| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Nielsen, Huiqiong Deng, Michelle A Patriquin, Mark J Harding, John Oldham, Ramiro Salas, J Christopher Fowler, B Christopher Frue. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. European archives of psychiatry and clinical neuroscience. vol 270. issue 5. 2021-04-05. PMID:30923939. |
variants in three genes coding for components of the serotonergic system, the tryptophan hydroxylase 1 (tph1) rs1799913, serotonin transporter (slc6a4) 5-httlpr, and serotonin receptor 2a (htr2a) rs6311, were evaluated for association with suicidal ideation (si) and with recovery from si in a psychiatric inpatient population. |
2021-04-05 |
2023-08-13 |
Not clear |
| Silvia Vicenzi, Lisa Foa, Robert J Gasperin. Serotonin functions as a bidirectional guidance molecule regulating growth cone motility. Cellular and molecular life sciences : CMLS. vol 78. issue 5. 2021-03-29. PMID:32939562. |
extracellular gradients of 50 µm serotonin elicited attraction, mediated by the serotonin 5-ht2a receptor while 100 µm serotonin elicited repulsion mediated by the 5-ht1b receptor. |
2021-03-29 |
2023-08-13 |
Not clear |
| Xiaohan Li, Linlin He, Jinting Liu, Wenxuan Guo, Quanhe Wang, Pengpeng Fang, Xing Yang, Mengfei Zhang, Chunlan Wang, Pingyuan Gon. The rs6311 of serotonin receptor 2A (5-HT2A) gene is associated with alexithymia and mental health. Journal of affective disorders. vol 272. 2021-02-15. PMID:32553368. |
inspired by the links between serotonin functions and affective disorders, this study investigated associations of the serotonin receptor 2a (5-ht2a) gene with alexithymia and mental health. |
2021-02-15 |
2023-08-13 |
Not clear |
| Katarzyna Kamińska, Paweł Świt, Kamilla Male. 2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOME): A Harmful Hallucinogen Review. Journal of analytical toxicology. vol 44. issue 9. 2021-02-04. PMID:32128596. |
these substances are a new class of potent serotonin 5-ht2a receptor agonist hallucinogens with potential harmful effects. |
2021-02-04 |
2023-08-13 |
Not clear |
| Matheus Libarino-Santos, Ana Catherine Gomes de Santana Santos, Elisangela G Cata-Preta, Thaísa Barros-Santos, Nina Rosa Nunes Brandão, Aurea Lorena Nunes Borges, Renan Santos-Baldaia, André W Hollais, Marilia A Baldaia, Laís F Berro, Eduardo A V Marinho, Roberto Frussa-Filho, Alexandre J Oliveira-Lim. Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice. Drug and alcohol dependence. vol 208. 2021-01-18. PMID:31954952. |
evidence suggests that aripiprazole, a partial dopamine d2 and serotonin 5-ht1a receptor agonist and 5-ht2a receptor antagonist, show significant efficacy in reducing alcohol use. |
2021-01-18 |
2023-08-13 |
mouse |
| P Campos-Bedolla, R De-La-Cruz-Negrete, M H Vargas, E Torrejón-González, D Mejía-Mendoza, A Islas-Hernández, P Segura-Medina, G Córdoba-Rodríguez, S Orozco-Suárez, J L Arreola-Ramíre. Allergic sensitization increases contractile responses to 5-HT in guinea pig aorta. Physiological research. vol 69. issue 1. 2020-11-04. PMID:31852196. |
we concluded that in this guinea pig model of asthma, allergic sensitization is not confined to airways, but also affects arterial contractile responses to 5-ht; changes in the expression of the 5-ht2a receptor appear not to be involved in this phenomenon. |
2020-11-04 |
2023-08-13 |
Not clear |
| David Nutt, David Erritzoe, Robin Carhart-Harri. Psychedelic Psychiatry's Brave New World. Cell. vol 181. issue 1. 2020-10-16. PMID:32243793. |
outcomes of neuroscience and clinical research into 5-hydroxytryptamine 2a (5-ht2a) receptor agonists, such as psilocybin, show promise for addressing a range of serious disorders, including depression and addiction. |
2020-10-16 |
2023-08-13 |
Not clear |
| Ko Eun Shong, Chang-Myung Oh, Jun Namkung, Sangkyu Park, Hail Ki. Erratum: Correction of Figure. Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A. Endocrinology and metabolism (Seoul, Korea). vol 35. issue 3. 2020-10-06. PMID:32759630. |
serotonin regulates de novo lipogenesis in adipose tissues through serotonin receptor 2a. |
2020-10-06 |
2023-08-13 |
Not clear |
| Michael A Ruderman, Susan B Powell, Mark A Geye. A Kappa Opioid Model of Atypical Altered Consciousness and Psychosis: U50488, DOI, AC90179 Effects on Prepulse Inhibition and Locomotion in Mice. Journal of young investigators. vol 19. issue 13. 2020-10-01. PMID:25346645. |
significant interaction and reversal effects between ka and the serotonin/2a (5-ht2a) system - the serotonin sub-type associated with classical psychedelics - were observed in three bpm measures. |
2020-10-01 |
2023-08-13 |
mouse |
| Ayça Kiliç, Evrim Erten, Armağan Özdemi. Tardive Blepharospasm and Meige Syndrome during Treatment with Quetiapine and Olanzapine. Noro psikiyatri arsivi. vol 52. issue 2. 2020-10-01. PMID:28360708. |
atypical antipsychotics have less extrapyramidal side effects because of a weak dopamine d2 receptor binding affinity or a strong antagonistic effect to serotonin 5-ht2a receptor and have been known to cause less tardive dyskinesia than typical antipsychotics. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Xiang Li, Alexander O Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fux. Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. ACS omega. vol 2. issue 8. 2020-10-01. PMID:28920103. |
there are many 5-ht subtypes involved; some need to be blocked (e.g., 5-ht2a, 5-ht3, and 5-ht7), whereas others need to be activated (e.g., postjunctional 5-ht1a and 5-ht4). |
2020-10-01 |
2023-08-13 |
Not clear |
| Raquel Romay-Tallon, Erin Kulhawy, Kyle J Brymer, Josh Allen, Tania Rivera-Baltanas, Jose M Olivares, Lisa E Kalynchuk, Hector J Carunch. Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30374301. |
naïve depression patients show alterations in serotonin transporter (sert) and serotonin 2a (5ht2a) receptor clustering in peripheral lymphocytes, and these alterations have been proposed as a biomarker of therapeutic efficacy in major depression. |
2020-10-01 |
2023-08-13 |
human |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Xiaoxue Du, Benson Oa Botchway, Marong Fan. Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105836. |
5-hydroxytryptamine receptors 2a and 1a (5-ht2a and 5-ht1a receptors) are most closely related to anxiety-like behavior in post-traumatic stress disorder. |
2020-10-01 |
2023-08-13 |
mouse |
| Zhiying Hu, Yang Yang, Keqiang Gao, John A Rudd, Marong Fan. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Experimental and therapeutic medicine. vol 11. issue 1. 2020-09-30. PMID:26889223. |
in addition, treatment with e2 and p4 was associated with increased expression levels of choline acetyltransferase and 5-hydroxytryptamine receptor 2a (5-ht2a), and decreased expression levels of the glial fibrillary acidic protein in the hippocampus of the rats. |
2020-09-30 |
2023-08-13 |
rat |
| Taichi Ochi, Natalya M Vyalova, Innokentiy S Losenkov, Diana Z Paderina, Ivan V Pozhidaev, Anton J M Loonen, German G Simutkin, Nikolay A Bokhan, Svetlana A Ivanova, Bob Wilffer. Limited Associations Between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients With Depression. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31956308. |
serotonin regulation of amygdala activity is attained through activation of three 5-ht2 family receptor subtypes, 5-ht2a, 5-ht2b, and 5-ht2c. |
2020-09-30 |
2023-08-13 |
Not clear |
| Pooja Mitra, Aishwarya Rastogi, Mayank Rajpoot, Ajay Kumar, Vivek Srivastav. A QSAR model of Olanzapine derivatives as potential inhibitors for 5-HT2A Receptor. Bioinformation. vol 13. issue 10. 2020-09-29. PMID:29162966. |
recently, a numbers of marketed drugs for schizophrenia are available against dopamine d2 and serotonin 5-ht2a receptors. |
2020-09-29 |
2023-08-13 |
Not clear |
| Lakshmi N Yatham, Eduard Vieta, Roger S McIntyre, Rakesh Jain, Mehul Patel, Willie Earle. Broad Efficacy of Cariprazine on Depressive Symptoms in Bipolar Disorder and the Clinical Implications. The primary care companion for CNS disorders. vol 22. issue 5. 2020-09-29. PMID:32942346. |
cariprazine, a dopamine d₃-preferring d₃/d₂ receptor partial agonist with serotonin 5-ht1a receptor partial agonist and serotonin 5-ht2a antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jaime Lee, Shane Thwaites, Andrea Gogos, Maarten van den Buus. Pharmacological Mechanisms Involved in Sensory Gating Disruption Induced by (±)-3,4-Methylene- Dioxymethamphetamine (MDMA): Relevance to Schizophrenia. Brain sciences. vol 10. issue 1. 2020-09-28. PMID:31941052. |
pretreatment of the animals with the dopamine d1 receptor antagonist, sch23390, the dopamine d2 receptor antagonist, haloperidol, the serotonin (5-ht)1a receptor antagonist, way100635, or the 5-ht2a receptor antagonist, ketanserin, all blocked the effect of mdma, although the drugs differentially affected the individual s1 and s2 amplitudes. |
2020-09-28 |
2023-08-13 |
rat |
| Lulu Wang, Xiangcheng Fan, Jichun Han, Minxuan Cai, Xiaozhong Wang, Yan Wang, Jing Shan. Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32477107. |
brl-3a cells were treated with 1 mm free fatty acids (ffas) and/or 50 μm 5-ht, and then small interfering rna (sirna) targeting the 5-ht2a receptor (htr2a) and the pparγ pharmaceutical agonist, pioglitazone, were applied. |
2020-09-28 |
2023-08-13 |
rat |
| Jate Bernard, Abigail Greenhalgh, Oscar Istas, Nicole T Marguerite, Robin L Coope. The Effect of Bacterial Endotoxin LPS on Serotonergic Modulation of Glutamatergic Synaptic Transmission. Biology. vol 9. issue 8. 2020-09-28. PMID:32781679. |
at the model glutamatergic synapse of the crayfish neuromuscular junction (nmj), 5-ht primarily acts through a 5-ht2a receptor subtype to enhance transmission to the motor neurons. |
2020-09-28 |
2023-08-13 |
Not clear |