| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ho-Geun Kang, Hee-Yun Kim, Hyunwoo Jee, Hwanseok Jun, Hosong Cho, Dongjun Park, Hyun-Jong Ahn, Hyung-Min Kim, Hyun-Ja Jeon. Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice. Reproductive sciences (Thousand Oaks, Calif.). 2022-11-05. PMID:36333646. |
values for hypothalamic serotonin (5-ht), dopamine, norepinephrine, estrogen receptor (er)-β, 5-ht1a, and 5-ht2a were significantly enhanced, while value for hypothalamic monoamine oxidase a was reduced in cwhl and caudatin groups compared with the ovx group. |
2022-11-05 |
2023-08-14 |
mouse |
| Mona Darwish, Dragana Bugarski-Kirola, Julie Passarell, Joel Owen, David Jaworowicz, Daryl DeKarske, Srdjan Stankovi. Pimavanserin Exposure-Response Analyses in Patients With Schizophrenia: Results From the Phase 2 ADVANCE Study. Journal of clinical psychopharmacology. 2022-10-03. PMID:36190440. |
pimavanserin is a selective serotonin 5-ht2a receptor inverse agonist/antagonist being investigated in patients with negative symptoms of schizophrenia. |
2022-10-03 |
2023-08-14 |
Not clear |
| S Parker Singleton, Andrea I Luppi, Robin L Carhart-Harris, Josephine Cruzat, Leor Roseman, David J Nutt, Gustavo Deco, Morten L Kringelbach, Emmanuel A Stamatakis, Amy Kuceyesk. Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape. Nature communications. vol 13. issue 1. 2022-10-03. PMID:36192411. |
serotonin 2a (5-ht2a) receptor agonism by these compounds is associated with more diverse (entropic) brain activity. |
2022-10-03 |
2023-08-14 |
Not clear |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-08-14 |
rat |
| Jean E M Ramirez, Ahmed B Alarabi, Fadi T Khasawneh, Fatima Z Alshboo. A Novel Antibody Targeting the Second Extracellular Loop of the Serotonin 5-HT2A Receptor Inhibits Platelet Function. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955928. |
a novel antibody targeting the second extracellular loop of the serotonin 5-ht2a receptor inhibits platelet function. |
2022-08-12 |
2023-08-14 |
Not clear |
| Takahiro Maekawa, Naoyoshi Sakitani, Youngjae Ryu, Atsushi Takashima, Shuhei Murase, Julius Fink, Motoshi Nagao, Toru Ogata, Masahiro Shinohara, Yasuhiro Sawad. Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents. Journal of visualized experiments : JoVE. issue 185. 2022-08-08. PMID:35938802. |
by using this system, it was demonstrated that phm recapitulates the serotonin (5-hydroxytryptamine, hereafter referred to as 5-ht) receptor subtype 2a (5-ht2a) signaling in the prefrontal cortex (pfc) neurons of mice. |
2022-08-08 |
2023-08-14 |
mouse |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
we studied changes in the behavior, content of 5-ht and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa), and the expression of genes encoding the key enzymes of 5-ht metabolism, tryptophan hydroxylases tph1a, tph1b, tph2, monoamine oxidase (mao), 5-ht transporter, and 5-ht1a and 5-ht2a receptors in the brain of zebrafish reared for 60 days under short (04:20 h) compared to those reared at normal (12:12 h) photoperiod. |
2022-07-17 |
2023-08-14 |
zebrafish |
| Filipa Viegas, Tiago Ferreira, Cláudia Campo. Using Cariprazine to Ameliorate Negative Symptoms and Metabolic Side Effects of Clozapine and Paliperidone - Clinical Cases. Neuropsychiatric disease and treatment. vol 18. 2022-06-17. PMID:35712695. |
it presents distinct pharmacodynamic properties, such as d3/d2 partial agonism, preferential binding to d3 receptors, antagonism at the serotonin 5-ht2a and 5-ht2b receptors, partial agonism at 5-ht1a receptors, and low affinity to other receptors (including noradrenergic, histaminergic, and cholinergic). |
2022-06-17 |
2023-08-14 |
Not clear |
| Emanuela Dyrmishi, Marco De Pieri, Marco Ferrari, Rafael Traber, Matteo Preve, Luca De Peri, Emilio Boll. Case Report: Long-Acting Oral Cariprazine. Frontiers in psychiatry. vol 13. 2022-05-16. PMID:35573352. |
cariprazine is a partial agonist at dopamine receptors d2 and d3 and serotonin receptor 5ht1a and an antagonist at serotonin receptors 5ht2b and 5ht2a. |
2022-05-16 |
2023-08-13 |
Not clear |
| Błażej D Pędzich, Sarah Rubens, Mehdi Sekssaoui, Anouk Pierre, Andries Van Schuerbeek, Philippe Marin, Joel Bockaert, Emmanuel Valjent, Carine Bécamel, Dimitri De Bunde. Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-04-22. PMID:35449450. |
the serotonin 2a (5-ht2a) receptor is a key target underlying the effects of psychedelics on emotional arousal but its role in fear processing remains controversial. |
2022-04-22 |
2023-08-13 |
mouse |
| Sanne Beerens, Jochen Winterer, David Lukacsovich, Csaba Földy, Christian Wozn. Transcriptomically-guided pharmacological experiments in neocortical and hippocampal NPY-positive GABAergic interneurons. eNeuro. 2022-04-19. PMID:35437266. |
specifically, although the application of 5ht led to a depolarisation of both auditory and ca3 npy-positive neurons, the 5ht2a receptor antagonist ketanserin only reversed membrane potential changes in auditory npy-positive neurons. |
2022-04-19 |
2023-08-13 |
mouse |
| Yasuhiro Kyono, Lori Ellezian, YueYue Hu, Kanella Eliadis, Junlone Moy, Elizabeth B Hirsch, Michael J Federle, Stephanie A Flower. The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli. Journal of bacteriology. 2022-04-13. PMID:35416690. |
while aaps primarily target dopamine (d2) and serotonin (5ht2a and 5ht1a) receptors, they also exhibit intrinsic antimicrobial activity as an off-target effect. |
2022-04-13 |
2023-08-13 |
Not clear |
| Ashish Patel, Arya Patel, Darshini Patel, Krina Patel, Tushar Bambharoliy. Mini Review on Cariprazine: A Promising Antipsychotic Agent. CNS & neurological disorders drug targets. 2022-03-25. PMID:35331126. |
however, due to the partial agonist action on dopamine d2, d3 receptors, and serotonin 5-ht1a receptors as well as antagonist effect on 5-ht2a, 5-ht2b, and h1 receptors, cariprazine differentiate pharmacologically from other apds, both typical and atypical. |
2022-03-25 |
2023-08-13 |
Not clear |
| Xiao Cui Yuan, Yu-Ying Wang, Li-Xia Tian, Xiang-Ji Yan, Yi-Xiao Guo, Yu-Long Zhao, Sani Sa'idu Baba, Hong Jia, Hui-Sheng Wang, Man Li, Fu-Quan Hu. Spinal 5-HT2A Receptor is Involved in Electroacupuncture Inhibition of Chronic Pain. Molecular pain. 2022-03-04. PMID:35240891. |
5-ht2a is a g protein-coupled receptor and it is involved in 5-ht descending pain modulation system. |
2022-03-04 |
2023-08-13 |
mouse |
| Jacqueline Chyr, Haoran Gong, Xiaobo Zho. DOTA: Deep Learning Optimal Transport Approach to Advance Drug Repositioning for Alzheimer's Disease. Biomolecules. vol 12. issue 2. 2022-02-25. PMID:35204697. |
these drugs target important brain receptors involved in memory, learning, and cognition, including serotonin 5-ht2a, dopamine d2, and orexin receptors. |
2022-02-25 |
2023-08-13 |
Not clear |
| Christoph U Correll, Anissa Abi-Dargham, Oliver Howe. Emerging Treatments in Schizophrenia. The Journal of clinical psychiatry. vol 83. issue 1. 2022-02-16. PMID:35172048. |
positive phase 2 trial results indicating efficacy and safety of the taar1 agonist ulotaront (sep-363856) and of the muscarinic m1/m4 agonist karxt (xanomeline plus trospium) for total, positive, and negative symptoms in patients with acute exacerbation of schizophrenia, and of the serotonin 5-ht2a agonist/antagonist pimavanserin in patients with schizophrenia and predominant negative symptoms for negative symptom control are encouraging. |
2022-02-16 |
2023-08-13 |
Not clear |
| Hector Vargas-Perez, Taryn Elizabeth Grieder, Derek van der Koo. Neural Plasticity in the Ventral Tegmental Area, Aversive Motivation during Drug Withdrawal and Hallucinogenic Therapy. Journal of psychoactive drugs. 2022-02-04. PMID:35114904. |
recent studies point out that serotonin (5-hydroxytryptamine, 5-ht) receptors, especially the 2a (5-ht2a) subtype, play an important role in bdnf-related neural plasticity in the vta. |
2022-02-04 |
2023-08-13 |
Not clear |
| Colleen Synan, Carrie Bowen, David J Heal, Christelle Froger-Colléaux, Patrick M Beardsley, Nina Dedic, Seth C Hopkins, Una Campbell, Kenneth S Kobla. Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats. Drug and alcohol dependence. vol 231. 2022-01-16. PMID:35033729. |
unlike available antipsychotics, the efficacy of ulotaront is not mediated by blockade of dopamine d2 or serotonin 5-ht2a receptors. |
2022-01-16 |
2023-08-13 |
rat |
| Lila Wollman, Andrew Hill, Brady Hasse, Christina Young, Giovanni Hernandez-De La Pena, Richard B Levine, Ralph F Fregos. Influence of developmental nicotine exposure on serotonergic control of breathing-related motor output. Developmental neurobiology. 2022-01-11. PMID:35016263. |
we applied 5ht alone, or together with antagonists of 5ht1a, 5ht2a or 5ht7 receptor subtypes. |
2022-01-11 |
2023-08-13 |
rat |
| Manoj K Doss, Maxwell B Madden, Andrew Gaddis, Mary Beth Nebel, Roland R Griffiths, Brian N Mathur, Frederick S Barret. Models of psychedelic drug action: modulation of cortical-subcortical circuits. Brain : a journal of neurology. 2021-12-13. PMID:34897383. |
human and animal studies of psychedelic drug action in the brain have demonstrated the involvement of the serotonin 2a (5-ht2a) receptor and the cerebral cortex in acute psychedelic drug action, but different models have evolved to try to explain the impact of 5-ht2a activation on neural systems. |
2021-12-13 |
2023-08-13 |
human |