| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn Lanza, Christopher Bisho. Serotonergic targets for the treatment of L-DOPA-induced dyskinesia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29305656. |
this review discusses the rationale for continued investigation of several potential anti-dyskinetic strategies including 5-ht stimulation of 5-ht1a and 5-ht1b receptors and blockade of 5-ht2a receptors and sert. |
2019-11-04 |
2023-08-13 |
Not clear |
| Leslie Citrome, James C Norton, Kathy Chi-Burris, George Demo. Pimavanserin for the treatment of Parkinson's disease psychosis: number needed to treat, number needed to harm, and likelihood to be helped or harmed. CNS spectrums. vol 23. issue 3. 2019-09-30. PMID:29098976. |
our aim was to describe the efficacy and tolerability of pimavanserin, a highly selective serotonin 5-ht2a receptor inverse agonist/antagonist indicated for the treatment of hallucinations and delusions associated with parkinson's disease psychosis (pdp), using the metrics of number needed to treat (nnt) and number needed to harm (nnh). |
2019-09-30 |
2023-08-13 |
Not clear |
| Peter U Hámor, Jana Šírová, Tomáš Páleníček, Magdalena Zaniewska, Věra Bubeníková-Valešová, Marek Schwend. Chronic methamphetamine self-administration dysregulates 5-HT2A and mGlu2 receptor expression in the rat prefrontal and perirhinal cortex: Comparison to chronic phencyclidine and MK-801. Pharmacology, biochemistry, and behavior. vol 175. 2019-09-30. PMID:30240581. |
serotonin 2a (5-ht2a) and metabotropic glutamate 2 (mglu2) receptors co-regulate psychosis-like behaviors and cognitive function in animals. |
2019-09-30 |
2023-08-13 |
rat |
| Elizabeth Fleming, Court Hul. Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition. Journal of neurophysiology. vol 121. issue 1. 2019-08-22. PMID:30281395. |
we find that 5-ht depolarizes golgi cells, likely by activating 5-ht2a receptors, but does not directly act on either granule cells or mossy fibers. |
2019-08-22 |
2023-08-13 |
rat |
| Farhana Sakloth, Elizabeth Leggett, Megan J Moerke, E Andrew Townsend, Matthew L Banks, S Stevens Negu. Effects of acute and repeated treatment with serotonin 5-HT2A receptor agonist hallucinogens on intracranial self-stimulation in rats. Experimental and clinical psychopharmacology. vol 27. issue 3. 2019-07-22. PMID:30628811. |
effects of acute and repeated treatment with serotonin 5-ht2a receptor agonist hallucinogens on intracranial self-stimulation in rats. |
2019-07-22 |
2023-08-13 |
rat |
| Yong Kee Choi, Nika Adham, Béla Kiss, István Gyertyán, Frank I Taraz. Long-term effects of aripiprazole exposure on monoaminergic and glutamatergic receptor subtypes: comparison with cariprazine. CNS spectrums. vol 22. issue 6. 2019-06-28. PMID:28059046. |
this study examined the chronic effects of aripiprazole and cariprazine on serotonin (5-ht1a and 5-ht2a) and glutamate (nmda and ampa) receptor subtypes. |
2019-06-28 |
2023-08-13 |
Not clear |
| B Kumar, A Kuhad, A Kuha. Lumateperone: a new treatment approach for neuropsychiatric disorders. Drugs of today (Barcelona, Spain : 1998). vol 54. issue 12. 2019-05-08. PMID:30596390. |
it possesses a potent antagonistic activity at 5-hydroxytryptamine (serotonin) 2a (5-ht2a) receptors and also binds to dopamine (d1, d2) receptors with partial agonism at presynaptic d2 receptors and postsynaptic antagonism. |
2019-05-08 |
2023-08-13 |
Not clear |
| Jennifer de la Cruz, Clinton Cana. Can pimavanserin help patients with Parkinson disease psychosis? JAAPA : official journal of the American Academy of Physician Assistants. vol 32. issue 1. 2019-04-15. PMID:30589736. |
pimavanserin is a first-in-class selective serotonin 5-ht2a receptor inverse agonist approved for the treatment of parkinson disease psychosis. |
2019-04-15 |
2023-08-13 |
Not clear |
| Li Liu, Mengsi Fu, Siran Pei, Liangliang Zhou, Jing Shan. R-Fluoxetine Increases Melanin Synthesis Through a 5-HT1A/2A Receptor and p38 MAPK Signaling Pathways. International journal of molecular sciences. vol 20. issue 1. 2019-04-03. PMID:30585252. |
in addition, we found that r-fluoxetine induced melanin synthesis through the serotonin1a receptor (5-ht1a) and serotonin 2a receptor (5-ht2a). |
2019-04-03 |
2023-08-13 |
human |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Benson O A Botchway, Marong Fan. Stimulation of Anxiety-Like Behavior via ERK Pathway by Competitive Serotonin Receptors 2A and 1A in Post-Traumatic Stress Disordered Mice. Neuro-Signals. vol 25. issue 1. 2019-03-05. PMID:28977803. |
serotonin 5ht2a and 5ht1a receptors (5ht2ar, 5ht1ar) have the closest connection to anxiety-like behavior in post-traumatic stress disorder (ptsd). |
2019-03-05 |
2023-08-13 |
mouse |
| Daniel E Felsing, Noelle C Anastasio, Joanna M Miszkiel, Scott R Gilbertson, John A Allen, Kathryn A Cunningha. Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. PloS one. vol 13. issue 8. 2019-02-12. PMID:30157263. |
biophysical validation of serotonin 5-ht2a and 5-ht2c receptor interaction. |
2019-02-12 |
2023-08-13 |
Not clear |
| Daniel E Felsing, Noelle C Anastasio, Joanna M Miszkiel, Scott R Gilbertson, John A Allen, Kathryn A Cunningha. Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. PloS one. vol 13. issue 8. 2019-02-12. PMID:30157263. |
the serotonin (5-ht) 5-ht2a receptor (5-ht2ar) and 5-ht2c receptor (5-ht2cr) in the central nervous system are implicated in a range of normal behaviors (e.g., appetite, sleep) and physiological functions (e.g., endocrine secretion) while dysfunctional 5-ht2ar and/or 5-ht2cr are implicated in neuropsychiatric disorders (e.g., addiction, obesity, schizophrenia). |
2019-02-12 |
2023-08-13 |
Not clear |
| Alireza Mohammadi, Ehsan Rashidi, Vahid Ghasem Amooeia. Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia. Psychiatry research. vol 265. 2019-01-16. PMID:29680514. |
the levels of dopamine, tyrosine hydroxylase (th), serotonin or 5-hydroxytryptamine (5-ht) receptor 1a and b (5-htr1a and 5-htr1b), and 5-ht1b were significantly increased in scz patients, while the levels of gamma-aminobutyric acid (gaba), 5-ht transporter (5-htt), and 5-ht receptor 2a (5-htr2a) were decreased. |
2019-01-16 |
2023-08-13 |
human |
| F Jiménez-Trejo, I Coronado-Mares, M Boeta, I González-Santoyo, R Vigueras-Villaseñor, C Arriaga-Canon, L A Herrera, M Tapia-Rodrígue. Identification of serotoninergic system components in stallion sperm. Histology and histopathology. vol 33. issue 9. 2019-01-10. PMID:29658099. |
therefore, using both immunofluorescence and western blot techniques, we searched for and found some serotonin markers such as 5-ht, 5-ht1b, 5-ht2a, 5-ht₃ receptors, both tph1 and maoa enzymes, and serotonin transporter (5-htt) in stallion sperm. |
2019-01-10 |
2023-08-13 |
Not clear |
| Wonsuk Choi, Jun Namkung, Inseon Hwang, Hyeongseok Kim, Ajin Lim, Hye Jung Park, Hye Won Lee, Kwang-Hyub Han, Seongyeol Park, Ji-Seon Jeong, Geul Bang, Young Hwan Kim, Vijay K Yadav, Gerard Karsenty, Young Seok Ju, Chan Choi, Jae Myoung Suh, Jun Yong Park, Sangkyu Park, Hail Ki. Serotonin signals through a gut-liver axis to regulate hepatic steatosis. Nature communications. vol 9. issue 1. 2018-12-19. PMID:30446669. |
here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2a (htr2a) signaling. |
2018-12-19 |
2023-08-13 |
mouse |
| A S Tsybko, T V Ilchibaeva, D V Bazovkina, V S Naumenk. [Functional Responses to the Chronic Activation of 5-HT1A Receptors in Mice with Genetic Predisposition to Catalepsy]. Molekuliarnaia biologiia. vol 52. issue 2. 2018-12-11. PMID:29695693. |
the chronic activation of 5-ht1a receptor downregulated 5-ht1a gene expression, as well as the expression of the gene that encodes tryptophan hydroxylase 2, a key enzyme of 5-ht biosynthesis, in the midbrain and the expression of the gene that encodes the 5-ht2a receptor in the frontal cortex of cba, but not c57bl/6 mice. |
2018-12-11 |
2023-08-13 |
mouse |
| Solange Glória, João Marques, Joana Feiteiro, Helena Marcelino, Ignacio Verde, Elisa Cairrã. Tributyltin role on the serotonin and histamine receptors in human umbilical artery. Toxicology in vitro : an international journal published in association with BIBRA. vol 50. 2018-10-15. PMID:29580985. |
moreover, at long term exposures, the arteries treated with 100 μm of tbt do not have contraction capacity when 5-ht is added, and the gene expression of 5-ht2a receptor decrease. |
2018-10-15 |
2023-08-13 |
human |
| Miriam A Snider, David L Harmon, James L Klot. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. Journal of animal science. vol 96. issue 4. 2018-10-09. PMID:29471490. |
prior work using a contractility bioassay determined that the serotonin (5-ht) receptor subtype 5-ht2a is present in bovine lateral saphenous veins and plays a role in ergot alkaloid (ea)-induced vascular contraction in steers grazing endophyte-infected (epichloë coenophiala) tall fescue (lolium arundinaceum). |
2018-10-09 |
2023-08-13 |
cattle |
| Miriam A Snider, David L Harmon, James L Klot. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. Journal of animal science. vol 96. issue 4. 2018-10-09. PMID:29471490. |
to determine what 5-ht receptors are involved in vasoconstriction of gut vasculature, contractility of ruminal and mesenteric arteries and veins collected from cattle was evaluated in the presence of agonists selective for 5-ht1b (cp 93129), 5-ht1d (l-694, 247), 5-ht2a (tcb-2), 5-ht2b (bw 723c86), 5-ht4 (bimu-8), and 5-ht7 (lp 44) receptors. |
2018-10-09 |
2023-08-13 |
cattle |
| Marwa Ahmed Amin Atallah, Samah M Elaidy, Mona K Tawfi. Assessment of the possible roles of SB-269970 versus ketanserin on carbon tetrachloride-induced liver fibrosis in rats: Oxidative stress/TGF-β Pharmacological reports : PR. vol 70. issue 3. 2018-10-09. PMID:29660654. |
serotonin (5-ht) through its hscs-expressed receptors, especially 5-ht2a and 7, shows crucial events in fibrogenesis of chronic liver diseases. |
2018-10-09 |
2023-08-13 |
rat |