| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Ma, Suguru Okuda, Hiroki Okanishi, Minhui Xu, Chunhuan Jin, Hitoshi Endou, Ryuichi Ohgaki, Yoshikatsu Kana. Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells. Journal of pharmacological sciences. vol 155. issue 1. 2024-03-29. PMID:38553134. |
our results show that atf4 upregulation counteracts the suppressive effect of nanvuranlat on cell proliferation in pancreatic ductal adenocarcinoma cell lines, suggesting a role for atf4 in cellular adaptation to lat1 inhibition. |
2024-03-29 |
2024-04-01 |
Not clear |
| Adrien Corne, Florine Adolphe, Jérôme Estaquier, Sébastien Gaumer, Jean-Marc Cors. ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor. Biology. vol 13. issue 3. 2024-03-27. PMID:38534416. |
the precise role of atf4 during viral infection is unclear and depends on cell hosts, viral agents, and models. |
2024-03-27 |
2024-03-29 |
human |
| Yongzhe Liu, Li Sun, Yaqun Ma, Biyu Wei, Minglong Gao, Lixin Shan. High glucose and bupivacaine‑induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK‑ATF4‑CHOP and IRE1‑TRAF2 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-02-04. PMID:31524237. |
the effects that 3‑ma (autophagy inhibitor) and rapamycin (rapa; autophagy inducer) exerted on cell apoptosis, autophagy and the expression of protein kinase r‑like endoplasmic reticulum kinase (perk)‑activating transcription factor 4 (atf4)‑c/ebp‑homologous protein (chop) and inositol‑requiring enzyme 1 (ire1)‑tumor necrosis factor receptor associated factor 2 (traf2) signaling proteins were measured in high glucose and bupivacaine‑treated cells. |
2020-02-04 |
2023-08-13 |
human |
| Xiaotian Sun, Jin Liu, John F Crary, Cristina Malagelada, David Sulzer, Lloyd A Greene, Oren A Lev. ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 6. 2013-04-01. PMID:23392669. |
atf4 may exert either protective or deleterious effects on cell survival, depending on the paradigm. |
2013-04-01 |
2023-08-12 |
mouse |
| Daima Ord, Kati Meerits, Tõnis Or. TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4. Experimental cell research. vol 313. issue 16. 2007-11-05. PMID:17707795. |
in the present study, we investigate the effect of atf4 and trb3 on cell growth and viability, using both the enforced expression and silencing of the genes. |
2007-11-05 |
2023-08-12 |
Not clear |