| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Britt, R R Powell, C McMahan, T F Bruce, S K Ducket. The effect of ergot alkaloid exposure during gestation on the microscopic morphology and vasculature of the ovine placenta. Journal of histotechnology. vol 44. issue 4. 2021-12-04. PMID:33913402. |
ergot alkaloids, a class of mycotoxins associated with ergotism, act as agonists on serotonin (5ht) receptors, specifically 5ht2a, which mediate smooth muscle contraction and vasoconstriction. |
2021-12-04 |
2023-08-13 |
Not clear |
| Guy A Higgins, Edward M Seller. 5-HT Progress in brain research. vol 259. 2021-11-24. PMID:33541678. |
this chapter focusses on approaches targeted to the serotonin (5-ht) system, namely, selective serotonin reuptake inhibitors (ssri's) which served a pioneer role in the investigation of serotoninergic modulators in human smoking cessation trials; and secondly drugs selectively interacting with the 5-ht2a and 5-ht2c receptor systems. |
2021-11-24 |
2023-08-13 |
human |
| Kinsley Tate, Brenna Kirk, Alisia Tseng, Abigail Ulffers, Karen Litw. Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex. International journal of molecular sciences. vol 22. issue 19. 2021-11-08. PMID:34638815. |
cortical spheroids also appropriately express serotonin receptors, such as synaptic 5-ht2a and glial 5-ht5a. |
2021-11-08 |
2023-08-13 |
human |
| Romina Gonzalez-Pons, Kiera McRae, Janice M Thompson, Stephanie W Watt. 5-HT7 Receptor Restrains 5-HT-induced 5-HT2A Mediated Contraction in the Isolated Abdominal Vena Cava. Journal of cardiovascular pharmacology. vol 78. issue 2. 2021-10-29. PMID:34029269. |
the 5-ht2a receptor agonists tcb-2 and nboh were more potent in the aorta compared with 5-ht but less efficacious, serving as partial agonists. |
2021-10-29 |
2023-08-13 |
rat |
| Karimah Best, Dena H Tran, Camille Bulte, Avelino C Verceles, Miriam B Michae. Antipsychotic Medication-Induced Hyperthermia Leading to Cerebrovascular Accident: A Case Report. Cureus. vol 13. issue 10. 2021-10-22. PMID:34659926. |
antipsychotic medications are used in the management of schizophrenia. antipsychotic medications treat both positive and negative symptoms via the dopamine d2 receptor and serotonin 5-ht2a blockade pathway. |
2021-10-22 |
2023-08-13 |
Not clear |
| Marianna Mazza, Giuseppe Marano, Gianandrea Traversi, Gabriele Sani, Luigi Janir. Evidence on the New Drug Lumateperone (ITI-007) for Psychiatric and Neurological Disorders. CNS & neurological disorders drug targets. vol 19. issue 4. 2021-09-06. PMID:32479249. |
lumateperone (iti-007) is a tosylate salt with binding affinities to receptors implicated in the therapeutic actions of antipsychotic medications, including the serotonin 5ht2a receptors, dopamine d2 and d1 receptors and the serotonin transporter. |
2021-09-06 |
2023-08-13 |
Not clear |
| Jan Terock, Antoine Weihs, Alexander Teumer, Johanna Klinger-König, Deborah Janowitz, Hans J Grab. Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples. Psychiatry research. vol 298. 2021-08-19. PMID:33567384. |
specifically, genetic polymorphisms of the serotonin receptors 5-ht1a and 5-ht2a were found to be associated with alexithymia. |
2021-08-19 |
2023-08-13 |
human |
| Yang Lyu, Daniel E L Promislow, Scott D Pletche. Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster. Communications biology. vol 4. issue 1. 2021-08-12. PMID:34131274. |
importantly, these effects are mediated by serotonin signaling, as a mutation in serotonin receptor 2a (5-ht2a) eliminated the effects of nutrient choice. |
2021-08-12 |
2023-08-13 |
drosophila_melanogaster |
| Yang Lyu, Daniel E L Promislow, Scott D Pletche. Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster. Communications biology. vol 4. issue 1. 2021-08-12. PMID:34131274. |
our data suggest that the behavioral or perceptual consequences of exposure to individual macronutrients, involving serotonin signaling through 5-ht2a, qualitatively change the state of metabolic networks throughout the organism from one that is highly connected and robust to one that is fragmented, fragile, and vulnerable to perturbations. |
2021-08-12 |
2023-08-13 |
drosophila_melanogaster |
| Nicholas Keks, Judith Hope, Darren Schwartz, Harold McLennan, David Copolov, Graham Meadow. Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia. CNS drugs. vol 34. issue 5. 2021-08-05. PMID:32246399. |
in contrast to aripiprazole, brexpiprazole has lower intrinsic dopamine d2 activity and higher affinity for the serotonin 5-ht1a and 5-ht2a receptors, while cariprazine has the highest affinity for the dopamine d3 receptor, and the longest half-life. |
2021-08-05 |
2023-08-13 |
Not clear |
| Jeffery L Cummings, D P Devanand, Stephen M Stah. Dementia-related psychosis and the potential role for pimavanserin. CNS spectrums. 2021-07-30. PMID:32811586. |
pimavanserin, an atypical antipsychotic, is a selective serotonin inverse agonist/antagonist at 5-ht2a receptors. |
2021-07-30 |
2023-08-13 |
Not clear |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
similarly, ligands of the serotonin 2a receptor (5-ht2a) were shown to alter anxiety level. |
2021-07-08 |
2023-08-13 |
mouse |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
as an initial step to define the function of 5-ht transmission in the insula, we quantified the proportion of specific neuronal populations of the insula expressing 5-ht1a or 5-ht2a. |
2021-07-08 |
2023-08-13 |
mouse |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
these observations suggest that most glutamatergic neurons can respond to 5-ht through 5-ht1a or 5-ht2a in the insula, and that 5-ht directly affects a limited number of gabaergic neurons. |
2021-07-08 |
2023-08-13 |
mouse |
| Ying Wang, Johnson Joseph, Yinli Gao, Baichun Hu, Xiaohui Geng, Di Wu, Jian Wang, Fengjiao Zhan. Revealing the interaction modes of 5-HT2A receptor antagonists and the Structure-Based virtual screening from FDA and TCMNP database. Journal of biomolecular structure & dynamics. vol 39. issue 10. 2021-07-02. PMID:32406337. |
5-hydroxytryptamine 2a (5-ht2a) receptor is emerging as an important target for numerous psychoactive drugs due to its imperative roles in psychological diseases. |
2021-07-02 |
2023-08-13 |
Not clear |
| Yafei Kang, Wei Zhang, Yahui Lv, Suping Cai, Hanxiao Xu, Jijun Wang, Liyu Huan. Effects of the 5-HT2A and DRD3 genotypes on cortical morphology and functional connectivity density in drug-naïve first episode schizophrenia. Schizophrenia research. vol 216. 2021-06-17. PMID:31813806. |
the 5-hydroxytryptamine 2a receptor (5-ht2a) and dopamine d3 receptor (drd3) have been extensively studied as promising candidate genes for schizophrenia. |
2021-06-17 |
2023-08-13 |
human |
| Ko Eun Shong, Chang-Myung Oh, Jun Namkung, Sangkyu Park, Hail Ki. Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A. Endocrinology and metabolism (Seoul, Korea). vol 35. issue 2. 2021-06-11. PMID:32615731. |
serotonin regulates de novo lipogenesis in adipose tissues through serotonin receptor 2a. |
2021-06-11 |
2023-08-13 |
Not clear |
| Zied Oueghlani, Laurent Juvin, François M Lambert, Laura Cardoit, Gilles Courtand, Frédérique Masmejean, Jean-René Cazalets, Grégory Barrièr. Serotonergic modulation of sacral dorsal root stimulation-induced locomotor output in newborn rat. Neuropharmacology. vol 170. 2021-06-03. PMID:31634501. |
at later stages, serotonin (5-ht) and quipazine (5-ht2a receptor agonist) at concentrations sub-threshold for direct locomotor network activation promoted sacral stimulation-induced fictive locomotion. |
2021-06-03 |
2023-08-13 |
rat |
| Zied Oueghlani, Laurent Juvin, François M Lambert, Laura Cardoit, Gilles Courtand, Frédérique Masmejean, Jean-René Cazalets, Grégory Barrièr. Serotonergic modulation of sacral dorsal root stimulation-induced locomotor output in newborn rat. Neuropharmacology. vol 170. 2021-06-03. PMID:31634501. |
the 5-ht2a receptor antagonist ketanserin could reverse the agonist's action but was ineffective when fictive locomotion was already expressed in the absence of 5-ht (mainly before p2). |
2021-06-03 |
2023-08-13 |
rat |
| Nagara Takao, Toshiya Murai, Hironobu Fujiwar. Treatment-resistant schizophrenia characterised by dopamine supersensitivity psychosis and efficacy of asenapine. BMJ case reports. vol 14. issue 4. 2021-05-14. PMID:33849886. |
previous animal studies have reported that antipsychotics increase serotonin 5-ht2a receptor density in the striatum and that 5-ht2a receptor blockers suppress dopamine-sensitive psychomotor activity, which may be linked to the pathophysiology of dsp. |
2021-05-14 |
2023-08-13 |
Not clear |