| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Hock, K Heese, C Hulette, C Rosenberg, U Otte. Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Archives of neurology. vol 57. issue 6. 2000-07-13. PMID:10867782. |
region-specific neurotrophin imbalances in alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. |
2000-07-13 |
2023-08-12 |
Not clear |
| H F Farhadi, S J Mowla, K Petrecca, S J Morris, N G Seidah, R A Murph. Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818141. |
neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor. |
2000-06-15 |
2023-08-12 |
Not clear |
| R M Holsinger, J Schnarr, P Henry, V T Castelo, M Fahnestoc. Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain research. Molecular brain research. vol 76. issue 2. 2000-06-05. PMID:10762711. |
furthermore, brain-derived neurotrophic factor regulates the function of hippocampal and cortical neurons. |
2000-06-05 |
2023-08-12 |
human |
| R M Holsinger, J Schnarr, P Henry, V T Castelo, M Fahnestoc. Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain research. Molecular brain research. vol 76. issue 2. 2000-06-05. PMID:10762711. |
a decrease in brain-derived neurotrophic factor synthesis could have detrimental effects on hippocampal, cortical and basal forebrain cholinergic neurons and may account for their selective vulnerability in alzheimer's disease. |
2000-06-05 |
2023-08-12 |
human |
| M M Bolton, A J Pittman, D C L. Brain-derived neurotrophic factor differentially regulates excitatory and inhibitory synaptic transmission in hippocampal cultures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 9. 2000-06-02. PMID:10777787. |
brain-derived neurotrophic factor differentially regulates excitatory and inhibitory synaptic transmission in hippocampal cultures. |
2000-06-02 |
2023-08-12 |
Not clear |
| S Reibel, B Vivien-Roels, B T Lê, Y Larmet, J Carnahan, C Marescaux, A Depauli. Overexpression of neuropeptide Y induced by brain-derived neurotrophic factor in the rat hippocampus is long lasting. The European journal of neuroscience. vol 12. issue 2. 2000-05-25. PMID:10712639. |
overexpression of neuropeptide y induced by brain-derived neurotrophic factor in the rat hippocampus is long lasting. |
2000-05-25 |
2023-08-12 |
rat |
| D Muller, Z Djebbara-Hannas, P Jourdain, L Vutskits, P Durbec, G Rougon, J Z Kis. Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 8. 2000-05-17. PMID:10760298. |
brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus. |
2000-05-17 |
2023-08-12 |
mouse |
| E Carro, A Nuñez, S Busiguina, I Torres-Alema. Circulating insulin-like growth factor I mediates effects of exercise on the brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 8. 2000-05-15. PMID:10751445. |
thus, brain uptake of igf-i after either intracarotid injection or after exercise elicited the same pattern of neuronal accumulation of igf-i, an identical widespread increase in neuronal c-fos, and a similar stimulation of hippocampal brain-derived neurotrophic factor. |
2000-05-15 |
2023-08-12 |
rat |
| K D Murray, P J Isackson, T A Eskin, M A King, S P Montesinos, L A Abraham, S N Rope. Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. The Journal of comparative neurology. vol 418. issue 4. 2000-04-12. PMID:10713570. |
altered mrna expression for brain-derived neurotrophic factor and type ii calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. |
2000-04-12 |
2023-08-12 |
Not clear |
| K D Murray, P J Isackson, T A Eskin, M A King, S P Montesinos, L A Abraham, S N Rope. Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. The Journal of comparative neurology. vol 418. issue 4. 2000-04-12. PMID:10713570. |
both calcium/calmodulin-dependent protein kinase ii and brain-derived neurotrophic factor are localized heavily within the hippocampus and have been implicated in regulating hippocampal activity (kang and schuman [1995] science 267:1658-1662; suzuki [1994] intl j biochem 26:735-744). |
2000-04-12 |
2023-08-12 |
Not clear |
| K D Murray, P J Isackson, T A Eskin, M A King, S P Montesinos, L A Abraham, S N Rope. Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. The Journal of comparative neurology. vol 418. issue 4. 2000-04-12. PMID:10713570. |
also, the autocrine and paracrine actions of brain-derived neurotrophic factor within the central nervous system make it a likely candidate for mediating morphologic changes typically seen in the epileptic hippocampus. |
2000-04-12 |
2023-08-12 |
Not clear |
| K D Murray, P J Isackson, T A Eskin, M A King, S P Montesinos, L A Abraham, S N Rope. Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. The Journal of comparative neurology. vol 418. issue 4. 2000-04-12. PMID:10713570. |
relative to autopsy control tissue, decreased hybridization to mrna of the alpha subunit of calcium/calmodulin-dependent protein kinase ii and increased hybridization to brain-derived neurotrophic factor mrna were found throughout the granule cells of the epileptic hippocampus. |
2000-04-12 |
2023-08-12 |
Not clear |
| P R Blanque. Identification of two persistently activated neurotrophin-regulated pathways in rat hippocampus. Neuroscience. vol 95. issue 3. 2000-03-01. PMID:10670437. |
brain-derived neurotrophic factor contributes profoundly to modulate activity-dependent synaptic plasticity in adult brain areas such as the hippocampus, but the mechanisms underlying this important role still remain unclear. |
2000-03-01 |
2023-08-12 |
rat |
| P R Blanque. Identification of two persistently activated neurotrophin-regulated pathways in rat hippocampus. Neuroscience. vol 95. issue 3. 2000-03-01. PMID:10670437. |
recently, we have shown that two serine/threonine kinases, calcium/calmodulin-dependent protein kinase-2 and casein kinase-2, are capable of mediating brain-derived neurotrophic factor responses in adult rat hippocampus. |
2000-03-01 |
2023-08-12 |
rat |
| P R Blanque. Identification of two persistently activated neurotrophin-regulated pathways in rat hippocampus. Neuroscience. vol 95. issue 3. 2000-03-01. PMID:10670437. |
in the present study, using hippocampal slices from adult rat, we show that phospholipase c-regulated calcium signals couple the brain-derived neurotrophic factor receptor to two distinct pathways: a pathway in which calcium/calmodulin-dependent protein kinase-2 stimulates a signalling module involving the p38 subfamily of mitogen-activated protein kinases and its downstream target, usually named mitogen-activated protein kinase-activated protein kinase-2; and a pathway in which the extracellular signal-regulated kinase subfamily of mitogen-activated protein kinases activates casein kinase-2. |
2000-03-01 |
2023-08-12 |
rat |
| S D Croll, C Suri, D L Compton, M V Simmons, G D Yancopoulos, R M Lindsay, S J Wiegand, J S Rudge, H E Scharfma. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501474. |
brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. |
1999-12-09 |
2023-08-12 |
mouse |
| S D Croll, C Suri, D L Compton, M V Simmons, G D Yancopoulos, R M Lindsay, S J Wiegand, J S Rudge, H E Scharfma. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501474. |
hippocampal slices from brain-derived neurotrophic factor transgenic mice showed hyperexcitability in area ca3 and entorhinal cortex, but not in dentate gyrus. |
1999-12-09 |
2023-08-12 |
mouse |
| P Osehobo, B Adams, M Sazgar, Y Xu, R J Racine, M Fahnestoc. Brain-derived neurotrophic factor infusion delays amygdala and perforant path kindling without affecting paired-pulse measures of neuronal inhibition in adult rats. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426491. |
kindling also increases the expression of nerve growth factor, brain-derived neurotrophic factor, and brain-derived neurotrophic factor receptor messenger rnas in both the hippocampus and cerebral cortex and causes structural changes in the hippocampus including hilar hypertrophy. |
1999-10-08 |
2023-08-12 |
human |
| P Osehobo, B Adams, M Sazgar, Y Xu, R J Racine, M Fahnestoc. Brain-derived neurotrophic factor infusion delays amygdala and perforant path kindling without affecting paired-pulse measures of neuronal inhibition in adult rats. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426491. |
acute injection of brain-derived neurotrophic factor increases neuronal excitability and causes seizures, whereas chronic brain-derived neurotrophic factor infusion in rats slows hippocampal kindling. |
1999-10-08 |
2023-08-12 |
human |
| P Osehobo, B Adams, M Sazgar, Y Xu, R J Racine, M Fahnestoc. Brain-derived neurotrophic factor infusion delays amygdala and perforant path kindling without affecting paired-pulse measures of neuronal inhibition in adult rats. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426491. |
brain-derived neurotrophic factor infused into the hippocampus had no effect on the stimulus intensity function (input/output curves); there was also no significant effect on paired-pulse inhibition. |
1999-10-08 |
2023-08-12 |
human |