| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcy J Bubar, Kathryn A Cunningha. Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence. Current topics in medicinal chemistry. vol 6. issue 18. 2006-11-30. PMID:17017968. |
two key modulators of da output are the serotonin (5-ht)2a receptor (5-ht2a r) and the 5-ht2c r. these receptors are known to control the neurochemical and behavioral effects of psychostimulants, and in particular, the in vivo effects of cocaine. |
2006-11-30 |
2023-08-12 |
human |
| Samarjit Bhattacharyya, Ishier Raote, Aditi Bhattacharya, Ricardo Miledi, Mitradas M Panicke. Activation, internalization, and recycling of the serotonin 2A receptor by dopamine. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 41. 2006-11-28. PMID:17005723. |
here, we use recombinant serotonin (5-ht) 2a (5-ht2a) receptors to further investigate direct interactions between dopamine and 5-ht receptors. |
2006-11-28 |
2023-08-12 |
xenopus_laevis |
| Jolanta Obniska, Ewa Tatarczyńska, Agnieszka Nikiforuk, Sijka Charakchieva-Minol, Beata Duszyńsk. Synthesis and 5-HT1A/5-HT2A receptor activity of N-(4-arylpiperazin-1-yl)alkyl derivatives of 2-azaspiro([4.4]nonane and [4.5]decane-1,3-dione. Pharmacological reports : PR. vol 58. issue 1. 2006-11-09. PMID:16531637. |
two series of n-[(4-arylpiperazin-1-yl)-alkyl]-2-azaspiro[4.4]nonane (5-10) and [4.5]decane-1,3-dione (11-16) derivatives were synthesized and their serotonin 5-ht1a and 5-ht2a receptor affinities were determined. |
2006-11-09 |
2023-08-12 |
Not clear |
| Ola M Ghoneim, Jacqueline A Legere, Alexander Golbraikh, Alexander Tropsha, Raymond G Boot. Novel ligands for the human histamine H1 receptor: synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes. Bioorganic & medicinal chemistry. vol 14. issue 19. 2006-11-06. PMID:16782354. |
the apts also were examined for activity at human serotonin 5-ht2a and 5-ht2c receptors, which are phylogenetically closely related to the h1 receptor. |
2006-11-06 |
2023-08-12 |
human |
| Anna M S Kindlundh-Högberg, Per Svenningsson, Helgi B Schiöt. Quantitative mapping shows that serotonin rather than dopamine receptor mRNA expressions are affected after repeated intermittent administration of MDMA in rat brain. Neuropharmacology. vol 51. issue 4. 2006-11-06. PMID:16820177. |
we used real-time rt-pcr to determine the gene expression of serotonin 5ht1a, 5ht1b, 5ht2a, 5ht2c, 5ht3, 5ht6 receptors and dopamine d1, d2, d3 receptors in seven brain nuclei. |
2006-11-06 |
2023-08-12 |
rat |
| Motoko Honda, Kunitoshi Uchida, Mitsuo Tanabe, Hideki On. Fluvoxamine, a selective serotonin reuptake inhibitor, exerts its antiallodynic effects on neuropathic pain in mice via 5-HT2A/2C receptors. Neuropharmacology. vol 51. issue 4. 2006-11-06. PMID:16846619. |
these results indicate that fluvoxamine exerts its antiallodynic effects on neuropathic pain via descending 5-ht fibers and spinal 5-ht2a or 5-ht2c receptors, and the antinociception on acute mechanical pain via 5-ht3 receptors. |
2006-11-06 |
2023-08-12 |
mouse |
| Timo Heinrich, Henning Böttcher, Helmut Prücher, Rudolf Gottschlich, Karl-August Ackermann, Christoph van Amsterda. 1-(1-phenethylpiperidin-4-yl)-1-phenylethanols as potent and highly selective 5-HT2A antagonists. ChemMedChem. vol 1. issue 2. 2006-11-02. PMID:16892357. |
selectivity for the serotonin 5-ht2a receptor was optimized, decreasing the affinity of these antagonists toward the adrenergic alpha1 and dopaminergic d2 receptors, and especially to the 5-ht2c receptor. |
2006-11-02 |
2023-08-12 |
Not clear |
| Toshiaki Suguro, Takuya Watanabe, Tomoko Kanome, Syuusuke Kodate, Tsutomu Hirano, Akira Miyazaki, Mitsuru Adach. Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. Atherosclerosis. vol 186. issue 2. 2006-11-01. PMID:16157345. |
immunoblotting analysis showed that 5-ht at 10 microm increased acat-1 protein expression level by two-fold, and this effect was abolished completely by a 5-ht2a receptor antagonist (sarpogrelate), its major metabolite (m-1), a g protein inactivator (gdp-beta-s), a protein kinase c (pkc) inhibitor (rottlerin), a src family inhibitor (pp2), or a mitogen-activated protein kinase (mapk) kinase inhibitor (pd98059). |
2006-11-01 |
2023-08-12 |
human |
| Toshiaki Suguro, Takuya Watanabe, Tomoko Kanome, Syuusuke Kodate, Tsutomu Hirano, Akira Miyazaki, Mitsuru Adach. Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. Atherosclerosis. vol 186. issue 2. 2006-11-01. PMID:16157345. |
the results of the present study suggested that 5-ht may play a crucial role in macrophage-derived foam cell formation by up-regulating acat-1 expression via the 5-ht2a receptor/g protein/c-src/pkc/mapk pathway, contributing to the progression of atherosclerotic plaque. |
2006-11-01 |
2023-08-12 |
human |
| Jeffrey R Bishop, Jessica Moline, Vicki L Ellingrod, Susan K Schultz, Anita H Clayto. Serotonin 2A -1438 G/A and G-protein Beta3 subunit C825T polymorphisms in patients with depression and SSRI-associated sexual side-effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16710319. |
the occurrence of sexual side-effects from antidepressants is thought to be mediated through serotonin 2a (5ht2a) receptors. |
2006-11-01 |
2023-08-12 |
Not clear |
| Jeffrey R Bishop, Jessica Moline, Vicki L Ellingrod, Susan K Schultz, Anita H Clayto. Serotonin 2A -1438 G/A and G-protein Beta3 subunit C825T polymorphisms in patients with depression and SSRI-associated sexual side-effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16710319. |
it is currently unknown if functional polymorphisms in the 5ht2a receptor or its g-protein second messenger complex are related to sexual dysfunction in patients taking an selective serotonin reuptake inhibitor (ssri) for depression. |
2006-11-01 |
2023-08-12 |
Not clear |
| L van den Berg, L Kwant, M S Hestand, B A van Oost, P A J Leegwate. Structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4). The Journal of heredity. vol 96. issue 7. 2006-10-31. PMID:16251523. |
structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1a gene (htr1a), serotonin receptor 2a gene (htr2a), and serotonin transporter gene (slc6a4). |
2006-10-31 |
2023-08-12 |
dog |
| V I Kulinskiĭ, S S Gavrilo. [Neuroprotective effect of antipsychotic drugs (neuroleptics) in global brain ischemia]. Eksperimental'naia i klinicheskaia farmakologiia. vol 69. issue 4. 2006-10-24. PMID:16995432. |
the neuroprotective effect is also not correlated with their affinity to serotonin 5-ht2a and dopamine d2 receptors, but is closely related to the development of deep hypothermia. |
2006-10-24 |
2023-08-12 |
Not clear |
| Damiaan Denys, Filip Van Nieuwerburgh, Dieter Deforce, Herman G M Westenber. Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder. Journal of affective disorders. vol 91. issue 1. 2006-10-04. PMID:16443280. |
the purpose of the present study was to investigate the role of the serotonin transporter (5-htt) and serotonin 5-ht1b and 5-ht2a receptor genes in ocd. |
2006-10-04 |
2023-08-12 |
Not clear |
| Xuejiao Chen, Feihong Bing, Peifang Dai, Yanguo Hon. Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat. Pharmacology, biochemistry, and behavior. vol 84. issue 1. 2006-10-02. PMID:16730785. |
subcutaneous injection of 5-ht (50 microg) and alpha-methylserotonin (alpha-m-5-ht, 5-ht2a receptor agonist, 50 microg) into the unilateral hindpaw evoked significant decreases in paw withdrawal latency (pwl). |
2006-10-02 |
2023-08-12 |
rat |
| Xuejiao Chen, Feihong Bing, Peifang Dai, Yanguo Hon. Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat. Pharmacology, biochemistry, and behavior. vol 84. issue 1. 2006-10-02. PMID:16730785. |
these results demonstrate that pkc activation was involved in the development of nociceptive responses elicited by 5-ht and activation of peripheral 5-ht2a, but not 5-ht1a, receptors. |
2006-10-02 |
2023-08-12 |
rat |
| Hsien-Yuan Lane, Cheng-Chun Lee, Yi-Ching Liu, Wen-Ho Chan. Pharmacogenetic studies of response to risperidone and other newer atypical antipsychotics. Pharmacogenomics. vol 6. issue 2. 2006-09-28. PMID:15882132. |
recent studies suggest that the 5-hydroxytryptamine receptor 2a (5-ht2a) gene (htr2a) t102c and g-1438a polymorphisms may influence treatment response of risperidone or olanzapine for schizophrenia's negative symptoms (e.g., blunted affect and social withdrawal). |
2006-09-28 |
2023-08-12 |
Not clear |
| Takashi Yamamoto, Seiji Niwa, Satoshi Iwayama, Hajime Koganei, Shin-ichi Fujita, Tomoko Takeda, Morikazu Kito, Yukitsugu Ono, Yuki Saitou, Akira Takahara, Seinosuke Iwata, Hiroshi Yamamoto, Masataka Shoj. Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity. Bioorganic & medicinal chemistry. vol 14. issue 15. 2006-09-22. PMID:16616501. |
as a consequence of the optimization, we found 13 with potent n-type calcium channel inhibitory activity which had lower inhibitory activities against l-type calcium channel, histamine (h1), and serotonin (5-ht2a) receptors than those of cyp. |
2006-09-22 |
2023-08-12 |
rat |
| Sophia Stamouli, Lefteris Lykoura. Quetiapine-induced obsessive-compulsive symptoms: a series of five cases. Journal of clinical psychopharmacology. vol 26. issue 4. 2006-09-18. PMID:16855458. |
quetiapine is a novel and atypical antipsychotic agent with serotonin 5-ht2a antagonism higher than d2 blockade. |
2006-09-18 |
2023-08-12 |
Not clear |
| Jolanta Obniska, Marcin Kołaczkowski, Sijka Charakchieva-Minol, Krystyna Nedza, Małgorzata Dybała, Andrzej J Bojarsk. Synthesis, anticonvulsant properties and 5-HT1A/5-HT2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-propyl]-2-aza-spiro[4.4]nonane and [4.5]decane-1,3-dione derivatives. Pharmacological reports : PR. vol 57. issue 3. 2006-09-07. PMID:15985716. |
in addition, since the investigated compounds belong to a class of long-chain arylpiperazines, their serotonin 5-ht1a and 5-ht2a receptor affinity was determined. |
2006-09-07 |
2023-08-12 |
Not clear |