| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jade M Franklin, Gonzalo A Carrasc. G-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors. The Journal of biological chemistry. vol 288. issue 22. 2013-08-06. PMID:23592773. |
we have recently reported that cannabinoid agonists can up-regulate and enhance the activity of serotonin 2a (5-ht2a) receptors in the prefrontal cortex (pfcx). |
2013-08-06 |
2023-08-12 |
rat |
| W Pitcho. [Medication of the month. asenapine (Sycrest]. Revue medicale de Liege. vol 68. issue 4. 2013-07-29. PMID:23755711. |
like other atypicals, asenapine acts as an antagonist at both dopamine d2 and serotonin 5-ht2a receptors. |
2013-07-29 |
2023-08-12 |
Not clear |
| Bit Na Kang, Sung Gil Ha, Nooshin S Bahaie, M Reza Hosseinkhani, Xiao Na Ge, Malcolm N Blumenthal, Savita P Rao, P Sriramara. Regulation of serotonin-induced trafficking and migration of eosinophils. PloS one. vol 8. issue 1. 2013-07-26. PMID:23372779. |
more extensive studies with murine bm-eos demonstrated the role of 5-ht in promoting rolling in vivo within inflamed post-capillary venules of the mouse cremaster microcirculation and confirmed that down-stream signaling of 5-ht2a activation involves rock, mapk, pi3k, pkc and calmodulin similar to aml14.3d10 cells. |
2013-07-26 |
2023-08-12 |
mouse |
| Mario F Juruena, Eduardo Pondé de Sena, Irismar Reis de Oliveir. Sertindole in the management of schizophrenia. Journal of central nervous system disease. vol 3. 2013-07-17. PMID:23861640. |
in vitro studies showed that sertindole exerts a potent antagonism at serotonin 5-ht2a, 5-ht2c, dopamine d2, and αl adrenergic receptors. |
2013-07-17 |
2023-08-12 |
Not clear |
| Kathryn A Cunningham, Noelle C Anastasio, Robert G Fox, Sonja J Stutz, Marcy J Bubar, Sarah E Swinford, Cheryl S Watson, Scott R Gilbertson, Kenner C Rice, Sharon Rosenzweig-Lipson, F Gerard Moelle. Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336050. |
synergism between a serotonin 5-ht2a receptor (5-ht2ar) antagonist and 5-ht2cr agonist suggests new pharmacotherapeutics for cocaine addiction. |
2013-07-02 |
2023-08-12 |
Not clear |
| Tomomi Tenjin, Seiya Miyamoto, Yuriko Ninomiya, Rei Kitajima, Shin Ogino, Nobumi Miyake, Noboru Yamaguch. Profile of blonanserin for the treatment of schizophrenia. Neuropsychiatric disease and treatment. vol 9. 2013-06-24. PMID:23766647. |
it belongs to a series of 4-phenyl-2-(1-piperazinyl)pyridines and acts as an antagonist at dopamine d2, d3, and serotonin 5-ht2a receptors. |
2013-06-24 |
2023-08-12 |
Not clear |
| Agnes Fehér, Anna Juhász, Anna László, Magdolna Pákáski, János Kálmán, Zoltán Jank. Serotonin transporter and serotonin receptor 2A gene polymorphisms in Alzheimer's disease. Neuroscience letters. vol 534. 2013-06-18. PMID:23274704. |
serotonin transporter and serotonin receptor 2a gene polymorphisms in alzheimer's disease. |
2013-06-18 |
2023-08-12 |
Not clear |
| Agnes Fehér, Anna Juhász, Anna László, Magdolna Pákáski, János Kálmán, Zoltán Jank. Serotonin transporter and serotonin receptor 2A gene polymorphisms in Alzheimer's disease. Neuroscience letters. vol 534. 2013-06-18. PMID:23274704. |
we examined polymorphisms of the serotonin transporter (slc6a4) and serotonin receptor 2a (htr2a) genes for possible association with ad, and therefore genotyped 5-httlpr, stin2-vntr and htr2a t102c polymorphisms in 252 hungarian ad patients and 234 ethnically matched control individuals. |
2013-06-18 |
2023-08-12 |
Not clear |
| Li Li, Guozhen Qiu, Shengyuan Ding, Fu-Ming Zho. Serotonin hyperinnervation and upregulated 5-HT2A receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient Pitx3 mutant mice. Brain research. vol 1491. 2013-05-31. PMID:23159831. |
serotonin hyperinnervation and upregulated 5-ht2a receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient pitx3 mutant mice. |
2013-05-31 |
2023-08-12 |
mouse |
| Li Li, Guozhen Qiu, Shengyuan Ding, Fu-Ming Zho. Serotonin hyperinnervation and upregulated 5-HT2A receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient Pitx3 mutant mice. Brain research. vol 1491. 2013-05-31. PMID:23159831. |
the striatum receives serotonin (5-hydroxytryptamine, 5-ht) innervation and expresses 5-ht2a receptors (5-ht2ars) and other 5-ht receptors, raising the possibility that the striatal 5-ht system may undergo adaptive changes after chronic severe dopamine (da) loss and contribute to the function and dysfunction of the striatum. |
2013-05-31 |
2023-08-12 |
mouse |
| Pau Celada, M Victoria Puig, Francesc Artiga. Serotonin modulation of cortical neurons and networks. Frontiers in integrative neuroscience. vol 7. 2013-04-30. PMID:23626526. |
5-ht and selective receptor agonists modulate the excitability of cortical neurons and their discharge rate through the activation of several receptor subtypes, of which the 5-ht1a, 5-ht1b, 5-ht2a, and 5-ht3 subtypes play a major role. |
2013-04-30 |
2023-08-12 |
Not clear |
| Pau Celada, M Victoria Puig, Francesc Artiga. Serotonin modulation of cortical neurons and networks. Frontiers in integrative neuroscience. vol 7. 2013-04-30. PMID:23626526. |
5-ht can also stimulate excitatory (5-ht2a and 5-ht3) and inhibitory (5-ht1a) receptors in gaba interneurons to modulate synaptic gaba inputs onto pyramidal neurons. |
2013-04-30 |
2023-08-12 |
Not clear |
| Maria Ramirez, Teresa Gallego-Martin, Elena Olea, Asuncion Rocher, Ana Obeso, Constancio Gonzale. Serotonin dynamics and actions in the rat carotid body: preliminary findings. Advances in experimental medicine and biology. vol 758. 2013-04-16. PMID:23080170. |
5-ht and the 5-ht2a antagonist ketanserin dose-dependently activated chemoreceptor cells as assessed by their capacity to release catecholamines from freshly isolated cb. |
2013-04-16 |
2023-08-12 |
rat |
| Gyorgy Bagdy, Gabriella Juhasz, Xenia Gond. A new clinical evidence-based gene-environment interaction model of depression. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 14. issue 4. 2013-04-12. PMID:23269207. |
in the newmood cohort polymorphisms of the genes of the serotonin transporter, 5-ht1a, 5-ht1b and 5-ht2a and endocannabinoid cb1 receptors, tryptophan hydroxylase, creb1, bdnf and girk provide evidence for the involvement of these genes in the development of depression. |
2013-04-12 |
2023-08-12 |
human |
| Ishier Raote, Samarjit Bhattacharyya, Mitradas M Panicke. Functional selectivity in serotonin receptor 2A (5-HT2A) endocytosis, recycling, and phosphorylation. Molecular pharmacology. vol 83. issue 1. 2013-04-09. PMID:23034456. |
we show that the serotonin receptor 2a (5-ht(2a)), a prototypical gpcr in the study of functional selectivity at a signaling receptor, is functionally selective in endocytosis and recycling in response to five ligands tested: endogenous agonists serotonin (5-ht) and dopamine (da), synthetic agonist 1-(2,5-dimethoxy-4-iodophenyl)-aminopropane (doi), antagonist ketanserin, and inverse agonist and antipsychotic drug clozapine. |
2013-04-09 |
2023-08-12 |
Not clear |
| Deeann Wallis, Denise S Hill, Ian A Mendez, Louise C Abbott, Richard H Finnell, Paul J Wellman, Barry Setlo. Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction. Brain research. vol 1463. 2013-04-08. PMID:22575564. |
most notably, we found changes in dopamine and serotonin receptors and transporters (dat1, drd4, 5htt, 5ht2a), changes in neurotransmitter metabolism genes (th, gad1), as well as changes in neural developmental genes (nurr, ncam). |
2013-04-08 |
2023-08-12 |
mouse |
| Yan-Jun Xu, Ming Zhang, Lei Ji, Vijayan Elimban, Li Chen, Naranjan S Dhall. Suppression of high lipid diet induced by atherosclerosis sarpogrelate. Journal of cellular and molecular medicine. vol 16. issue 10. 2013-03-26. PMID:22348587. |
sarpogrelate (sp), a serotonin (5-ht2a) receptor antagonist, is used as an anti-platelet agent for the treatment of some vascular diseases. |
2013-03-26 |
2023-08-12 |
Not clear |
| Philip R Buskohl, Michelle J Sun, Michelle L Sun, Robert P Thompson, Jonathan T Butche. Serotonin potentiates transforming growth factor-beta3 induced biomechanical remodeling in avian embryonic atrioventricular valves. PloS one. vol 7. issue 8. 2013-01-10. PMID:22880017. |
blockade of the 5ht2b receptor, but not 5-ht2a receptor or serotonin transporter (sert), resulted in complete cessation of tgfβ3 induced mechanical strengthening. |
2013-01-10 |
2023-08-12 |
Not clear |
| H Y Meltzer, B W Massey, M Horiguch. Serotonin receptors as targets for drugs useful to treat psychosis and cognitive impairment in schizophrenia. Current pharmaceutical biotechnology. vol 13. issue 8. 2012-12-18. PMID:22283753. |
the 5-ht2a receptor, along with 5-ht1a, 5-ht 2c, 5-ht 6 or 5-ht 7 receptors, all of which are components of the mechanism of action of clozapine, represent important targets for treating multiple aspects of schizophrenia, especially psychosis and cognitive impairment. |
2012-12-18 |
2023-08-12 |
Not clear |
| H Y Meltzer, B W Massey, M Horiguch. Serotonin receptors as targets for drugs useful to treat psychosis and cognitive impairment in schizophrenia. Current pharmaceutical biotechnology. vol 13. issue 8. 2012-12-18. PMID:22283753. |
we review here the extensive preclinical evidence to support the importance of 5-ht2a receptor inverse agonism to the action of clozapine and related atypical apds, and evidence supporting the potential of selective 5-ht2a, 5-ht 6 , and 5-ht 7, antagonists, 5-ht1a partial agonists and 5-ht2c agonists for development of drugs which ameliorate psychosis or cognitive impairment. |
2012-12-18 |
2023-08-12 |
Not clear |