| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carine Bécamel, Coralie Berthoux, Alexander Barre, Philippe Mari. Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28459524. |
5-ht2a receptors are a principal g protein-coupled receptor subtype mediating the excitatory effects of serotonin. |
2018-02-07 |
2023-08-13 |
Not clear |
| Min Su, Ye Ran, Xun Han, Yufei Liu, Xu Zhang, Qingche Tan, Ruisheng Li, Shengyuan Y. Rizatriptan overuse promotes hyperalgesia induced by dural inflammatory stimulation in rats by modulation of the serotonin system. The European journal of neuroscience. vol 44. issue 4. 2018-02-01. PMID:27288111. |
clinical and preclinical studies have implicated serotonin (5-ht) and the 5-ht2a receptor (5-ht2ar) in the pathogenesis of medication-overuse headache (moh). |
2018-02-01 |
2023-08-13 |
rat |
| Alba Iglesias, Sonia Lage, Maria Isabel Cadavid, Maria Isabel Loza, José Bre. Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening. Journal of biomolecular screening. vol 21. issue 8. 2018-01-24. PMID:27095818. |
development of a multiplex assay for studying functional selectivity of human serotonin 5-ht2a receptors and identification of active compounds by high-throughput screening. |
2018-01-24 |
2023-08-13 |
human |
| Alba Iglesias, Sonia Lage, Maria Isabel Cadavid, Maria Isabel Loza, José Bre. Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening. Journal of biomolecular screening. vol 21. issue 8. 2018-01-24. PMID:27095818. |
the serotonin 2a (5-ht2a) receptor regulates multiple physiological functions, is involved in the pathophysiology of schizophrenia, and serves as an important target of atypical antipsychotic drugs. |
2018-01-24 |
2023-08-13 |
human |
| Anna Rickli, Olivier D Moning, Marius C Hoener, Matthias E Liecht. Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 8. 2018-01-23. PMID:27216487. |
we investigated binding affinities at human monoamine receptors and determined functional serotonin (5-hydroxytryptamine [5-ht]) 5-ht2a and 5-ht2b receptor activation. |
2018-01-23 |
2023-08-13 |
human |
| Enzo Tagliazucchi, Leor Roseman, Mendel Kaelen, Csaba Orban, Suresh D Muthukumaraswamy, Kevin Murphy, Helmut Laufs, Robert Leech, John McGonigle, Nicolas Crossley, Edward Bullmore, Tim Williams, Mark Bolstridge, Amanda Feilding, David J Nutt, Robin Carhart-Harri. Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Current biology : CB. vol 26. issue 8. 2018-01-19. PMID:27085214. |
the cortical areas showing increased global connectivity overlapped significantly with a map of serotonin 2a (5-ht2a) receptor densities (the key site of action of psychedelic drugs [4]). |
2018-01-19 |
2023-08-13 |
human |
| Tobias Buchborn, Helmut Schröder, Volker Höllt, Gisela Grecksc. Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling. Journal of psychopharmacology (Oxford, England). vol 28. issue 6. 2018-01-16. PMID:24785760. |
a re-balance of postsynaptic serotonin (5-ht) receptor signalling, with an increase in 5-ht1a and a decrease in 5-ht2a signalling, is a final common pathway multiple antidepressants share. |
2018-01-16 |
2023-08-13 |
rat |
| Tobias Buchborn, Helmut Schröder, Volker Höllt, Gisela Grecksc. Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling. Journal of psychopharmacology (Oxford, England). vol 28. issue 6. 2018-01-16. PMID:24785760. |
given that the 5-ht1a/2a agonist lysergic acid diethylamide (lsd), when repeatedly applied, selectively downregulates 5-ht2a, but not 5-ht1a receptors, one might expect lsd to similarly re-balance the postsynaptic 5-ht signalling. |
2018-01-16 |
2023-08-13 |
rat |
| A Komorowski, G M James, C Philippe, G Gryglewski, A Bauer, M Hienert, M Spies, A Kautzky, T Vanicek, A Hahn, T Traub-Weidinger, D Winkler, W Wadsak, M Mitterhauser, M Hacker, S Kasper, R Lanzenberge. Association of Protein Distribution and Gene Expression Revealed by PET and Post-Mortem Quantification in the Serotonergic System of the Human Brain. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 1. 2018-01-15. PMID:27909009. |
pet binding values and gene expression intensities were correlated for the main inhibitory (5-ht1a) and excitatory (5-ht2a) serotonin receptor, the serotonin transporter (sert) as well as monoamine oxidase-a (mao-a), using spearman's correlation coefficients (rs) in a voxel-wise and region-wise analysis. |
2018-01-15 |
2023-08-13 |
human |
| Daniel R Wyskiel, Rodrigo Andrad. Serotonin excites hippocampal CA1 GABAergic interneurons at the stratum radiatum-stratum lacunosum moleculare border. Hippocampus. vol 26. issue 9. 2018-01-08. PMID:27328460. |
therefore in the current work, we have used a bac transgenic mouse line expressing egfp under the control of the 5-ht2a r promoter to identify the interneuron subtype(s) regulated by serotonin via 5-ht2a rs. |
2018-01-08 |
2023-08-13 |
mouse |
| Daniel R Wyskiel, Rodrigo Andrad. Serotonin excites hippocampal CA1 GABAergic interneurons at the stratum radiatum-stratum lacunosum moleculare border. Hippocampus. vol 26. issue 9. 2018-01-08. PMID:27328460. |
we then show that these cells are depolarized and excited by serotonin acting through 5-ht2a rs and appear to belong predominantly to the perforant pathway-associated and schaffer collateral/commissural pathway-associated subtypes. |
2018-01-08 |
2023-08-13 |
mouse |
| Daniel R Wyskiel, Rodrigo Andrad. Serotonin excites hippocampal CA1 GABAergic interneurons at the stratum radiatum-stratum lacunosum moleculare border. Hippocampus. vol 26. issue 9. 2018-01-08. PMID:27328460. |
these results indicate that serotonin interneurons expressing 5-ht2a rs are localized primarily along the sr-slm border of the ca1 region and represent a newly identified target for serotonin regulation in the hippocampus. |
2018-01-08 |
2023-08-13 |
mouse |
| Thi Thu Ha Nguyen, Antoine Pariente, Jean-Louis Montastruc, Maryse Lapeyre-Mestre, Vanessa Rousseau, Olivier Rascol, Bernard Bégaud, François Montastru. An original pharmacoepidemiological-pharmacodynamic method: application to antipsychotic-induced movement disorders. British journal of clinical pharmacology. vol 83. issue 3. 2018-01-05. PMID:27687785. |
the aim of the present study was to combine pharmacovigilance and pharmacodynamic data to investigate the association between dopamine d2, serotonin 5ht2a, and muscarinic m1 receptor occupancy and the risks of antipsychotic drug (ap)-induced movement disorders. |
2018-01-05 |
2023-08-13 |
Not clear |
| Tatsuya Ishii, Yasuyuki Kimura, Masanori Ichise, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Manabu Kubota, Ming-Rong Zhang, Makiko Yamada, Makoto Higuchi, Yoshiro Okubo, Tetsuya Suhar. Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain. PloS one. vol 12. issue 12. 2018-01-04. PMID:29220382. |
anatomical relationships between serotonin 5-ht2a and dopamine d2 receptors in living human brain. |
2018-01-04 |
2023-08-13 |
human |
| R Forcén, E Latorre, J Pardo, A I Alcalde, M D Murillo, L Gras. Toll-like receptors 2 and 4 exert opposite effects on the contractile response induced by serotonin in mouse colon: role of serotonin receptors. Experimental physiology. vol 101. issue 8. 2018-01-01. PMID:27282784. |
alterations in 5-ht2a and 5-ht2c receptors explain the increase of the response to serotonin in tlr2(-/-) mice. |
2018-01-01 |
2023-08-13 |
mouse |
| Ayaka Hori, Takashi Nishida, Shogo Takashiba, Satoshi Kubota, Masaharu Takigaw. Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT2A and 5-HT2B receptors in chondrocytes. PloS one. vol 12. issue 11. 2017-12-26. PMID:29145495. |
regulatory mechanism of ccn2 production by serotonin (5-ht) via 5-ht2a and 5-ht2b receptors in chondrocytes. |
2017-12-26 |
2023-08-13 |
human |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
the overarching goal of this review is to present recent findings from studies examining the serotonergic pathway in mdd, with a focus on sert and the serotonin 1a (5-ht1a), serotonin 1b (5-ht1b), and serotonin 2a (5-ht2a) receptors. |
2017-12-22 |
2023-08-13 |
mouse |
| Dhwanil A Dalwadi, Seongcheol Kim, Shahnawaz M Amdani, Zhenglan Chen, Ren-Qi Huang, John A Schet. Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz. Pharmacological research. vol 110. 2017-12-21. PMID:27157251. |
prolonged exposure to efavirenz reduces 5-ht2a receptor density and responsiveness to 5-ht. |
2017-12-21 |
2023-08-13 |
Not clear |
| Chris M Panzini, Daniel G Ehlinger, Adele M Alchahin, Yueping Guo, Kathryn G Common. 16p11.2 deletion syndrome mice perseverate with active coping response to acute stress - rescue by blocking 5-HT2A receptors. Journal of neurochemistry. vol 143. issue 6. 2017-12-20. PMID:28948999. |
taken together, these observations indicate notable changes in endogenous serotonin signaling in 16p11.2 deletion mice and support the therapeutic utility of 5-ht2a receptor antagonists. |
2017-12-20 |
2023-08-13 |
mouse |
| Chuan-Chia Chang, Wen-Hui Fang, Hsin-An Chang, Tieh-Ching Chang, Jia-Fwa Shyu, San-Yuan Huan. Serotonin 2A receptor (5-HT2A) gene promoter variant interacts with chronic perceived stress to modulate resting parasympathetic activity in humans. Psychoneuroendocrinology. vol 76. 2017-12-12. PMID:27912162. |
serotonin 2a receptor (5-ht2a) gene promoter variant interacts with chronic perceived stress to modulate resting parasympathetic activity in humans. |
2017-12-12 |
2023-08-13 |
human |