor identity of control and transfected C6 glial/5-HT1D beta cells was determined by reverse transcription-polymerase chain reaction using primers specific for rat 5-HT1A, rat 5-HT1B, rat 5-HT1D alpha, human 5-HT1D beta, and rat 5-HT2A receptor genes. 1996-01-24 2022-01-07 Not clear
P A Pierce, G X Xie, S J Peroutka, P G Green, J D Levin. 5-Hydroxytryptamine-induced synovial plasma extravasation is mediated via 5-hydroxytryptamine2A receptors on sympathetic efferent terminals. The Journal of pharmacology and experimental therapeutics vol 275 issue 1 1995 7562592 Polymerase chain reaction amplification of 5-HT receptor cDNA demonstrates that 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A and 5-HT3, but not the 5-HT2C, receptor subtypes are present in lumbar sympathetic ganglia. 1995-11-21 2022-01-07 Not clear
C Davidson, J A Stamfor. Evidence that 5-hydroxytryptamine release in rat dorsal raph\\xc3\\xa9 nucleus is controlled by 5-HT1A, 5-HT1B and 5-HT1D autoreceptors. British journal of pharmacology vol 114 issue 6 1995 7620698 These results suggest that 5-HT release in the rat DRN is under the control of 5-HT1A, 5-HT1B and 5-HT1D autoreceptors. 1995-08-31 2022-01-07 Not clear
C Davidson, J A Stamfor. Evidence that 5-hydroxytryptamine release in rat dorsal raph\\xc3\\xa9 nucleus is controlled by 5-HT1A, 5-HT1B and 5-HT1D autoreceptors. British journal of pharmacology vol 114 issue 6 1995 7620698 Evidence that 5-hydroxytryptamine release in rat dorsal raph\xc3\xa9 nucleus is controlled by 5-HT1A, 5-HT1B and 5-HT1D autoreceptors. 1995-08-31 2022-01-07 Not clear
J R Herdman, N J Delva, R E Hockney, G M Campling, P J Cowe. Neuroendocrine effects of sumatriptan. Psychopharmacology vol 113 issue 3-4 1995 7862876 The neuroendocrine effects of sumatriptan differ from those of previously described 5-HT-receptor agonists, and may be a consequence of selective activation of 5-HT1D or 5-HT1B receptors. 1995-03-20 2022-01-07 human
A T Bruinvels, B Landwehrmeyer, E L Gustafson, M M Durkin, G Mengod, T A Branchek, D Hoyer, J M Palacio. Localization of 5-HT1B, 5-HT1D alpha, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain. Neuropharmacology vol 33 issue 3-4 1994 7984275 Localization of 5-HT1B, 5-HT1D alpha, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain. 1994-12-30 2022-01-07 Not clear
A T Bruinvels, B Landwehrmeyer, E L Gustafson, M M Durkin, G Mengod, T A Branchek, D Hoyer, J M Palacio. Localization of 5-HT1B, 5-HT1D alpha, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain. Neuropharmacology vol 33 issue 3-4 1994 7984275 5-HT1B and 5-HT1D alpha hybridization signals were predominantly present in caudate-putamen and cortical areas; in addition, 5-HT1B mRNA was also detected in hippocampus, cerebellum and cerebral arteries. 1994-12-30 2022-01-07 Not clear
T J Lee, M Ueno, N Sunagane, M H Su. Serotonin relaxes porcine pial veins. The American journal of physiology vol 266 issue 3 Pt 2 1994 8160803 The 5-HT inhibition of SRC and SAT is predominant and is mediated by 5-HT1-like receptors, which, however, do not seem to correspond to 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT1E, or 5-HT1F receptor subtypes. 1994-05-19 2022-01-07 Not clear
M J Millan, H Canton, A Gobert, F Lejeune, J M Rivet, K Bervoets, M Brocco, P Widdowson, T Mennini, V Audino. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. The Journal of pharmacology and experimental therapeutics vol 268 issue 1 1994 8301575 The affinities of S 14489, S 15535 and S 15931 for other 5-HT receptor types (5-HT1B, 5-HT1C, 5-HT1D, 5-HT2 and 5-HT3) were about 50 to 1000-fold lower. 1994-03-10 2022-01-07 Not clear
M S Beer, J A Stanton, Y Bevan, A Heald, A J Reeve, L J Street, V G Matassa, R J Hargreaves, D N Middlemis. L-694,247: a potent 5-HT1D receptor agonist. British journal of pharmacology vol 110 issue 3 1994 8298808 L-694,247 had an affinity (pIC50) of 10.03 at the 5-HT1D binding site and 9.08 at the 5-HT1B binding site (sumatriptan: pIC50 values 8.22 and 5.94 respectively). 1994-03-04 2022-01-07 Not clear
M Briley, C More. Neurobiological mechanisms involved in antidepressant therapies. Clinical neuropharmacology vol 16 issue 5 1993 8221701 The firing rate of dorsal raphe serotonergic neurons is under the control of somatodendritic 5-hydroxytryptamine 1A (5-HT1A) autoreceptors, the release of serotonin from nerve terminals is under the control of 5-HT autoreceptors (5-HT1B subtype in rodents, 5-HT1D in other species), whereas the control of the activity of tryptophan hydroxylase, the rate-limiting enzyme of serotonin synthesis, is complex, involving 5-HT1A but possibly other 5-HT receptors including the 5-HT1B/D subtype. 1993-12-22 2022-01-07 Not clear
A T Bruinvels, J M Palacios, D Hoye. Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn-Schmiedeberg's archives of pharmacology vol 347 issue 6 1993 8361548 The pharmacology of the [125I]GTI binding sites was analysed using compounds known to display high affinity for and/or distinguish between 5-HT1B and 5-HT1D sites: 5-carboxamidotryptamine (5-CT), sumatriptan, CP 93129 (5-hydroxy-3(4-1,2,5,6-tetrahydropyridyl)-4-azaindole), (-)pindolol, PAPP (4[2-[4-[3-(trifluoromethyl)phenyl]-1- piperazinyl]ethyl]benzeneamine), rauwolscine, and 8-OH-DPAT. 1993-09-28 2022-01-07 Not clear
A T Bruinvels, J M Palacios, D Hoye. Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn-Schmiedeberg's archives of pharmacology vol 347 issue 6 1993 8361548 By contrast, the selective 5-HT1B compound CP 93129 and (-)pindolol produced biphasic curves showing a majority of high affinity sites in the globus pallidus and the substantia nigra, whereas PAPP and sumatriptan (which are somewhat 5-HT1D selective) produced biphasic curves indicating a minority of high affinity sites in these areas. 1993-09-28 2022-01-07 Not clear
A T Bruinvels, J M Palacios, D Hoye. Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn-Schmiedeberg's archives of pharmacology vol 347 issue 6 1993 8361548 Low densities of the 5-HT1D recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-HT1B sites were always observed in the same structures. 1993-09-28 2022-01-07 Not clear
M S Beer, J A Stanton, L M Hawkins, D N Middlemis. 5-Carboxamidotryptamine-insensitive 5-HT1-like receptors are concentrated in guinea pig but not rat, claustrum. European journal of pharmacology vol 236 issue 1 1993 8319743 5-CT (5-carboxamidotryptamine)-insensitive (5-HT1E/5-HT1F) 5-HT1-like recognition sites have been mapped autoradiographically in rat and guinea pig brain using [3H]5-HT in the presence of 5-CT and mesulergine to mask 5-HT1A, 5-HT1B, 5-HT1D and 5-HT2C binding sites. 1993-07-30 2022-01-07 Not clear
L O Wilkinson, L M Hawkins, M S Beer, M F Hibert, D N Middlemis. Stereoselective actions of the isomers of metitepine at 5-HT1D receptors in the guinea pig brain. Neuropharmacology vol 32 issue 3 1993 8474615 These findings support the identification of the guinea pig 5-HT terminal autoreceptor as a 5-HT1D receptor and reinforce the species homology between the 5-HT1B and 5-HT1D receptors. 1993-05-17 2022-01-07 Not clear
F J Monsma, Y Shen, R P Ward, M W Hamblin, D R Sible. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular pharmacology vol 43 issue 3 1993 7680751 Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. 1993-04-13 2022-01-07 Not clear
M A Metcalf, R W McGuffin, M W Hambli. Conversion of the human 5-HT1D beta serotonin receptor to the rat 5-HT1B ligand-binding phenotype by Thr355Asn site directed mutagenesis. Biochemical pharmacology vol 44 issue 10 1992 1449511 We now report that Thr355Asn mutagenesis of the human 5-HT1D beta receptor alters the binding characteristics of the recombinant receptor in [3H]5-HT binding assays to a profile very similar to that of the rat 5-HT1B binding site. 1992-12-24 2022-01-07 Not clear
D Hoyer, H Lery, C Waeber, A T Bruinvels, J Nozulak, J M Palacio. \"5-HT1R\" or 5-HT1D sites? Evidence for 5-HT1D binding sites in rabbit brain. Naunyn-Schmiedeberg's archives of pharmacology vol 346 issue 3 1992 1407010 Radioligand binding studies were performed in membranes of rabbit whole brain and striatum using the novel iodinated radioligand for 5-hydroxytryptamine 5-HT1B and 5-HT1D sites, Serotonin-5-O-Carboxymethyl-Glycyl[125I]Tyrosinamide ([125I]GTI). 1992-11-19 2022-01-07 Not clear
M O Den Boer, C M Villal\\xc3\\xb3n, P R Saxen. 5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved? Naunyn-Schmiedeberg's archives of pharmacology vol 345 issue 5 1992 1326717 The effect of metergoline (1 mg.kg-1), a substance with a very high affinity for the 5-HT1D receptor as well as for the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT2 receptors, was studied on the responses to 5-HT and sumatriptan. 1992-10-22 2022-01-07 Not clear
M R Pranzatelli, J Ballett. Serotonin receptors in human neuroblastoma: a possible biologic tumor marker. Experimental neurology vol 115 issue 3 1992 1537397 No 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2, or 5-HT uptake sites were found in any of the tumors, although all were detected in human or rat brain. 1992-04-02 2022-01-09 Not clear
H Sijbesma, J Schipper, J C Cornelissen, E R de Kloe. Species differences in the distribution of central 5-HT1 binding sites: a comparative autoradiographic study between rat and guinea pig. Brain research vol 555 issue 2 1991 1834309 Good correlations were found between species in the regional distribution of 5-HT1 sites labelled with [3H]5-HT (r = 0.73), 5-HT1A sites labelled with [3H]8-OH-DPAT (r = 0.87), and 5-HT1B versus 5-HT1D sites labelled with [3H]5-HT in the presence of ipsapirone and DOI (r = 0.76). 1991-12-23 2022-01-07 Not clear
H Sijbesma, J Schipper, J C Cornelissen, E R de Kloe. Species differences in the distribution of central 5-HT1 binding sites: a comparative autoradiographic study between rat and guinea pig. Brain research vol 555 issue 2 1991 1834309 Areas almost exclusively containing 5-HT1B or 5-HT1D sites, such as the ventral pallidum, globus pallidus and substantia nigra, expressed markedly more [3H]5-HT binding in rat as compared to guinea pig, while the opposite occurred in claustrum, dorsal endopiriform nucleus, lateral geniculate nucleus, and superficial grey layer of the superior colliculus. 1991-12-23 2022-01-07 Not clear
F P Zemlan, E F Schwa. Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein. Journal of neurochemistry vol 57 issue 6 1991 1834802 [3H]5-HT competition studies performed in the presence of 100 nM 8-OH-DPAT and 10 nM RU 24969 (to block 5-HT1A and 5-HT1B receptors, respectively) indicated that the remaining 49% of [3H]5-HT binding did not possess the pharmacologic profile previous reported for 5-HT1C, 5-HT1D, 5-HT1E, 5-HT2, or 5-HT3 receptors. 1991-12-18 2022-01-07 Not clear
L Segu, J Chauveau, P Boulenguez, A Morel, J Lanoir, M Delaag. [Synthesis and pharmacological study of radioiodinated serotonin derivative specific of 5-HT1B and 5-HT1D binding sites of the central nervous system]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie vol 312 issue 13 1991 1913239 Quantitative autoradiographic studies on rat and guinea pig brain sections incubated with 2 nM [3H]5-HT showed a preferential affinity of S-CM-GTNH2 for 5-HT1B and 5-HT1D sites. 1991-10-28 2022-01-07 Not clear
P Schoeffter, D Hoye. Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. European journal of pharmacology vol 196 issue 2 1991 1678720 Oxymetazoline was recognized with nanomolar affinity by 5-HT1A, 5-HT1B and 5-HT1D binding sites and mimicked the effects of 5-hydroxytryptamine with about the same potency and intrinsic activity as the endogenous amine in the corresponding functional tests. 1991-09-20 2022-01-07 Not clear
E Hamel, D Bouchar. Contractile 5-HT1 receptors in human isolated pial arterioles: correlation with 5-HT1D binding sites. British journal of pharmacology vol 102 issue 1 1991 2043924 A correlation analysis performed between the agonists vascular potency (pD2 values) and their affinities (pKD values) published at various subtypes of 5-HT binding sites showed a positive significant correlation with rat cortical 5-HT1B (r = 0.86; P less than 0.01) and human caudate 5-HT1D (r = 0.98; P less than 0.005) subtypes. 1991-07-16 2022-01-07 Not clear
M Hamon, L Lanfumey, S el Mestikawy, C Boni, M C Miquel, F Bola\\xc3\\xb1os, L Schechter, H Gozla. The main features of central 5-HT1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 3 issue 5-6 1991 2078271 The 5-HT1 receptor family comprises five different pharmacologic subtypes, designated 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, and 5-HT1E, whose common property is to bind 5-HT with nanomolar affinity. 1991-04-29 2022-01-07 Not clear
M G\\xc3\\xb6thert, G J Molderings, K Fink, E Schlicke. Heterogeneity of presynaptic serotonin receptors on sympathetic neurones in blood vessels. Blood vessels vol 28 issue 1-3 1991 2001464 In the rat vena cava, they are of the 5-HT1B subtype, in the pig coronary artery they belong to a novel, so far unknown class of 5-HT receptors, and in the human saphenous vein they could be classified as 5-HT1D. 1991-04-12 2022-01-07 Not clear
M G\\xc3\\xb6thert, E Schlicke. Identification and classification of 5-HT1 receptor subtypes. Journal of cardiovascular pharmacology vol 15 Suppl 7 issue 1991 1702482 In addition, the drugs with antagonistic properties at the 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1D receptors block other 5-HT receptors or even entirely different receptors (e.g., beta-adrenoceptors); as a rule, they do not discriminate between the four 5-HT receptor subtypes. 1991-02-11 2022-01-07 Not clear
D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences vol 600 issue 1991 2252308 The distribution of 5-HT1B and 5-HT1D receptors in all species examined so far, is very similar: high concentrations of sites are found in the nigro-striatal pathway, caudate-putamen, globus pallidus and especially substantia nigra. 1991-01-14 2022-01-07 Not clear
D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences vol 600 issue 1991 2252308 Further, it is established that terminal 5-HT autoreceptors are of the 5-HT1B type in rat cortex, and of the 5-HT1D type in guinea-pig, pig, human and possibly rabbit cortex. 1991-01-14 2022-01-07 Not clear
D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences vol 600 issue 1991 2252308 5-HT1 receptor subtypes are labeled with [3H]5-HT and present a large heterogeneity: no less than 4 subtypes have been characterized: 5-HT1B and 5-HT1D are labeled respectively with [125I]cyanopindolol, and [3H]5-HT under appropriate conditions. 1991-01-14 2022-01-07 Not clear
R A Glennon, C Chaurasia, M Titele. Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. Journal of medicinal chemistry vol 33 issue 10 1990 2213830 Whereas tryptamine derivatives generally display little selectivity for the various populations of 5-HT receptors, N1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (Ki = 12 nM) and selectivity at 5-HT2 receptors relative to 5-HT1A (Ki = 7100 nM), 5-HT1B (Ki = 5000 nM), 5-HT1C (Ki = 120 nM), and 5-HT1D (Ki greater than 10,000 nM) receptors. 1990-11-20 2022-01-07 Not clear
S A Montgomery, N Fineber. Is there a relationship between serotonin receptor subtypes and selectivity of response in specific psychiatric illnesses? The British journal of psychiatry. Supplement vol issue 8 1990 2692641 Identification of 5-HT receptor subtypes--5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2 (possibly A and B), 5-HT3 subtypes, and possibly 5-HT4--has encouraged the manufacture of 5-HT receptor inhibitors with greater subtype specificity. 1990-03-15 2022-01-07 Not clear
C Waeber, P Schoeffter, J M Palacios, D Hoye. 5-HT1D receptors in guinea-pig and pigeon brain. Radioligand binding and biochemical studies. Naunyn-Schmiedeberg's archives of pharmacology vol 340 issue 5 1990 2533324 The rank order of affinities of agonists and antagonists (5-CT (5-carboxamidotryptamine) greater than 5-HT greater than RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydro-4- pyridinyl)-1H indole succinate) greater than yohimbine greater than or equal to rauwolscine greater than DP-5-CT (N,N dipropyl-5-carboxamidotryptamine) greater than or equal to mianserin greater than 8-OH-DPAT greater than mesulergine greater than SDZ 21-009 ((+/-)-4(3-tert-butyl-amino-2-hydroxypropoxy)-indol-2 carbonic acid isopropyl ester) greater than (-)propranolol), as well as their individual pKD values, were very similar to those at porcine caudate 5-HT1D sites and clearly different from those at rat cortex 5-HT1B sites. 1990-03-01 2022-01-07 Not clear
P Schoeffter, D Hoye. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn-Schmiedeberg's archives of pharmacology vol 340 issue 3 1989 2572975 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. 1989-12-12 2022-01-07 Not clear
P Schoeffter, D Hoye. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn-Schmiedeberg's archives of pharmacology vol 340 issue 3 1989 2572975 The results strengthen the identity between 5-HT receptors mediating inhibition of adenylate cyclase activity in rat and calf substantia nigra and 5-HT1B and 5-HT1D binding sites, respectively. 1989-12-12 2022-01-07 Not clear
W C Xiong, D L Nelso. Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. Life sciences vol 45 issue 16 1989 2811600 The present findings demonstrate the presence of a high-affinity [3H]5-HT binding site in rabbit CN, designated 5-HT1R, that is different from previously defined 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, and 5-HT2 sites. 1989-12-05 2022-01-07 Not clear
W C Xiong, D L Nelso. Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. Life sciences vol 45 issue 16 1989 2811600 Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. 1989-12-05 2022-01-07 Not clear
P Schoeffter, D Hoye. How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology vol 340 issue 1 1989 2552330 GR 43175 displayed the following order of affinity for 5-HT recognition sites (pKD values, -log mol/l, in parentheses): 5-HT1D (7.54) greater than 5-HT1B (6.35) greater than 5-HT1A (6.13) much greater than 5-HT1C (4.13) greater than 5-HT2 (3.67). 1989-11-08 2022-01-07 Not clear
P Schoeffter, D Hoye. Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn-Schmiedeberg's archives of pharmacology vol 339 issue 6 1989 2770889 Among reported 5-HT1B receptor selective drugs, TFMPP had similar potency at 5-HT1A, 5-HT1B and 5-HT1C receptors, mCPP did not separate between 5-HT1B and 5-HT1C receptors, CGS 12066 was equipotent at 5-HT1B and 5-HT1D receptors, and isamoltane was only slightly 5-HT1B versus 5-HT1A selective. 1989-10-12 2022-01-07 Not clear
S Leonhardt, K Herrick-Davis, M Titele. Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein. Journal of neurochemistry vol 53 issue 2 1989 2664084 To investigate the non-5-HT1D component of the binding, 100 nM 5-CT (to block 5-HT1A, 5-HT1B, and 5-HT1D receptors) was coincubated with [3H]5-HT, membranes, and mesulergine. 1989-08-25 2022-01-07 Not clear
S J Peroutka, B G McCarth. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. European journal of pharmacology vol 163 issue 1 1989 2545459 Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. 1989-08-21 2022-01-07 Not clear
S J Peroutka, B G McCarth. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. European journal of pharmacology vol 163 issue 1 1989 2545459 Sumatriptan displayed the highest affinity for 5-HT1D (Ki = 17 nM) and 5-HT1B (Ki = 27 nM) binding sites and was slightly less potent at 5-HT1A binding sites (Ki = 100 nM). 1989-08-21 2022-01-07 Not clear
S J Peroutka, B G McCarth. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. European journal of pharmacology vol 163 issue 1 1989 2545459 These data indicate that sumatriptan interacts selectively with 5-HT1B and 5-HT1D sites and suggest that these interactions may be the basis of its apparent efficacy in the acute treatment of migraine. 1989-08-21 2022-01-07 Not clear
E Adler-Graschinsky, A B Elgoyhen, N V Butt. Different receptor subtypes mediate the dual presynaptic effects of 5-hydroxytryptamine on peripheral sympathetic neurones. Journal of autonomic pharmacology vol 9 issue 1 1989 2524497 In the guinea-pig isolated atria, the inhibitory effect of 5-HT on the chronotropic responses to cardioaccelerans nerve stimulation was mimicked by the mixed 5-HT1A + 5-HT1B + 5-HT1D receptor agonist 5-carboxamidotryptamine (5-CT 0.1 and 1 microM). 1989-06-29 2022-01-07 Not clear
C A Stratford, G L Tan, M W Hamblin, R D Ciaranell. Differential inactivation and G protein reconstitution of subtypes of [3H]5-hydroxytryptamine binding sites in brain. Molecular pharmacology vol 34 issue 4 1988 3139989 These data suggest that NEM exerts its effects on 5-HT1A, 5-HT1B, and 5-HT1D binding sites by inactivating the G protein(s) associated with the 5-HT receptor subtypes. 1988-11-17 2022-01-07 Not clear
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