All Relations between 5-ht receptor 2a and serotonin

Publication Sentence Publish Date Extraction Date Species
Damiaan Denys, Filip Van Nieuwerburgh, Dieter Deforce, Herman G M Westenber. Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial. The Journal of clinical psychiatry. vol 68. issue 5. 2007-05-21. PMID:17503984. the purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-htt), 5-ht1b, and 5-ht2a receptor genes affect the efficacy of sri treatment in ocd. 2007-05-21 2023-08-12 Not clear
Kazue Hisaoka, Minoru Takebayashi, Mami Tsuchioka, Natsuko Maeda, Yoshihiro Nakata, Shigeto Yamawak. Antidepressants increase glial cell line-derived neurotrophic factor production through monoamine-independent activation of protein tyrosine kinase and extracellular signal-regulated kinase in glial cells. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17210798. although 5-hydroxytryptamine (serotonin) (5-ht), but not noradrenaline or dopamine, increased erk activation and gdnf release via 5-ht2a receptors, ketanserin, a 5-ht2a receptor antagonist, did not have any effect on the amitriptyline-induced erk activation. 2007-05-14 2023-08-12 human
In Hee Cho, Hee Jeong Yoo, Mira Park, Young Sik Lee, Soon Ae Ki. Family-based association study of 5-HTTLPR and the 5-HT2A receptor gene polymorphisms with autism spectrum disorder in Korean trios. Brain research. vol 1139. 2007-05-08. PMID:17280648. promoter region polymorphisms (5-httlpr) of the serotonin transporter gene (slc6a4) and the 5-ht2a receptor gene (htr2a) have been studied as potential candidate genes in autism spectrum disorder (asd). 2007-05-08 2023-08-12 human
Jie Li, Yong-Xiao Cao, Hao Liu, Cang-Bao X. Enhanced G-protein coupled receptors-mediated contraction and reduced endothelium-dependent relaxation in hypertension. European journal of pharmacology. vol 557. issue 2-3. 2007-05-04. PMID:17204265. an in vitro myograph system was used to obtain concentration-contraction curves mediated by endothelin et(a), endothelin et(b), 5-hydroxytryptamine 2a (5-ht2a)-receptors and alpha1-adrenoceptors in the arterial segments. 2007-05-04 2023-08-12 rat
Jie Li, Yong-Xiao Cao, Hao Liu, Cang-Bao X. Enhanced G-protein coupled receptors-mediated contraction and reduced endothelium-dependent relaxation in hypertension. European journal of pharmacology. vol 557. issue 2-3. 2007-05-04. PMID:17204265. specific antagonists for 5-ht2a receptors or alpha1-adrenoceptors rightward shifted the concentration-contractile curves induced by 5-ht or noradrenaline, while the emax were not significantly altered, suggesting that the contractions were mediated by 5-ht2a receptors and alpha1-adrenoceptors, respectively. 2007-05-04 2023-08-12 rat
Orazio Prezzavento, Agata Campisi, Simone Ronsisvalle, Giovanni Li Volti, Agostino Marrazzo, Vincenzo Bramanti, Giuseppe Cannavò, Luca Vanella, Alfredo Cagnotto, Tiziana Mennini, Riccardo Ientile, Giuseppe Ronsisvall. Novel sigma receptor ligands: synthesis and biological profile. Journal of medicinal chemistry. vol 50. issue 5. 2007-04-23. PMID:17328523. binding affinity studies showed that 4b binding on n-methyl-d-aspartate (nmda), dopaminergic (d1, d2, d3), muscarinic, histaminergic h1, adrenergic (alpha1, alpha2), serotoninergic (5-ht2a, 5-ht2c, 5-ht3, 5-ht4, 5-ht6), da (dat), and 5-ht (sert) transporters was not significant. 2007-04-23 2023-08-12 Not clear
Eva Lindström, Sten Levande. Sertindole: efficacy and safety in schizophrenia. Expert opinion on pharmacotherapy. vol 7. issue 13. 2007-04-19. PMID:16925508. sertindole is an antipsychotic drug with affinity for dopamine d2, serotonin 5-ht2a and 5-ht2c, and alpha1-adrenoreceptors. 2007-04-19 2023-08-12 Not clear
K D Alex, E A Pehe. Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacology & therapeutics. vol 113. issue 2. 2007-04-19. PMID:17049611. several subtypes, including the 5-ht1a, 5-ht1b, 5-ht2a, 5-ht3 and 5-ht4 receptors, act to facilitate da release, while the 5-ht2c receptor mediates an inhibitory effect of 5-ht on da release. 2007-04-19 2023-08-12 Not clear
Vincenzo Garzya, Ian T Forbes, Andrew D Gribble, Mike S Hadley, Andrew P Lightfoot, Andrew H Payne, Alexander B Smith, Sara E Douglas, David G Cooper, Ian G Stansfield, Malcom Meeson, Emma E Dodds, Declan N C Jones, Martyn Wood, Charlie Reavill, Carol A Scorer, Angela Worby, Graham Riley, Peter Eddershaw, Chris Ioannou, Daniele Donati, Jim J Hagan, Emiliangelo A Ratt. Studies towards the identification of a new generation of atypical antipsychotic agents. Bioorganic & medicinal chemistry letters. vol 17. issue 2. 2007-04-09. PMID:17084080. the lead optimisation programme led to the identification of sulfonamide (25), a molecule combining dopamine d2/d3 receptor antagonism with serotonin 5-ht2a, 5-ht2c, 5-ht6 receptor antagonism for an effective treatment of schizophrenia. 2007-04-09 2023-08-12 Not clear
b' Fa\\xc3\\xafza Benaliouad, Shitij Kapur, Pierre-Paul Rompr\\xc3\\xa. Blockade of 5-HT2a receptors reduces haloperidol-induced attenuation of reward. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 3. 2007-04-05. PMID:16794561.' as blockade of the serotonin type 2a (5-ht2a) receptors is a common property of the newer antipsychotics, the present study compared the effect of haloperidol, clozapine, and m100907 (a selective 5-ht2a antagonist) and the combined effect of haloperidol and m100907 treatment on brain stimulation reward (bsr). 2007-04-05 2023-08-12 rat
D Micheli, C Bonvicini, A Rocchi, R Ceravolo, M Mancuso, G Tognoni, M Gennarelli, G Siciliano, L Murr. No evidence for allelic association of serotonin 2A receptor and transporter gene polymorphisms with depression in Alzheimer disease. Journal of Alzheimer's disease : JAD. vol 10. issue 4. 2007-04-03. PMID:17183148. the aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (t102c of serotonin receptor 5-ht2a and serotonin transporter linked polymorphic region -5-httlpr- of slc6a4 gene) with depressive symptoms and considering their possible interactions with apolipoprotein e (apoe) and between themselves, in a sample of 208 sporadic ad patients and 116 normal controls from italy. 2007-04-03 2023-08-12 human
M Olga Rojas-Corrales, Juan Gibert-Rahola, Juan A Mic. Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior. Psychopharmacology. vol 190. issue 2. 2007-03-30. PMID:17102981. the selective serotonin (5-ht) reuptake inhibitors (ssris) represent the first-line pharmacotherapy for obsessive-compulsive disorder (ocd), and atypical antipsychotic drugs, which block 5-ht2a receptors, are used in augmentation strategies. 2007-03-30 2023-08-12 Not clear
Mario Alvarado, María Barceló, Laura Carro, Christian F Masaguer, Enrique Raviñ. Synthesis and biological evaluation of new quinazoline and cinnoline derivatives as potential atypical antipsychotics. Chemistry & biodiversity. vol 3. issue 1. 2007-03-23. PMID:17193223. four new diaza analogues (14, 15, 23, and 24) of the conformationally constrained aminobutyrophenone derivatives qf0104b (5) and qf0108b (6) were synthesized (schemes 2 and 3), and evaluated for their binding affinities (table) towards the serotonin 5-ht2a and 5-ht2c, and the dopamine d2 receptors. 2007-03-23 2023-08-12 Not clear
Mario Alvarado, María Barceló, Laura Carro, Christian F Masaguer, Enrique Raviñ. Synthesis and biological evaluation of new quinazoline and cinnoline derivatives as potential atypical antipsychotics. Chemistry & biodiversity. vol 3. issue 1. 2007-03-23. PMID:17193223. among the new compounds, the quinazoline derivative 15 (= 7-{[4-(4-fluorobenzoyl)piperidin-1-yl]methyl}-5,6,7,8-tetrahydroquinazolin-5-one) exhibited the highest affinities towards the serotonin 5-ht2a and dopamine d2 receptors, and it is in the borderline of potential atypical antipsychotics. 2007-03-23 2023-08-12 Not clear
Agnieszka Słopién, Monika Dmitrzak-Weglarz, Filip Rybakowski, Andrzej Rajewski, Joanna Hause. [Genetic background of ADHD: population studies, genes of the catecholamine system]. Psychiatria polska. vol 40. issue 1. 2007-03-20. PMID:16756025. in other articles authors describe abnormalities of the serotonergic system, such as the polymorphism of the serotonin transporter gene (5htt/sert), serotonin receptors genes 5ht2a and 5ht1b in the development ofadhd. 2007-03-20 2023-08-12 Not clear
Regina L Myers, David C Airey, D Hal Manier, Richard C Shelton, Elaine Sanders-Bus. Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression. Biological psychiatry. vol 61. issue 2. 2007-03-15. PMID:16697352. polymorphisms in the regulatory region of the human serotonin 5-ht2a receptor gene (htr2a) influence gene expression. 2007-03-15 2023-08-12 human
Regina L Myers, David C Airey, D Hal Manier, Richard C Shelton, Elaine Sanders-Bus. Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression. Biological psychiatry. vol 61. issue 2. 2007-03-15. PMID:16697352. genomic variation in the regulatory region of the serotonin (5-ht) 2a receptor gene (htr2a) may contribute to altered levels of 5-ht2a receptor and to psychiatric disease. 2007-03-15 2023-08-12 human
Yoshihisa Kitamura, Kouhei Kitagawa, Yoshika Fujitani, Kazuhiko Shibata, Hiroaki Araki, Toshiaki Sendou, Yutaka Gomit. The 5-HT1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT2A receptor hyperfunction in rats: involvement of 5-HT1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats. Biological & pharmaceutical bulletin. vol 30. issue 1. 2007-03-13. PMID:17202670. we examined the influence of 8-hydroxy-2-di-n-propylamino tetralin (8-oh-dpat), a serotonin 1a (5-ht1a) receptor full agonist, on the wet-dog shake response induced by the (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi), a 5-ht2a receptor agonist, in adrenocorticotropic hormone (acth)-treated rats. 2007-03-13 2023-08-12 rat
M Bliziotes, A Eshleman, B Burt-Pichat, X-W Zhang, J Hashimoto, K Wiren, C Chen. Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells. Bone. vol 39. issue 6. 2007-02-20. PMID:16884969. the clonal murine osteocytic cell line, mlo-y4, demonstrates expression of the serotonin transporter (5-htt), and the 5-ht1a, and 5-ht2a receptors by real-time rt-pcr and immunoblot analysis. 2007-02-20 2023-08-12 human
Wiesław Jerzy Cubała, Jerzy Landowsk. [Serotoninergic system and limbic-hypothalamic-pituitary-adrenal axis (LHPA axis) in depression]. Psychiatria polska. vol 40. issue 3. 2007-02-08. PMID:17037809. in depression, the 5-ht system exhibits impaired presynaptic activity of 5-ht neurones, an increased activity of central postsynaptic 5-ht2a receptors, decreased activity of postsynaptic 5-ht1a receptors and altered synaptic 5-ht uptake. 2007-02-08 2023-08-12 Not clear