| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stuart A Collins, Courtney Huff, Nicolas Chiaia, Gary A Gudelsky, Bryan K Yamamot. 3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26670377. |
mdma increases serotonin (5ht) release and activates 5ht2a receptors. |
2016-08-22 |
2023-08-13 |
rat |
| Marek Śmieja, Dawid Warszyck. Average Information Content Maximization--A New Approach for Fingerprint Hybridization and Reduction. PloS one. vol 11. issue 1. 2016-08-16. PMID:26784447. |
this methodology, applied to the ligands of five cognate serotonin receptors (5-ht2a, 5-ht2b, 5-ht2c, 5-ht5a, 5-ht6), proved that 100 bits selected from four non-hashed fingerprints reflect almost all structural information required for a successful in silico discrimination test. |
2016-08-16 |
2023-08-13 |
Not clear |
| Xueping Tu, Jinjing Zuo, Ke Hu, Jing Kang, Yongtian Mei, Nian Wan. Effect of Systemic Application of 5-Hydroxytryptamine on Hypoglossal Nerve Discharge in Anesthetized Rats. Journal of molecular neuroscience : MN. vol 57. issue 3. 2016-08-10. PMID:26076739. |
the 5-ht evoked biphasic manner of hypoglossal output and hypoglossal nerve activity ltf (hltf) were 5-ht2a receptor-dependent and coupled to pkc activation. |
2016-08-10 |
2023-08-13 |
rat |
| Belén Goitia, María Celeste Rivero-Echeto, Noelia V Weisstaub, Jay A Gingrich, Edgar Garcia-Rill, Verónica Bisagno, Francisco J Urban. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26484945. |
we combined whole-cell patch clamp recordings of miniature inhibitory post-synaptic currents (mipscs) in ventrobasal thalamic neurons during local (puff) application of 5-ht in wild type (wt) or knockout mice lacking 5-ht2a receptors (5-ht2a -/-). |
2016-08-05 |
2023-08-13 |
mouse |
| Belén Goitia, María Celeste Rivero-Echeto, Noelia V Weisstaub, Jay A Gingrich, Edgar Garcia-Rill, Verónica Bisagno, Francisco J Urban. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26484945. |
inhibition of mipscs frequency by low (10 μm) and high (100 μm) 5-ht concentrations was observed in ventrobasal neurons from 5-ht2a -/- mice. |
2016-08-05 |
2023-08-13 |
mouse |
| Belén Goitia, María Celeste Rivero-Echeto, Noelia V Weisstaub, Jay A Gingrich, Edgar Garcia-Rill, Verónica Bisagno, Francisco J Urban. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26484945. |
in 5-ht2a -/- mice, nan-190, a specific 5-ht1a antagonist, prevented the 100 μm 5-ht inhibition while blocking h-currents that prolonged inhibition during post-puff periods. |
2016-08-05 |
2023-08-13 |
mouse |
| Belén Goitia, María Celeste Rivero-Echeto, Noelia V Weisstaub, Jay A Gingrich, Edgar Garcia-Rill, Verónica Bisagno, Francisco J Urban. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26484945. |
the inhibitory effects of 100 μm 5-ht were enhanced in cocaine binge-treated 5-ht2a -/- mice. |
2016-08-05 |
2023-08-13 |
mouse |
| Víctor Rovira, Emilio Geijo-Barriento. Intra- and Interhemispheric Propagation of Electrophysiological Synchronous Activity and Its Modulation by Serotonin in the Cingulate Cortex of Juvenile Mice. PloS one. vol 11. issue 3. 2016-08-02. PMID:26930051. |
these actions of serotonin were mimicked by the activation of either 5-ht1b or 5-ht2a receptors, but not by the activation of the 5-ht1a subtype. |
2016-08-02 |
2023-08-13 |
mouse |
| Emma D Deek. Flibanserin: First Global Approval. Drugs. vol 75. issue 15. 2016-07-29. PMID:26412054. |
the drug has a high affinity for serotonin 5-ht1a and 5-ht2a receptors (5-ht1a agonist/5-ht2a antagonist) and is believed to treat hsdd by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain. |
2016-07-29 |
2023-08-13 |
Not clear |
| Karen Wolf, Attila Braun, Elizabeth J Haining, Yu-Lun Tseng, Peter Kraft, Michael K Schuhmann, Sanjeev K Gotru, Wenchun Chen, Heike M Hermanns, Guido Stoll, Klaus-Peter Lesch, Bernhard Nieswand. Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice. PloS one. vol 11. issue 1. 2016-07-19. PMID:26800051. |
blood 5-ht has been proposed to regulate hemostasis by acting as a vasoconstrictor and by triggering platelet signaling through 5-ht receptor 2a (5htr2a). |
2016-07-19 |
2023-08-13 |
mouse |
| François Montastruc, Aurore Palmaro, Haleh Bagheri, Laurent Schmitt, Jean-Louis Montastruc, Maryse Lapeyre-Mestr. Role of serotonin 5-HT2C and histamine H1 receptors in antipsychotic-induced diabetes: A pharmacoepidemiological-pharmacodynamic study in VigiBase. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 10. 2016-07-12. PMID:26256010. |
we investigated potential relationships between antipsychotics׳ receptor occupancy (serotonin 5-ht1a, 5-ht2a, 5-ht2c, histamine h1, muscarinic m3, adrenergic α1, α2 or dopaminergic d2 d3 occupancies) and reports of diabetes using vigibase(®), the world health organization (who) global individual case safety report (icsr) database. |
2016-07-12 |
2023-08-13 |
Not clear |
| François Montastruc, Aurore Palmaro, Haleh Bagheri, Laurent Schmitt, Jean-Louis Montastruc, Maryse Lapeyre-Mestr. Role of serotonin 5-HT2C and histamine H1 receptors in antipsychotic-induced diabetes: A pharmacoepidemiological-pharmacodynamic study in VigiBase. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 10. 2016-07-12. PMID:26256010. |
a significant and positive association was found between histamine h1, muscarinic m3 and serotonin 5-ht2c, 5-ht2a receptor occupancies and reports of diabetes. |
2016-07-12 |
2023-08-13 |
Not clear |
| Claire Chevreuil, Elisabeth Polard, Eric Lemonnier, Paul Guillemot, Danièle Bentué-Ferre. [Not Available]. Therapie. vol 66. issue 2. 2016-07-12. PMID:27393647. |
its mechanism of action is different as aripiprazole is a partial dopamine d2 and serotonin 5-ht1a receptor agonist and 5-ht2a receptor antagonist. |
2016-07-12 |
2023-08-13 |
Not clear |
| A Spiacci, T de Oliveira Sergio, G S F da Silva, M L Glass, L C Schenberg, N Garcia-Cairasco, H Zangross. Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia. Neuroscience. vol 307. 2016-07-06. PMID:26319117. |
intra-dpag injection of 5-ht (20 nmol), (±)-8-hydroxy-2-(di-n-propylamino) tetralin hydrobromide (8-oh-dpat) (8 nmol), a 5-ht1a receptor agonist, or (±)-2,5-dimethoxy-4-iodo amphetamine hydrochloride (doi) (16 nmol), a preferential 5-ht2a agonist, reduced the number of upward jumps directed to the border of the experimental chamber during hypoxia, interpreted as escape attempts, without affecting the rats' locomotion. |
2016-07-06 |
2023-08-13 |
rat |
| Ling Huang, Wenjun Zhang, Xiaohua Zhang, Lei Yin, Bangyin Chen, Jinchun Son. Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics. Bioorganic & medicinal chemistry letters. vol 25. issue 22. 2016-06-28. PMID:26483200. |
the present study describes the optimization of a series of novel benzoxazole-piperidine (piperazine) derivatives combining high dopamine d2 and serotonin 5-ht1a, 5-ht2a receptor affinities. |
2016-06-28 |
2023-08-13 |
human |
| Martin Reznitsky, Per Plenge, Anders Hay-Schmid. Serotonergic projections from the raphe nuclei to the subthalamic nucleus; a retrograde- and anterograde neuronal tracing study. Neuroscience letters. vol 612. 2016-06-28. PMID:26683905. |
autoradiography showed that serotonin receptors 5-ht1b and 5-ht2c and the serotonin transporter were present in stn, whereas the 5-ht1a and 5-ht2a not were present. |
2016-06-28 |
2023-08-13 |
rat |
| Beatriz Restrepo, Mónica García, Alicia Rodríguez-Barbero, Luis San Román, María Luisa Martin, Asunción Morá. Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. European journal of pharmacology. vol 659. issue 1. 2016-06-27. PMID:21414306. |
in long-term diabetic rats, vasoconstriction elicited by 5-ht and α-methyl-5-ht was significantly decreased by ritanserin (a 5-ht2 receptor antagonist), spiperone (a 5-ht2a receptor antagonist), and the cyclooxygenase (cox) inhibitors, indomethacin (non-selective cox inhibitor), fr 122047 or nimesulide (selective cox-1 and cox-2 inhibitors, respectively), but was not modified by pretreatment with sb 206553 (3,5-dihydro-5-methyl-n-3-pyridinylbenzo[1,2.b:4,5-b']dipyrrole(1h)-carboxamide hydrochloride), a non-selective 5-ht2c receptor antagonist, prazosin, propranolol, enalapril or losartan. |
2016-06-27 |
2023-08-12 |
rat |
| Beatriz Restrepo, Mónica García, Alicia Rodríguez-Barbero, Luis San Román, María Luisa Martin, Asunción Morá. Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. European journal of pharmacology. vol 659. issue 1. 2016-06-27. PMID:21414306. |
our data suggest that, in the in-situ autoperfused kidney of long-term diabetic rats, 5-ht vasoconstrictor action is mediated, through cyclooxygenase pathway, by local activation of 5-ht2a receptors. |
2016-06-27 |
2023-08-12 |
rat |
| Sarah L Grei. Brexpiprazole: First Global Approval. Drugs. vol 75. issue 14. 2016-06-24. PMID:26310190. |
brexpiprazole is a novel serotonin-dopamine activity modulator that acts as a partial agonist of serotonin 1a (5-ht1a) and dopamine d2 receptors, as well as a potent antagonist of 5-ht2a receptors and noradrenergic α1b and α2c receptors. |
2016-06-24 |
2023-08-13 |
Not clear |
| Matthew E Peters, Vijay Vaidya, Lea T Drye, Davangere P Devanand, Jacobo E Mintzer, Bruce G Pollock, Anton P Porsteinsson, Paul B Rosenberg, Lon S Schneider, David M Shade, Daniel Weintraub, Jerome Yesavage, Constantine G Lyketsos, Dimitri Avramopoulo. Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences. Journal of geriatric psychiatry and neurology. vol 29. issue 2. 2016-06-16. PMID:26303700. |
six functional genetic variants were studied in the following genes: serotonin receptor 2a (htr2a-t102c), serotonin receptor 2c (htr2c-cys23ser), serotonin transporter (5htt-lpr), brain-derived neurotropic factor (bdnf-val66met), apolipoprotein e (ε2, ε3, ε4 variants), and cytochrome p450 (cyp2c19). |
2016-06-16 |
2023-08-13 |
Not clear |