| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katsunori Nonogaki, Takao Kaj. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice. Journal of diabetes research. vol 2018. 2018-09-24. PMID:29484303. |
liraglutide, a glp-1 receptor agonist, which decreases hypothalamic 5-ht2a receptor expression, reduces appetite and body weight independently of serotonin synthesis in mice. |
2018-09-24 |
2023-08-13 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice. Journal of diabetes research. vol 2018. 2018-09-24. PMID:29484303. |
a recent report suggested that brain-derived serotonin (5-ht) is critical for maintaining weight loss induced by glucagon-like peptide-1 (glp-1) receptor activation in rats and that 5-ht2a receptors mediate the feeding suppression and weight loss induced by glp-1 receptor activation. |
2018-09-24 |
2023-08-13 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice. Journal of diabetes research. vol 2018. 2018-09-24. PMID:29484303. |
these findings suggest that liraglutide reduces appetite and body weight independently of 5-ht synthesis in mice, whereas glp-1 receptor activation downregulates the gene expression of hypothalamic 5-ht2a receptors. |
2018-09-24 |
2023-08-13 |
mouse |
| Michael P Bogenschutz, Stephen Ros. Therapeutic Applications of Classic Hallucinogens. Current topics in behavioral neurosciences. vol 36. 2018-09-20. PMID:28512684. |
this chapter reviews what is known about the therapeutic uses of the serotonergic or classic hallucinogens, i.e., psychoactive drugs such as lsd and psilocybin that exert their effects primarily through agonist activity at serotonin 2a (5ht2a) receptors. |
2018-09-20 |
2023-08-13 |
human |
| David A Martin, Charles D Nichol. The Effects of Hallucinogens on Gene Expression. Current topics in behavioral neurosciences. vol 36. 2018-09-20. PMID:28677095. |
the immediate and acute effects on both behaviors and network connectivity are likely mediated by effector pathways downstream of serotonin 5-ht2a receptor activation. |
2018-09-20 |
2023-08-13 |
Not clear |
| Alia Sadiq, Ahmed Shah, Marc G Jeschke, Cassandra Belo, Muhammad Qasim Hayat, Sheeba Murad, Saeid Amini-Ni. The Role of Serotonin during Skin Healing in Post-Thermal Injury. International journal of molecular sciences. vol 19. issue 4. 2018-09-05. PMID:29596386. |
whereas, fluoxetine (a selective serotonin reuptake inhibitor) and ketanserin (serotonin receptor 2a inhibitor) reversed these effects. |
2018-09-05 |
2023-08-13 |
mouse |
| Jegath C Athilingam, Roy Ben-Shalom, Caroline M Keeshen, Vikaas S Sohal, Kevin J Bende. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. eLife. vol 6. 2018-08-22. PMID:29206101. |
here, we show that serotonin (5ht), which is known to regulate gamma power, acts via 5ht2a receptors to suppress an inward-rectifying potassium conductance in fsis. |
2018-08-22 |
2023-08-13 |
mouse |
| Kenmei Mizutani, Shigeru Sonoda, Hideaki Wakit. Ritanserin, a serotonin-2 receptor antagonist, inhibits functional recovery after cerebral infarction. Neuroreport. vol 29. issue 1. 2018-07-31. PMID:29135714. |
here, the role of 5-ht was verified using ritanserin, a potent 5-ht2a receptor antagonist, and protein expression and modification were analyzed to further understand the association between paralysis recovery and molecular mechanisms in the brain. |
2018-07-31 |
2023-08-13 |
rat |
| Iris Lim, Russ Chess-Williams, Donna Seller. 5-HT2A receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-HT in young and old animals. European journal of pharmacology. vol 818. 2018-07-27. PMID:29104045. |
5-ht2a receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-ht in young and old animals. |
2018-07-27 |
2023-08-13 |
Not clear |
| Cristy A Ku, Renee C Ryals, Dan Jiang, Aaron S Coyner, Kyle K Weller, Wrik Sinha, Bryan M Robb, Paul Yang, Mark E Pennes. The Role of ERK1/2 Activation in Sarpogrelate-Mediated Neuroprotection. Investigative ophthalmology & visual science. vol 59. issue 1. 2018-07-27. PMID:29368005. |
to characterize the mediators of 5-ht2a serotonin receptor-driven retinal neuroprotection. |
2018-07-27 |
2023-08-13 |
Not clear |
| Stefano Fortinguerra, Alessandro Buriani, Vincenzo Sorrenti, Michele Lenzi, Pietro Giust. Molecular network-selected pharmacogenomics in a case of bipolar spectrum disorder. Pharmacogenomics. vol 18. issue 18. 2018-07-24. PMID:29173093. |
results from the pharmacogenomic analysis were consistent with the pharmacological history and indicate mutations associated with low monoaminergic tone, but also a hyperactive 5ht2a receptor, a feature that associates to a high probability of developing a bipolar condition, especially under 5-hydroxytryptamine potentiating pharmacology. |
2018-07-24 |
2023-08-13 |
Not clear |
| Patricia Pilkinton, Carlos Berry, Seth Norrholm, Al Bartolucci, Badari Birur, Lori L Davi. An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder. Psychopharmacology bulletin. vol 46. issue 2. 2018-07-16. PMID:27738377. |
asenapine is a novel atypical antipsychotic that possesses a high serotonin (5-ht2a) to dopamine (d2) affinity ratio and alpha-adrenergic antagonism, which may be advantageous in treating ptsd. |
2018-07-16 |
2023-08-13 |
Not clear |
| b' Eldina Rizvi\\xc4\\x87, Goran Jankovi\\xc4\\x87, Sla\\xc4\\x91ana Kosti\\xc4\\x87-Raja\\xc4\\x8di\\xc4\\x87, Miroslav M Savi\\xc4\\x8. Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors. Bosnian journal of basic medical sciences. vol 17. issue 3. 2018-07-12. PMID:28628756.' |
here, we analyzed the affinity of lerimazoline for dopamine receptor d2, serotonin 5-ht1a and 5-ht2a receptors and α1-adrenoceptor, and investigated lerimazoline contractile effects in isolated rat thoracic aorta. |
2018-07-12 |
2023-08-13 |
rat |
| R L Carhart-Harris, D J Nut. Serotonin and brain function: a tale of two receptors. Journal of psychopharmacology (Oxford, England). vol 31. issue 9. 2018-05-17. PMID:28858536. |
in this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and researched brain receptors: the 5-ht1a and 5-ht2a receptors. |
2018-05-17 |
2023-08-13 |
Not clear |
| Zsofia Majlath, Izabella Obal, Laszlo Vecse. Treatment Possibilities for Psychosis in Parkinson's Disease with An Emphasis on the Newly Approved Drug: Pimavanserin. CNS & neurological disorders drug targets. vol 16. issue 3. 2018-05-11. PMID:27719624. |
extensive research has shown that the antipsychotic effect of these drugs could be attributed to serotonin 2a receptor (5-ht2a) triggered mechanisms. |
2018-05-11 |
2023-08-13 |
Not clear |
| Anna Czopek, Agnieszka Zagorska, Marcin Kolaczkowski, Adam Bucki, Beata Gryzlo, Joanna Rychtyk, Maciej Pawlowsk, Agata Siwek, Grzegorz Satala, Andrzej Bojarski, Monika Kubacka, Barbara Filipe. NEW SPIROHYDANTOIN DERIVATIVES - SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING STUDY. Acta poloniae pharmaceutica. vol 73. issue 6. 2018-05-03. PMID:29634109. |
a series of new arylpiperazinylpropyl derivatives of 8/6-phenyl-1,3-diazaspiro[4.5]decan-2,4-dione and spiro[imidazolidine-4,1'-indene/naphthalene]-2,5-dione was synthesized and their affinity was evaluated toward serotonin 5-htia, 5-ht2a, 5-ht7 receptors, dopaminergic d2, d3 receptors, adrenergic ox, receptors, and serotonin transporter (sert). |
2018-05-03 |
2023-08-13 |
Not clear |
| Sarah E Haskell, Cecilia Lo, Mitchell E Kent, Timothy M Eggleston, Kenneth A Volk, Benjamin E Reinking, Robert D Roghai. Cardiac Outcomes After Perinatal Sertraline Exposure in Mice. Journal of cardiovascular pharmacology. vol 70. issue 2. 2018-04-27. PMID:28459713. |
sertraline-exposed mice had increased cardiac hydroxyproline content, decreased 5-ht2b receptor mrna levels, and increased 5-ht2a receptor and serotonin transporter mrna levels on postnatal day 21 (p < 0.05). |
2018-04-27 |
2023-08-13 |
mouse |
| Line Marie Nielsen, Niels Bjerre Holm, Sebastian Leth-Petersen, Jesper Langgaard Kristensen, Lars Olsen, Kristian Linne. Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH. Drug testing and analysis. vol 9. issue 5. 2018-03-12. PMID:27400739. |
the dimethoxyphenyl-n-((2-methoxyphenyl)methyl)ethanamine (nbome) compounds are potent serotonin 5-ht2a receptor agonists and have recently been subject to recreational use due to their hallucinogenic effects. |
2018-03-12 |
2023-08-13 |
human |
| Isabella Salzer, Enkhbileg Gantumur, Arsalan Yousuf, Stefan Boeh. Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca(2+)-activated chloride channels. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:27511837. |
in all neurons investigated, 5ht potentiated capsaicin-evoked currents through trpv1 channels, an effect that was attenuated by antagonists at 5ht2a (4 f 4 pp), 5ht2b (sb 204741), as well as 5ht2c (rs 102221) receptors. |
2018-02-22 |
2023-08-13 |
rat |
| Carine Bécamel, Coralie Berthoux, Alexander Barre, Philippe Mari. Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28459524. |
the serotonin 2a (5-ht2a) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. |
2018-02-07 |
2023-08-13 |
Not clear |