| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah E Racine, Kristen M Culbert, Christine L Larson, Kelly L Klum. The possible influence of impulsivity and dietary restraint on associations between serotonin genes and binge eating. Journal of psychiatric research. vol 43. issue 16. 2010-01-27. PMID:19493540. |
although the t allele of the 5-ht2a receptor gene and the s allele of the 5-htt gene were associated with higher levels of impulsivity, there were no main effects of 5-ht genotypes on any binge eating measure, and interactions between genotypes, impulsivity, and dietary restraint were non-significant. |
2010-01-27 |
2023-08-12 |
Not clear |
| Sofia I I Kring, Thomas Werge, Claus Holst, Søren Toubro, Arne Astrup, Torben Hansen, Oluf Pedersen, Thorkild I A Sørense. Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes. PloS one. vol 4. issue 8. 2010-01-19. PMID:19690620. |
candidate genes of psychological importance include 5ht2a, 5ht2c, and comt, implicated in the serotonin, noradrenaline and dopamine pathways, which also may be involved in regulation of energy balance. |
2010-01-19 |
2023-08-12 |
Not clear |
| b' D Mart\\xc3\\xa1skov\\xc3\\xa1, L Slachtov\\xc3\\xa1, D Kemlink, D Z\\xc3\\xa1hor\\xc3\\xa1kov\\xc3\\xa1, H Papezov\\xc3\\xa. Polymorphisms in serotonin-related genes in anorexia nervosa. The first study in Czech population and metaanalyses with previously performed studies. Folia biologica. vol 55. issue 5. 2010-01-15. PMID:19863848.' |
the frequently studied polymorphisms in the serotonin 5-ht2a receptor gene (-1438a/g) and in serotonin transporter 5-htt gene (lpr, vntr) have led to controversial results in different populations. |
2010-01-15 |
2023-08-12 |
Not clear |
| P E Harrison-Rea. Antimanic potency of typical neuroleptic drugs and affinity for dopamine D2 and serotonin 5-HT2A receptors--a new analysis of data from the archives and implications for improved antimanic treatments. Journal of psychopharmacology (Oxford, England). vol 23. issue 8. 2010-01-12. PMID:18635692. |
antimanic potency of typical neuroleptic drugs and affinity for dopamine d2 and serotonin 5-ht2a receptors--a new analysis of data from the archives and implications for improved antimanic treatments. |
2010-01-12 |
2023-08-12 |
Not clear |
| P E Harrison-Rea. Antimanic potency of typical neuroleptic drugs and affinity for dopamine D2 and serotonin 5-HT2A receptors--a new analysis of data from the archives and implications for improved antimanic treatments. Journal of psychopharmacology (Oxford, England). vol 23. issue 8. 2010-01-12. PMID:18635692. |
datasets of antimanic potency ratings and receptor-binding affinities [inhibition constants (k(i))] at dopamine d2 and serotonin 5-ht2a brain receptors were accessed from published literature for a large series (n = 24) of typical neuroleptic drugs, many of which are now obsolete and unobtainable. |
2010-01-12 |
2023-08-12 |
Not clear |
| P E Harrison-Rea. Antimanic potency of typical neuroleptic drugs and affinity for dopamine D2 and serotonin 5-HT2A receptors--a new analysis of data from the archives and implications for improved antimanic treatments. Journal of psychopharmacology (Oxford, England). vol 23. issue 8. 2010-01-12. PMID:18635692. |
other considerations also suggest that combining drugs to achieve high affinity for and blockade of both dopamine d2 receptors and serotonin 5-ht2a receptors, possibly with additional direct or indirect stimulation of postsynaptic 5-ht1a receptors, might maximize antimanic efficacy. |
2010-01-12 |
2023-08-12 |
Not clear |
| F Hasler, E Studerus, K Lindner, S Ludewig, F X Vollenweide. Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA. Journal of psychopharmacology (Oxford, England). vol 23. issue 8. 2010-01-12. PMID:18635693. |
dopamine release and direct stimulation of dopamine d2 and serotonin 5-ht2a receptors also contributes to the overall action of mdma. |
2010-01-12 |
2023-08-12 |
human |
| Keith J Miller, Ginger Y Wu, Jeffrey G Varnes, Paul Levesque, Julia Li, Danshi Li, Jeffrey A Robl, Karen A Rossi, Dean A Wacke. Position 5.46 of the serotonin 5-HT2A receptor contributes to a species-dependent variation for the 5-HT2C agonist (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: impact on selectivity and toxicological evaluation. Molecular pharmacology. vol 76. issue 6. 2009-12-17. PMID:19767451. |
position 5.46 of the serotonin 5-ht2a receptor contributes to a species-dependent variation for the 5-ht2c agonist (r)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2h)-one: impact on selectivity and toxicological evaluation. |
2009-12-17 |
2023-08-12 |
human |
| F Fiorino, B Severino, F De Angelis, E Perissutti, E Magli, F Frecentese, A Esposito, P Massarelli, C Nencini, B Viti, V Santagada, G Caliend. Synthesis and in vitro pharmacological evaluation of a new series of 5-HT1A 5-HT2A and 5-HT2C receptor ligands containing a norbornene nucleus. Die Pharmazie. vol 64. issue 9. 2009-11-25. PMID:19827295. |
a series of 4-substituted piperazine derivatives bearing a norbornene nucleus have been prepared and their affinity for serotonin 5-ht1a, 5-ht2a and 5-ht2c receptors has been evaluated. |
2009-11-25 |
2023-08-12 |
Not clear |
| Eugene Lin, Po See Chen, Hui Hua Chang, Po-Wu Gean, Hsin Chun Tsai, Yen Kuang Yang, Ru-Band L. Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 7. 2009-11-17. PMID:19560507. |
four serotonin-related genes including guanine nucleotide binding protein beta polypeptide 3 (gnb3), 5-hydroxytryptamine receptor 1a (htr1a; serotonin receptor 1a), 5-hydroxytryptamine receptor 2a (htr2a; serotonin receptor 2a), and solute carrier family 6 member 4 (slc6a4; serotonin neurotransmitter transporter) have been suggested to be candidate genes for influencing antidepressant treatment outcome. |
2009-11-17 |
2023-08-12 |
Not clear |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
both brain-derived neurotrophic factor (bdnf) and the serotonin receptor 2a (5-ht(2a)) have been related to depression pathology. |
2009-11-17 |
2023-08-12 |
mouse |
| Anders Kling, Marit Danell-Boman, Hans Stenlund, Rune Dahlqvis. Association between the use of serotonin receptor 2A-blocking antidepressants and joint disorders. Arthritis and rheumatism. vol 61. issue 10. 2009-11-17. PMID:19790123. |
there are case reports about antidepressants causing arthritis and arthralgia, and the majority of these reports deal with atypical antidepressants, which are serotonin receptor 2a (5-ht(2a))-blocking substances. |
2009-11-17 |
2023-08-12 |
Not clear |
| Raymond G Booth, Lijuan Fang, Yingsu Huang, Andrzej Wilczynski, Sashikala Sivendra. (1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity. European journal of pharmacology. vol 615. issue 1-3. 2009-11-10. PMID:19397907. |
(1r, 3s)-(-)-trans-pat: a novel full-efficacy serotonin 5-ht2c receptor agonist with 5-ht2a and 5-ht2b receptor inverse agonist/antagonist activity. |
2009-11-10 |
2023-08-12 |
mouse |
| Gongliang Zhang, Swapna Krishnamoorthy, Zhiyuan Ma, Nick P Vukovich, Xupei Huang, Rui Ta. Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. European journal of pharmacology. vol 615. issue 1-3. 2009-11-10. PMID:19464285. |
in the last series of experiments, the excessive increases in 5-ht were pharmacologically separated into primary and secondary component effluxes with the 5-ht2a receptor antagonists cyproheptadine and ketanserin and nmda receptor antagonist (+)-mk-801. |
2009-11-10 |
2023-08-12 |
rat |
| Gongliang Zhang, Swapna Krishnamoorthy, Zhiyuan Ma, Nick P Vukovich, Xupei Huang, Rui Ta. Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. European journal of pharmacology. vol 615. issue 1-3. 2009-11-10. PMID:19464285. |
our results suggest that the primary component efflux was caused by direct drug effects on 5-ht biosynthetic and metabolic pathways and secondary efflux ascribed to indirect drug effect on a positive-feedback circuit involving 5-ht2a and nmda receptors. |
2009-11-10 |
2023-08-12 |
rat |
| Saida Abdel Regal Aly, Murad Hossain, Mohiuddin Ahmed Bhuiyan, Takashi Nakamura, Takafumi Nagatom. Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate. Journal of pharmacological sciences. vol 110. issue 4. 2009-10-15. PMID:19672037. |
assessment of binding affinity to 5-hydroxytryptamine 2a (5-ht2a) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate. |
2009-10-15 |
2023-08-12 |
Not clear |
| Elvan Ozal. [The genetics of suicidal behavior]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 20. issue 1. 2009-10-06. PMID:19306130. |
the most important candidate genes include the serotonin transporters (serts), tryptophan hydroxylase (tph), some serotonin receptors (5ht1a, 5ht1b, and 5ht2a), catechol-o-methyltransferase (comt), monoamine oxidase-a (mao-a), and tyrosine hydroxylase (th). |
2009-10-06 |
2023-08-12 |
Not clear |
| Santiago Vilar González, Francesc Montañá Puig, Sebastiá Sabater Martí, Ma Victoria Villas Sánchez, Ma del Mar Sevillano Capellán, Manuel Aguayo Marto. [Trazodone: a new selective approach to the treatment of hot flashes induced by androgen deprivation in prostate carcinoma?]. Actas urologicas espanolas. vol 33. issue 6. 2009-10-02. PMID:19711746. |
this suggests that abrupt sexual hormone deprivation gives rise to a reduction in blood serotonin - with a subsequent increase in its hypothalamic 5-ht2a receptors. |
2009-10-02 |
2023-08-12 |
Not clear |
| Santiago Vilar González, Francesc Montañá Puig, Sebastiá Sabater Martí, Ma Victoria Villas Sánchez, Ma del Mar Sevillano Capellán, Manuel Aguayo Marto. [Trazodone: a new selective approach to the treatment of hot flashes induced by androgen deprivation in prostate carcinoma?]. Actas urologicas espanolas. vol 33. issue 6. 2009-10-02. PMID:19711746. |
the use of trazodone, increasing the serotonin concentrations and blocking the 5-ht2a and 5-ht1a receptors, could be viewed as a novel management approach more in line with the physiopathology of hot flashes. |
2009-10-02 |
2023-08-12 |
Not clear |
| András Sümeg. [Neurobiological and pharmacologic aspects of atypical antipsychotic drugs]. Orvosi hetilap. vol 150. issue 33. 2009-09-18. PMID:19643718. |
the currently approved atypical antipsychotic drugs, which are available, are characterized by relatively weak affinities for d2-type dopamine receptors and relatively high affinities for 5-ht2a serotonin receptors, when compared with typical (conventional) antipsychotic drugs. |
2009-09-18 |
2023-08-12 |
Not clear |