| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J V Wallac. Endogenous hallucinogens as ligands of the trace amine receptors: a possible role in sensory perception. Medical hypotheses. vol 72. issue 1. 2009-02-25. PMID:18805646. |
additionally, while activity at the serotonin 5-ht2a receptor has been proposed as being responsible for the hallucinogenic affects of administered hallucinogens, in their natural setting the 5-ht2a receptor may not interact with the endogenous hallucinogens at all. |
2009-02-25 |
2023-08-12 |
Not clear |
| J V Wallac. Endogenous hallucinogens as ligands of the trace amine receptors: a possible role in sensory perception. Medical hypotheses. vol 72. issue 1. 2009-02-25. PMID:18805646. |
additionally 5-ht2a agonist activity is unable to account for the visual altering effects of many of the administered hallucinogens; these effects may be mediated by one of the endogenous hallucinogen trace amine receptors rather than the serotonin 5-ht2a receptor. |
2009-02-25 |
2023-08-12 |
Not clear |
| Lorenzo Beretta, Marta Cossu, Maurizio Marchini, Francesca Cappiello, Andrea Artoni, Giovanna Motta, Raffaella Scorz. A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation. Arthritis research & therapy. vol 10. issue 5. 2009-02-20. PMID:18761744. |
a polymorphism in the human serotonin 5-ht2a receptor gene may protect against systemic sclerosis by reducing platelet aggregation. |
2009-02-20 |
2023-08-12 |
human |
| Andrew Holme. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18439676. |
serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c, 5-ht3a, 5-ht4, 5-ht5a, 5-ht6, 5-ht7), reuptake (serotonin transporter), and degradation (monoamine oxidase a). |
2009-02-19 |
2023-08-12 |
mouse |
| Stefania Butini, Sandra Gemma, Giuseppe Campiani, Silvia Franceschini, Francesco Trotta, Marianna Borriello, Nicoletta Ceres, Sindu Ros, Salvatore Sanna Coccone, Matteo Bernetti, Meri De Angelis, Margherita Brindisi, Vito Nacci, Isabella Fiorini, Ettore Novellino, Alfredo Cagnotto, Tiziana Mennini, Karin Sandager-Nielsen, Jesper Tobias Andreasen, Jorgen Scheel-Kruger, Jens D Mikkelsen, Caterina Fattoruss. Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior. Journal of medicinal chemistry. vol 52. issue 1. 2009-02-06. PMID:19072656. |
discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-ht1a and 5-ht2a receptors: design, synthesis, and effects on behavior. |
2009-02-06 |
2023-08-12 |
Not clear |
| Cynthia L Bethea, Maria Luisa Centeno, Judy L Camero. Neurobiology of stress-induced reproductive dysfunction in female macaques. Molecular neurobiology. vol 38. issue 3. 2009-02-02. PMID:18931961. |
however, even in the absence of stress, the stress-sensitive animals have lower secretion of the ovarian steroids, estrogen and progesterone, have higher heart rates, have lower serotonin function, have fewer serotonin neurons and lower expression of pivotal serotonin-related genes, have lower expression of 5ht2a and 2c genes in the hypothalamus, have higher gene expression of gad67 and crh in the hypothalamus, and have reduced gonadotropin-releasing hormone transport to the anterior pituitary. |
2009-02-02 |
2023-08-12 |
Not clear |
| Alice Egerton, Rabia Ahmad, Ella Hirani, Paul M Grasb. Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists: [11C]raclopride PET studies in the rat. Psychopharmacology. vol 200. issue 4. 2009-01-29. PMID:18597077. |
antagonism at serotonin 5-ht2a and 5-ht2c receptors modulates cortical and striatal dopamine (da) release and may underlie some aspects of the clinical efficacy of 'atypical' antipsychotic compounds. |
2009-01-29 |
2023-08-12 |
rat |
| Nurper Erberk-Oze. Manic symptoms probably associated with short-term low-dose quetiapine use. Advances in therapy. vol 25. issue 1. 2009-01-22. PMID:18224291. |
several studies have suggested that quetiapine-induced mania/hypomania may be associated with frontal dopamine release via serotonin 5ht2a receptor blockade. |
2009-01-22 |
2023-08-12 |
Not clear |
| Karine Thibault, Juliette Van Steenwinckel, Marie-Jeanne Brisorgueil, Jacqueline Fischer, Michel Hamon, Bernard Calvino, Marie Conrat. Serotonin 5-HT2A receptor involvement and Fos expression at the spinal level in vincristine-induced neuropathy in the rat. Pain. vol 140. issue 2. 2009-01-13. PMID:18930597. |
serotonin 5-ht2a receptor involvement and fos expression at the spinal level in vincristine-induced neuropathy in the rat. |
2009-01-13 |
2023-08-12 |
mouse |
| Matthias F Seidel, Bernd L Fiebich, Gudrun Ulrich-Merzenich, Eduardo Candelario-Jalil, Franz-Walter Koch, Hans Vette. Serotonin mediates PGE2 overexpression through 5-HT2A and 5-HT3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells. Rheumatology international. vol 28. issue 10. 2008-12-19. PMID:18368410. |
serotonin mediates pge2 overexpression through 5-ht2a and 5-ht3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells. |
2008-12-19 |
2023-08-12 |
Not clear |
| Shlomit Flaisher-Grinberg, Oded Klavir, Daphna Joe. The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder. The international journal of neuropsychopharmacology. vol 11. issue 6. 2008-12-18. PMID:18339223. |
serotonin 5-ht2a and 5-ht2c receptors have been implicated in the pathophysiology of obsessive-compulsive disorder (ocd) and in the mechanism mediating the anti-compulsive effects of serotonin reuptake inhibitors. |
2008-12-18 |
2023-08-12 |
rat |
| Juliette Van Steenwinckel, Marie-Jeanne Brisorgueil, Jacqueline Fischer, Daniel Vergé, Jay A Gingrich, Sylvie Bourgoin, Michel Hamon, Rozenn Bernard, Marie Conrat. Role of spinal serotonin 5-HT2A receptor in 2',3'-dideoxycytidine-induced neuropathic pain in the rat and the mouse. Pain. vol 137. issue 1. 2008-12-01. PMID:17888573. |
role of spinal serotonin 5-ht2a receptor in 2',3'-dideoxycytidine-induced neuropathic pain in the rat and the mouse. |
2008-12-01 |
2023-08-12 |
mouse |
| K Wedzony, A Chocyk, M Maćkowia. A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59. issue 2. 2008-11-25. PMID:18622042. |
a search for colocalization of serotonin 5-ht2a and 5-ht1a receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. |
2008-11-25 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, M Maćkowia. A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59. issue 2. 2008-11-25. PMID:18622042. |
recently developed antipsychotic drugs ameliorating the negative symptoms of schizophrenia act not only on dopamine d2 receptors but also on serotonin 2a (5-ht2a) and 1a (5-ht1a) receptors in specific regions of the cerebral cortex. |
2008-11-25 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, M Maćkowia. A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59. issue 2. 2008-11-25. PMID:18622042. |
since it is not yet known whether serotonin 5-ht1a and 5-ht2a receptors coexist in the same population of neurons in the cortex, the present study investigated their colocalization in the rat medial prefrontal (mpc) and entorhinal (ec) cortices. |
2008-11-25 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, M Maćkowia. A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59. issue 2. 2008-11-25. PMID:18622042. |
using antibodies that recognize epitopes specific to the serotonin 5-ht2a or 5-ht1a receptors, studies employing confocal microscopy have shown that in the mpc 5-ht2a receptors are preferentially, if not exclusively, present on the pyramidal neurons and that 5-ht1a-immunopositive material is present in the axonal hillocks and, to lower extend, in cytoplasm of presumably pyramidal cell bodies. |
2008-11-25 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, M Maćkowia. A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59. issue 2. 2008-11-25. PMID:18622042. |
present in shafts and axonal hillocks) we found that about 38% of neurons positive for the presence of serotonin 5-ht2a receptors, are also positive for serotonin 5-ht1a receptors in the mpc. |
2008-11-25 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, M Maćkowia. A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59. issue 2. 2008-11-25. PMID:18622042. |
in the respect of cytoplasmatic serotonin 5-ht1a receptor-immunoreactivity (possibly inactive receptors), 65% and 73% of serotonin 5-ht2a receptor-positive neurons were colocalized with serotonin 5-ht1a receptors in the mpc and ec, respectively. |
2008-11-25 |
2023-08-12 |
rat |
| K Wedzony, A Chocyk, M Maćkowia. A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59. issue 2. 2008-11-25. PMID:18622042. |
data obtained on serotonin 5-ht2a and 5-ht1a receptor localization provide anatomical grounds for at least three distinct populations of pyramidal neurons, one governed only by 5-ht2a, one only by 5-ht1a and one by both types of serotonin receptors. |
2008-11-25 |
2023-08-12 |
rat |
| Didier Cussac, Elisa Boutet-Robinet, Marie-Christine Ailhaud, Adrian Newman-Tancredi, Jean-Claude Martel, Nathalie Danty, Isabelle Rauly-Lestienn. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. European journal of pharmacology. vol 594. issue 1-3. 2008-11-25. PMID:18703043. |
agonist-directed trafficking of signalling at serotonin 5-ht2a, 5-ht2b and 5-ht2c-vsv receptors mediated gq/11 activation and calcium mobilisation in cho cells. |
2008-11-25 |
2023-08-12 |
human |