All Relations between 5-ht receptor 2a and serotonin

Publication Sentence Publish Date Extraction Date Species
Jia Zhou, Kun-kun Geng, Feng-feng Ping, Yue-ying Gao, Lei Liu, Bai-nian Fen. Cross-talk between 5-hydroxytryptamine and substance P in the melanogensis and apoptosis of B16F10 melanoma cells. European journal of pharmacology. vol 775. 2016-12-13. PMID:26872989. 5-ht and 5-ht2a receptor agonist could mitigate this apoptotic effect of sp. 2016-12-13 2023-08-13 Not clear
Jihua Fu, Shaoxin Ma, Xin Li, Shanshan An, Tao Li, Keke Guo, Min Lin, Wei Qu, Shanshan Wang, Xinyue Dong, Xiaoyu Han, Ting Fu, Xinping Huang, Tianying Wang, Siyu H. Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver. International journal of biological sciences. vol 12. issue 2. 2016-12-13. PMID:26884719. lts with hyperglucocorticoidemia induced hepatic 5-ht synthetic increase with tryptophan hydroxylase 1 (tph1) up-regulation, and 5-ht2 receptor (5-ht2r, including 5-ht2a, 2b receptor) up-regulation in liver and visceral adipose, as well as hepatic mtor activation with triglycerides and vldl overproduction with steatosis, and visceral adipose lipolytic increase with high blood free fatty acids (ffas) level. 2016-12-13 2023-08-13 rat
James Francescangeli, Sonia Vaida, Anthony S Bonavi. Perioperative Diagnosis and Treatment of Serotonin Syndrome Following Administration of Methylene Blue. The American journal of case reports. vol 17. 2016-12-13. PMID:27210537. serotonin syndrome (ss) involves serotonergic hyperactivity caused by excessive activation of 5-ht2a receptors. 2016-12-13 2023-08-13 Not clear
Ichiro Yasue, Shinji Matsunaga, Taro Kishi, Kiyoshi Fujita, Nakao Iwat. Serotonin 2A Receptor Inverse Agonist as a Treatment for Parkinson's Disease Psychosis: A Systematic Review and Meta-analysis of Serotonin 2A Receptor Negative Modulators. Journal of Alzheimer's disease : JAD. vol 50. issue 3. 2016-10-31. PMID:26757194. there is uncertainty about the efficacy and tolerability of serotonin 2a (5-ht2a) receptor negative modulators for parkinson's disease psychosis (pdp). 2016-10-31 2023-08-13 Not clear
José L Moreno, Patricia Miranda-Azpiazu, Aintzane García-Bea, Jason Younkin, Meng Cui, Alexey Kozlenkov, Ariel Ben-Ezra, Georgios Voloudakis, Amanda K Fakira, Lia Baki, Yongchao Ge, Anastasios Georgakopoulos, José A Morón, Graeme Milligan, Juan F López-Giménez, Nikolaos K Robakis, Diomedes E Logothetis, J Javier Meana, Javier González-Maes. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Science signaling. vol 9. issue 410. 2016-10-10. PMID:26758213. previous findings demonstrated that the gq/11-coupled serotonin 5-ht2a receptor and the gi/o-coupled metabotropic glutamate 2 (mglu2) receptor-gpcrs that are involved in signaling alterations associated with psychosis-assemble into a heteromeric complex in the mammalian brain. 2016-10-10 2023-08-13 mouse
Kota Naito, Chizuru Tanaka, Manami Mitsuhashi, Hajime Moteki, Mitsutoshi Kimura, Hideshi Natsume, Masahiko Ogihar. Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes. Biological & pharmaceutical bulletin. vol 39. issue 1. 2016-10-06. PMID:26567725. hepatocyte parenchymal cells maintained in a serum-free, defined medium, synthesized dna and proliferated in the presence of 5-ht or a selective 5-ht2b receptor agonist, bw723c86, but not in the presence of 5-ht2a, or 5-ht2c receptor agonists (tcb-2 and cp809101, respectively), in a time- and dose-dependent manner. 2016-10-06 2023-08-13 rat
Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. we used selective antagonists of serotonin receptors (isamoltan 5-ht1b, brl 15572 5-ht1d, ketanserin 5-ht2a, ondansetron 5-ht3 and sb-269970 5-ht7). 2016-10-05 2023-08-13 mouse
Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. selective antagonists for 5-ht1b, 5-ht2a, 5-ht3 receptors at doses of 0.1, 1 and 10 µg, reversed the antihyperalgesic effect induced by 250 ng serotonin. 2016-10-05 2023-08-13 mouse
Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. these results demonstrated for the first time, the peripheral mechanical antihyperalgesic effect of serotonin, and participation of 5-ht1b, 5-ht2a and 5-ht3 receptors in this event. 2016-10-05 2023-08-13 mouse
Eric J Nordstrom, Katie C Bittner, Michael J McGrath, Clinton R Parks, Frank H Burto. "Hyperglutamatergic cortico-striato-thalamo-cortical circuit" breaker drugs alleviate tics in a transgenic circuit model of Tourette׳s syndrome. Brain research. vol 1629. 2016-09-22. PMID:26453289. here we have examined whether these mice׳s tics are countered by drugs that "break" sequential elements of their hyperactive cortical/amygdalar glutamatergic and efferent striatal circuit: anti-serotonoceptive and anti-noradrenoceptive corticostriatal glutamate output blockers (the serotonin 5-ht2a,c receptor antagonist ritanserin and the ne alpha-1 receptor antagonist prazosin); agmatinergic striatothalamic gaba output blockers (the presynaptic agmatine/imidazoline i1 receptor agonist moxonidine); and nigrostriatal dopamine output blockers (the presynaptic d2 receptor agonist bromocriptine). 2016-09-22 2023-08-13 mouse
Ibrahim M Shokry, John J Callanan, John Sousa, Rui Ta. Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome. Journal of visualized experiments : JoVE. issue 103. 2016-09-16. PMID:26437182. this hypothesis can be tested using in situ hybridization to detect the serotonin 5-ht2a receptor gene htr2a. 2016-09-16 2023-08-13 rat
Ibrahim M Shokry, John J Callanan, John Sousa, Rui Ta. Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome. Journal of visualized experiments : JoVE. issue 103. 2016-09-16. PMID:26437182. hybridization probes used for this study include dapb (a bacterial gene coding for dihydrodipicolinate reductase), ppib (a housekeeping gene coding for peptidylprolyl isomerase b), and htr2a (a serotonin gene coding for 5-ht2a receptors). 2016-09-16 2023-08-13 rat
C Anthony Altar, Joseph Carhart, Josiah D Allen, Daniel Hall-Flavin, Joel Winner, Bryan Dechair. Clinical Utility of Combinatorial Pharmacogenomics-Guided Antidepressant Therapy: Evidence from Three Clinical Studies. Molecular neuropsychiatry. vol 1. issue 3. 2016-09-08. PMID:27606312. forty-four allelic variations were measured in genes for the cytochrome p450 (cyp) enzymes cyp2d6, cypc19, and cyp1a2, the serotonin transporter (slc6a4), and the 5-ht2a receptor (htr2a). 2016-09-08 2023-08-13 human
Gitte M Knudsen, Peter S Jensen, David Erritzoe, William F C Baaré, Anders Ettrup, Patrick M Fisher, Nic Gillings, Hanne D Hansen, Lars Kai Hansen, Steen G Hasselbalch, Susanne Henningsson, Matthias M Herth, Klaus K Holst, Pernille Iversen, Lars V Kessing, Julian Macoveanu, Kathrine Skak Madsen, Erik L Mortensen, Finn Årup Nielsen, Olaf B Paulson, Hartwig R Siebner, Dea S Stenbæk, Claus Svarer, Terry L Jernigan, Stephen C Strother, Vibe G Frokjae. The Center for Integrated Molecular Brain Imaging (Cimbi) database. NeuroImage. vol 124. issue Pt B. 2016-09-06. PMID:25891375. the data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-ht1a, 5-ht1b, 5-ht2a, and 5-ht4 and the 5-ht transporter (5-htt), but can easily serve other purposes. 2016-09-06 2023-08-13 human
b' Yasmine Chabbi-Achengli, Tereza Coman, Corinne Collet, Jacques Callebert, Michelangelo Corcelli, Hil\\xc3\\xa8ne Lin, Rachel Rignault, Michel Dy, Marie-Christine de Vernejoul, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin Is Involved in Autoimmune Arthritis through Th17 Immunity and Bone Resorption. The American journal of pathology. vol 186. issue 4. 2016-09-06. PMID:26968113.' ex vivo serotonin and agonists of the 5-ht2a and 5-ht2b receptors restored il-17 secretion from splenocytes and th17 cell differentiation in tph1(-/-) mice. 2016-09-06 2023-08-13 mouse
Leslie Citrom. Cariprazine for the Treatment of Schizophrenia: A Review of this Dopamine D3-Preferring D3/D2 Receptor Partial Agonist. Clinical schizophrenia & related psychoses. vol 10. issue 2. 2016-09-01. PMID:27440212. cariprazine is also a partial agonist at the serotonin 5-ht1a receptor and acts as an antagonist at 5-ht2b and 5-ht2a receptors. 2016-09-01 2023-08-13 Not clear
Marco Bocchio, Giulia Fucsina, Lydia Oikonomidis, Stephen B McHugh, David M Bannerman, Trevor Sharp, Marco Capogn. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 13. 2016-08-25. PMID:26052039. ex vivo patch-clamp recordings demonstrated that the depolarizing effect of 5-ht on pvins was mediated by 5-ht2a receptor. 2016-08-25 2023-08-13 mouse
Marco Bocchio, Giulia Fucsina, Lydia Oikonomidis, Stephen B McHugh, David M Bannerman, Trevor Sharp, Marco Capogn. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 13. 2016-08-25. PMID:26052039. this deficit was because of reduced 5-ht2a function and not because of increased 5-ht uptake. 2016-08-25 2023-08-13 mouse
Stuart A Collins, Courtney Huff, Nicolas Chiaia, Gary A Gudelsky, Bryan K Yamamot. 3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26670377. mdma increases serotonin (5ht) release and activates 5ht2a receptors. 2016-08-22 2023-08-13 rat
Marek Śmieja, Dawid Warszyck. Average Information Content Maximization--A New Approach for Fingerprint Hybridization and Reduction. PloS one. vol 11. issue 1. 2016-08-16. PMID:26784447. this methodology, applied to the ligands of five cognate serotonin receptors (5-ht2a, 5-ht2b, 5-ht2c, 5-ht5a, 5-ht6), proved that 100 bits selected from four non-hashed fingerprints reflect almost all structural information required for a successful in silico discrimination test. 2016-08-16 2023-08-13 Not clear