All Relations between fatty acid amide hydrolase and hippocampus

Publication Sentence Publish Date Extraction Date Species
Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M Kogan, Aron Welle. Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835237. serum levels of brain-derived neurotrophic factor (bdnf), numerous endocannabinoids and hippocampal fatty acid amide hydrolase (faah) levels were assessed. 2023-02-25 2023-08-14 human
Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M Kogan, Aron Welle. Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835237. the effect of cbda-me in females was accompanied by elevated serum bdnf and some endocannabinoids and low hippocampal expression of faah. 2023-02-25 2023-08-14 human
Jeremy J Watts, Elisa Guma, Sofia Chavez, Rachel F Tyndale, Ruth A Ross, Sylvain Houle, Alan A Wilson, Mallar Chakravarty, Pablo M Rusjan, Romina Mizrah. In vivo brain endocannabinoid metabolism is related to hippocampus glutamate and structure - a multimodal imaging study with PET, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-07-29. PMID:35906490. although preclinical studies provide strong evidence linking anandamide and faah to hippocampus neurotransmission and structure, these relationships remain poorly understood in humans. 2022-07-29 2023-08-14 Not clear
Jeremy J Watts, Elisa Guma, Sofia Chavez, Rachel F Tyndale, Ruth A Ross, Sylvain Houle, Alan A Wilson, Mallar Chakravarty, Pablo M Rusjan, Romina Mizrah. In vivo brain endocannabinoid metabolism is related to hippocampus glutamate and structure - a multimodal imaging study with PET, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-07-29. PMID:35906490. we recruited young adults with and without psychotic disorders and measured faah activity, hippocampal glutamate and glutamine (glx), and hippocampal volume using [ 2022-07-29 2023-08-14 Not clear
Sherif S Abdel Mageed, Ramy M Ammar, Noha N Nassar, Helmy Moawad, Ahmed S Kame. Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat. Neuropharmacology. 2021-12-30. PMID:34968475. role of pi3k/akt axis in mitigating hippocampal ischemia-reperfusion injury via cb1 receptor stimulation by paracetamol and faah inhibitor in rat. 2021-12-30 2023-08-13 rat
Jing Liu, Kirstin Hester, Carey Pop. Dose- and time-related effects of acute diisopropylfluorophosphate intoxication on forced swim behavior and sucrose preference in rats. Neurotoxicology. vol 82. 2021-10-29. PMID:33232745. adult male rats were treated with vehicle (peanut oil, 1 ml/kg, sc) or dfp (2.0, 2.25 or 2.5 mg/kg) followed by sacrifice 4 h later for measurement of op-sensitive serine hydrolases (cholinesterase [che], fatty acid amide hydrolase [faah], and monoacylglycerol lipase [magl]) in hippocampus. 2021-10-29 2023-08-13 rat
Dorsa Rafiei, Nathan J Koll. Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review. International journal of molecular sciences. vol 22. issue 3. 2021-09-06. PMID:33494322. three key findings emerged: (1) faah expression is significantly increased in depressive-like phenotypes; (2) genetic knockout or pharmacological inhibition of faah effectively reduces depressive-like behavior, with a dose-dependent effect; and (3) differences in faah expression in depressive-like phenotypes were largely localized to animal prefrontal cortex, hippocampus and striatum. 2021-09-06 2023-08-13 Not clear
Shirley Alteba, Tomer Mizrachi Zer-Aviv, Adi Tenenhaus, Gilad Ben David, Jacob Adelman, Cecilia J Hillard, Ravid Doron, Irit Akira. Antidepressant-like effects of URB597 and JZL184 in male and female rats exposed to early life stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 39. 2021-08-26. PMID:32891517. faah and magl inhibitors during late-adolescence prevented: (i) the long-term effects of els on depression- and anxiety-like behavior and the impairment in social behavior and neuronal plasticity in males and females; (ii) els-induced alterations in magl activity in males' hippocampus and females' hippocampus and nac; and (iii) els-induced alterations in bdnf in males' hippocampus and nac and females' hippocampus. 2021-08-26 2023-08-13 rat
Luca Carnevali, Rosario Statello, Federica Vacondio, Francesca Ferlenghi, Gilberto Spadoni, Silvia Rivara, Marco Mor, Andrea Sgoif. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31948828. conversely, pharmacological inhibition of faah activity with urb694 restored both aea and bdnf levels within the hippocampus of socially isolated rats and prevented the development of behavioral and physiological alterations. 2021-08-10 2023-08-13 rat
Luca Carnevali, Rosario Statello, Federica Vacondio, Francesca Ferlenghi, Gilberto Spadoni, Silvia Rivara, Marco Mor, Andrea Sgoif. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31948828. these results suggest a potential interplay between aea-mediated signaling and hippocampal bdnf in the pathogenesis of depression-relevant behaviors and physiological alterations and antidepressant action of faah inhibition in socially isolated female rats. 2021-08-10 2023-08-13 rat
Erica Zamberletti, Marina Gabaglio, Marie Woolley-Roberts, Sharon Bingham, Tiziana Rubino, Daniela Parolar. Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31447649. prenatal vpa exposure increased cb1 receptor, faah and magl levels, enhanced gfap, cd11b, and tnfα levels and triggered microglia activation restricted to the hippocampus. 2020-09-29 2023-08-13 rat
Manjunath Lamani, Michael S Malamas, Shrouq I Farah, Vidyanand G Shukla, Michael F Almeida, Catherine M Weerts, Joseph Anderson, JodiAnne T Wood, Karen L G Farizatto, Ben A Bahr, Alexandros Makriyanni. Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology. Bioorganic & medicinal chemistry. vol 27. issue 23. 2020-09-24. PMID:31629610. faah inhibitors 9 and 31 were evaluated for neuroprotection in rat hippocampal slice cultures. 2020-09-24 2023-08-13 human
I Smaga, D Gawlinski, J Brodowicz, M Fili. Brain region-dependent changes in the expression of endocannabinoid-metabolizing enzymes in rats following antidepressant drugs. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 70. issue 5. 2020-06-15. PMID:31889042. on the other hand, esc treatment provoked an increase in the magl expression in the prefrontal cortex or nape-pld and in daglα in the hippocampus and dorsal striatum, while reducing the faah expression in the dorsal striatum. 2020-06-15 2023-08-13 rat
Roberto Colangeli, Massimo Pierucci, Arcangelo Benigno, Giuseppe Campiani, Stefania Butini, Giuseppe Di Giovann. Author Correction: The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity. Scientific reports. vol 8. issue 1. 2020-05-11. PMID:30546129. author correction: the faah inhibitor urb597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity. 2020-05-11 2023-08-13 Not clear
Hsiao-Jou Cortina Chen, Jereme G Spiers, Conrad Sernia, Nickolas A Lavidi. Inhibition of Fatty Acid Amide Hydrolase by PF-3845 Alleviates the Nitrergic and Proinflammatory Response in Rat Hippocampus Following Acute Stress. The international journal of neuropsychopharmacology. vol 21. issue 8. 2020-04-07. PMID:29579222. inhibition of fatty acid amide hydrolase by pf-3845 alleviates the nitrergic and proinflammatory response in rat hippocampus following acute stress. 2020-04-07 2023-08-13 rat
Tina Zimmermann, Julia C Bartsch, Annika Beer, Ermelinda Lomazzo, Stephan Guggenhuber, Maren D Lange, Laura Bindila, Hans-Christian Pape, Beat Lut. Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 8. 2020-03-31. PMID:30532004. in the present study, using the cre/loxp system combined with an adeno-associated virus (aav)-mediated delivery system, faah was selectively overexpressed in hippocampal ca1-ca3 glutamatergic neurons of adult mice. 2020-03-31 2023-08-13 mouse
Tina Zimmermann, Julia C Bartsch, Annika Beer, Ermelinda Lomazzo, Stephan Guggenhuber, Maren D Lange, Laura Bindila, Hans-Christian Pape, Beat Lut. Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 8. 2020-03-31. PMID:30532004. this approach led to specific faah overexpression at the postsynaptic site of ca1-ca3 neurons, to increased faah enzymatic activity, and, in consequence, to decreased hippocampal levels of aea and palmitoylethanolamide (pea), but the levels of the second major endocannabinoid 2-arachidonoyl glycerol (2-ag) and of oleoylethanolamide (oea) were unchanged. 2020-03-31 2023-08-13 mouse
Roberto Colangeli, Massimo Pierucci, Arcangelo Benigno, Giuseppe Campiani, Stefania Butini, Giuseppe Di Giovann. Author Correction: The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity. Scientific reports. vol 8. issue 1. 2019-11-20. PMID:29531281. author correction: the faah inhibitor urb597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity. 2019-11-20 2023-08-13 Not clear
Gaëtan Philippot, Stefan Hallgren, Torsten Gordh, Anders Fredriksson, Robert Fredriksson, Henrik Viber. A Cannabinoid Receptor Type 1 (CB1R) Agonist Enhances the Developmental Neurotoxicity of Acetaminophen (Paracetamol). Toxicological sciences : an official journal of the Society of Toxicology. vol 166. issue 1. 2019-10-17. PMID:30165669. these adult adverse effects may at least in part be explained by a reduction of transcript levels of hippocampal synaptophysin (syp) and tropomyosin receptor kinase b (trkb), and cerebral cortical fatty acid amide hydroxylase (faah), 24 h after exposure. 2019-10-17 2023-08-13 mouse
Patricia Rivera, María Del Mar Fernández-Arjona, Daniel Silva-Peña, Eduardo Blanco, Antonio Vargas, María Dolores López-Ávalos, Jesús M Grondona, Antonia Serrano, Francisco Javier Pavón, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30098312. pharmacological blockade of fatty acid amide hydrolase (faah) by urb597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure. 2019-07-08 2023-08-13 rat