| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang-Zheng Zhang, Qian-Xing Zhuang, Ye-Cheng He, Guang-Ying Li, Jing-Ning Zhu, Jian-Jun Wan. 5-HT2A receptor-mediated excitation on cerebellar fastigial nucleus neurons and promotion of motor behaviors in rats. Pflugers Archiv : European journal of physiology. vol 466. issue 7. 2015-02-23. PMID:24145983. |
furthermore, selective 5-ht2a receptor antagonist m100907 concentration-dependently blocks the excitatory effects of 5-ht and tcb-2, a 5-ht2a receptor agonist, on fn neurons. |
2015-02-23 |
2023-08-12 |
rat |
| Benjamin Rolland, Renaud Jardri, Ali Amad, Pierre Thomas, Olivier Cottencin, Régis Borde. Pharmacology of hallucinations: several mechanisms for one single symptom? BioMed research international. vol 2014. 2015-02-23. PMID:24991548. |
there are at least three different pharmacological ways to induce hallucinations: (1) activation of dopamine d2 receptors (d2rs) with psychostimulants, (2) activation of serotonin 5ht2a receptors (ht2ars) with psychedelics, and (3) blockage of glutamate nmda receptors (nmdars) with dissociative anesthetics. |
2015-02-23 |
2023-08-13 |
Not clear |
| Zoya Marinova, Susanne Walitza, Edna Grünblat. Real-time impedance-based cell analyzer as a tool to delineate molecular pathways involved in neurotoxicity and neuroprotection in a neuronal cell line. Journal of visualized experiments : JoVE. issue 90. 2015-02-23. PMID:25146163. |
in the current protocol we describe the use of a real-time impedance-based cell analyzer to determine neuroprotective effects of serotonin 2a (5-ht2a) receptor agonists in a neuronal cell line under label-free and real-time conditions using impedance measurements. |
2015-02-23 |
2023-08-13 |
Not clear |
| Vladimir S Naumenko, Elena M Kondaurova, Daria V Bazovkina, Anton S Tsybko, Tatyana V Il'chibaeva, Nina K Popov. On the role of 5-HT(1A) receptor gene in behavioral effect of brain-derived neurotrophic factor. Journal of neuroscience research. vol 92. issue 8. 2015-02-21. PMID:24706292. |
functional activity of 5-ht2a receptors and 5-ht(2a) receptor mrna levels in the midbrain and hippocampus of 76c mice were decreased compared with akr mice. |
2015-02-21 |
2023-08-13 |
mouse |
| Hilde Lavreysen, Xavier Langlois, Luc Ver Donck, José María Cid Nuñez, Stefan Pype, Robert Lütjens, Anton Megen. Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813. Pharmacology research & perspectives. vol 3. issue 2. 2015-02-18. PMID:25692027. |
jnj-40411813/adx71149 (1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl) pyridin-2(1h)-one) is a positive allosteric modulator (pam) of the mglu2 receptor, which also displays 5-hydroxytryptamine (5ht2a) antagonism after administration in rodents due to a rodent-specific metabolite. |
2015-02-18 |
2023-08-13 |
mouse |
| Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization. The Journal of pharmacology and experimental therapeutics. vol 351. issue 3. 2015-02-17. PMID:25225185. |
using electrophysiologic techniques, the present study assessed the in vivo action of brexpiprazole on serotonin (5-ht) receptor subtypes 5-ht1a, 5-ht1b, and 5-ht2a; dopamine (da) d2 autoreceptors, and α1- and α2-adrenergic receptors. |
2015-02-17 |
2023-08-13 |
Not clear |
| Douglas A Smith, Jessica M Bailey, Diarria Williams, William E Fantegross. Tolerance and cross-tolerance to head twitch behavior elicited by phenethylamine- and tryptamine-derived hallucinogens in mice. The Journal of pharmacology and experimental therapeutics. vol 351. issue 3. 2015-02-17. PMID:25271256. |
the serotonin 5-hydroxytryptamine 2a (5-ht2a) receptor is a potential therapeutic target to a host of neuropsychiatric conditions, but agonist actions at this site are linked to abuse-related hallucinogenic effects that may limit therapeutic efficacy of chronic drug administration. |
2015-02-17 |
2023-08-13 |
mouse |
| Rui Tao, Mary Rudacille, Gongliang Zhang, Zhiyuan M. Changes in intensity of serotonin syndrome caused by adverse interaction between monoamine oxidase inhibitors and serotonin reuptake blockers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24577320. |
serotonin syndrome is elicited by excessive 5-ht in the brain (presynaptic mechanism), whereas syndrome intensity is attributed to neural circuits involving 5-ht2a and nmda receptors (postsynaptic mechanism). |
2015-02-12 |
2023-08-12 |
rat |
| Marlies Oostland, M Renate Buijink, Guus M Teunisse, Lars von Oerthel, Marten P Smidt, Johannes A van Hoof. Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice. Cerebellum (London, England). vol 13. issue 4. 2015-02-09. PMID:24788088. |
we thus show a novel role for serotonin in controlling function of the cerebellum via 5-ht2a receptors expressed by cerebellar granule cells. |
2015-02-09 |
2023-08-13 |
mouse |
| Claudia Rangel-Barajas, Maninder Malik, Suwanna Vangveravong, Robert H Mach, Robert R Luedtk. Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds. Neuropharmacology. vol 83. 2015-01-29. PMID:24680675. |
this observation suggests a functional interaction between dopaminergic and serotonergic systems through d2 dopamine receptors and the 5-ht2a serotonin receptors in vivo. |
2015-01-29 |
2023-08-12 |
mouse |
| Valquíria Camin de Bortoli, Paula Shimene de Melo Yamashita, Hélio Zangross. 5-HT1A and 5-HT2A receptor control of a panic-like defensive response in the rat dorsomedial hypothalamic nucleus. Journal of psychopharmacology (Oxford, England). vol 27. issue 12. 2015-01-27. PMID:23787365. |
in the dorsal periaqueductal gray matter (dpag), another key panic-associated area, serotonin, through the activation of 5-ht1a and 5-ht2a receptors, exerts an inhibitory role on escape expression. |
2015-01-27 |
2023-08-12 |
rat |
| Margherita Brindisi, Stefania Butini, Silvia Franceschini, Simone Brogi, Francesco Trotta, Sindu Ros, Alfredo Cagnotto, Mario Salmona, Alice Casagni, Marco Andreassi, Simona Saponara, Beatrice Gorelli, Pia Weikop, Jens D Mikkelsen, Jorgen Scheel-Kruger, Karin Sandager-Nielsen, Ettore Novellino, Giuseppe Campiani, Sandra Gemm. Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies. Journal of medicinal chemistry. vol 57. issue 22. 2015-01-27. PMID:25343529. |
targeting dopamine d3 and serotonin 5-ht1a and 5-ht2a receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies. |
2015-01-27 |
2023-08-13 |
Not clear |
| Margherita Brindisi, Stefania Butini, Silvia Franceschini, Simone Brogi, Francesco Trotta, Sindu Ros, Alfredo Cagnotto, Mario Salmona, Alice Casagni, Marco Andreassi, Simona Saponara, Beatrice Gorelli, Pia Weikop, Jens D Mikkelsen, Jorgen Scheel-Kruger, Karin Sandager-Nielsen, Ettore Novellino, Giuseppe Campiani, Sandra Gemm. Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies. Journal of medicinal chemistry. vol 57. issue 22. 2015-01-27. PMID:25343529. |
combination of dopamine d3 antagonism, serotonin 5-ht1a partial agonism, and antagonism at 5-ht2a leads to a novel approach to potent atypical antipsychotics. |
2015-01-27 |
2023-08-13 |
Not clear |
| Alejandro D Hofmann, Florian Friedmacher, Manuela Hunziker, Hiromizu Takahashi, Johannes W Duess, Jan-Hendrik Gosemann, Prem Pur. Upregulation of serotonin-receptor-2a and serotonin transporter expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Journal of pediatric surgery. vol 49. issue 6. 2015-01-20. PMID:24888825. |
it exerts its constricting effects on the vessels via serotonin receptor 2a (5-ht2a) and induces pulmonary smooth muscle cell proliferation via the serotonin transporter (5-htt). |
2015-01-20 |
2023-08-13 |
rat |
| Huirong Guo, Yuming Ren, Ning Zhao, Yali Wang, Shuying Li, He Cui, Sijia Zhang, Jianhua Zhan. Synergistic effect of 5-HT2A receptor gene and MAOA gene on the negative emotion of patients with depression. Clinical physiology and functional imaging. vol 34. issue 4. 2015-01-14. PMID:24314147. |
to analyse the synergistic effect of polymorphism of the tandem repeat sequence u-vntr of 5-hydroxytryptamine 2a (5-ht2a) receptor gene and monoamine oxidase a (maoa) gene on the negative emotion in frontal lobe of patients with depression through functional magnetic resonance imaging (fmri) technique. |
2015-01-14 |
2023-08-12 |
Not clear |
| Zhang Tianzhu, Yang Shihai, Du Jua. Antidepressant-like effects of cordycepin in a mice model of chronic unpredictable mild stress. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-14. PMID:25587342. |
then the serotonin (5-ht) and noradrenaline (ne) concentrations in hippocampal were evaluated by hplc; tumor necrosis factor-α (tnf-α) and interleukin-6 (il-6) in hippocampal were evaluated, and the proteins of tnf-α, il-6, nf-κbp65 5-ht2a receptor (5-ht2ar), and brain-derived neurotrophic factor (bdnf) in hippocampal were evaluated by western blot. |
2015-01-14 |
2023-08-13 |
mouse |
| Sjoerd J Finnema, Vladimir Stepanov, Anders Ettrup, Ryuji Nakao, Nahid Amini, Marie Svedberg, Charlotte Lehmann, Martin Hansen, Gitte M Knudsen, Christer Halldi. Characterization of [(11)C]Cimbi-36 as an agonist PET radioligand for the 5-HT(2A) and 5-HT(2C) receptors in the nonhuman primate brain. NeuroImage. vol 84. 2014-12-18. PMID:23994452. |
only recently the first successful serotonin 2a (5-ht2a) receptor agonist pet radioligands have been described, with [(11)c]cimbi-36 reported as the most promising in the pig brain so far. |
2014-12-18 |
2023-08-12 |
monkey |
| Mei-Yi Lee, Chun-Cheng Chiang, Hong-Yi Chiu, Ming-Huan Chan, Hwei-Hsien Che. N-acetylcysteine modulates hallucinogenic 5-HT(2A) receptor agonist-mediated responses: behavioral, molecular, and electrophysiological studies. Neuropharmacology. vol 81. 2014-12-15. PMID:24534112. |
recent evidence demonstrated that functional interactions between serotonin 5-ht2a receptor (5-ht(2a)r) and mglur2 are responsible to unique cellular responses when targeted by hallucinogenic drugs. |
2014-12-15 |
2023-08-12 |
mouse |
| Simona Bertoni, Valentina Arcaro, Valentina Vivo, Alberto Rapalli, Massimiliano Tognolini, Anna Maria Cantoni, Francesca Saccani, Lisa Flammini, Giuseppe Domenichini, Vigilio Ballabeni, Elisabetta Barocell. Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice. Pharmacological research. vol 81. 2014-12-15. PMID:24548822. |
second, the effects produced by intravenous administration of 5-ht1a ligands (partial agonist buspirone 10mgkg(-1), antagonist way100135 0.5-5mgkg(-1)), 5-ht2a antagonist sarpogrelate (10mgkg(-1)), 5-ht3 antagonist alosetron (0.1mgkg(-1)), 5-ht4 antagonist gr125487 (5mgkg(-1)) and 5-ht re-uptake inhibitor fluoxetine (10mgkg(-1)) on i/r-induced inflammatory response were investigated in i/r mice and compared to those obtained in sham-operated animals (s). |
2014-12-15 |
2023-08-12 |
mouse |
| Yong-Hai Sun, Hong-Shi Li, Chao Zhu, Wei Hu, Jing Yang, Guo-Li Zhao, Gui-Jun Lu, Sheng-Xi Wu, Yu-Lin Don. The analgesia effect of duloxetine on post-operative pain via intrathecal or intraperitoneal administration. Neuroscience letters. vol 568. 2014-12-09. PMID:24686187. |
these findings indicate that duloxetine inhibits pop by increasing spinal na and 5-ht levels and activating spinal 5-ht2a or α2-noradrenergic receptors. |
2014-12-09 |
2023-08-12 |
rat |