| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elias B Nascimento, João Gabriel T Seniuk, Adriana M Godin, Wallace C Ferreira, Marcela B Dutra, Antônio Carlos P Oliveira, Leandro F S Bastos, Bernd L Fiebich, Márcio M Coelh. Peripheral 5-HT1B and 5-HT2A receptors mediate the nociceptive response induced by 5-hydroxytryptamine in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21699915. |
peripheral 5-ht1b and 5-ht2a receptors mediate the nociceptive response induced by 5-hydroxytryptamine in mice. |
2011-12-09 |
2023-08-12 |
mouse |
| Cong Wei, Jian-ke Han, Hong-tao Wang, Zhen-hua Jia, Li-Ping Chang, Yi-ling W. [Effects of fatigue and restraint stress on the expression of carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors in aorta of rats]. Zhonghua yi xue za zhi. vol 91. issue 13. 2011-11-15. PMID:21600121. |
to investigate the effect of fatigue and restraint stress on the expressions of cpt (carnitine palmitoyltransferase)-i, ppar (peroxisome proliferator-activated receptor) δ, 5-ht (hydroxytryptamine) 1d and 5-ht2a receptors in aorta of rats. |
2011-11-15 |
2023-08-12 |
rat |
| María Juliana Orejarena, Laurence Lanfumey, Rafael Maldonado, Patricia Robled. Involvement of 5-HT2A receptors in MDMA reinforcement and cue-induced reinstatement of MDMA-seeking behaviour. The international journal of neuropsychopharmacology. vol 14. issue 7. 2011-11-10. PMID:20942998. |
current evidence indicates that serotonin 5-ht2a receptors (5-ht2ars) modulate mesolimbic dopamine (da) activity and several behavioural responses related to the addictive properties of psychostimulants. |
2011-11-10 |
2023-08-12 |
mouse |
| Jean-Charles Viemari, Alfredo J Garcia, Atsushi Doi, Jan-Marino Ramire. Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro. The European journal of neuroscience. vol 33. issue 12. 2011-10-24. PMID:21615559. |
blockade of fictive gasping by α2-nr antagonists was prevented by activation of 5-hydroxytryptamine type 2a receptors (5-ht2a). |
2011-10-24 |
2023-08-12 |
mouse |
| Brian L Crabtree, John Montgomer. Iloperidone for the management of adults with schizophrenia. Clinical therapeutics. vol 33. issue 3. 2011-09-16. PMID:21600386. |
it is a piperidinyl-benzisoxazole derivative with mixed serotonin (5ht2a) and d2 dopamine antagonist properties. |
2011-09-16 |
2023-08-12 |
Not clear |
| Bun-Hee Lee, Yong-Ku Ki. Potential peripheral biological predictors of suicidal behavior in major depressive disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:20708058. |
decreased serotonin functioning has been measured using cerebral spinal fluid (csf) 5-hiaa, fenfluramine challenge studies, and platelet 5-ht2a receptors. |
2011-09-13 |
2023-08-12 |
Not clear |
| José L Moreno, Terrell Holloway, Laura Albizu, Stuart C Sealfon, Javier González-Maes. Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neuroscience letters. vol 493. issue 3. 2011-09-01. PMID:21276828. |
hallucinogenic drugs, including mescaline, psilocybin and lysergic acid diethylamide (lsd), act at serotonin 5-ht2a receptors (5-ht2ars). |
2011-09-01 |
2023-08-12 |
mouse |
| Alexandra Kekewska, Harald Hübner, Peter Gmeiner, Heinz H Pert. The bulky N6 substituent of cabergoline is responsible for agonism of this drug at 5-hydroxytryptamine 5-HT2A and 5-HT2B receptors and thus is a determinant of valvular heart disease. The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21518772. |
the bulky n6 substituent of cabergoline is responsible for agonism of this drug at 5-hydroxytryptamine 5-ht2a and 5-ht2b receptors and thus is a determinant of valvular heart disease. |
2011-08-30 |
2023-08-12 |
human |
| David F Cummings, Diana C Canseco, Pratikkumar Sheth, James E Johnson, John A Schet. Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorganic & medicinal chemistry. vol 18. issue 13. 2011-07-21. PMID:20570529. |
synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-ht1a, 5-ht2a, 5-ht2c receptor subtypes. |
2011-07-21 |
2023-08-12 |
human |
| David F Cummings, Diana C Canseco, Pratikkumar Sheth, James E Johnson, John A Schet. Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorganic & medicinal chemistry. vol 18. issue 13. 2011-07-21. PMID:20570529. |
twenty aplysinopsin derivatives were synthesized, purified and tested for their affinities for cloned human serotonin 5-ht1a, 5-ht2a, and 5-ht2c receptor subtypes. |
2011-07-21 |
2023-08-12 |
human |
| David F Cummings, Diana C Canseco, Pratikkumar Sheth, James E Johnson, John A Schet. Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorganic & medicinal chemistry. vol 18. issue 13. 2011-07-21. PMID:20570529. |
the compound (e)-5-((5,6-dichloro-1h-indol-3-yl)methylene)-2-imino-1,3-dimethylimidazolidin-4-one (unt-twu-22, 16) had approximately 2100-fold selectivity for the serotonin 5-ht2c receptor subtype: an affinity for 5-ht2c equal to 46 nm and no detectable affinity for the 5-ht1a or 5-ht2a receptor subtypes. |
2011-07-21 |
2023-08-12 |
human |
| Ashish Aggarwal, R C Jiloh. Olanzapine induced tardive dystonia. Indian journal of pharmacology. vol 40. issue 5. 2011-07-14. PMID:20040965. |
compared to typical antipsychotics, it has a greater affinity for serotonin 5-ht2a than dopamine d2 receptors, with preferential action at mesolimbic than nigrostriatal dopaminergic pathways. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ercan Ozdemir, I Bagcivan, S Gursoy, A Altun, N Durmu. Effects of fluoxetine and LY 367265 on tolerance to the analgesic effect of morphine in rats. Acta physiologica Hungarica. vol 98. issue 2. 2011-07-14. PMID:21616779. |
the aim of this study was to investigate effects of fluoxetine, a specific serotonin (5-ht) reuptake inhibitor, and ly 367265, an inhibitor of the 5-ht transporter and 5-ht2a receptor antagonist, on tolerance induced to the analgesic effect of morphine in rats. |
2011-07-14 |
2023-08-12 |
rat |
| Concetta Crisafulli, Chiara Fabbri, Stefano Porcelli, Antonio Drago, Edoardo Spina, Diana De Ronchi, Alessandro Serrett. Pharmacogenetics of antidepressants. Frontiers in pharmacology. vol 2. 2011-07-14. PMID:21687501. |
they include the cytochrome p450 superfamily, the p-glycoprotein (abcb1), the tryptophan hydroxylase, the catechol-o-methyltransferase, the monoamine oxidase a, the serotonin transporter (5-httlpr), the norepinephrine transporter, the dopamine transporter, variants in the 5-hydroxytryptamine receptors (5-ht1a, 5-ht2a, 5-ht3a, 5-ht3b, and 5-ht6), adrenoreceptor beta-1 and alpha-2, the dopamine receptors (d2), the g protein beta 3 subunit, the corticotropin releasing hormone receptors (crhr1 and crhr2), the glucocorticoid receptors, the c-amp response-element binding, and the brain-derived neurotrophic factor. |
2011-07-14 |
2023-08-12 |
human |
| Vignir Isberg, Thomas Balle, Tommy Sander, Flemming Steen Jørgensen, David E Gloria. G protein- and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations. Journal of chemical information and modeling. vol 51. issue 2. 2011-06-02. PMID:21261291. |
g protein- and agonist-bound serotonin 5-ht2a receptor model activated by steered molecular dynamics simulations. |
2011-06-02 |
2023-08-12 |
Not clear |
| Vicky Katsidoni, Kalliopi Apazoglou, George Panagi. Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:20577718. |
role of serotonin 5-ht2a and 5-ht2c receptors on brain stimulation reward and the reward-facilitating effect of cocaine. |
2011-05-24 |
2023-08-12 |
Not clear |
| M J Dowie, M L Howard, L F B Nicholson, R L M Faull, A J Hannan, M Glas. Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice. Neuroscience. vol 170. issue 1. 2011-05-24. PMID:20600638. |
molecular characterisation of brains at the end of the study showed that there were no significant effects of hu210 or thc treatment on the ligand binding of cannabinoid cb1, dopamine d1, d2, serotonin 5ht2a or gaba(a) receptors, nor cb1 or fatty acid amide hydrolase (faah) mrna expression in r6/1 mice. |
2011-05-24 |
2023-08-12 |
mouse |
| Jun-Xu Li, Caroline Crocker, Wouter Koek, Kenner C Rice, Charles P Franc. Effects of serotonin (5-HT)1A and 5-HT2A receptor agonists on schedule-controlled responding in rats: drug combination studies. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:21174080. |
effects of serotonin (5-ht)1a and 5-ht2a receptor agonists on schedule-controlled responding in rats: drug combination studies. |
2011-05-24 |
2023-08-12 |
rat |
| Leslie Citrom. A review of aripiprazole in the treatment of patients with schizophrenia or bipolar I disorder. Neuropsychiatric disease and treatment. vol 2. issue 4. 2011-05-17. PMID:19412492. |
although it is a dopamine partial agonist, it also has substantial binding affinity for the serotonin 5ht2a receptor. |
2011-05-17 |
2023-08-12 |
Not clear |
| Jesus D Mena, Ken Sadeghian, Brian A Bald. Induction of hyperphagia and carbohydrate intake by μ-opioid receptor stimulation in circumscribed regions of frontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 9. 2011-05-13. PMID:21368037. |
muscimol-mediated inactivation of the vmpfc, and intra-vmpfc stimulation of κ-opioid receptors or blockade of 5-ht2a (5-hydroxytryptamine receptor 2a) receptors, suppressed motor activity and increased feeding bout duration-a profile opposite to that seen with damgo. |
2011-05-13 |
2023-08-12 |
rat |