| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zigor Aira, Itsaso Buesa, Mónica Gallego, Gontzal García del Caño, Nahia Mendiable, Janire Mingo, Diego Rada, Juan Bilbao, Manfred Zimmermann, Jon Jatsu Azku. Time-dependent cross talk between spinal serotonin 5-HT2A receptor and mGluR1 subserves spinal hyperexcitability and neuropathic pain after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 39. 2012-12-10. PMID:23015446. |
time-dependent cross talk between spinal serotonin 5-ht2a receptor and mglur1 subserves spinal hyperexcitability and neuropathic pain after nerve injury. |
2012-12-10 |
2023-08-12 |
rat |
| Zigor Aira, Itsaso Buesa, Mónica Gallego, Gontzal García del Caño, Nahia Mendiable, Janire Mingo, Diego Rada, Juan Bilbao, Manfred Zimmermann, Jon Jatsu Azku. Time-dependent cross talk between spinal serotonin 5-HT2A receptor and mGluR1 subserves spinal hyperexcitability and neuropathic pain after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 39. 2012-12-10. PMID:23015446. |
upregulation of the serotonin receptor 2a (5-ht(2a)r) in dorsal horn neurons promotes spinal hyperexcitation and impairs spinal μ-opioid mechanisms during neuropathic pain. |
2012-12-10 |
2023-08-12 |
rat |
| Nobumi Miyake, Seiya Miyamoto, L Fredrik Jarsko. New serotonin/dopamine antagonists for the treatment of schizophrenia: are we making real progress? Clinical schizophrenia & related psychoses. vol 6. issue 3. 2012-11-29. PMID:23006237. |
relatively potent antagonism of serotonin 5-ht2a receptors coupled with relatively weaker antagonism of dopamine d2 receptors is the central pharmacological characteristic shared by most sgas. |
2012-11-29 |
2023-08-12 |
Not clear |
| Eiji Kirin. Efficacy and safety of aripiprazole in child and adolescent patients. European child & adolescent psychiatry. vol 21. issue 7. 2012-11-26. PMID:22447196. |
aripiprazole (apz) has a unique pharmacological profile, as a partial agonist at the dopamine d2 and serotonin 5ht1a receptors and an antagonist at the serotonin 5ht2a receptor; this drug has few side effects (such as extrapyramidal syndrome, hyperprolactinemia, weight gain, metabolic disorders, and sedation) which are typical problems with other antipsychotic drugs. |
2012-11-26 |
2023-08-12 |
Not clear |
| Heng-Fen Li, Xue Yu, Kun Yang, Cha-Ye He, Shao-Jie Kou, Su-Xia Cao, Guang-Rong Xi. The relationship between single nucleotide polymorphisms in 5-HT2A signal transduction-related genes and the response efficacy to selective serotonin reuptake inhibitor treatments in Chinese patients with major depressive disorder. Genetic testing and molecular biomarkers. vol 16. issue 7. 2012-11-19. PMID:22480177. |
the relationship between single nucleotide polymorphisms in 5-ht2a signal transduction-related genes and the response efficacy to selective serotonin reuptake inhibitor treatments in chinese patients with major depressive disorder. |
2012-11-19 |
2023-08-12 |
Not clear |
| Heng-Fen Li, Xue Yu, Kun Yang, Cha-Ye He, Shao-Jie Kou, Su-Xia Cao, Guang-Rong Xi. The relationship between single nucleotide polymorphisms in 5-HT2A signal transduction-related genes and the response efficacy to selective serotonin reuptake inhibitor treatments in Chinese patients with major depressive disorder. Genetic testing and molecular biomarkers. vol 16. issue 7. 2012-11-19. PMID:22480177. |
to explore the possible relationship between six single nucleotide polymorphisms (snps) (rs6311 and rs6305 of 5-ht2a, rs5443 of gβ3, rs2230739 of acdy9, rs1549870 of pde1a and rs255163 of creb1, which are all related with 5-ht2a the signal transduction pathway) and the response efficacy to selective serotonin reuptake inhibitor (ssri) treatments in major depressive disorder (mdd) chinese. |
2012-11-19 |
2023-08-12 |
Not clear |
| Elizabeth Gilday, Henry A Nasralla. Clinical pharmacology of paliperidone palmitate a parenteral long-acting formulation for the treatment of schizophrenia. Reviews on recent clinical trials. vol 7. issue 1. 2012-10-30. PMID:22023179. |
its mechanism of action, like all other atypical agents, is attributed to the antagonism of brain dopamine d2 and serotonin 5-ht2a receptors. |
2012-10-30 |
2023-08-12 |
Not clear |
| M L Berger, R Palangsuntikul, P Rebernik, P Wolschann, H Berne. Screening of 64 tryptamines at NMDA, 5-HT1A, and 5-HT2A receptors: a comparative binding and modeling study. Current medicinal chemistry. vol 19. issue 18. 2012-10-18. PMID:22519402. |
the most potent inhibitors at 5-ht1a receptors were 5-carboxamido-t (ic50 0.00015 μm) and serotonin (0.0016 μm), at 5-ht2a receptors 2-me-4,7-cl2-t (1.2 μm) and 2,7-me2-4-cl-t (2.0 μm). |
2012-10-18 |
2023-08-12 |
rat |
| Hideho Arit. [The neuroscience of suicide]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 8. 2012-10-18. PMID:22868884. |
genetic polymorphisms in tph, 5-ht transporter (5-httlpr allele), and 5-ht2a receptor were examined for their association with depression-related suicide, but no consistent associations were found. |
2012-10-18 |
2023-08-12 |
Not clear |
| Young Ho Lee, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Son. Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatology international. vol 32. issue 2. 2012-10-15. PMID:21120487. |
the authors conducted a meta-analysis on associations between serotonin transporter (5-htt) gene-linked polymorphic region (5-httlpr) s/l allele, catechol-o-methltransferase (comt) val158met, and serotonin 2a (5-ht2a) receptor 102t/c polymorphisms and fibromyalgia susceptibility as determined using the following: (1) allele contrast, (2) recessive, (3) dominant models, and (4) contrast of homozygotes. |
2012-10-15 |
2023-08-12 |
Not clear |
| B T Carrol. The universal field hypothesis of catatonia and neuroleptic malignant syndrome. CNS spectrums. vol 5. issue 7. 2012-10-02. PMID:18197153. |
this hypothesis considers both disorders as a single entity that result from variable combinations of the following: 1) gamma-aminobutyric acid (gaba) hypoactivity at the gabaa receptor; 2) dopamine hypoactivity at the d2 receptor; 3) serotonin hyperactivity at the 5-ht1a receptor and hypoactivity at the 5-ht2a receptor; and 4) glutamate hypoactivity at the n-methyl-d-aspartate (ndma) receptor. |
2012-10-02 |
2023-08-12 |
human |
| Patrick M Fisher, Julie C Price, Carolyn C Meltzer, Eydie L Moses-Kolko, Carl Becker, Sarah L Berga, Ahmad R Harir. Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity. Biology of mood & anxiety disorders. vol 1. issue 1. 2012-10-02. PMID:22738071. |
the colocalization of 5-ht1a and 5-ht2a receptors on mpfc glutamatergic neurons suggests that their functional interactions may mediate 5-ht effects on this circuit through top-down regulation of amygdala reactivity. |
2012-10-02 |
2023-08-12 |
human |
| Sandip Shah, Dipti Josh. Tolerability and efficacy of paliperidone ER compared to olanzapine in the treatment of schizophrenia: A randomized, double-blind, multicentric trial. Industrial psychiatry journal. vol 20. issue 1. 2012-10-02. PMID:22969177. |
paliperidone is an active metabolite of risperidone and actss through a combination of central dopamine type 2 (d2) and serotonin type 2 (5ht2a) receptor antagonism. |
2012-10-02 |
2023-08-12 |
Not clear |
| Patricia K Seitz, Nicole M Bremer, Andrew G McGinnis, Kathryn A Cunningham, Cheryl S Watso. Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2C receptors. BMC neuroscience. vol 13. 2012-09-27. PMID:22397586. |
quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in cho cells stably expressing serotonin (5-ht) 5-ht2a or 5-ht2c receptors. |
2012-09-27 |
2023-08-12 |
Not clear |
| Mark D Underwood, Suham A Kassir, Mihran J Bakalian, Hanga Galfalvy, J John Mann, Victoria Arang. Neuron density and serotonin receptor binding in prefrontal cortex in suicide. The international journal of neuropsychopharmacology. vol 15. issue 4. 2012-09-05. PMID:21733245. |
therefore, we measured neuron density and serotonin transporter (sert), 5-ht1a and 5-ht2a binding in matched suicides and controls. |
2012-09-05 |
2023-08-12 |
Not clear |
| Ji-Wen Yang, Yan-Chun Xu, Lin Sun, Xiao-Dan Tia. 5-hydroxytryptamine level and 5-HT2A receptor mRNA expression in the guinea pigs eyes with spectacle lens-induced myopia. International journal of ophthalmology. vol 3. issue 4. 2012-08-23. PMID:22553578. |
5-hydroxytryptamine level and 5-ht2a receptor mrna expression in the guinea pigs eyes with spectacle lens-induced myopia. |
2012-08-23 |
2023-08-12 |
Not clear |
| Ji-Wen Yang, Yan-Chun Xu, Lin Sun, Xiao-Dan Tia. 5-hydroxytryptamine level and 5-HT2A receptor mRNA expression in the guinea pigs eyes with spectacle lens-induced myopia. International journal of ophthalmology. vol 3. issue 4. 2012-08-23. PMID:22553578. |
to investigate 5-hydroxytryptamine (5-ht) function and 5-ht receptor 2a (5-ht2a) mrna expression in the formation of lens-induced myopia (lim). |
2012-08-23 |
2023-08-12 |
Not clear |
| Jae B Park, Thomas T Y Wan. Safflomide increases the expression of adiponectin in vitro and in vivo: potential implication for hypoadiponectemia, visceral obesity, and insulin resistance. Journal of agricultural and food chemistry. vol 60. issue 16. 2012-08-10. PMID:22428927. |
the upregulation was partially suppressed by treatment with 5-ht2a agonists (serotonin and α-me-5-ht), suggesting that safflomide may upregulate adiponectin expression more than by blocking 5-ht2a receptors in 3t3-l1 cells. |
2012-08-10 |
2023-08-12 |
rat |
| Janusz K Rybakowski, Piotr Czerski, Monika Dmitrzak-Weglarz, Sebastian Kliwicki, Anna Leszczynska-Rodziewicz, Agnieszka Permoda-Osip, Maria Skibinska, Aleksandra Suwalska, Aleksandra Szczepankiewicz, Joanna Hause. Clinical and pathogenic aspects of candidate genes for lithium prophylactic efficacy. Journal of psychopharmacology (Oxford, England). vol 26. issue 3. 2012-08-03. PMID:21890592. |
some association with lithium prophylactic efficacy was found for the polymorphisms of 5htt, drd1, comt, bdnf and fyn genes, but not for 5ht2a, 5ht2c, drd2, drd3, drd4, gsk-3, ntrk2, grin2b and mmp-9. |
2012-08-03 |
2023-08-12 |
Not clear |
| Lisbeth Marne. Communication among neurons. Danish medical journal. vol 59. issue 4. 2012-08-02. PMID:22459725. |
the established serotonin 5-ht2a ligand [18f]altanersin was evaluated in a two-year follow-up study in elderly subjects. |
2012-08-02 |
2023-08-12 |
human |