All Relations between 5-ht receptor 2 and 5-ht receptor 1d

Reference Sentence Publish Date Extraction Date Species
E J Pappert, C G Goetz, G T Stebbins, M Belden, P M Carve. 5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes. European journal of pharmacology vol 347 issue 1 1998 9650847 Guinea pigs were pre-treated with carbidopa (50 mg) followed by one of eight 5-HT antagonists: (-)-N-tert-butyl-3-[4-(2-methoxyphenyl) piperazin-1-yl]-2-phenyl propionamide ((-)-WAY 100135) (5-HT1A), N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-N-(2-pyridyl)-cy clohexancarboxamide (WAY 100635) (5-HT1A), methiothepin mesylate (5-HT1/2), mesulergine hydrochloride (5-HT2A/2C), N[4-methoxy-3-(4-methyl-L-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2 ,4-oxadizol-3-yl) (GR 127935) (5-HT1D), trans-4-[(3Z)3-(2-dimethylaminoethyl)oxyimino-3(2-fluorop hen yl) propen-1-yl]phenol, hemifumarate (SR 46349) (5-HT2), ondansetron hydrochloride (5-HT3), and [1-[2-[methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-5-fluoro-2-meth oxy-1H-indole-3-carboxylate (GR 125487) (5-HT4). 1998-09-01 2022-01-08 Not clear
A Merzak, S Koochekpour, M P Fillion, G Fillion, G J Pilkingto. Expression of serotonin receptors in human fetal astrocytes and glioma cell lines: a possible role in glioma cell proliferation and migration. Brain research. Molecular brain research vol 41 issue 1-2 1997 8883928 Expression of seven serotonin or 5-hydroxytryptamine (5-HT) receptors (5-HT1D alpha, 5-HT1E, 5-HT2, 5-HT1A, 5-HT1C, 5-HT1D beta, and 5-HT6) was investigated in human normal fetal astrocytes and eight glioma cell lines by reverse transcription and polymerase chain reaction (RT-PCR). 1997-02-20 2022-01-07 Not clear
D Hoyer, G R Marti. Classification and nomenclature of 5-HT receptors: a comment on current issues. Behavioural brain research vol 73 issue 1-2 1996 8788515 At the time of the Serotonin Satellite meeting in Chicago, the IUPHAR classification of receptors for 5-HT recognised four distinct receptor classes (5-HT1, 5-HT2, 5-HT3 and 5-HT4), comprising seven fully characterised functional receptor subtypes and four recombinant receptors (5-HT1D alpha, 5-HT1D beta, 5-ht1E and 5-ht1F). 1996-12-04 2022-01-07 Not clear
D Baldwin, S Rudg. The role of serotonin in depression and anxiety. International clinical psychopharmacology vol 9 Suppl 4 issue 1995 7622823 However, we do know that 5-HT1A agonists are involved in the treatment of certain anxiety disorders, that 5-HT1C and 5-HT2 receptor antagonists may be indicated for the treatment of generalized anxiety disorder, and that 5-HT1D receptor agonists are used in the treatment of migraine. 1995-08-31 2022-01-07 Not clear
M J Millan, H Canton, A Gobert, F Lejeune, J M Rivet, K Bervoets, M Brocco, P Widdowson, T Mennini, V Audino. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. The Journal of pharmacology and experimental therapeutics vol 268 issue 1 1994 8301575 The affinities of S 14489, S 15535 and S 15931 for other 5-HT receptor types (5-HT1B, 5-HT1C, 5-HT1D, 5-HT2 and 5-HT3) were about 50 to 1000-fold lower. 1994-03-10 2022-01-07 Not clear
B Arranz, A Eriksson, E Mellerup, P Plenge, J Marcusso. Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. Brain research vol 620 issue 1 1993 8402192 5-HT1A, 5-HT1D, 5-HT2 binding sites and affinity and 5-HT uptake sites were simultaneously determined in frontal cortex samples from 23 control subjects, aged 16-75 years. 1993-11-09 2022-01-07 human
M R Pranzatelli, P T Tailor, P Raz. Brainstem serotonin receptors in the guinea pig: implications for myoclonus. Neuropharmacology vol 32 issue 3 1993 8474616 There were fewer 5-HT1A and 5-HT1C binding sites and 5-HT uptake sites in guinea pig than rat brainstem, more 5-HT1D and antagonist-labeled 5-HT2 sites, but the differences were 2-fold or less. 1993-05-17 2022-01-07 Not clear
M R Pranzatelli, P T Tailor, P Raz. Brainstem serotonin receptors in the guinea pig: implications for myoclonus. Neuropharmacology vol 32 issue 3 1993 8474616 In guinea pig brainstem, the rank order of binding site density was: 5-HT transporter site >> 5-HT1D > antagonist-labeled 5-HT2 > 5-HT1A, 5-HT1C > 5-HT1E > agonist-labeled 5-HT2 binding site. 1993-05-17 2022-01-07 Not clear
M G Erlander, T W Lovenberg, B M Baron, L de Lecea, P E Danielson, M Racke, A L Slone, B W Siegel, P E Foye, K Canno. Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. Proceedings of the National Academy of Sciences of the United States of America vol 90 issue 8 1993 7682702 Both were insensitive to 5-HT1A, 5-HT1D or 5-HT2 serotonergic ligands [8-hydroxy-2-(di-n-propylamino)tetralin, sumatriptan, and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane]. 1993-05-17 2022-01-07 Not clear
F J Monsma, Y Shen, R P Ward, M W Hamblin, D R Sible. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular pharmacology vol 43 issue 3 1993 7680751 Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. 1993-04-13 2022-01-07 Not clear
M T Barr\\xc3\\xbas, J Mar\\xc3\\xadn, J Villamor, G Balfag\\xc3\\xb3. Receptors involved in the modulation of 5-hydroxytryptamine release in bovine cerebral arteries. The Journal of pharmacy and pharmacology vol 44 issue 10 1993 1360508 Electrically-stimulated tritium release was decreased by tetrodotoxin (0.8 microM), Ca-free medium, denervation with 6-OHDA (1.46 mM, 10 min), 5-HT (10 microM), noradrenaline (1 microM) and the agonist of alpha 2-adrenoceptors B-HT 920 (0.1 and 1 microM), enhanced by metitepine (1 microM, antagonists of presynaptic 5-HT1 receptors) and rauwolscine (1 microM, antagonist at alpha 2-adrenoceptors, and also of 5-HT1D receptors) and not affected by ketanserin (1 microM, antagonist of 5-HT2 receptors), methysergide (0.1 microM, antagonist of 5-HT1 and 5-HT2 receptors) and phentolamine (1 and 3 microM antagonist of alpha-adrenoceptors and less potent of 5-HT1 receptors). 1993-01-04 2022-01-07 Not clear
M O Den Boer, C M Villal\\xc3\\xb3n, P R Saxen. 5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved? Naunyn-Schmiedeberg's archives of pharmacology vol 345 issue 5 1992 1326717 The effect of metergoline (1 mg.kg-1), a substance with a very high affinity for the 5-HT1D receptor as well as for the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT2 receptors, was studied on the responses to 5-HT and sumatriptan. 1992-10-22 2022-01-07 Not clear
D N Middlemiss, M D Trickleban. Centrally active 5-HT receptor agonists and antagonists. Neuroscience and biobehavioral reviews vol 16 issue 1 1992 1553108 Eleven subtypes of central 5-HT receptor have so far been postulated, four of which have been cloned (5-HT1A, 5-HT1C, 5-HT1D and 5-HT2) and a fifth (the 5-HT3 receptor) purified. 1992-04-24 2022-01-09 Not clear
M R Pranzatelli, J Ballett. Serotonin receptors in human neuroblastoma: a possible biologic tumor marker. Experimental neurology vol 115 issue 3 1992 1537397 No 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2, or 5-HT uptake sites were found in any of the tumors, although all were detected in human or rat brain. 1992-04-02 2022-01-09 Not clear
G Gross, X Xin, M Gastpa. Trimipramine: pharmacological reevaluation and comparison with clozapine. Neuropharmacology vol 30 issue 11 1992 1663593 In radioligand binding studies, D,L-trimipramine showed fairly high affinities (KI 10-60 nM) for some dopamine (DA), noradrenaline and 5-hydroxytryptamine (5-HT) receptor subtypes (5-HT2 receptors = alpha 1A/B-adrenoceptors greater than or equal to D2 receptors), intermediate affinities (300-550 nM) for D1 receptors, alpha 2B-adrenoceptors and 5-HT1C receptors but only low affinities (greater than 1000 nM) for alpha 2A-adrenoceptors, 5-HT1A, 5-HT1D and 5-HT3 receptors. 1992-03-05 2022-01-07 Not clear
F P Zemlan, E F Schwa. Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein. Journal of neurochemistry vol 57 issue 6 1991 1834802 [3H]5-HT competition studies performed in the presence of 100 nM 8-OH-DPAT and 10 nM RU 24969 (to block 5-HT1A and 5-HT1B receptors, respectively) indicated that the remaining 49% of [3H]5-HT binding did not possess the pharmacologic profile previous reported for 5-HT1C, 5-HT1D, 5-HT1E, 5-HT2, or 5-HT3 receptors. 1991-12-18 2022-01-07 Not clear
G J Molderings, K Werner, J Likungu, M G\\xc3\\xb6ther. Inhibition of noradrenaline release from the sympathetic nerves of the human saphenous vein via presynaptic 5-HT receptors similar to the 5-HT 1D subtype. Naunyn-Schmiedeberg's archives of pharmacology vol 342 issue 4 1991 2255330 These data exclude the idea that the inhibitory presynaptic 5-HT receptor on the sympathetic nerves belongs to the 5-HT2 and 5-HT3 receptor class; the pattern of agonist potencies suggests that the receptor is very similar to the 5-HT1D receptor subtype. 1991-01-22 2022-01-07 Not clear
R A Glennon, C Chaurasia, M Titele. Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. Journal of medicinal chemistry vol 33 issue 10 1990 2213830 Whereas tryptamine derivatives generally display little selectivity for the various populations of 5-HT receptors, N1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (Ki = 12 nM) and selectivity at 5-HT2 receptors relative to 5-HT1A (Ki = 7100 nM), 5-HT1B (Ki = 5000 nM), 5-HT1C (Ki = 120 nM), and 5-HT1D (Ki greater than 10,000 nM) receptors. 1990-11-20 2022-01-07 Not clear
S A Montgomery, N Fineber. Is there a relationship between serotonin receptor subtypes and selectivity of response in specific psychiatric illnesses? The British journal of psychiatry. Supplement vol issue 8 1990 2692641 Identification of 5-HT receptor subtypes--5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2 (possibly A and B), 5-HT3 subtypes, and possibly 5-HT4--has encouraged the manufacture of 5-HT receptor inhibitors with greater subtype specificity. 1990-03-15 2022-01-07 Not clear
W C Xiong, D L Nelso. Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. Life sciences vol 45 issue 16 1989 2811600 The present findings demonstrate the presence of a high-affinity [3H]5-HT binding site in rabbit CN, designated 5-HT1R, that is different from previously defined 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, and 5-HT2 sites. 1989-12-05 2022-01-07 Not clear
P Schoeffter, D Hoye. How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology vol 340 issue 1 1989 2552330 GR 43175 displayed the following order of affinity for 5-HT recognition sites (pKD values, -log mol/l, in parentheses): 5-HT1D (7.54) greater than 5-HT1B (6.35) greater than 5-HT1A (6.13) much greater than 5-HT1C (4.13) greater than 5-HT2 (3.67). 1989-11-08 2022-01-07 Not clear
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