| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gongliang Zhang, Robert W Stackma. The role of serotonin 5-HT2A receptors in memory and cognition. Frontiers in pharmacology. vol 6. 2015-10-27. PMID:26500553. |
the role of serotonin 5-ht2a receptors in memory and cognition. |
2015-10-27 |
2023-08-13 |
Not clear |
| Gongliang Zhang, Robert W Stackma. The role of serotonin 5-HT2A receptors in memory and cognition. Frontiers in pharmacology. vol 6. 2015-10-27. PMID:26500553. |
serotonin 5-ht2a receptors (5-ht2ars) are widely distributed in the central nervous system, especially in brain region essential for learning and cognition. |
2015-10-27 |
2023-08-13 |
Not clear |
| Anna Partyka, Grażyna Chłoń-Rzepa, Anna Wasik, Magdalena Jastrzębska-Więsek, Adam Bucki, Marcin Kołaczkowski, Grzegorz Satała, Andrzej J Bojarski, Anna Wesołowsk. Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25435254. |
continuing our earlier study in a group of purine-2,6-dione derivatives of long chain arylpiperazines (lcaps), a series of 8-unsubstituted 7-phenylpiperazin-4-yl-alkyl (4-14) and 7-tetrahydroisoquinolinyl-alkyl (15-17) analogues were synthesized and their serotonin 5-ht1a, 5-ht2a, 5-ht6, 5-ht7 and dopamine d2 receptor affinities were determined. |
2015-10-22 |
2023-08-13 |
mouse |
| Magdalena Zaniewska, Natalia Alenina, Karolina Wydra, Sebastian Fröhler, Maciej Kuśmider, Andrew C McCreary, Wei Chen, Michael Bader, Małgorzata Fili. Discovering the mechanisms underlying serotonin (5-HT)2A and 5-HT2C receptor regulation following nicotine withdrawal in rats. Journal of neurochemistry. vol 134. issue 4. 2015-10-19. PMID:26031442. |
5-ht, serotonin; 5-ht2a r, 5-ht2a receptor; 5-ht2c r, 5-ht2c receptor. |
2015-10-19 |
2023-08-13 |
rat |
| Theresa M Carbonaro, Amy J Eshleman, Michael J Forster, Kejun Cheng, Kenner C Rice, Michael B Gatc. The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice. Psychopharmacology. vol 232. issue 1. 2015-10-16. PMID:24985890. |
the role of 5-ht2a, 5-ht 2c and mglu2 receptors in the behavioral effects of tryptamine hallucinogens n,n-dimethyltryptamine and n,n-diisopropyltryptamine in rats and mice. |
2015-10-16 |
2023-08-13 |
mouse |
| Theresa M Carbonaro, Amy J Eshleman, Michael J Forster, Kejun Cheng, Kenner C Rice, Michael B Gatc. The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice. Psychopharmacology. vol 232. issue 1. 2015-10-16. PMID:24985890. |
serotonin 5-ht2a and 5-ht2c receptors are thought to be the primary pharmacological mechanisms for serotonin-mediated hallucinogenic drugs, but recently there has been interest in metabotropic glutamate (mglur2) receptors as contributors to the mechanism of hallucinogens. |
2015-10-16 |
2023-08-13 |
mouse |
| J M Cooper, D A Newby, I M Whyte, G Carter, A L Jones, G K Isbiste. Serotonin toxicity from antidepressant overdose and its association with the T102C polymorphism of the 5-HT2A receptor. The pharmacogenomics journal. vol 14. issue 4. 2015-10-08. PMID:24394202. |
serotonin toxicity from antidepressant overdose and its association with the t102c polymorphism of the 5-ht2a receptor. |
2015-10-08 |
2023-08-12 |
Not clear |
| Melissa A Silverman, Jonathan G Leung, Kathryn M Scha. Aripiprazole-associated hiccups: a case and closer look at the association between hiccups and antipsychotics. Journal of pharmacy practice. vol 27. issue 6. 2015-09-30. PMID:25107419. |
aripiprazole's pharmacologic properties (including dopamine 2 and 5-hydroxytryptamine 1a [5ht1a] receptor partial agonism and 5ht2a receptors antagonism) may be associated with the onset of hiccups. |
2015-09-30 |
2023-08-13 |
Not clear |
| Li-Bo Li, Li Zhang, Yi-Na Sun, Ling-Na Han, Zhong-Heng Wu, Qiao-Jun Zhang, Jian Li. Activation of serotonin2A receptors in the medial septum-diagonal band of Broca complex enhanced working memory in the hemiparkinsonian rats. Neuropharmacology. vol 91. 2015-09-28. PMID:25486618. |
intra-ms-db injection of high affinity 5-ht2a receptor agonist tcb-2 enhanced working memory, increased firing rate of pv-positive neurons and peak frequency of hippocampal theta rhythm, elevated da levels in the hippocampus and mpfc, and decreased 5-ht level in the hippocampus in control and lesioned rats. |
2015-09-28 |
2023-08-13 |
rat |
| Matthias Liecht. Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling. Swiss medical weekly. vol 145. 2015-09-25. PMID:25588018. |
typically, stimulants inhibit the transport of dopamine and noradrenaline (pipradrols, pyrovalerone cathinones) or induce the release of these monoamines (amphetamines and methamphetamine-like cathinones), entactogens predominantly enhance serotonin release (phenylpiperazines, aminoindanes, para-substituted amphetamines, and mdma-like cathinones) similar to mdma (ecstasy), and hallucinogens (tryptamines, hallucinogenic phenethylamines) are direct agonists at serotonergic 5-ht2a receptors. |
2015-09-25 |
2023-08-13 |
Not clear |
| L Samalin, M Ben Gharbia, M Garnier, P-M Llorc. [Short-term efficacy and safety of lurasidone in the treatment of schizophrenia]. L'Encephale. vol 40. issue 6. 2015-09-21. PMID:25453735. |
like other second-generation antipsychotics, lurasidone is an antagonist of d2 dopamine and 5ht2a serotonin receptors, but differs from the other second-generation antipsychotics in its action profile for certain receptors. |
2015-09-21 |
2023-08-13 |
Not clear |
| Katarina Nikolic, Lazaros Mavridis, Oscar M Bautista-Aguilera, José Marco-Contelles, Holger Stark, Maria do Carmo Carreiras, Ilaria Rossi, Paola Massarelli, Danica Agbaba, Rona R Ramsay, John B O Mitchel. Predicting targets of compounds against neurological diseases using cheminformatic methodology. Journal of computer-aided molecular design. vol 29. issue 2. 2015-09-16. PMID:25425329. |
the cheminformatic targets identifications were in agreement with four 3d-qsar (h3r/d1r/d2r/5-ht2ar) models and by in vitro assays for serotonin 5-ht1a and 5-ht2a receptor binding of the most promising ligand (71/mba-veg8). |
2015-09-16 |
2023-08-13 |
Not clear |
| Francisco García-Oscos, Oswaldo Torres-Ramírez, Lu Dinh, Luis Galindo-Charles, Elsy Arlene Pérez Padilla, Juan Carlos Pineda, Marco Atzori, Humberto Salgad. Activation of 5-HT receptors inhibits GABAergic transmission by pre-and post-synaptic mechanisms in layer II/III of the juvenile rat auditory cortex. Synapse (New York, N.Y.). vol 69. issue 3. 2015-09-10. PMID:25482075. |
the inhibiting influence of 5-ht in the gabaergic synaptic activity was mimicked by using the selective agonists of the 5-ht1a and 5-ht2a receptors, 8(oh)-dpat (10 µm) and doi (10 µm), respectively; and it was prevented by their respective antagonists nan-190 (1 µm) and ritanserin (1 μm). |
2015-09-10 |
2023-08-13 |
rat |
| Luciana Romina Frick, Micaela Bernardez-Vidal, Christian Hocht, Bonifacio Silvano Zanutto, Maximiliano Rapanell. Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors. Behavioural brain research. vol 277. 2015-09-08. PMID:24949809. |
dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-ht1a, 5-ht2a and 5-ht3 receptors. |
2015-09-08 |
2023-08-13 |
rat |
| Luciana Romina Frick, Micaela Bernardez-Vidal, Christian Hocht, Bonifacio Silvano Zanutto, Maximiliano Rapanell. Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors. Behavioural brain research. vol 277. 2015-09-08. PMID:24949809. |
given that the major serotonergic circuit in the rat brain comprises the dorsal raphe nuclei and the medial prefrontal cortex (mpfc), and because the latter structure is involved in the control of complex behaviors and expresses 1a (5-ht1a), 2a (5-ht2a), and 3 (5-ht3) receptors, the aim was to study the role of 5-ht and of these receptors in the acquisition and extinction of a reward-dependent operant conditioning task. |
2015-09-08 |
2023-08-13 |
rat |
| Luciana Romina Frick, Micaela Bernardez-Vidal, Christian Hocht, Bonifacio Silvano Zanutto, Maximiliano Rapanell. Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors. Behavioural brain research. vol 277. 2015-09-08. PMID:24949809. |
long evans rats were trained in an operant conditioning task while receiving fluoxetine (serotonin reuptake inhibitor, 10mg/kg), tianeptine (serotonin reuptake enhancer, 10mg/kg), buspirone (5-ht1a partial agonist, 10mg/kg), risperidone (5-ht2a antagonist, 1mg/kg), ondansetron (5-ht3 antagonist, 2mg/kg) or vehicle. |
2015-09-08 |
2023-08-13 |
rat |
| Adam L Halberstad. Recent advances in the neuropsychopharmacology of serotonergic hallucinogens. Behavioural brain research. vol 277. 2015-09-08. PMID:25036425. |
this article reviews the evidence demonstrating the serotonin 5-ht2a receptor is the primary site of hallucinogen action. |
2015-09-08 |
2023-08-13 |
human |
| Suxia Cao, Hengfen Li, Lihong Lou, Zheng Xie, Xiaofeng Zhao, Jianyue Pang, Jingjing Sui, Guangrong Xi. Association study between 5-HT2A and NET gene polymorphisms and recurrent major depression disorder in Chinese Han population. Pakistan journal of pharmaceutical sciences. vol 28. issue 3 Suppl. 2015-09-08. PMID:26051731. |
a functional net t-182c polymorphism (rs2242446) in the promoter region, a synonymous polymorphisms g1287a in the exon 9(rs5569) and a functional serotonin 2a (5-ht2a) receptor (rs6311) genes in the promoter region were associated with mdd in different populations. |
2015-09-08 |
2023-08-13 |
Not clear |
| H Craig Heller, Ahmad Salehi, Bayarsaikhan Chuluun, Devsmita Das, Bill Lin, Sarah Moghadam, Craig C Garner, Damien Cola. Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors. Neurobiology of learning and memory. vol 116. 2015-08-07. PMID:25463650. |
we show that both serotonin content and 5ht2a receptors are increased in the frontal cortex of ts65dn mice and that pharmacological blockage of 5ht2a receptors in ts65dn mice rescues their context dependent nest building impairment. |
2015-08-07 |
2023-08-13 |
mouse |
| Milt Teitler, Katharine Herrick-Davi. Determining the oligomer number of native GPCR using florescence correlation spectroscopy and drug-induced inactivation-reactivation. Current pharmaceutical biotechnology. vol 15. issue 10. 2015-08-06. PMID:25213307. |
studies of the 5-ht7 and 5-ht2a serotonin receptors have revealed that binding of a pseudo-irreversible antagonist ("inactivator") to one of the orthosteric sites of a homodimer abolishes all receptor activity, and subsequent binding of a competitive antagonist to the orthosteric site of the second protomer releases the inactivator, allowing the receptor to return to an active state. |
2015-08-06 |
2023-08-13 |
rat |