| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Rosaria Anna Muscatello, Antonio Bruno, Paolo Micali Bellinghieri, Gianluca Pandolfo, Rocco Antonio Zoccal. Sertindole in schizophrenia: efficacy and safety issues. Expert opinion on pharmacotherapy. vol 15. issue 13. 2014-12-05. PMID:25084209. |
it has high affinity for dopamine d2, serotonin 5-ht2a, 5-ht2c and a1-adrenergic receptors, and a low potential for extrapyramidal symptoms. |
2014-12-05 |
2023-08-13 |
Not clear |
| Eiji Kirin. Profile of aripiprazole in the treatment of bipolar disorder in children and adolescents. Adolescent health, medicine and therapeutics. vol 5. 2014-12-04. PMID:25473324. |
aripiprazole acts as a serotonin 5-ht2a receptor antagonist, as well as a partial agonist of the serotonin 5-ht1a and dopamine d2 receptors. |
2014-12-04 |
2023-08-13 |
Not clear |
| Xia Chen, Hongyun Wang, Ji Jiang, Rui Chen, Ying Zhou, Wen Zhong, Hongzhong Liu, Pei H. The pharmacokinetic and safety profiles of blonanserin in healthy Chinese volunteers after single fasting doses and single and multiple postprandial doses. Clinical drug investigation. vol 34. issue 3. 2014-11-24. PMID:24399453. |
blonanserin is a novel atypical antipsychotic drug acting as a mixed serotonin 5-ht2a and dopamine d2 receptor antagonist. |
2014-11-24 |
2023-08-12 |
human |
| Johanna Nyffeler, Susanne Walitza, Elise Bobrowski, Ronnie Gundelfinger, Edna Grünblat. Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism. Journal of molecular psychiatry. vol 2. issue 1. 2014-11-21. PMID:25408912. |
the serotonergic and oxytocinergic systems are of interest in autism for several reasons: (i) both systems are implicated in social behavior, and abnormal levels of serotonin and oxytocin have been found in people with asd; (ii) treatment with selective serotonin reuptake inhibitors and oxytocin can yield improvements; and (iii) previous association studies have linked the serotonin transporter (sert; slc6a4), serotonin receptor 2a (htr2a), and oxytocin receptor (oxtr) genes with asd. |
2014-11-21 |
2023-08-13 |
Not clear |
| Bettina Hornboll, Julian Macoveanu, James Rowe, Rebecca Elliott, Olaf B Paulson, Hartwig R Siebner, Gitte M Knudse. Acute serotonin 2A receptor blocking alters the processing of fearful faces in the orbitofrontal cortex and amygdala. Journal of psychopharmacology (Oxford, England). vol 27. issue 10. 2014-11-15. PMID:23824248. |
the serotonin 2a (5-ht2a) receptor has been implicated in neural-processing of emotionally salient information. |
2014-11-15 |
2023-08-12 |
Not clear |
| Justin L Poklis, Deborah J Clay, Alphonse Pokli. High-performance liquid chromatography with tandem mass spectrometry for the determination of nine hallucinogenic 25-NBOMe designer drugs in urine specimens. Journal of analytical toxicology. vol 38. issue 3. 2014-11-10. PMID:24535338. |
we present a high-performance liquid chromatography triple quadrupole mass spectrometry (hplc-ms-ms) method for the identification and quantification of nine serotonin 5-ht2a receptor agonist hallucinogenic substances from a new class of n-methoxybenzyl derivatives of methoxyphenylethylamine (nbome) designer drugs in human urine: 25h-nbome, 2cc-nbome, 25i-nbf, 25d-nbome, 25b-nbome, 2ct-nbome, 25i-nbmd, 25g-nbome and 25i-nbome. |
2014-11-10 |
2023-08-12 |
human |
| Noé Dumas, Marcelle Moulin-Sallanon, Nathalie Ginovart, Benjamin B Tournier, Peggy Suzanne, Thomas Cailly, Frédéric Fabis, Sylvain Rault, Yves Charnay, Philippe Mille. Small-animal single-photon emission computed tomographic imaging of the brain serotoninergic systems in wild-type and mdr1a knockout rats. Molecular imaging. vol 13. 2014-11-04. PMID:24622810. |
thus, we compared the performances of 123i-p-mppi, 123i-r91150, 123i-sb207710, and 123i-adam radioligands, for imaging of their respective targets (5-hydroxytryptamine [5-ht]1a, 5-ht2a, 5-ht4, and serotonin transporter [sert]), in wt and mdr1a knockout (ko) rats. |
2014-11-04 |
2023-08-12 |
rat |
| b' Zofia Rog\\xc3\\xb3\\xc5\\xb. Combined treatment with atypical antipsychotics and antidepressants in treatment-resistant depression: preclinical and clinical efficacy. Pharmacological reports : PR. vol 65. issue 6. 2014-10-14. PMID:24553002.' |
moreover, atypical antipsychotics administered in a low dose enhanced the antidepressant-like activity of antidepressants, with (among other mechanisms) the serotonin 5-ht1a, 5-ht2a and adrenergic α2 receptors likely playing an important role in their action. |
2014-10-14 |
2023-08-12 |
rat |
| Akio Kodama, Takeo Itoh, Kimihiro Komor. Possible roles of 5-HT in vein graft failure due to intimal hyperplasia 5-HT, nitric oxide and vein graft. Surgery today. vol 44. issue 2. 2014-09-29. PMID:23532320. |
recent studies have demonstrated that 5-ht induces vasoconstriction through the activation of 5-ht2a receptors in smooth muscle cells or vasodilatation through the activation of endothelial 5-ht1b receptors in arteries from various animals. |
2014-09-29 |
2023-08-12 |
rat |
| Kenji Maeda, Linda Lerdrup, Haruhiko Sugino, Hitomi Akazawa, Naoki Amada, Robert D McQuade, Tine Bryan Stensbøl, Christoffer Bundgaard, Jørn Arnt, Tetsuro Kikuch. Brexpiprazole II: antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator. The Journal of pharmacology and experimental therapeutics. vol 350. issue 3. 2014-09-29. PMID:24947464. |
brexpiprazole (opc-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1h)-one) is a novel serotonin-dopamine activity modulator with partial agonist activity at serotonin 1a (5-ht1a) and d2/3 receptors, combined with potent antagonist effects on 5-ht2a, α1b-, and α2c-adrenergic receptors. |
2014-09-29 |
2023-08-13 |
rat |
| Mirjana Carli, Roberto W Invernizz. Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24966814. |
in this review, we focus on the 5-choice serial reaction time task which is able to provide various measures of attention and executive control over performance in rodents and the ability of prefrontocortical and striatal serotonin 5-ht1a, 5-ht2a, and 5-ht2c as well as dopamine d1- and d2-like receptors to modulate different aspects of executive and attention disturbances induced by nmda receptor hypofunction in the prefrontal cortex. |
2014-09-24 |
2023-08-13 |
Not clear |
| Mirjana Carli, Roberto W Invernizz. Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24966814. |
these studies illustrate the control of attention selectivity by serotonin 5-ht1a, 5-ht2a, 5-ht2c, and dopamine d1- but not d2-like receptors and a distinct contribution of these cortical and striatal serotonin and dopamine receptors to the control of different aspects of executive control over performance such as impulsivity and compulsivity. |
2014-09-24 |
2023-08-13 |
Not clear |
| David Baumeister, Georgina Barnes, Giovanni Giaroli, Derek Trac. Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles. Therapeutic advances in psychopharmacology. vol 4. issue 4. 2014-08-01. PMID:25083275. |
these drugs appear to exert their psychedelic effects through their agonist or partial agonist activity at the serotonergic 5-ht2a receptor, though they also have affinity for other metabotropic serotonin receptors. |
2014-08-01 |
2023-08-13 |
Not clear |
| Anna Alexande. Headache may be caused by activation of 5-HT2A receptors in serotonin toxicity. BMJ (Clinical research ed.). vol 348. 2014-07-28. PMID:24647167. |
headache may be caused by activation of 5-ht2a receptors in serotonin toxicity. |
2014-07-28 |
2023-08-12 |
Not clear |
| Clinton E Canal, Drake Morgan, Daniel Felsing, Krishnakanth Kondabolu, Neil E Rowland, Kimberly L Robertson, Rajeev Sakhuja, Raymond G Boot. A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses. The Journal of pharmacology and experimental therapeutics. vol 349. issue 2. 2014-07-18. PMID:24563531. |
a novel aminotetralin-type serotonin (5-ht) 2c receptor-specific agonist and 5-ht2a competitive antagonist/5-ht2b inverse agonist with preclinical efficacy for psychoses. |
2014-07-18 |
2023-08-12 |
mouse |
| Pelin Tanyeri, Mehmet Emin Buyukokuroglu, Oguz Mutlu, Guner Ulak, Furuzan Yildiz Akar, Ipek Komsuoglu Celikyurt, Bekir Faruk Erde. Evidence that the anxiolytic-like effects of the beta3 receptor agonist amibegron involve serotoninergic receptor activity. Pharmacology, biochemistry, and behavior. vol 110. 2014-07-15. PMID:23756183. |
we administered the serotonin 5-ht1a receptor antagonist way-100635, the serotonin 5-ht2a receptor antagonist ketanserin and the serotonin 5-ht3 receptor antagonist ondansetron in mice and evaluated their performance in the elevated plus-maze test. |
2014-07-15 |
2023-08-12 |
mouse |
| Pelin Tanyeri, Mehmet Emin Buyukokuroglu, Oguz Mutlu, Guner Ulak, Furuzan Yildiz Akar, Ipek Komsuoglu Celikyurt, Bekir Faruk Erde. Evidence that the anxiolytic-like effects of the beta3 receptor agonist amibegron involve serotoninergic receptor activity. Pharmacology, biochemistry, and behavior. vol 110. 2014-07-15. PMID:23756183. |
this effect of amibegron may be mediated by interactions with the serotonin 5-ht1a, 5-ht2a and 5-ht3 receptors. |
2014-07-15 |
2023-08-12 |
mouse |
| Camila Catherine H Aquino, Anthony E Lan. Tardive dyskinesia syndromes: current concepts. Parkinsonism & related disorders. vol 20 Suppl 1. 2014-07-11. PMID:24262160. |
the advent of atypical antipsychotics, which have lower affinity for dopamine receptors and act on 5-ht2a and 5-ht2c serotonin receptors, was expected to dramatically reduce the prevalence and incidence of this iatrogenic problem. |
2014-07-11 |
2023-08-12 |
Not clear |
| Jiamei Lian, Xu-Feng Huang, Nagesh Pai, Chao Den. Effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-HT2A and dopamine D2 receptor binding density. Progress in neuro-psychopharmacology & biological psychiatry. vol 47. 2014-07-02. PMID:23994047. |
effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-ht2a and dopamine d2 receptor binding density. |
2014-07-02 |
2023-08-12 |
rat |
| José L Moreno, Javier González-Maes. Preclinical models of antipsychotic drug action. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:23745738. |
serotonin 5-ht2a and metabotropic glutamate 2 receptors have been involved in the mechanism of action of psychedelic and dissociative drugs. |
2014-07-01 |
2023-08-12 |
human |