| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Cano-Colino, Rita Almeida, Albert Compt. Serotonergic modulation of spatial working memory: predictions from a computational network model. Frontiers in integrative neuroscience. vol 7. 2013-10-17. PMID:24133418. |
in all our simulations agonists of 5-ht1a receptors and antagonists of 5-ht2a receptors produced behavioral and physiological effects in line with global 5-ht level increases. |
2013-10-17 |
2023-08-12 |
Not clear |
| Tomoko Horisawa, Hiroyuki Nishikawa, Satoko Toma, Atsushi Ikeda, Masakuni Horiguchi, Michiko Ono, Takeo Ishiyama, Mutsuo Taij. The role of 5-HT7 receptor antagonism in the amelioration of MK-801-induced learning and memory deficits by the novel atypical antipsychotic drug lurasidone. Behavioural brain research. vol 244. 2013-09-30. PMID:23376699. |
lurasidone is a novel atypical antipsychotic with high affinity for dopamine d2, serotonin 5-ht7 and 5-ht2a receptors. |
2013-09-30 |
2023-08-12 |
rat |
| Tomomi Tenjin, Seiya Miyamot. [Blonanserin in the treatment of schizophrenia]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 4. 2013-09-25. PMID:23678596. |
it has high affinity for dopamine d2/3 and serotonin 5-ht2a receptors, but shows low affinity for adrenergic alpha1, histamine h1, and muscarinic m1 receptors. |
2013-09-25 |
2023-08-12 |
Not clear |
| Nobuhiro Nagai, Koichiro Watanab. [Olanzapine]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 4. 2013-09-25. PMID:23678597. |
olanzapine has various affinities for multiple receptors, including dopamine d2 receptor, serotonin 5-ht2a, 5-ht2c, 5-ht6 receptors, and adrenaline alpha1, histamine h1, muscarine m1-m5 receptors as well. |
2013-09-25 |
2023-08-12 |
Not clear |
| Martin A Santini, Cecilia Ratner, Susana Aznar, Anders B Klein, Gitte M Knudsen, Jens D Mikkelse. Enhanced prefrontal serotonin 2A receptor signaling in the subchronic phencyclidine mouse model of schizophrenia. Journal of neuroscience research. vol 91. issue 5. 2013-09-10. PMID:23404493. |
prefrontal serotonin 2a receptors (5-ht2a rs) have been linked to the pathogenesis and treatment of schizophrenia. |
2013-09-10 |
2023-08-12 |
mouse |
| Michelle N Edelmann, Catherine H Demers, Anthony P Auge. Maternal touch moderates sex differences in juvenile social play behavior. PloS one. vol 8. issue 2. 2013-09-03. PMID:23460849. |
control males had lower levels of 5ht2a receptor mrna levels contrasted to females; however, similar to its sex-dependent effect on juvenile social play, males that received additional somatosensory contact had higher serotonin 5ht2a receptor mrna levels than control males. |
2013-09-03 |
2023-08-12 |
human |
| Michelle N Edelmann, Catherine H Demers, Anthony P Auge. Maternal touch moderates sex differences in juvenile social play behavior. PloS one. vol 8. issue 2. 2013-09-03. PMID:23460849. |
as serotonin signaling typically opposes juvenile play behavior, these data suggest that maternal touch can program lasting differences in juvenile social play and 5ht2a receptors mrna levels within the juvenile amygdala. |
2013-09-03 |
2023-08-12 |
human |
| Michael Kometer, André Schmidt, Lutz Jäncke, Franz X Vollenweide. Activation of serotonin 2A receptors underlies the psilocybin-induced effects on α oscillations, N170 visual-evoked potentials, and visual hallucinations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 25. 2013-08-30. PMID:23785166. |
although the serotonergic hallucinogen psilocybin activates multiple serotonin (5-ht) receptors, recent evidence suggests that activation of 5-ht2a receptors may lead to the formation of visual hallucinations by increasing cortical excitability and altering visual-evoked cortical responses. |
2013-08-30 |
2023-08-12 |
human |
| L-Q Ren, J Wienecke, M Chen, M Møller, H Hultborn, M Zhan. The time course of serotonin 2C receptor expression after spinal transection of rats: an immunohistochemical study. Neuroscience. vol 236. 2013-08-26. PMID:23337537. |
serotonin 2a receptor and serotonin 2c receptor (5-ht2a and 2c receptors) are likely the most important 5-ht receptors for enhancing the motoneuron excitability by facilitating the persistent inward current (pic), and thus play an important role for the pathogenesis of spasticity after spinal cord injury. |
2013-08-26 |
2023-08-12 |
rat |
| Nina K Popova, Vladimir S Naumenk. 5-HT1A receptor as a key player in the brain 5-HT system. Reviews in the neurosciences. vol 24. issue 2. 2013-08-21. PMID:23492554. |
specifically, it describes the (1) functional interactions between 5-ht1a, 5-ht2a, 5-ht3, and 5-ht7 receptors; (2) cross-talk between 5-ht1a receptor and genes encoding key members of the brain 5-ht system; (3) implication of the 5-ht1a receptor in natural hibernation and genetic predisposition to different kinds of defensive behavior; and (4) role of 5-ht1a autoreceptors and heteroreceptors in anxiety, depression, and suicide, and in the antidepressant effect of serotonin reuptake inhibitors. |
2013-08-21 |
2023-08-12 |
Not clear |
| Yin Chen, Songlin Wang, Xiangqing Xu, Xin Liu, Minquan Yu, Song Zhao, Shicheng Liu, Yinli Qiu, Tan Zhang, Bi-Feng Liu, Guisen Zhan. Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics. Journal of medicinal chemistry. vol 56. issue 11. 2013-08-20. PMID:23675993. |
the discovery and synthesis of potential and novel antipsychotic coumarin derivatives, associated with potent dopamine d2, d3, and serotonin 5-ht1a and 5-ht2a receptor properties, are the focus of the present article. |
2013-08-20 |
2023-08-12 |
Not clear |
| Yin Chen, Songlin Wang, Xiangqing Xu, Xin Liu, Minquan Yu, Song Zhao, Shicheng Liu, Yinli Qiu, Tan Zhang, Bi-Feng Liu, Guisen Zhan. Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics. Journal of medicinal chemistry. vol 56. issue 11. 2013-08-20. PMID:23675993. |
this derivative possesses unique pharmacological features, including high affinity for dopamine d2 and d3 and serotonin 5-ht1a and 5-ht2a receptors. |
2013-08-20 |
2023-08-12 |
Not clear |
| Cassidy Delaney, Jason Gien, Gates Roe, Nicole Isenberg, Jenai Kailey, Steven H Abma. Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn. American journal of physiology. Lung cellular and molecular physiology. vol 304. issue 12. 2013-08-16. PMID:23605003. |
we studied the hemodynamic effects of 5-ht, ketanserin (5-ht2a receptor antagonist), and sertraline, an ssri, on pulmonary hemodynamics of the late gestation fetal sheep with pphn caused by prolonged constriction of the ductus arteriosis. |
2013-08-16 |
2023-08-12 |
Not clear |
| Cassidy Delaney, Jason Gien, Gates Roe, Nicole Isenberg, Jenai Kailey, Steven H Abma. Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn. American journal of physiology. Lung cellular and molecular physiology. vol 304. issue 12. 2013-08-16. PMID:23605003. |
we concluded that increased 5-ht contributes to high pvr in experimental pphn through activation of the 5-ht2a receptor and that ssri infusion further increases pvr in this model. |
2013-08-16 |
2023-08-12 |
Not clear |
| Jeffrey H Meye. Neurochemical imaging and depressive behaviours. Current topics in behavioral neurosciences. vol 14. 2013-08-08. PMID:23018753. |
lower extracellular serotonin is associated with greater pessimism in humans and chronic serotonin deficiency is associated with upregulation of 5-ht2a (serotonin2a) receptors in cortex. |
2013-08-08 |
2023-08-12 |
Not clear |
| Ya Liu, Hongyan Tian, Xiaoli Yan, Fenling Fan, Wenping Wang, Junli Ha. Serotonin inhibits apoptosis of pulmonary artery smooth muscle cells through 5-HT2A receptors involved in the pulmonary artery remodeling of pulmonary artery hypertension. Experimental lung research. vol 39. issue 2. 2013-08-06. PMID:23301505. |
serotonin inhibits apoptosis of pulmonary artery smooth muscle cells through 5-ht2a receptors involved in the pulmonary artery remodeling of pulmonary artery hypertension. |
2013-08-06 |
2023-08-12 |
rat |
| Ya Liu, Hongyan Tian, Xiaoli Yan, Fenling Fan, Wenping Wang, Junli Ha. Serotonin inhibits apoptosis of pulmonary artery smooth muscle cells through 5-HT2A receptors involved in the pulmonary artery remodeling of pulmonary artery hypertension. Experimental lung research. vol 39. issue 2. 2013-08-06. PMID:23301505. |
serotonin (5-ht) inhibits apoptosis in many pathologic processes by activating the 5-ht2a receptor. |
2013-08-06 |
2023-08-12 |
rat |
| Ya Liu, Hongyan Tian, Xiaoli Yan, Fenling Fan, Wenping Wang, Junli Ha. Serotonin inhibits apoptosis of pulmonary artery smooth muscle cells through 5-HT2A receptors involved in the pulmonary artery remodeling of pulmonary artery hypertension. Experimental lung research. vol 39. issue 2. 2013-08-06. PMID:23301505. |
therefore, we hypothesized that 5-ht may be the promoter of decreased apoptosis in pah through the 5-ht2a receptor. |
2013-08-06 |
2023-08-12 |
rat |
| Ya Liu, Hongyan Tian, Xiaoli Yan, Fenling Fan, Wenping Wang, Junli Ha. Serotonin inhibits apoptosis of pulmonary artery smooth muscle cells through 5-HT2A receptors involved in the pulmonary artery remodeling of pulmonary artery hypertension. Experimental lung research. vol 39. issue 2. 2013-08-06. PMID:23301505. |
in conclusion, 5-ht inhibited pasmc apoptosis by activating the 5-ht2a receptor through the perk1/2 and pdk pathways.5-ht decreasing apoptosis through 5-ht2a receptor is involved, at least in part, in pulmonary artery remolding. |
2013-08-06 |
2023-08-12 |
rat |
| Jade M Franklin, Gonzalo A Carrasc. G-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors. The Journal of biological chemistry. vol 288. issue 22. 2013-08-06. PMID:23592773. |
we have recently reported that cannabinoid agonists can up-regulate and enhance the activity of serotonin 2a (5-ht2a) receptors in the prefrontal cortex (pfcx). |
2013-08-06 |
2023-08-12 |
rat |