| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandre Bouro. Cellular neurobiology of hyperforin. Phytotherapy research : PTR. 2023-11-14. PMID:37963759. |
for instance, hyperforin possesses antidepressant properties, impairs the uptake of neurotransmitters, and stimulates the brain derived neurotrophic factor (bdnf)/trkb neurotrophic signaling pathway, the adult hippocampal neurogenesis, and the brain homeostasis of zinc. |
2023-11-14 |
2023-11-20 |
Not clear |
| Susu Lin, Ziwei Chen, Zhaoruncheng Wu, Fei Fei, Zijin Xu, Yingpeng Tong, Wenyu Sun, Ping Wan. Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes. Neurochemical research. 2023-11-07. PMID:37935859. |
the levels of inflammatory factors, corticosterone and pro brain-derived neurotrophic factor in crocetin-administrated mice serum were significantly reduced compared with those in the crs group, as well as the levels of inflammatory factors in hippocampus. |
2023-11-07 |
2023-11-20 |
mouse |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
then, we systematically discuss the possible mechanisms of how microglia regulate adult hippocampal neurogenesis in depression according to recent studies, which involve toll-like receptors, microglial polarization, fractalkine-c-x3-c motif chemokine receptor 1, hypothalamic-pituitary-adrenal axis, cytokines, brain-derived neurotrophic factor, and the microbiota-gut-brain axis, etc. |
2023-10-26 |
2023-11-08 |
Not clear |
| S Mohammad Ahmadi-Soleimani, Ghulam Yahya Amiry, Elnaz Khordad, Maha Masoudi, Farimah Behesht. Omega-3 fatty acids prevent nicotine withdrawal-induced impairment of learning and memory via affecting oxidative status, inflammatory response, cholinergic activity, BDNF and amyloid-B in rat hippocampal tissues. Life sciences. 2023-09-18. PMID:37722588. |
for this purpose, morris water maze and passive avoidance tests were performed on male wistar rats and the hippocampal levels of oxidative stress markers, inflammatory indices, brain-derived neurotrophic factor, nitrite, amyloid-b and acetylcholinesterase (ache) were measured. |
2023-09-18 |
2023-10-07 |
rat |
| M Hernandez, S Ghislin, R Lalonde, C Straziell. Corticosterone effects on postnatal cerebellar development in mice. Neurochemistry international. 2023-09-13. PMID:37704081. |
the cort treatment altered the morphology of the hippocampus and down-regulated gene transcription for corticotropin-releasing hormone (crh) and its type-1 receptor (crhr1), glucocorticoid receptor (nr3c1), and brain-derived neurotrophic factor bdnf and its receptor ntrk2 (neurotrophic receptor tyrosine kinase 2). |
2023-09-13 |
2023-10-07 |
mouse |
| Jiao Liu, Jing Tao, Guiyan Cai, Jie Chen, Lei Zhao, Yajun Wang, Shurui Xu, Ruilin Chen, Li Hu, Jin Cao, Lidian Chen, Yiheng T. The altered hippocampal functional connectivity and serum brain-derived neurotrophic factor level predict cognitive decline in patients with knee osteoarthritis. Cerebral cortex (New York, N.Y. : 1991). 2023-09-01. PMID:37653604. |
the altered hippocampal functional connectivity and serum brain-derived neurotrophic factor level predict cognitive decline in patients with knee osteoarthritis. |
2023-09-01 |
2023-09-07 |
Not clear |
| Asmaa Gaber, Osama M Ahmed, Yasser A Khadrawy, Khairy M A Zoheir, Rasha E Abo-ELeneen, Mohamed A Alblihed, Ahlam M Elbakr. Mesenchymal Stem Cells and Begacestat Mitigate Amyloid-β 25-35-Induced Cognitive Decline in Rat Dams and Hippocampal Deteriorations in Offspring. Biology. vol 12. issue 7. 2023-07-29. PMID:37508337. |
additionally, bm-msc or gsi-953 therapy reduced aβ 25-35-induced increases in tau phosphorylation and amyloid precursor protein levels in the neonates' hippocampus and elevated the lower levels of glycogen synthase kinase-3 and brain-derived neurotrophic factor; moreover, reversed aβ 25-35-induced alterations in gene expression in the neonatal hippocampus. |
2023-07-29 |
2023-08-14 |
rat |
| Xiaoyue Li, Jingping Hu, Xiangyang Zang, Jibin Xing, Xingying Mo, Ziqing Hei, Chulian Gong, Chaojin Chen, Shaoli Zho. Etomidate Improves the Antidepressant Effect of Electroconvulsive Therapy by Suppressing Hippocampal Neuronal Ferroptosis via Upregulating BDNF/Nrf2. Molecular neurobiology. 2023-07-19. PMID:37466875. |
compared to depressive rats without ect, those who received ect showed increased numbers of hippocampal neurons, increased expression of negative regulators of ferroptosis including glutathione peroxidase 4, ferritin heavy chain 1, and ferroptosis suppressor protein 1, upregulation of brain-derived neurotrophic factor and nuclear factor erythroid 2-related factor, and downregulation of acyl-coa synthetase long-chain family member 4, a positive regulator of ferroptosis in the hippocampus. |
2023-07-19 |
2023-08-14 |
rat |
| Chenjie Ge, Shiliang Wang, Xuqi Wu, Lilei Le. Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice. Journal of chemical neuroanatomy. 2023-07-19. PMID:37468078. |
quercetin also suppressed caspase-3 content but advanced vascular endothelial growth factor (vegf) and brain derived neurotrophic factor (bdnf) contents in hippocampus of cort-treated mice. |
2023-07-19 |
2023-08-14 |
mouse |
| James T Sangma, Amit K Trived. Light at night: effect on the daily clock, learning, memory, cognition, and expression of transcripts in different brain regions of rat. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023-06-19. PMID:37337065. |
in experiment three, after 30 days of treatment, animals were sampled, and transcript levels of brain-derived neurotrophic factor, tyrosine kinase, growth-associated protein 43, neurogranin, microrna-132, camp response element-binding protein, glycogen synthase kinase-3β, and tumor necrosis factor α were measured in hippocampus, thalamus, and cortex tissues. |
2023-06-19 |
2023-08-14 |
rat |
| Shaun Cade, Xin-Fu Zhou, Larisa Bobrovskay. An Imbalance in the Pro/mature BDNF Ratio Occurs in Multiple Brain Regions During Normal Ageing in Wild-Type Mice. Journal of molecular neuroscience : MN. 2023-06-14. PMID:37314606. |
the precursor of brain-derived neurotrophic factor, a well characterized neurotrophin, is increased in the hippocampus of aged rodents, while its mature isoform is relatively stable. |
2023-06-14 |
2023-08-14 |
mouse |
| Xiaoyu Dong, Dongxue Zha. Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies. CNS neuroscience & therapeutics. 2023-05-15. PMID:37183361. |
the mechanisms are achieved by enhancing monoamine oxidase a (moa) activity, inhibiting microglia activation and inflammatory factor release, anti-oxidative stress, promoting hippocampal nerve regeneration, increasing brain-derived neurotrophic factor secretion, regulating gut microbiome, and activating protein kinase b/collapsin response mediator protein 2 (akt/crmp2) signaling pathway. |
2023-05-15 |
2023-08-14 |
human |
| Yue-Ming Zhang, Ru-Meng Wei, Xue-Yan Li, Yi-Zhou Feng, Kai-Xuan Zhang, Yi-Jun Ge, Xiao-Yi Kong, Xue-Chun Liu, Gui-Hai Che. Long-term environmental enrichment overcomes depression, learning, and memory impairment in elderly CD-1 mice with maternal sleep deprivation exposure. Frontiers in aging neuroscience. vol 15. 2023-05-11. PMID:37168717. |
these effects were accompanied by upregulated interleukin (il)-1β, il-6, and tumor necrosis factor-α expression, and downregulated brain-derived neurotrophic factor, tyrosine kinase receptor b, postsynaptic density-95, and synaptophysin expression in the hippocampus. |
2023-05-11 |
2023-08-14 |
mouse |
| Chengcheng Guo, Yang Yao, Chunchao Ma, Zhiyun Wan. High-intensity interval training improves cognitive impairment of vascular dementia rats by up-regulating expression of brain-derived neurotrophic factor in the hippocampus. Neuroreport. vol 34. issue 8. 2023-04-27. PMID:37104097. |
high-intensity interval training improves cognitive impairment of vascular dementia rats by up-regulating expression of brain-derived neurotrophic factor in the hippocampus. |
2023-04-27 |
2023-08-14 |
rat |
| Reine Khoury, Joelle Saad, Vanessa Jabre, Litsa Maria Ghayad, Mohamad Khalifeh, Rouba Houbeika, Perla El Ahmad, Amar Mezher, Diala El Masri, Zena Haddad, Fady Eid, Nour Barmo, Patrick Nasrallah, Sama F Sleiman, Joseph S Stepha. Autophagy regulates the release of exercise factors and their beneficial effects on spatial memory recall. Heliyon. vol 9. issue 4. 2023-04-07. PMID:37025840. |
the positive effects of exercise are mediated by circulatory factors that predominantly increase brain derived neurotrophic factor (bdnf) signaling in the hippocampus. |
2023-04-07 |
2023-08-14 |
Not clear |
| Yang Du, Yan-Li Wang, Lei Chen, Qi-En Li, Yong Chen. Anti-depressant-like effects of rannasangpei and its active ingredient crocin-1 on chronic unpredictable mild stress mice. Frontiers in pharmacology. vol 14. 2023-04-03. PMID:37007014. |
moreover, our data indicated that rsnp or crocin-1 increased astrocyte number and brain-derived neurotrophic factor levels in the hippocampus of cums-treated mice after rsnp or crocin-1 administration. |
2023-04-03 |
2023-08-14 |
mouse |
| Einat K Brenner, Alexandra J Weigand, Lauren Edwards, Kelsey R Thomas, Emily C Edmonds, Mark W Bondi, Katherine J Bange. Brain Derived Neurotrophic Factor Interacts with White Matter Hyperintensities to Influence Processing Speed and Hippocampal Volume in Older Adults. Journal of Alzheimer's disease : JAD. 2023-03-27. PMID:36970903. |
brain derived neurotrophic factor interacts with white matter hyperintensities to influence processing speed and hippocampal volume in older adults. |
2023-03-27 |
2023-08-14 |
Not clear |
| Yawen Zhang, Rui Ma, Qian Deng, Wencheng Wang, Chi Cao, Chunyang Yu, Shulin Li, Lei Shi, Jianying Tia. S-adenosylmethionine Improves Cognitive Impairment in D-galactose-Induced Brain Aging by Inhibiting Oxidative Stress and Neuroinflammation. Journal of chemical neuroanatomy. 2023-01-12. PMID:36632907. |
sam reduced neuronal cell loss, increased brain-derived neurotrophic factor level in the hippocampus, inhibited amyloid-β level and microglia activation, as well as pro-inflammatory factors levels in the hippocampus and serum. |
2023-01-12 |
2023-08-14 |
rat |
| Ning Jiang, Yiwen Zhang, Caihong Yao, Yupei Liu, Yuzhen Chen, Fang Chen, Yan Wang, Muhammad Iqbal Choudhary, Xinmin Li. Tenuifolin ameliorates the sleep deprivation-induced cognitive deficits. Phytotherapy research : PTR. 2023-01-07. PMID:36608695. |
additionally, ten restored the downregulation of the brain-derived neurotrophic factor signaling cascade and the impaired hippocampal neurogenesis induced by sd. |
2023-01-07 |
2023-08-14 |
mouse |
| Wei Sun, Min Wen, Min Liu, Qingpeng Wang, Quiqin Liu, Lanjie Li, Hans-Christian Siebert, Gabriele Loers, Ruiyan Zhang, Ning Zhan. Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model. Frontiers in aging neuroscience. vol 14. 2022-12-19. PMID:36533180. |
the results showed that bhb treatment improved behavioral performance, prevented myelin loss, decreased the activation of astrocyte as well as microglia, and up-regulated the neurotrophin brain-derived neurotrophic factor in both the corpus callosum and hippocampus. |
2022-12-19 |
2023-08-14 |
mouse |