All Relations between 5-ht receptor 1b and 5-ht receptor 2

Reference Sentence Publish Date Extraction Date Species
D G Rainni. Serotonergic modulation of neurotransmission in the rat basolateral amygdala. Journal of neurophysiology vol 82 issue 1 1999 10400936 The effect of 5-HT was mimicked by the 5-HT2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-HT), but not by the 5-HT1A receptor agonist, (+/-) 8-hydroxydipropylaminotetralin hydrobromide (8-OH-DPAT), or the 5-HT1B agonist, CGS 12066A. 1999-08-10 2022-01-08 Not clear
B J Keck, J M Lakosk. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) administration for studies of 5-HT1A receptor binding site inactivation and turnover. Brain research. Brain research protocols vol 1 issue 4 1997 9384817 While age-related declines in the number of 5-HT1B and 5-HT2 receptors have been reported, little information is available describing the region-specific effects of aging on the functional dynamics of equilibrium binding at 5-HT receptors, including the 5-HT1A receptor subtype. 1997-12-10 2022-01-08 rat
M L Mamede Rosa, W A Prad. Antinociception induced by opioid or 5-HT agonists microinjected into the anterior pretectal nucleus of the rat. Brain research vol 757 issue 1 1997 9200507 The 5-HT1 agonist 5-carboxamidotryptamine (19 and 38 nanomol) and the 5-HT1B agonist, CGS 12066B (1.12 and 2.24 nanomol), but not the non-selective 5-HT agonist m-CPP (41 to 164 nanomol), 5-HT2 agonist alpha-methylserotonin (36 and 72 nanomol) and 5-HT3 agonist 2-methylserotonin (36 and 72 nanomol), produced a dose-dependent antinociceptive effect. 1997-08-12 2022-01-08 rat
Y Clement, K H Kia, G Daval, D Verg. An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors. Brain research vol 709 issue 2 1997 8833759 Among the numerous 5-HT receptor subtypes, several (5-HT1A, 5-HT1B, 5-HT2 and 5-HT3) could be involved in these etiologies. 1997-05-01 2022-01-07 Not clear
Y Nishimur. Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats. British journal of pharmacology vol 117 issue 6 1996 8882632 These findings suggest that 5-HT elicits vasoconstriction in rat basilar arteries by stimulation of a mixed receptor population of 5-HT2 and 5-HT1-like receptors (similar to the 5-HT1B receptor subtype), and that the contraction mediated by 5-HT1-like receptors is enhanced in the basilar artery from SHRSP. 1996-12-11 2022-01-07 rat
C Comoy, C Marot, T Podona, M L Baudin, L Morin-Allory, G Guillaumet, B Pfeiffer, D H Caignard, P Renard, M C Rettori, G Adam, B Guardiola-Lemaitr. 3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]. Journal of medicinal chemistry vol 39 issue 21 1996 8863806 Affinities for the 5-HT1A receptors were in the nanomolar range for the best compounds ((+)-11a,23) with a high selectivity versus other 5-HT (5-HT1B, 5-HT2, 5-HT3) or dopamine (D1, D2) receptor subtypes. 1996-11-25 2022-01-07 Not clear
R R Matsumoto, M J Hussong, D D Truon. Effects of selective serotonergic ligands on posthypoxic audiogenic myoclonus. Movement disorders : official journal of the Movement Disorder Society vol 10 issue 5 1996 8552114 In contrast, the following drugs were ineffective: (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide (8-OH-DPAT, 5-HT1A agonist), buspirone hydrochloride (5-HT1A agonist), 7-trifluoromethyl-4(4-methyl-l-piperazinyl)-pyrrolo[1,2- a]quinoxaline maleate (CGS 12066B, 5-HT1B agonist), ketanserin tartrate (5-HT2 antagonist), methysergide maleate (5-HT2 antagonist), fluoxetine (5-HT uptake blocker), and saline (vehicle). 1996-02-20 2022-01-07 rat
F J Miranda, G Torregrosa, J B Salom, J A Alabad\\xc3\\xad, T Jover, M D Barber\\xc3\\xa1, E Alborc. Characterization of 5-hydroxytryptamine receptors in goat cerebral arteries. General pharmacology vol 26 issue 6 1995 7590117 Pretreatment with the antagonist of 5-HT1A and 5-HT1B receptors cyanopindolol (10(-8), 10(-6) M), the antagonist of 5-HT1/5-HT2 receptors methysergide (10(-11), 10(-9) M) and the antagonist of 5-HT2 receptors ketanserin (10(-11), 10(-9) M) induced non-competitive inhibition of the concentration-response curve to 5-HT. 1995-12-07 2022-01-07 Not clear
W J McBride, J M Murphy, G J Gatto, A D Levy, K Yoshimoto, L Lumeng, T K L. CNS mechanisms of alcohol self-administration. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement vol 2 issue 1995 7748340 This is indicated by (a) lower contents of DA and 5-HT; (b) fewer 5-HT immunostained fibers; (c) lower densities of 5-HT1B, 5-HT2 and D2 receptors; and (d) higher densities of 5-HT1A receptors in the CNS of P rats compared to the alcohol-nonpreferring NP line of rats. 1995-06-22 2022-01-07 rat
T A Sipes, M A Geye. 8-OH-DPAT disruption of prepulse inhibition in rats: reversal with (+)WAY 100,135 and localization of site of action. Psychopharmacology vol 117 issue 1 1995 7724701 Both serotonin (5-HT) releasers and agonists at 5-HT1A, 5-HT1B, and 5-HT2 receptors reduce PPI in the rat. 1995-05-25 2022-01-07 rat
S J Kitchener, C T Douris. An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats. Psychopharmacology vol 113 issue 3-4 1995 7862847 Previous studies have shown that administration of 5-HT1B, 5-HT1C or 5-HT2 agonists decreases food intake in rats. 1995-03-20 2022-01-07 rat
S J Kitchener, C T Douris. An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats. Psychopharmacology vol 113 issue 3-4 1995 7862847 In the present study the post-prandial satiety sequence was used to characterise the actions of the 5-HT2 receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), the 5-HT1B/5-HT1C receptor agonists, 1-(3-chorophenyl) piperazine (mCPP) and 1-[3-(trifluoromethyl)phenyl] piperazine (TFMPP), and the 5-HT1B agonist, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)H-indole (RU 24969), on feeding in rats. 1995-03-20 2022-01-07 rat
M el Mansari, F Radja, A Ferron, T A Reader, E Molina-Holgado, L Descarrie. Hypersensitivity to serotonin and its agonists in serotonin-hyperinnervated neostriatum after neonatal dopamine denervation. European journal of pharmacology vol 261 issue 1-2 1995 8001641 Neonatal destruction of the nigrostriatal dopamine projection by intraventricular 6-hydroxydopamine leads to a serotonin (5-hydroxytryptamine, 5-HT) hyperinnervation of the adult neostriatum accompanied by increased radioligand binding to 5-HT1B, 5-HT1nonAB and 5-HT2 receptors. 1995-01-23 2022-01-07 rat
M R Pranzatelli, P T Tailor, R Pluchino, W Gonzales, S Simmen. p,p'-DDT myoclonic/epileptic model: serotonin receptor binding and behavioral studies in the rat. Neurotoxicology vol 15 issue 2 1995 7991214 At a time when low dose (80 mg/kg) p,p'-DDT elicited stimulus-sensitive and spontaneous myoclonus, there were no significant changes in Bmax or Kd of 5-HT1A, 5-HT1B, 5-HT1C sites in cortex, striatum, brainstem or spinal cord, agonist- or antagonist-labelled 5-HT2 sites in cortex, or 5-HT uptake sites. 1995-01-12 2022-01-07 rat
G Spurlock, P Buckland, M O'Donovan, P McGuffi. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter. Neuropharmacology vol 33 issue 3-4 1994 7984281 We have examined this hypothesis by treating rats over a time course of up to 32 days with either imipramine, mianserin, fluvoxamine, citalopram, amoxapine or saline and measuring the levels of mRNAs encoding the 5HT1A, 5HT1B, 5HT1C and 5HT2 receptors, the enzymes tryptophan hydroxylase and aromatic amino acid decarboxylase, and the 5HT transporter. 1994-12-30 2022-01-07 rat
Y Fujishima, H Hara, M Shimazawa, K Yokota, T Sukamot. [The effects of a novel Ca2+ channel blocker, KB-2796, on 5-HT-induced responses]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica vol 104 issue 1 1994 8076888 In rat cortical membrane, KB-2796 inhibited specific [3H]spiperone binding to 5-HT2 receptors in a competitive manner (Ki = 0.57 microM), but exhibited negligible affinity for radioligand binding to other 5-HT receptor subtypes such as 5-HT1, 5-HT1A, 5-HT1B, 5-HT1C and 5-HT3 at a concentration of 10 or 100 microM. 1994-10-04 2022-01-07 rat
M F\\xc3\\xa9l\\xc3\\xa9tou, O Dellazuana, J Duhaul. Serotoninergic receptor subtype in coronary artery smooth muscle from young and atherosclerotic rabbit. The Journal of pharmacology and experimental therapeutics vol 268 issue 1 1994 8301547 NAN 190, a 5HT1A antagonist, LY 53857, a 5HT1C and 5HT2 antagonist, cyanopindolol, a 5HT1A and 5HT1B antagonist and ICS 205-930, a 5HT3 and 5HT4 antagonist (up to 10(-6) M) did not inhibit the contractile response to 5HT. 1994-03-10 2022-01-07 Not clear
M J Millan, H Canton, A Gobert, F Lejeune, J M Rivet, K Bervoets, M Brocco, P Widdowson, T Mennini, V Audino. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. The Journal of pharmacology and experimental therapeutics vol 268 issue 1 1994 8301575 The affinities of S 14489, S 15535 and S 15931 for other 5-HT receptor types (5-HT1B, 5-HT1C, 5-HT1D, 5-HT2 and 5-HT3) were about 50 to 1000-fold lower. 1994-03-10 2022-01-07 Not clear
W Pinto, G Battagli. In vivo EEDQ dose-dependently inactivates rat brain 5-HT receptors but not 5-HT uptake sites. Neuroreport vol 5 issue 1 1994 8280861 The rank order of sensitivity to EEDQ inactivation was: 5-HT1A > 5-HT1B > 5-HT2 approximately 5-HT2/1C >>> 5-HT uptake sites. 1994-02-14 2022-01-07 rat
J C Tinajero, A Fabbri, M L Dufa. Serotonergic inhibition of rat Leydig cell function by propranolol. Endocrinology vol 133 issue 1 1993 8391422 The beta-adrenergic antagonist propranolol binds to serotonin (5HT) receptors (5HT1B > 5HT1A > 5HT2) in brain membranes. 1993-08-03 2022-01-07 Not clear
F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research vol 606 issue 2 1993 8490720 Even though the exact cause(s) of these receptor increases could not be determined, their anatomical distribution suggested that they were somehow related to the initial dopamine denervation in the case of the 5-HT1B and 5-HT1nonAB receptors, and more tightly linked to the 5-HT hyperinnervation in the case of the 5-HT2 receptors. 1993-06-14 2022-01-07 rat
F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research vol 606 issue 2 1993 8490720 5-HT1A, 5-HT1B, 5HT1nonAB and 5-HT2 sites were labeled with [3H]8-OH-DPAT, [125I]cyanopindolol, [3H]5-HT and [125I]DOI, respectively, and measured in the rostral and caudal halves of neostriatum and selected forebrain or midbrain regions. 1993-06-14 2022-01-07 rat
S Tokuyama, M Takahashi, H Kanet. Involvement of serotonergic receptor subtypes in the production of antinociception by psychological stress in mice. Japanese journal of pharmacology vol 61 issue 3 1993 8483301 These results suggest that 5-HT receptor (5-HT1A, 5-HT2 and 5-HT3 but not 5-HT1B)-mediated mechanisms play an important role in the production of PSY-SIA. 1993-06-03 2022-01-07 mouse
M J Millan, J M Rivet, H Canton, S Le Marouille-Girardon, A Gober. Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. The Journal of pharmacology and experimental therapeutics vol 264 issue 3 1993 8450471 Agonists at 5-HT1B, 5-HT1C, 5-HT2 and/or 5-HT3 receptors did not elicit hypothermia, and drugs releasing 5-HT elicited hyperthermia. 1993-04-14 2022-01-07 Not clear
F J Monsma, Y Shen, R P Ward, M W Hamblin, D R Sible. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular pharmacology vol 43 issue 3 1993 7680751 Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. 1993-04-13 2022-01-07 Not clear
J Sawynok, A Rei. Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes. European journal of pharmacology vol 223 issue 1 1993 1362158 The present study examined the involvement of spinal noradrenergic mechanisms in spinal antinociception by the 5-hydroxy-tryptamine (5-HT) receptor-selective agonists CGS 12066B (5-HT1B; 7-trifluoromethyl-4(4-methyl-1-piperazinyl)-pyrrolo[1,2-a]quinoxaline), TFMPP (5-HT1C; M-trifluoromethylphenyl-piperazine) and DOI (5-HT2; 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) using the rat hot plate test. 1993-02-05 2022-01-07 Not clear
T A Pugsley, C L Christofferson, A Corbin, H A DeWald, S Demattos, L T Meltzer, S L Myers, Y H Shih, S Z Whetzel, J N Wile. Pharmacological characterization of PD 118717, a putative piperazinyl benzopyranone dopamine autoreceptor agonist. The Journal of pharmacology and experimental therapeutics vol 263 issue 3 1993 1361570 It also had significant affinity for serotonin-(5-HT)1A but not 5-HT1B and 5-HT2 receptors. 1993-01-22 2022-01-07 monkey
E Chojnacka-W\\xc3\\xb3jci. Functional interaction between 5-HT1B and 5-HT1A or 5-HT2 receptors in mice. Polish journal of pharmacology and pharmacy vol 44 issue 3 1993 1470563 To investigate a possible functional interaction between 5-HT1B and 5-HT1A or 5-HT2 receptors we studied the effects of 5-HT1A selective agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and gepirone, of a 5-HT1A/5-HT2 agonist 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and of a putative 5-HT2 agonist (+/-)1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (+/- DOI) on the 5-HT1B receptor-mediated hypothermia induced by m-trifluoromethylphenylpiperazine (TFMPP) (25 mg/kg) or m-chlorophenylpiperazine (m-CPP) (20 mg/kg) in mice. 1993-01-22 2022-01-07 mouse
G Romero, E Toscano, D Montero, M C De Felipe, J Del Ri. Effect of prenatal exposure to tianeptine on different neurotransmitter receptors and 5-HT-stimulated inositol phosphate formation in rat brain. Journal of neural transmission. General section vol 90 issue 2 1993 1334416 Prenatal exposure to tianeptine significantly decreased the density of 3H-imipramine binding sites in the cerebral cortex of the pups without affecting beta-adrenoceptors, serotonin 5-HT2 and 5-HT1B receptors or inositol phosphate formation after a 5-HT challenge. 1993-01-21 2022-01-07 rat
J L Herndon, M E Pierson, R A Glenno. Mechanistic investigation of the stimulus properties of 1-(3-trifluoromethylphenyl)piperazine. Pharmacology, biochemistry, and behavior vol 43 issue 3 1992 1333084 The results of these and other published studies suggest roles for 5-hydroxytryptamine 1B (5-HT1B), 5-HT1C, and, possibly, sigma-receptors in the mediation of the TFMPP stimulus and indicate a lack of involvement of 5-HT1A, 5-HT2, dopaminergic, and adrenergic mechanisms in this behavior. 1992-12-30 2022-01-07 rat
M O Den Boer, C M Villal\\xc3\\xb3n, P R Saxen. 5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved? Naunyn-Schmiedeberg's archives of pharmacology vol 345 issue 5 1992 1326717 The effect of metergoline (1, a substance with a very high affinity for the 5-HT1D receptor as well as for the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT2 receptors, was studied on the responses to 5-HT and sumatriptan. 1992-10-22 2022-01-07 Not clear
J Ulrichsen, J S Partilla, E M Da. Long-term administration of m-chlorophenylpiperazine (mCPP) to rats induces changes in serotonin receptor binding, dopamine levels and locomotor activity without altering prolactin and corticosterone secretion. Psychopharmacology vol 107 issue 2-3 1992 1352053 Long-term mCPP treatment led to a 36% increase in [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) binding to 5-HT1a receptors in hippocampus and a 74% decrease in [3H]ketanserin binding to 5-HT2 receptors in cortex, while (-)[125I]iodocyanopindolol ([125I]CYP) binding to 5-HT1b receptors in hypothalamus and striatum was unchanged. 1992-07-30 2022-01-07 rat
S W Johnson, N B Mercuri, R A Nort. 5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 12 issue 5 1992 1578282 (+/-)-Cyanopindolol (100 nM), a 5-HT1B antagonist, blocked the effect of 5-HT (10 microM); spiperone (1 microM), which is an antagonist at 5-HT1A and 5-HT2 receptors, had no effect. 1992-06-05 2022-01-07 Not clear
M R Pranzatelli, J Ballett. Serotonin receptors in human neuroblastoma: a possible biologic tumor marker. Experimental neurology vol 115 issue 3 1992 1537397 No 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2, or 5-HT uptake sites were found in any of the tumors, although all were detected in human or rat brain. 1992-04-02 2022-01-09 Not clear
E A Audi, R M de Oliveira, F G Graef. Microinjection of propranolol into the dorsal periaqueductal gray causes an anxiolytic effect in the elevated plus-maze antagonized by ritanserin. Psychopharmacology vol 105 issue 4 1992 1685253 The present as well as previously reported results suggest that the anxiolytic effect of propranolol injected into the DPAG is due to increased release of 5-HT acting on post-synaptic 5-HT2 receptors, resultant from blockade of 5-HT1B autoreceptors that inhibit amine release from serotonergic nerve endings. 1992-02-27 2022-01-07 rat
F P Zemlan, E F Schwa. Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein. Journal of neurochemistry vol 57 issue 6 1991 1834802 [3H]5-HT competition studies performed in the presence of 100 nM 8-OH-DPAT and 10 nM RU 24969 (to block 5-HT1A and 5-HT1B receptors, respectively) indicated that the remaining 49% of [3H]5-HT binding did not possess the pharmacologic profile previous reported for 5-HT1C, 5-HT1D, 5-HT1E, 5-HT2, or 5-HT3 receptors. 1991-12-18 2022-01-07 Not clear
E Chojnacka-W\\xc3\\xb3jcik, E Tatarczy\\xc5\\x84ska, K Go\\xc5\\x82embiowska, E Przegali\\xc5\\x84sk. Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology vol 30 issue 7 1991 1681449 The anti-immobility effect of gepirone (10 mg/kg) was dose-dependently antagonized by the 5-HT1A receptor and alpha 1-adrenoceptor antagonist, NAN-190 (0.25 and 0.5 mg/kg), the beta-adrenoceptor blocker with the affinity for 5-HT1A and 5-HT1B receptors, pindolol (2 and 4 mg/kg), the 5-HT1A, 5-HT2 and dopamine receptor blocker spiperone (0.01 and 0.03 mg/kg) and by the dopamine receptor antagonist, haloperidol (0.125 and 0.25 mg/kg). 1991-11-04 2022-01-07 rat
H Tamir, K P Liu, S C Hsiung, P Y Yu, A L Kirchgessner, M D Gersho. Identification of serotonin receptors recognized by anti-idiotypic antibodies. Journal of neurochemistry vol 57 issue 3 1991 1861158 It is concluded that the anti-idiotypic antibodies generated with anti-5-HT serum recognize the 5-HT1B, 5-HT1C, and 5-HT2 receptor subtypes; however, neither 5-HT1A receptors nor 5-HT uptake sites appear to react with these antibodies. 1991-09-04 2022-01-07 Not clear
T Crisp, J L Stafinsky, L J Spanos, M Uram, V C Perni, H B Donepud. Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord. General pharmacology vol 22 issue 2 1991 1829046 The 5-HT receptor agonists examined in this study included the 5-HT1A agonist 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT), the 5-HT1B agonist m-trifluoromethylphenylpiperazine (TFMPP), the 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and the 5-HT3 agonist phenylbiguanide (PBG). 1991-07-31 2022-01-07 rat
M J Millan, K Bervoets, F C Colpaer. 5-hydroxytryptamine (5-HT)1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr-induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity. The Journal of pharmacology and experimental therapeutics vol 256 issue 3 1991 1826033 The response could not be elicited by CGS 12066B [7-trifluormethyl-4-(4-methyl-l-piperazonyl)-pyrrolol- [1-2-a] quinoxaline dimaleate], mCPP 1-(3-chlorophenyl)-piperazine-2-HCl, TFMPPm-trifluromethylphenylpiperazine HCl, MK 212 [6-chloro-2-(l-piperzinyl)pyrazine], quipazine and DOI (+-)-2,5-dimethoxy-4-iodophenyl-2-aminopropane HCl, which act in vivo as agonists at 5-HT1B, 5-HT1C and/or 5-HT2 receptors, or by the 5-HT3 agonist, 2-methyl-5-HT. 1991-04-24 2022-01-07 rat
E Edwards, K Harkins, C R Ashby, R Y Wan. Effect of 5-hydroxytryptamine3 receptor agonists on phosphoinositides hydrolysis in the rat fronto-cingulate and entorhinal cortices. The Journal of pharmacology and experimental therapeutics vol 256 issue 3 1991 1848625 The stimulatory action of 2-Me-5-HT and phenylbiguanide was blocked completely by granisetron, ondansetron and ICS 205-930 but not by other receptor antagonists such as (+/-)-pindolol (a beta, 5-HT1A and 5-HT1B receptor antagonist), methy-sergide (a 5-HT1 and 5-HT2 receptor antagonist), ritanserin (a 5-HT1C and 5-HT2 receptor antagonist), SR 95103 (gamma-aminobutyric acidA receptor antagonist), scopolamine (a muscarinic antagonist), (-)-eticlopride (a D2 receptor antagonist), SCH 23390 (a D1 5-HT2/1C receptor antagonist) and prazosin (an alpha-1 receptor antagonist). 1991-04-24 2022-01-07 Not clear
Y Claustre, J Benavides, B Scatto. Potential mechanisms involved in the negative coupling between serotonin 5-HT1A receptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus. Journal of neurochemistry vol 56 issue 4 1991 1848278 Various 5-HT1A receptor agonists were found to inhibit carbachol (10 microM)-stimulated formation of total inositol phosphates in immature rat hippocampal slices with the following rank order of potency (IC50 values in nM): 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (11) greater than ipsapirone (20) greater than gepirone (120) greater than RU 24969 (140) greater than buspirone (560) greater than 1-(m-trifluoromethylphenyl)piperazine (1,500) greater than methysergide (5,644); selective 5-HT1B, 5-HT2, and 5-HT3 receptor agonists were inactive. 1991-04-15 2022-01-07 Not clear
D A Jackson, S R Whit. Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology vol 29 issue 9 1991 2149874 Other 5-HT agonists, with relatively selective affinity for 5-HT1B, 5-HT1C and 5-HT2 receptors, increased the excitability of spinal motoneurons when applied iontophoretically or intravenously. 1991-04-09 2022-01-07 rat
D A Jackson, S R Whit. Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology vol 29 issue 9 1991 2149874 The iontophoretic results suggest that 5-HT1B, 5-HT1C and 5-HT2 receptors may all play a role in facilitation of the excitability of spinal motoneurons by locally applied 5-HT. 1991-04-09 2022-01-07 rat
A K\\xc5\\x82odzi\\xc5\\x84ska, E Chojnacka-W\\xc3\\xb3jci. Anorexia induced by M-trifluoromethylphenylpiperazine (TFMPP) in rats. Polish journal of pharmacology and pharmacy vol 42 issue 1 1991 2281017 1-[3-(trifluoromethyl) phenyl] piperazine (TFMPP), a putative 5-HT1B, 5-HT1C and 5-HT2 agonist decreased dose-dependently food intake over 4 h in freely feeding rats. 1991-03-13 2022-01-07 rat
R A Glennon, C Chaurasia, M Titele. Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. Journal of medicinal chemistry vol 33 issue 10 1990 2213830 Whereas tryptamine derivatives generally display little selectivity for the various populations of 5-HT receptors, N1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (Ki = 12 nM) and selectivity at 5-HT2 receptors relative to 5-HT1A (Ki = 7100 nM), 5-HT1B (Ki = 5000 nM), 5-HT1C (Ki = 120 nM), and 5-HT1D (Ki greater than 10,000 nM) receptors. 1990-11-20 2022-01-07 Not clear
N A Frambes, C L Kirstein, C A Moody, L P Spea. 5-HT1A, 5-HT1B and 5-HT2 receptor agonists induce differential behavioral responses in preweanling rat pups. European journal of pharmacology vol 182 issue 1 1990 2144825 Preweanling (postnatal day 17-18) Sprague-Dawley rat pups were tested in both the absence and presence of milk following administration of various doses of the 5-HT1A agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) or ipsapirone, the 5-HT1B agonist 1-(3-chlorophenyl)piperazine (mCPP) or the 5-HT2 agonist 1-(2,5-dimethoxy-4-iodo-phenyl)-2-aminopropane (DOI). 1990-10-19 2022-01-07 Not clear
N S Buckholtz, D F Zhou, D X Freedman, W Z Potte. Lysergic acid diethylamide (LSD) administration selectively downregulates serotonin2 receptors in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 3 issue 2 1990 1969270 Daily administration of LSD [130 micrograms/kg (0.27 mumol/kg) intraperitoneally (IP)] for 5 days produced a decrease in serotonin2 (5-hydroxytryptamine2, 5-HT2) binding in cortex (measured 24 hours after the last drug administration) but did not affect binding to other receptor systems (5-HT1A, 5-HT1B, beta-adrenergic, alpha 1- or alpha 2-adrenergic, D2-dopaminergic) or to a recognition site for 5-HT uptake. 1990-05-07 2022-01-07 rat
M Pawlik, P Kaulen, H G Baumgarten, H Rommelspache. Quantitative autoradiography of [3H]norharman [( 3H]beta-carboline) binding sites in the rat brain. Journal of chemical neuroanatomy vol 3 issue 1 1990 2156525 monoamine oxidase, benzodiazepine, tryptamine, 5-hydroxytryptamine receptors (5-HT1A, 5-HT1B, 5-HT1C, 5HT2], which suggests that a unique class of [3H]norharman binding sites exists in the rat brain. 1990-05-02 2022-01-07 Not clear
K A King, J R Holtma. Characterization of the effects of activation of ventral medullary serotonin receptor subtypes on cardiovascular activity and respiratory motor outflow to the diaphragm and larynx. The Journal of pharmacology and experimental therapeutics vol 252 issue 2 1990 2138222 The purpose of the present study was to characterize the cardiorespiratory effects of activation of 5-HT1A, 5-HT1B and 5-HT2 receptor subtypes at the intermediate area of the ventral surface of the medulla. 1990-04-16 2022-01-07 Not clear
C L Kirstein, J Traber, W H Gispen, L P Spea. ACTH-induced behaviors and their modulation by serotonergic agonists differ in neonatal and weanling rat pups. Psychopharmacology vol 100 issue 2 1990 2154832 Four-day-old (P4) and 21-22-day-old (P21-22) rat pups received an intracisternal injection of either ACTH1-16NH2 or saline followed by a subcutaneous (SC) injection of saline, the serotonergic (5HT)1A agonists 8-OH-DPAT or ipsapirone, the 5HT1B agonist TFMPP or the 5HT2 agonist DOI. 1990-03-27 2022-01-07 Not clear
S A Montgomery, N Fineber. Is there a relationship between serotonin receptor subtypes and selectivity of response in specific psychiatric illnesses? The British journal of psychiatry. Supplement vol issue 8 1990 2692641 Identification of 5-HT receptor subtypes--5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2 (possibly A and B), 5-HT3 subtypes, and possibly 5-HT4--has encouraged the manufacture of 5-HT receptor inhibitors with greater subtype specificity. 1990-03-15 2022-01-07 Not clear
M J Millan, K Bervoets, F C Colpaer. Apparent hyperalgesic action of the 5-HT1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks. Neuroscience letters vol 107 issue 1-3 1990 2533334 Agonists at other serotonin (5-HT) receptor types (5-HT1B, 5-HT1C, 5-HT2, 5-HT3) were inactive. 1990-03-14 2022-01-07 Not clear
M Matsumoto, H Togashi, M Yoshioka, H Sait. [Serotonin and blood pressure regulation--antihypertensive mechanism of ketanserin]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica vol 94 issue 4 1990 2575564 Central and peripheral 5-HT receptors can be divided into three receptor subtypes: 5-HT1 (5-HT1A, 5-HT1B, 5-HT1C), 5-HT2 and 5-HT3 receptors. 1990-03-06 2022-01-07 Not clear
D D Gillespie, D H Manier, F Sulse. Characterization of the inducible serotonin-sensitive dihydroalprenolol binding sites with low affinity for isoproterenol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 2 issue 4 1990 2610822 Neither the 5-HT1A agonist, 8-OH-DPAT, nor mianserin, a 5-HT2 and 5-HT1C antagonist, altered the induced RL receptor population, whereas the selective 5-HT1B agonist CGS-12066B reduced the increase in the RL receptor population with a potency equal to that of 5-HT. 1990-02-28 2022-01-07 Not clear
E Przegali\\xc5\\x84ski, B Budziszewska, A Warcho\\xc5\\x82-Kania, E B\\xc5\\x82aszczy\\xc5\\x84sk. Stimulation of corticosterone secretion by the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat. Pharmacology, biochemistry, and behavior vol 33 issue 2 1989 2530590 It is concluded that 8-OH-DPAT-induced increase in serum corticosterone concentration results from its action at a site different than the adrenal cortex and is mediated by postsynaptic 5-HT1A receptors, whereas other subtypes (5-HT1B, 5-HT2, 5-HT3) of 5-HT receptors do not participate in this response. 1989-12-19 2022-01-07 rat
L P Sheets, L L Cook, L W Reite. Serotonergic modulation of the acoustic startle response in rats during preweaning development. Pharmacology, biochemistry, and behavior vol 33 issue 2 1989 2530591 Three 5-HT receptor subtypes are reported to modulate the ASR in adult rats: 5-HT1A and 5-HT2 receptor agonists facilitate the ASR, whereas 5-HT1B agonists decrease the response. 1989-12-19 2022-01-07 rat
W C Xiong, D L Nelso. Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. Life sciences vol 45 issue 16 1989 2811600 The present findings demonstrate the presence of a high-affinity [3H]5-HT binding site in rabbit CN, designated 5-HT1R, that is different from previously defined 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, and 5-HT2 sites. 1989-12-05 2022-01-07 Not clear
P Schoeffter, D Hoye. How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology vol 340 issue 1 1989 2552330 GR 43175 displayed the following order of affinity for 5-HT recognition sites (pKD values, -log mol/l, in parentheses): 5-HT1D (7.54) greater than 5-HT1B (6.35) greater than 5-HT1A (6.13) much greater than 5-HT1C (4.13) greater than 5-HT2 (3.67). 1989-11-08 2022-01-07 Not clear
G A Kennett, P Whitton, K Shah, G Curzo. Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists. European journal of pharmacology vol 164 issue 3 1989 2767117 The effect of mCPP on social interaction was blocked by three antagonists which share a high affinity for 5-HT1C and 5-HT2 receptors: mianserin, cyproheptadine and metergoline but not by the 5-HT2 antagonists ketanserin or ritanserin or the 5-HT1A and 5-HT1B antagonists cyanopindolol and (-)-propranolol. 1989-10-05 2022-01-07 Not clear
R Samanin, T Mennini, C Bendotti, D Barone, S Caccia, S Garattin. Evidence that central 5-HT2 receptors do not play an important role in the anorectic activity of D-fenfluramine in the rat. Neuropharmacology vol 28 issue 5 1989 2566947 The results suggest that 5-HT receptors, other than 5-HT2, possibly 5-HT1B, are involved in the anorectic effect of D-fenfluramine in food-deprived rats. 1989-07-11 2022-01-07 rat
L D Van de Kar, S A Lorens, J H Urban, C L Bethe. Effect of selective serotonin (5-HT) agonists and 5-HT2 antagonist on prolactin secretion. Neuropharmacology vol 28 issue 3 1989 2524677 By deduction, these data suggest that 5-HT1B receptors, or as yet undefined 5-HT receptor subtypes may be involved in the stimulation of the secretion of prolactin by endogenously released 5-HT, and that 5-HT2 receptors may play a minor role in the serotonergic regulation of the secretion of prolactin. 1989-07-03 2022-01-07 rat
C Waeber, P Schoeffter, J M Palacios, D Hoye. Molecular pharmacology of 5-HT1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's archives of pharmacology vol 337 issue 6 1989 2975354 In contrast, these sites showed low affinity for drugs with high affinity and/or selectivity for 5-HT1A (8-OH-DPAT, buspirone), 5-HT1B (21-009, RU 24969), 5-HT1C (mesulergine, mianserin) and 5-HT2 sites (ketanserin, cinanserin). 1989-03-02 2022-01-07 Not clear
A Dumuis, R Bouhelal, M Sebben, R Cory, J Bockaer. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Molecular pharmacology vol 34 issue 6 1989 2849052 The action of antagonists acting on 5-HT1 or 5-HT2 receptors, such as methiothepin (5-HT1 and 5-HT2), metergoline (5-HT1 and 5-HT2), spiperone (5-HT1A and 5-HT2), (-)-pindolol (5-HT1B), mesulergine (5-HT1C), and ketanserin (5-HT2), were almost inactive in reversing the 5-HT stimulating effect. 1989-01-23 2022-01-07 Not clear
C R Gardne. Potential use of drugs modulating 5HT activity in the treatment of anxiety. General pharmacology vol 19 issue 3 1988 2901381 Development of 5HT agonists and antagonists selective for different 5HT receptor sub-types (5HT1A, 5HT1B, 5HT2, 5HT3) has opened a new avenue for investigation of the potential role of 5HT in anxiety. 1988-10-20 2022-01-07 Not clear
C L Kirstein, L P Spea. 5-HT1A, 5-HT1B and 5-HT2 receptor agonists induce differential behavioral responses in neonatal rat pups. European journal of pharmacology vol 150 issue 3 1988 2970973 Sprague-Dawley rat pups at 3-4 days prenatally were tested in both the absence and presence of milk following administration of various doses of either the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT), the 5-HT1B agonist 1-(3-chlorophenyl)piperazine (mCPP), or the 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). 1988-10-18 2022-01-07 Not clear
C L Kirstein, L P Spea. 5-HT1A, 5-HT1B and 5-HT2 receptor agonists induce differential behavioral responses in neonatal rat pups. European journal of pharmacology vol 150 issue 3 1988 2970973 Conversely, the 5-HT2 agonist DOI and the 5-HT1B agonist mCPP increased mouthing and decreased probing. 1988-10-18 2022-01-07 Not clear
K Seuwen, I Magnaldo, J Pouyss\\xc3\\xa9gu. Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein. Nature vol 335 issue 6187 1988 3045568 We show that the mitogenicity of 5-hydroxytryptamine can be uncoupled from phospholipase C activation that is mediated by 5-HT2 receptors, but correlates perfectly with inhibition of adenylate cyclase through 5-HT1B receptor. 1988-10-12 2022-01-07 Not clear
R E Solomon, G F Gebhar. Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats. The Journal of pharmacology and experimental therapeutics vol 245 issue 3 1988 2455040 The 5-HT1A agonist 8-hydroxy-N,N-dipropyl-2-aminotetralin and the 5HT1B agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU-24969) also produced depressor effects but, in contrast to 5-HT, facilitated the tail-flick reflex, whereas the 5-HT2 agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, 6-chloro-2-(1-piperazinyl)-pyrazine (MK-212) and quipazine produced dose-dependent antinociception and had little or no effect on blood pressure. 1988-07-29 2022-01-07 rat
D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters vol 85 issue 3 1988 2966310 In contrast, these sites showed low affinity for drugs with high affinity and/or selectivity for 5-HT1A (8-OH-DPAT, buspirone), 5-HT1B (21-009, RU 24969), 5-HT1C (mesulergine, mianserin) and 5-HT2 sites (ketanserin, cinanserin). 1988-06-02 2022-01-07 Not clear
M R Pranzatell. The comparative pharmacology of the behavioral syndromes induced by TRH and by 5-HT in the rat. General pharmacology vol 19 issue 2 1988 2895033 A 5-HT1A agonist (8-OH-DPAT) blocked WDS, but like putative 5-HT1B (RU 24969) and 5-HT2 (DOI) agonists and the 5-HT antagonists methysergide (non-selective), ritanserin (5-HT2 selective), and l-propranolol (5-HT1 selective), it did not block other antagonists behavioural effects of MK-771. 1988-05-12 2022-01-07 rat
G Gross, G Hanft, N Kolass. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn-Schmiedeberg's archives of pharmacology vol 336 issue 6 1988 2832770 In the present study, the affinities of these urapidil derivatives (5-acetyl, 5-formyl- and 5-methyl-urapidil) for 5-HT receptors were investigated using 3H-8-hydroxy-2-(di-n-propyl-amino)tetralin (3H-8-OH-DPAT), 125I-iodocyanopindolol (125I-ICYP) and 3H-ketanserin for labelling 5-HT1A, 5-HT1B and 5-HT2 binding sites, respectively. 1988-05-03 2022-01-07 Not clear
J R Ieni, L R Meyerso. The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. Life sciences vol 42 issue 3 1988 2961966 For example, 8-OH-DPAT 5HT1A had an IC50 of 117 nM; TFMPP 5HT1B (2.3 microM0 and PAPP 1A + 5HT2 (9 microM); ipsapirone 5HT1A (21.1 microM) and buspirone 5HT1A (greater than 100 microM); ketanserin 5HT2 (greater than 100 microM); 5-HT uptake inhibitors: paroxetine (13 nM); chlorimipramine (73 nM) and fluoxetine (653 nM). 1988-02-23 2022-01-07 Not clear
G J Molderings, K Fink, E Schlicker, M G\\xc3\\xb6ther. Inhibition of noradrenaline release via presynaptic 5-HT1B receptors of the rat vena cava. Naunyn-Schmiedeberg's archives of pharmacology vol 336 issue 3 1988 3683595 Ketanserin, a 5-HT2 receptor antagonist, and spiperone, which blocks 5-HT2 and 5-HT1A but not 5-HT1B or 5-HT1C receptors, failed to antagonize the effect of 5-HT. 1988-01-11 2022-01-07 Not clear
B S Alexander, M D Woo. Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. The Journal of pharmacy and pharmacology vol 39 issue 8 1987 2888864 The interaction of the enantiomers of mianserin and propranolol with the binding of [3H]5-hydroxytryptamine ([3H]5-HT) to the 5-HT1A, 5-HT1B and 5-HT1C sites, and with the binding of [3H]ketanserin to the 5-HT2 site, has been evaluated in rat brain membranes. 1987-10-26 2022-01-07 Not clear
G M Goodwin, R J DeSouza, A J Wood, A R Gree. Lithium decreases 5-HT1A and 5-HT2 receptor and alpha 2-adrenoceptor mediated function in mice. Psychopharmacology vol 90 issue 4 1987 3027734 By contrast with this reduction of 5-hydroxytryptamine (5-HT) function mediated by the 5-HT1A and 5-HT2 receptor sub-types, repeated lithium administration had no effect on the motor response to a putative 5-HT1B receptor agonist 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1H indole (RU 24969, 3 mg/kg IP). 1987-03-20 2022-01-07 mouse
H O Kalkman, G Engel, D Hoye. Inhibition of 5-carboxamidotryptamine-induced relaxation of guinea-pig ileum correlates with [125I]LSD binding. European journal of pharmacology vol 129 issue 1-2 1986 3770071 The results suggest that the 5-HT receptor-mediating relaxation in the guinea-pig ileum can be labelled with [125I]LSD and that this receptor does not belong to the 5-HT2, 5-HT1A, 5-HT1B or 5-HT1C receptor subtypes. 1986-12-11 2022-01-07 Not clear
M L Cohen, W E Colber. Relationship between receptors mediating serotonin (5-HT) contractions in the canine basilar artery to 5-HT1, 5-HT2 and rat stomach fundus 5-HT receptors. The Journal of pharmacology and experimental therapeutics vol 237 issue 3 1986 3712277 Similarity of the contractile effects of 5-HT in the rat stomach fundus and in the basilar artery coupled to the previous observations that receptors mediating 5-HT-induced contractions in the fundus were not 5-HT1, 5-HT1A, 5-HT1B or 5-HT2 led us to consider the possibility that 5-HT receptors in the canine basilar artery may resemble those in the rat stomach fundus. 1986-07-16 2022-01-07 Not clear
E W Taylor, S P Duckles, D L Nelso. Dissociation constants of serotonin agonists in the canine basilar artery correlate to Ki values at the 5-HT1A binding site. The Journal of pharmacology and experimental therapeutics vol 236 issue 1 1986 2934545 Logs of these KA values did not correlate with log Ki values for the inhibition of binding of the 5-HT2 ligand [3H] ketanserin (r = 0.2253, P greater than .05) or log IC50 values for inhibition of [3H]5-HT binding (r = 0.5732, P greater than 0.05), which labels both 5-HT1A and 5-HT1B sites. 1986-02-20 2022-01-07 Not clear
D N Middlemis. The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. The Journal of pharmacy and pharmacology vol 37 issue 6 1985 2862270 Moreover, since RU 24969 potently displaced ligand binding to the 5-HT1 and 5-HT1B recognition sites but was only weakly active at the 5-HT2 receptor, the results lend support to the claim for a pharmacological resemblance between the 5-HT autoreceptor and the 5-HT1 recognition site and in particular the low affinity 5-HT1B subtype. 1985-09-16 2022-01-07 Not clear
G M Goodwin, A R Gree. A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors. British journal of pharmacology vol 84 issue 3 1985 2580582 Radioligand binding techniques have demonstrated the existence of 5-hydroxytryptamine (5-HT) binding subtypes: 5-HT2, 5-HT1A and 5-HT1B. 1985-06-20 2022-01-07 mouse
M B Emerit, H Gozlan, M D Hall, M Hamon, A Marque. Irreversible blockade of central 5-HT binding sites by 8-methoxy-2'-chloro-PAT. Biochemical pharmacology vol 34 issue 6 1985 3156602 Although 8-methoxy-2'-chloro-PAT bound irreversibly to different classes of 5-HT binding sites (5-HT1A, 5-HT1B, presynaptic sites), it can be considered a selective alkylating agent, since it exerted no action on 3H-spiperone binding to 5-HT2 sites, 3H-muscimol binding to GABA sites, or 3H-flunitrazepam binding to benzodiazepine sites. 1985-04-17 2022-01-07 Not clear