| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Neely Ivgy-May, Frank Ruwe, Andrew Krystal, Thomas Rot. Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial. Sleep medicine. vol 16. issue 7. 2016-03-21. PMID:26047892. |
esmirtazapine (org 50081), a medication that binds with high affinity to serotonin 5-ht2a and histamine-1 receptors, was evaluated as a potential treatment for insomnia. |
2016-03-21 |
2023-08-13 |
Not clear |
| Mei-Yan Liu, Yan-Ping Ren, Wan-Lin Wei, Guo-Xiang Tian, Guo L. Changes of Serotonin (5-HT), 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression. Chinese medical journal. vol 128. issue 14. 2016-03-15. PMID:26168831. |
changes of serotonin (5-ht), 5-ht2a receptor, and 5-ht transporter in the sprague-dawley rats of depression, myocardial infarction and myocardial infarction co-exist with depression. |
2016-03-15 |
2023-08-13 |
rat |
| Mei-Yan Liu, Yan-Ping Ren, Wan-Lin Wei, Guo-Xiang Tian, Guo L. Changes of Serotonin (5-HT), 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression. Chinese medical journal. vol 128. issue 14. 2016-03-15. PMID:26168831. |
to evaluate whether serotonin (5-ht), 5-ht2a receptor (5-ht2ar), and 5-ht transporter (serotonin transporter [sert]) are associated with different disease states of depression, myocardial infarction (mi) and mi co-exist with depression in sprague-dawley rats. |
2016-03-15 |
2023-08-13 |
rat |
| N K Popova, A V Kulikov, E M Kondaurova, A S Tsybko, E A Kulikova, I B Krasnov, B S Shenkman, E Yu Bazhenova, N A Sinyakova, V S Naumenk. Risk neurogenes for long-term spaceflight: dopamine and serotonin brain system. Molecular neurobiology. vol 51. issue 3. 2016-03-08. PMID:25084757. |
however, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-ht transporter, 5-ht1a, and 5-ht3 receptor genes, though it reduced 5-ht2a receptor gene expression in the hypothalamus. |
2016-03-08 |
2023-08-13 |
mouse |
| N K Popova, A V Kulikov, E M Kondaurova, A S Tsybko, E A Kulikova, I B Krasnov, B S Shenkman, E Yu Bazhenova, N A Sinyakova, V S Naumenk. Risk neurogenes for long-term spaceflight: dopamine and serotonin brain system. Molecular neurobiology. vol 51. issue 3. 2016-03-08. PMID:25084757. |
we revealed risk da and 5-ht neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-o-methyltransferase, and d1 receptor in the nigrostriatal system; d1 and 5-ht2a receptors in the hypothalamus; and monoamine oxidase a (mao a) in the frontal cortex). |
2016-03-08 |
2023-08-13 |
mouse |
| Latham H L Fink, Noelle C Anastasio, Robert G Fox, Kenner C Rice, F Gerard Moeller, Kathryn A Cunningha. Individual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor System. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25666313. |
individual differences in impulsive action reflect variation in the cortical serotonin 5-ht2a receptor system. |
2016-03-08 |
2023-08-13 |
rat |
| Shuji Gamoh, Tasuku Kanai, Naoko Tanaka-Totoribe, Masamichi Ohkura, Masachika Kuwabara, Eisaku Nakamura, Atsuko Yokota, Tetsuo Yamasaki, Akiko Watanabe, Masahiro Hayashi, Shouichi Fujimoto, Ryuichi Yamamot. Water-soluble jack-knife prawn extract inhibits 5-hydroxytryptamine-induced vasoconstriction and platelet aggregation in humans. Food & function. vol 6. issue 2. 2016-03-01. PMID:25464143. |
first, we evaluated the effect of water-soluble ocean resource extracts on the response to 5-ht in hek293 cells which have forcibly expressed cyan fluorescent protein-fused 5-ht2a receptors (5-ht2a-cfp). |
2016-03-01 |
2023-08-13 |
human |
| Anna Czopek, Marcin Kołaczkowski, Adam Bucki, Hanna Byrtus, Maciej Pawłowski, Grzegorz Kazek, Andrzej J Bojarski, Agata Piaskowska, Justyna Kalinowska-Tłuścik, Anna Partyka, Anna Wesołowsk. Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent. Bioorganic & medicinal chemistry. vol 23. issue 13. 2016-02-26. PMID:25936259. |
a series of novel spirohydantoin derivatives with arylpiperazinylbutyl moiety were synthesized and evaluated for serotonin 5-ht1a, 5-ht2a, 5-ht7 and dopamine d2 receptors. |
2016-02-26 |
2023-08-13 |
mouse |
| Filiz Civil Arslan, Emel Korkmaz Uysal, Evrim Ozkorumak, Ahmet Tiryak. Trazodone induced galactorrhea: a case report. General hospital psychiatry. vol 37. issue 4. 2016-02-23. PMID:25920951. |
trazodone is a heterocyclic antidepressant that exerts its effect via the inhibition of selective serotonin reuptake and the antagonism of 5-ht2a and 5-ht2c receptors. |
2016-02-23 |
2023-08-13 |
Not clear |
| N S Hunter, K C Anderson, A Co. Pimavanserin. Drugs of today (Barcelona, Spain : 1998). vol 51. issue 11. 2016-02-11. PMID:26744739. |
pimavanserin (acp-103) is a selective inverse agonist of the 5-hydroxytryptamine 2a (5-ht2a) receptor intended to treat patients with parkinson's disease psychosis (pdp). |
2016-02-11 |
2023-08-13 |
Not clear |
| Emmanuel Deau, Elodie Robin, Raluca Voinea, Nathalie Percina, Grzegorz Satała, Adriana-Luminita Finaru, Agnès Chartier, Gilles Tamagnan, David Alagille, Andrzej J Bojarski, Séverine Morisset-Lopez, Franck Suzenet, Gérald Guillaume. Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [(18)F]-PET Imaging in a Primate Brain. Journal of medicinal chemistry. vol 58. issue 20. 2016-02-02. PMID:26348247. |
rational design, pharmacomodulation, and synthesis of dual 5-hydroxytryptamine 7 (5-ht7)/5-hydroxytryptamine 2a (5-ht2a) receptor antagonists and evaluation by [(18)f]-pet imaging in a primate brain. |
2016-02-02 |
2023-08-13 |
Not clear |
| James G Pfau. Treatment for hypoactive sexual desire. Cell. vol 163. issue 3. 2016-02-01. PMID:26496594. |
flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-ht1a autoreceptors and block postsynaptic action of serotonin at 5-ht2a receptors. |
2016-02-01 |
2023-08-13 |
Not clear |
| Giuseppe Blasi, Pierluigi Selvaggi, Leonardo Fazio, Linda Antonella Antonucci, Paolo Taurisano, Rita Masellis, Raffaella Romano, Marina Mancini, Fengyu Zhang, Grazia Caforio, Teresa Popolizio, Jose Apud, Daniel R Weinberger, Alessandro Bertolin. Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25563748. |
variation in dopamine d2 and serotonin 5-ht2a receptor genes is associated with working memory processing and response to treatment with antipsychotics. |
2016-01-25 |
2023-08-13 |
human |
| Giuseppe Blasi, Pierluigi Selvaggi, Leonardo Fazio, Linda Antonella Antonucci, Paolo Taurisano, Rita Masellis, Raffaella Romano, Marina Mancini, Fengyu Zhang, Grazia Caforio, Teresa Popolizio, Jose Apud, Daniel R Weinberger, Alessandro Bertolin. Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25563748. |
dopamine d2 and serotonin 5-ht2a receptors contribute to modulate prefrontal cortical physiology and response to treatment with antipsychotics in schizophrenia. |
2016-01-25 |
2023-08-13 |
human |
| Rajeev Sakhuja, Krishnakanth Kondabolu, Tania Córdova-Sintjago, Sean Travers, Adam S Vincek, Myong Sang Kim, Khalil A Abboud, Lijuan Fang, Zhuming Sun, Clinton E Canal, Raymond G Boot. Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors. Bioorganic & medicinal chemistry. vol 23. issue 7. 2016-01-22. PMID:25703249. |
syntheses were undertaken of derivatives of (2s,4r)-(-)-trans-4-phenyl-n,n-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine (4-phenyl-2-dimethylaminotetralin, pat), a stereospecific agonist at the serotonin 5-ht2c g protein-coupled receptor (gpcr), with inverse agonist activity at 5-ht2a and 5-ht2b gpcrs. |
2016-01-22 |
2023-08-13 |
human |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
in order to examine the influence of the substituent in the position 8 of the purine moiety on the affinity for the serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors, a series of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl (thiq) derivatives of 8-amino-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione were synthesized. |
2016-01-21 |
2023-08-13 |
Not clear |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
all the final compounds were investigated in in vitro competition binding experiments for serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors. |
2016-01-21 |
2023-08-13 |
Not clear |
| Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Maciej Pawłowski, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Elżbieta Pękala, Karolina Słoczyńsk. New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773907. |
to obtain potential antidepressants and/or antipsychotics, a series of new long-chain arylpiperazine derivatives of 8-alkoxy-purine-2,6-dione (10-24) and dihydro[1,3]oxazolo[2,3-f]purinedione (30-34) were synthesized and their serotonin (5-ht1a , 5-ht2a , 5-ht6 , 5-ht7 ) and dopamine (d2 ) receptor affinities were determined. |
2016-01-21 |
2023-08-13 |
mouse |
| Satoko Baba, Takeshi Murai, Tomokazu Nakako, Takeshi Enomoto, Michiko Ono, Isao Shimizu, Kazuhito Iked. The serotonin 5-HT₁A receptor agonist tandospirone improves executive function in common marmosets. Behavioural brain research. vol 287. 2016-01-19. PMID:25804359. |
on the other hand, blonanserin (0.1-0.3mg/kg), an atypical antipsychotic highly selective for dopamine d2/d3 and serotonin 5-ht2a receptors, did not affect the number of correct responses in both the easy and difficult trials. |
2016-01-19 |
2023-08-13 |
Not clear |
| Ichiro Kusumi, Shuken Boku, Yoshito Takahash. Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis. Psychiatry and clinical neurosciences. vol 69. issue 5. 2016-01-18. PMID:25296946. |
a variety of serotonin (5-ht) receptors, such as 5-ht2a / 2c , 5-ht1a , 5-ht6 and 5-ht7 receptors, may contribute to the mechanisms of action of 'atypicality'. |
2016-01-18 |
2023-08-13 |
Not clear |