| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaohui Jiang, Lina Chen, Zhongyuan Zheng, Ying Chen, Xiaogang Weng, Yuan Guo, Kai Li, Ting Yang, Shuiqing Qu, Hui Liu, Yujie Li, Xiaoxin Zh. Synergistic Effect of Combined Artesunate and Tetramethylpyrazine in Experimental Cerebral Malaria. ACS infectious diseases vol 6 issue 9 2021 32786270 |
this combination downregulated the expression of adhesion molecules and sequestration of parasitized red blood cells (prbcs), increased cerebral blood flow, nerve growth factor (b-ngf), vascular endothelial growth factor a (vegf-a), and neurotrophin (brain-derived neurotrophic factor (bdnf), neurotrophic factor-3 (nt-3)) levels, and alleviated hippocampal neuronal damage and astrocyte activation. |
2021-06-23 |
2022-01-13 |
Not clear |
| Ge Wang, Hongyang Zhang, Jiancong Sun, Yuwei Zhang, Fen He, Juntao Zo. Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-\\xce\\xb3-Shh-BDNF pathway. International immunopharmacology vol 96 issue 2021 33993101 |
however, the shh pathway receptor agonist sag could block the impairment of cognitive ability and the decrease of hippocampal neurogenesis and brain-derived neurotrophic factor (bdnf) level induced by csa. |
2021-06-22 |
2022-01-13 |
Not clear |
| Min-Tae Jeon, Gyeong Joon Moon, Sehwan Kim, Minji Choi, Yong-Seok Oh, Dong Woon Kim, Hyung-Jun Kim, Kea Joo Lee, Youngshik Choe, Chang Man Ha, Il-Sung Jang, Michiko Nakamura, Catriona McLean, Won-Suk Chung, Won-Ho Shin, Seok-Geun Lee, Sang Ryong Ki. Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo. British journal of pharmacology vol 177 issue 3 2021 31658360 |
we recently reported that aav1-rheb(s16h) transduction could protect hippocampal neurons through the induction of brain-derived neurotrophic factor (bdnf) in the rat hippocampus in vivo. |
2021-06-21 |
2022-01-13 |
Not clear |
| Siqing Zhu, Shouguo Zhang, Lulu Pang, Ge Ou, Lin Zhu, Jinqiu Ma, Ruiteng Li, Yijing Liu, Lin Wang, Lifeng Wang, Lina Du, Yiguang Ji. Effects of armodafinil nanocrystal nasal hydrogel on recovery of cognitive function in sleep-deprived rats. International journal of pharmaceutics vol 597 issue 2021 33545288 |
moreover, we speculated that armodafinil ncsg had a protective effect on hippocampal neurons in cortical area 1 (ca1), which is closely related to cognitive function, by upregulating brain-derived neurotrophic factor (bdnf) protein expression. |
2021-06-17 |
2022-01-13 |
Not clear |
| Jizu Ling, Qin Yu, Yuning Li, Xinhui Yuan, Xiaoya Wang, Weiying Liu, Ting Guo, Yanni Duan, Lifang L. Edaravone Improves Intermittent Hypoxia-Induced Cognitive Impairment and Hippocampal Damage in Rats. Biological & pharmaceutical bulletin vol 43 issue 8 2021 32475934 |
furthermore, edaravone significantly increased the inhibition of hydroxyl free radicals; reduced expressions of superoxide anion, malondialdehyde, and 8-hydroxy-2'-deoxyguanosine; and upregulated the expression of manganese superoxide dismutase, catalase, camp, protein kinase a, phosphorylated-camp response element-binding (p-creb), b-cell lymphoma 2, and brain-derived neurotrophic factor in the hippocampal tissue of ih rats. |
2021-05-28 |
2022-01-13 |
Not clear |
| Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itak. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle. Biomaterials vol 270 issue 2021 33517206 |
by intraventricular administration of mrna encoding brain-derived neurotrophic factor (bdnf) using a polymer-based carrier, polyplex nanomicelle, the mrna significantly increased the survival rate of hippocampal neurons after tgi, with a rapid rise of bdnf in the hippocampus. |
2021-05-25 |
2022-01-13 |
Not clear |
| Paula Moyano, Javier Sanjuan, Jos\\xc3\\xa9 Manuel Garc\\xc3\\xada, Mar\\xc3\\xada Jos\\xc3\\xa9 Anadon, Maria Victoria Naval, Emma Sola, Jimena Garc\\xc3\\xada, Mar\\xc3\\xada Teresa Frejo, Javier Del Pin. Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol 144 issue 2021 32738378 |
primary hippocampal wildtype or \xce\xb2app-tau silenced cells were co-treated with pq with or without e2, n-acetylcysteine (nac), ns-398 (cyclooxygenase-2 inhibitor), mf63 (pges-1 inhibitor) and/or recombinant brain-derived neurotrophic factor (bdnf) during one- and fourteen-days to studied pq effect on prostaglandin e2 (pge2) and bdnf signaling and their involvement in hyperphosphorylated tau (ptau) and amyloid-beta (a\xce\xb2) protein formation, and oxidative stress generation, that lead to neuronal cell loss through estrogenic disruption, as a possible mechanism of cognitive dysfunctions produced by pq. |
2021-05-21 |
2022-01-13 |
Not clear |
| Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J Gonzalez, Kalipada Paha. Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPAR\\xce\\xb1. JCI insight vol 5 issue 10 2021 32315292 |
this study underlines the importance of hex in inducing the expression of brain-derived neurotrophic factor (bdnf) from hippocampal neurons via ppar\xce\xb1. |
2021-05-18 |
2022-01-13 |
Not clear |
| Byoungjin Park, Yong-Jae Le. Pterostilbene Improves Stress-Related Behaviors and Partially Reverses Underlying Neuroinflammatory and Hormonal Changes in Stress-Challenged Mice. Journal of medicinal food vol 24 issue 3 2021 33739881 |
hippocampal brain-derived neurotrophic factor (bdnf) levels, endocrine hormone levels, oxidative stress parameters, and histopathological features were assessed. |
2021-05-14 |
2022-01-13 |
Not clear |
| Shouhei Miyazaki, Yoshio Fujita, Hirotaka Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikaw. Combination of syringaresinol-di-O-\\xce\\xb2-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Scientific reports vol 10 issue 1 2021 33097741 |
it also induces glucocorticoid production and changes in hippocampal brain-derived neurotrophic factor (bdnf) levels. |
2021-05-10 |
2022-01-13 |
Not clear |
| Bingjie Yang, Guodong Luo, Chen Zhang, Luqiu Feng, Xianmei Luo, Ling Ga. Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway. Scientific reports vol 10 issue 1 2021 33335121 |
in the present study, for the first time, the protective effects of curcumin against prv-induced oxidative stress, apoptosis, and mitochondrial dysfunction in rat hippocampal neurons and the brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) pathway were investigated. |
2021-05-10 |
2022-01-13 |
Not clear |
| Masahiro To, Masahiro Sugimoto, Juri Saruta, Yuko Yamamoto, Wakako Sakaguchi, Akira Kawata, Masato Matsuo, Keiichi Tsukinok. Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics. Journal of clinical medicine vol 10 issue 8 2021 33920851 |
specifically, cognitive impairment can be induced by decreased hippocampal brain-derived neurotrophic factor (bdnf) expression. |
2021-05-02 |
2022-01-13 |
Not clear |
| Fabienne Agasse, Indira Mendez-David, Wilhelm Christaller, R\\xc3\\xa9mi Carpentier, Barbara Y Braz, Denis J David, Fr\\xc3\\xa9d\\xc3\\xa9ric Saudou, Sandrine Humber. Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin. Cell reports vol 32 issue 1 2021 32640230 |
chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (cort) correlates with reduced levels of both brain-derived neurotrophic factor (bdnf) and hippocampal neurogenesis. |
2021-04-28 |
2022-01-13 |
Not clear |
| Thomas H Lee, Brian R Christie, Henriette van Praag, Kangguang Lin, Parco Ming-Fai Siu, Aimin Xu, Kwok-Fai So, Suk-Yu Ya. AdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis. International journal of molecular sciences vol 22 issue 4 2021 33669795 |
immunosorbent assays were used to measure the serum levels of factors that can regulate hippocampal neurogenesis, including adiponectin, brain-derived neurotrophic factor (bdnf), and corticosterone. |
2021-04-15 |
2022-01-13 |
Not clear |
| Qian Zhou, Ayumi Suzuki, Mitsuo Iinuma, Ke-Yong Wang, Kin-Ya Kubo, Kagaku Azum. Effects of Maternal Chewing on Prenatal Stress-Induced Cognitive Impairments in the Offspring via Multiple Molecular Pathways. International journal of molecular sciences vol 21 issue 16 2021 32781547 |
immunohistochemistry and western blot findings revealed that maternal chewing alleviated hippocampal neurogenesis impairment and increased the expression of hippocampal brain-derived neurotrophic factor in the offspring. |
2021-02-18 |
2022-01-13 |
Not clear |
| Qian Zhou, Ayumi Suzuki, Mitsuo Iinuma, Ke-Yong Wang, Kin-Ya Kubo, Kagaku Azum. Effects of Maternal Chewing on Prenatal Stress-Induced Cognitive Impairments in the Offspring via Multiple Molecular Pathways. International journal of molecular sciences vol 21 issue 16 2021 32781547 |
our findings suggest that maternal chewing could ameliorate prenatal stress-induced cognitive impairments in the offspring at least in part by protecting placenta barrier function, alleviating hippocampal nuclear gr transport impairment and increasing the hippocampal brain-derived neurotrophic factor (bdnf) level. |
2021-02-18 |
2022-01-13 |
Not clear |
| Cong-Rong Tang, Xu-Ben Yu, Hai-Na Zhang, Yan-Cheng Cao, Fan Yang, Lei-Mei Xu, Ruo-Lan Sun, Zi Ye, Ye-Xuan Wang, Jin Lian. Lovastatin Prevents Depressive Behaviors and Increased Hippocampal Neurogenesis in Streptozotocin-Induced Diabetic Mice. Pharmacology vol 105 issue 5-6 2021 31722363 |
the study further showed that these treatments improved the hippocampal neurogenesis as evidenced by increased bromodeoxyuridine-positive cells in the dentate gyrus with higher expression of mature brain-derived neurotrophic factor and increased phosphorylation of camp-response element-binding protein. |
2021-02-03 |
2022-01-14 |
Not clear |
| Xiaoxia Huang, Wu Li, Bangyan You, Wanpei Tang, Tingsheng Gan, Chao Feng, Congfa Li, Ruili Yan. Serum Metabonomic Study on the Antidepressant-like Effects of Ellagic Acid in a Chronic Unpredictable Mild Stress-Induced Mouse Model. Journal of agricultural and food chemistry vol 68 issue 35 2021 32786855 |
furthermore, ea attenuated the cums-induced hippocampal damage and significantly increased the brain-derived neurotrophic factor (bdnf) and the serotonin (5-ht) levels as well as suppressed the inflammatory response. |
2021-02-03 |
2022-01-13 |
Not clear |
| Yue Liu, Wenqian Tang, Chunhui Ji, Jianghong Gu, Yanmei Chen, Jie Huang, Xinyi Zhao, Yingfang Sun, Chengniu Wang, Wei Guan, Jianfeng Liu, Bo Jian. The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway. Frontiers in pharmacology vol 11 issue 2021 33519490 |
arn-3236 treatment also completely reversed the down-regulating effects of csds and cums on the hippocampal brain-derived neurotrophic factor (bdnf) system and neurogenesis. |
2021-02-02 |
2022-01-13 |
Not clear |
| Amin Mokhtari-Zaer, Saeideh Saadat, Narges Marefati, Mahmoud Hosseini, Mohammad Hossein Boskabad. Treadmill exercise restores memory and hippocampal synaptic plasticity impairments in ovalbumin-sensitized juvenile rats: Involvement of brain-derived neurotrophic factor (BDNF). Neurochemistry international vol 135 issue 2021 31982414 |
treadmill exercise restores memory and hippocampal synaptic plasticity impairments in ovalbumin-sensitized juvenile rats: involvement of brain-derived neurotrophic factor (bdnf). |
2021-01-25 |
2022-01-13 |
Not clear |