| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesc Artiga. Developments in the field of antidepressants, where do we go now? European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 5. 2016-01-13. PMID:23706576. |
this will lead to the synthesis of new agents blocking the serotonin (and possibly norepinephrine) transporter which will also activate or block 5-ht receptors playing respectively positive (e.g., postsynaptic 5-ht1a, 5-ht4) or negative (e.g., presynaptic 5-ht1a,/1b, 5-ht2a, 5-ht2c,5-ht3, etc.) |
2016-01-13 |
2023-08-12 |
Not clear |
| Antony Loebel, Leslie Citrom. Lurasidone: a novel antipsychotic agent for the treatment of schizophrenia and bipolar depression. BJPsych bulletin. vol 39. issue 5. 2016-01-12. PMID:26755968. |
in addition to full antagonist activity at dopamine d2 (k i(d2) = 1 nm) and serotonin 5-ht2a (k i(5-ht2a) = 0.5 nm) receptors, the pharmacodynamic profile of lurasidone is notable for its high affinity for serotonin 5-ht7 receptors (k i(5-ht7) = 0.5 nm) and its partial agonist activity at 5-ht1a receptors (k i(5-ht1a) = 6.4 nm). |
2016-01-12 |
2023-08-13 |
Not clear |
| Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Asenapine alters the activity of monoaminergic systems following its subacute and long-term administration: an in vivo electrophysiological characterization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25656272. |
taken together, asenapine had profound effects on both catecholamine systems, potently blocked 5-ht2a receptors, and enhanced 5-ht tone, effects that could be important in treatment of mood disorders and schizophrenia. |
2016-01-11 |
2023-08-13 |
Not clear |
| Tamaki Ishima, Takashi Futamura, Yuta Ohgi, Noriko Yoshimi, Tetsuro Kikuchi, Kenji Hashimot. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25687838. |
potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-ht1a and 5-ht2a receptors. |
2016-01-11 |
2023-08-13 |
Not clear |
| Tamaki Ishima, Takashi Futamura, Yuta Ohgi, Noriko Yoshimi, Tetsuro Kikuchi, Kenji Hashimot. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25687838. |
the drug is known to act through a combination of partial agonistic activity at 5-hydroxytryptamine (5-ht)1a, and dopamine d2 receptors, and antagonistic activity at 5-ht2a receptors. |
2016-01-11 |
2023-08-13 |
Not clear |
| Jin-Yu Wang, Cun-Xian Jia, Ying Lian, Shi-Hua Sun, Ming Lyu, Andrew W. Association of the HTR2A 102T/C polymorphism with attempted suicide: a meta-analysis. Psychiatric genetics. vol 25. issue 4. 2016-01-11. PMID:26075944. |
an association between the serotonin 2a receptor (5-ht2a receptor) gene and suicidal behavior has been reported in many studies. |
2016-01-11 |
2023-08-13 |
Not clear |
| Toshiyuki Ueki, Kazushige Mizoguchi, Takuji Yamaguchi, Akinori Nishi, Kyoji Sekiguchi, Yasushi Ikarashi, Yoshio Kas. Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice. Journal of ethnopharmacology. vol 166. 2016-01-07. PMID:25732836. |
finally, we examined the density and mrna levels of serotonin 2a (5-ht2a) receptors. |
2016-01-07 |
2023-08-13 |
mouse |
| Kinshi Kato, Miho Sekiguchi, Shin-ichi Kikuchi, Shin-ichi Konn. The effect of a 5-HT2A receptor antagonist on pain-related behavior, endogenous 5-hydroxytryptamine production, and the expression 5-HT2A receptors in dorsal root ganglia in a rat lumbar disc herniation model. Spine. vol 40. issue 6. 2015-12-28. PMID:25584948. |
the effect of a 5-ht2a receptor antagonist on pain-related behavior, endogenous 5-hydroxytryptamine production, and the expression 5-ht2a receptors in dorsal root ganglia in a rat lumbar disc herniation model. |
2015-12-28 |
2023-08-13 |
rat |
| M J Varela, S Lage, H J Caruncho, M I Cadavid, M I Loza, J Bre. Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: a comparative study. Neuroscience. vol 290. 2015-12-15. PMID:25637489. |
reelin influences the expression and function of dopamine d2 and serotonin 5-ht2a receptors: a comparative study. |
2015-12-15 |
2023-08-13 |
mouse |
| M J Varela, S Lage, H J Caruncho, M I Cadavid, M I Loza, J Bre. Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: a comparative study. Neuroscience. vol 290. 2015-12-15. PMID:25637489. |
thus, we hypothesized that a genetic deficit in reelin would affect the expression and function of dopamine d2 and serotonin 5-ht2a receptors that are associated with the action of current antipsychotic drugs. |
2015-12-15 |
2023-08-13 |
mouse |
| M J Varela, S Lage, H J Caruncho, M I Cadavid, M I Loza, J Bre. Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: a comparative study. Neuroscience. vol 290. 2015-12-15. PMID:25637489. |
we observed increased expression (p<0.05) in striatum membranes and decreased expression (p<0.05) in frontal cortex membranes for both dopamine d2 and serotonin 5-ht2a receptors from hrm compared to wtm. |
2015-12-15 |
2023-08-13 |
mouse |
| Xinli Duan, Min Zhang, Xin Zhang, Fang Wang, Ming Le. Molecular modeling and docking study on dopamine D2-like and serotonin 5-HT2A receptors. Journal of molecular graphics & modelling. vol 57. 2015-12-15. PMID:25728902. |
molecular modeling and docking study on dopamine d2-like and serotonin 5-ht2a receptors. |
2015-12-15 |
2023-08-13 |
human |
| Xinli Duan, Min Zhang, Xin Zhang, Fang Wang, Ming Le. Molecular modeling and docking study on dopamine D2-like and serotonin 5-HT2A receptors. Journal of molecular graphics & modelling. vol 57. 2015-12-15. PMID:25728902. |
accordingly, homology models of dopamine d2, d3, d4 and serotonin 5-ht2a receptors have been built on the high-resolution crystal structure of the β2-adrenergic receptor, and refined by molecular dynamics simulations. |
2015-12-15 |
2023-08-13 |
human |
| Giuliano Alagona, Caterina Ghio, Peter I Nag. Theoretical Conformational Analysis for Neurotransmitters in the Gas Phase and in Aqueous Solution. Serotonin. Journal of chemical theory and computation. vol 1. issue 5. 2015-12-09. PMID:26641896. |
conformational analyses have been performed for protonated serotonin in the gas phase, aqueous solution, and in the binding cavity of a 5-ht2a receptor model. |
2015-12-09 |
2023-08-13 |
Not clear |
| Liping Chen, Geng Chen, Yibin Guo, Lei Liu, Li Xiao, Wenmei Fan, Bingyi Shi, Yeyong Qia. Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 20. issue 11. 2015-12-08. PMID:25045122. |
in this process, the roles of serotonin [5-hydroxytryptamine (5-ht)] and the 5-ht2a receptor subtype are still unknown. |
2015-12-08 |
2023-08-13 |
rat |
| Liping Chen, Geng Chen, Yibin Guo, Lei Liu, Li Xiao, Wenmei Fan, Bingyi Shi, Yeyong Qia. Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 20. issue 11. 2015-12-08. PMID:25045122. |
in this study, we analyzed markers of portal fibroblast (pf)/myofibroblast (mf) transdifferentiation such as transforming growth factor β1 (tgf-β1), phosphorylated smad2/3, α-smooth muscle actin (α-sma), collagen i, and collagen iii in a primary culture system of pfs after the administration of 5-ht or 5-ht plus ketanserin (a selective 5-ht2a receptor antagonist). |
2015-12-08 |
2023-08-13 |
rat |
| Liping Chen, Geng Chen, Yibin Guo, Lei Liu, Li Xiao, Wenmei Fan, Bingyi Shi, Yeyong Qia. Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 20. issue 11. 2015-12-08. PMID:25045122. |
we concluded that the profibrotic activity of 5-ht occurred through the activation of tgf-β1 signaling and the 5-ht2a receptor. |
2015-12-08 |
2023-08-13 |
rat |
| Rudolph M Navar. 5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy. Biochimica et biophysica acta. vol 1848. issue 10 Pt B. 2015-11-24. PMID:25838122. |
olanzapine, a fda approved antipsychotic that blocks multiple neurotransmitters: dopamine at d1, d2, d3, d4 brain receptors, serotonin at 5-ht2a, 5-ht2c, 5-ht3, 5-ht6 receptors, catecholamines at alpha1 adrenergic receptors, acetylcholine at muscarinic receptors, and histamine at h1 receptors, has emerged in recent trials as an effective preventative agent for chemotherapy-induced emesis and nausea, as well as a very effective agent for the treatment of breakthrough emesis and nausea. |
2015-11-24 |
2023-08-13 |
Not clear |
| Pingyuan Gong, Jinting Liu, Philip R Blue, She Li, Xiaolin Zho. Serotonin receptor gene (HTR2A) T102C polymorphism modulates individuals' perspective taking ability and autistic-like traits. Frontiers in human neuroscience. vol 9. 2015-11-11. PMID:26557070. |
inspired by the finding that the serotonin receptor 2a gene (htr2a) modulates the availability of serotonin, this study investigated to what extent htr2a modulates individuals' perspective taking ability and autistic-like traits. |
2015-11-11 |
2023-08-13 |
Not clear |
| Konstantin Glebov, Marie Löchner, Ronald Jabs, Thorsten Lau, Olaf Merkel, Patrick Schloss, Christian Steinhäuser, Jochen Walte. Serotonin stimulates secretion of exosomes from microglia cells. Glia. vol 63. issue 4. 2015-10-29. PMID:25451814. |
here, we demonstrate expression of serotonin receptors, including 5-ht2a,b and 5-ht4 in microglial cells and their functional involvement in the modulation of exosome release by serotonin. |
2015-10-29 |
2023-08-13 |
Not clear |