| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amanda Nunes Santiago, Marco Aurélio Mori, Francisco Silveira Guimarães, Humberto Milani, Rúbia Maria Weffort de Oliveir. Effects of Cannabidiol on Diabetes Outcomes and Chronic Cerebral Hypoperfusion Comorbidities in Middle-Aged Rats. Neurotoxicity research. vol 35. issue 2. 2019-03-11. PMID:30430393. |
cannabidiol attenuated the decrease in hippocampal levels of brain-derived neurotrophic factor induced by cch in diabetic animals, but it did not affect the levels of neuroplasticity markers (growth-associated protein-43 and synaptophysin) in middle-aged diabetic rats. |
2019-03-11 |
2023-08-13 |
rat |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the pi3k/akt pathway. |
2019-03-05 |
2023-08-13 |
rat |
| Ting-Hsuan Yu, Yi-Jen Wu, Miao-Er Chien, Kuei-Sen Hs. Transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor. Neuropharmacology. vol 144. 2019-03-04. PMID:30439417. |
transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor. |
2019-03-04 |
2023-08-13 |
rat |
| Tingxu Yan, Bosai He, Shutong Wan, Mengjie Xu, Huilin Yang, Feng Xiao, Kaishun Bi, Ying Ji. Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism. Scientific reports. vol 7. issue 1. 2019-02-19. PMID:28761074. |
additionally, cums exposure significantly decreased brain derived neurotrophic factor (bdnf) levels in hippocampus as indicated by elisa, immunohistochemistry and immunofluorescence assays, accompanied by down-regulated tyrosine kinase receptor b (trkb)/camp-response element binding protein (creb)/extracellular signal-regulated kinase (erk) and phosphatidylinositol 3 kinase (pi3k)/ protein kinase b (akt)/ glycogen synthase kinase-3β (gsk-3β) signaling pathways. |
2019-02-19 |
2023-08-13 |
mouse |
| Liyuan Zhang, Denggui Fan, Qingyun Wang, Gerold Baie. Effects of brain-derived neurotrophic factor and noise on transitions in temporal lobe epilepsy in a hippocampal network. Chaos (Woodbury, N.Y.). vol 28. issue 10. 2019-02-15. PMID:30384669. |
effects of brain-derived neurotrophic factor and noise on transitions in temporal lobe epilepsy in a hippocampal network. |
2019-02-15 |
2023-08-13 |
Not clear |
| Alessio Travaglia, Adam B Steinmetz, Janelle M Miranda, Cristina M Alberin. Mechanisms of critical period in the hippocampus underlie object location learning and memory in infant rats. Learning & memory (Cold Spring Harbor, N.Y.). vol 25. issue 4. 2019-02-04. PMID:29545389. |
furthermore, as for aversive experiences, nol learning at pn17 engages critical period mechanisms in the dorsal hippocampus: it induces a switch in the glun2a/2b-nmda receptor ratio, and brain-derived neurotrophic factor injected bilaterally into the dorsal hippocampus immediately after training results in long-lasting memory expression. |
2019-02-04 |
2023-08-13 |
rat |
| Zhen Liu, Fan Liu, Xiaowen Liu, Chao Ma, Jing Zha. Surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala. Molecular pain. vol 14. 2019-01-14. PMID:30232930. |
surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala. |
2019-01-14 |
2023-08-13 |
mouse |
| Lucas Melo Neves, Carla Silva-Batista, Raquel Marquesini, Telma Fátima da Cunha, Elisa Dimateo, Luciana Nascimento, Acácio Moreira-Neto, Angelo Corrêa de Lima Miliatto, Sheila das Chagas Mendes, Flavia Saad, Jamile Sanches Codogno, Renato Hoffmann Nunes, Raphael Mendes Ritti-Dias, Valeria Juday, Beny Lafer, Carlos Ugrinowitsc. Aerobic exercise program with or without motor complexity as an add-on to the pharmacological treatment of depression - study protocol for a randomized controlled trial. Trials. vol 19. issue 1. 2019-01-07. PMID:30305151. |
therefore, this randomized controlled trial will compare the effects of cae and aemc on depression score, cognitive function, hippocampal volume, brain-derived neurotrophic factor expression, sleep parameters, cardiovascular risk parameters, suicidal behavior, functionality, and treatment costs in patients with depression. |
2019-01-07 |
2023-08-13 |
Not clear |
| Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Effects of Epigallocatechin Gallate on Behavioral and Cognitive Impairments, Hypothalamic-Pituitary-Adrenal Axis Dysfunction, and Alternations in Hippocampal BDNF Expression Under Single Prolonged Stress. Journal of medicinal food. vol 21. issue 10. 2019-01-02. PMID:30273101. |
the administration of egcg also significantly moderated memory-related decreases in the alternation of camp-response element-binding protein and brain-derived neurotrophic factor in the hippocampus. |
2019-01-02 |
2023-08-13 |
rat |
| Prasant Kumar Jena, Lili Sheng, Jacopo Di Lucente, Lee-Way Jin, Izumi Maezawa, Yu-Jui Yvonne Wa. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 5. 2018-12-31. PMID:29401580. |
the results showed that long-term wd intake reduced hippocampal synaptic plasticity and the level of brain-derived neurotrophic factor mrna in the brain and isolated microglia. |
2018-12-31 |
2023-08-13 |
mouse |
| Kenichi Kawahori, Koshi Hashimoto, Xunmei Yuan, Kazutaka Tsujimoto, Nozomi Hanzawa, Miho Hamaguchi, Saori Kase, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Yasuyo Nakajima, Nobuyuki Shibusawa, Masanobu Yamada, Yoshihiro Ogaw. Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring. Thyroid : official journal of the American Thyroid Association. vol 28. issue 3. 2018-12-21. PMID:29415629. |
mild maternal hypothyroxinemia during pregnancy induces persistent dna hypermethylation in the hippocampal brain-derived neurotrophic factor gene in mouse offspring. |
2018-12-21 |
2023-08-13 |
mouse |
| Kenichi Kawahori, Koshi Hashimoto, Xunmei Yuan, Kazutaka Tsujimoto, Nozomi Hanzawa, Miho Hamaguchi, Saori Kase, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Yasuyo Nakajima, Nobuyuki Shibusawa, Masanobu Yamada, Yoshihiro Ogaw. Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring. Thyroid : official journal of the American Thyroid Association. vol 28. issue 3. 2018-12-21. PMID:29415629. |
this may be due to the persistent reduced expression of the hippocampal brain-derived neurotrophic factor gene bdnf, which plays a crucial role in cns development. |
2018-12-21 |
2023-08-13 |
mouse |
| b' N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington\'s Disease. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29526016.' |
we found that pacap treatment rescued pac1 level in r6/1 mice, promoted expression of the hippocampal brain-derived neurotrophic factor, and reduced the formation of mutant huntingtin aggregates. |
2018-12-17 |
2023-08-13 |
mouse |
| S-E Jang, S-M Lim, J-J Jeong, H-M Jang, H-J Lee, M J Han, D-H Ki. Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice. Mucosal immunology. vol 11. issue 2. 2018-12-11. PMID:28612842. |
treatment with tnbs or ec induced nf-κb activation and tumor necrosis factor-α expression in the hippocampus of mice, as well as suppressed brain-derived neurotrophic factor expression. |
2018-12-11 |
2023-08-13 |
mouse |
| Ze-Mei Zhu, Ji-Hua Yang, Si-Si Yang, Jian-Qin He, Kai-Fang Zhang, Shui-Dong Feng, Hong-Yan Lin. [The effects of dihydromyricetin on cognitive dysfunction in type 2 diabetes mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 33. issue 4. 2018-11-14. PMID:29926637. |
to observe the effects of dihydromyricetin(dhm) on cognitive dysfunction and expression of brain derived neurotrophic factor(bdnf) protein in hippocampus of type 2 diabetic mice(t2dm). |
2018-11-14 |
2023-08-13 |
mouse |
| Emanuela Mhillaj, Maria Grazia Morgese, Paolo Tucci, Anna Furiano, Livio Luongo, Maria Bove, Sabatino Maione, Vincenzo Cuomo, Stefania Schiavone, Luigia Trabac. Celecoxib Prevents Cognitive Impairment and Neuroinflammation in Soluble Amyloid β-treated Rats. Neuroscience. vol 372. 2018-11-13. PMID:29306052. |
interestingly, rats treated with saβ showed long-term memory deficits, as confirmed by a significant reduction of discrimination index in the novel object recognition test, along with reduced brain-derived neurotrophic factor expression and increased noradrenaline levels in the hipp. |
2018-11-13 |
2023-08-13 |
rat |
| Stine N Hansen, Jane M Bjørn Jørgensen, Jens R Nyengaard, Jens Lykkesfeldt, Pernille Tveden-Nybor. Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model. Nutrients. vol 10. issue 6. 2018-11-01. PMID:29890692. |
we hypothesized that vitc deficiency leads to decreased brain-derived neurotrophic factor and synaptic plasticity markers in selected brain areas (frontal cortex, hippocampus and striatum) and cause morphological changes in cornu ammonis 1 pyramidal neurons of the hippocampus either through a direct effect or indirectly by increased oxidative stress. |
2018-11-01 |
2023-08-13 |
Not clear |
| Nisha Kemse, Anvita Kale, Preeti Chavan-Gautam, Sadhana Josh. Increased intake of vitamin B Food & function. vol 9. issue 7. 2018-10-29. PMID:29955747. |
in the pih group, brain-derived neurotrophic factor levels (bdnf) were lower in the offspring at birth, while the adult offspring showed lower levels of docosahexaenoic acid (dha) in the hippocampus and bdnf (p < 0.05 for both) in the cortex as compared to in the control group. |
2018-10-29 |
2023-08-13 |
rat |
| Naoya Hashikawa, Yuta Utaka, Takumi Ogawa, Ryo Tanoue, Yuna Morita, Sayumi Yamamoto, Satoru Yamaguchi, Masafumi Kayano, Yoshito Zamami, Narumi Hashikawa-Hobar. HSP105 prevents depression-like behavior by increasing hippocampal brain-derived neurotrophic factor levels in mice. Science advances. vol 3. issue 5. 2018-10-10. PMID:28580422. |
hsp105 prevents depression-like behavior by increasing hippocampal brain-derived neurotrophic factor levels in mice. |
2018-10-10 |
2023-08-13 |
mouse |
| Bingyou Yang, Bo Liu, Yan Liu, Hua Han, Haixue Kuan. Cognitive enhancement of volatile oil from the stems of Schisandra chinensis Baill. in Alzheimer's disease rats. Canadian journal of physiology and pharmacology. vol 96. issue 6. 2018-10-03. PMID:29714500. |
alzheimer's disease (ad) models were established by injecting aβ(1-42) into the rat hippocampus and the effects of learning and memory were observed by a morris water maze test, immunohistological alterations, and correlative indicators covering nerve growth (brain-derived neurotrophic factor, glial-cell-derived trophic factor, and nerve growth factor), interleukin 1β, tumor necrosis factor, superoxide dismutase (sod), glutathione peroxidase (gsh-px), malondialdehyde (mda), glial fibrillary acidic protein (gfap), and microglial cd11b in ad rats. |
2018-10-03 |
2023-08-13 |
rat |