All Relations between fatty acid amide hydrolase and cannabinoids

Reference Sentence Publish Date Extraction Date Species
Chaoling Chen, Weili Wang, Justin L Poklis, Aron H Lichtman, Joseph K Ritter, Gaizun Hu, Dengpiao Xie, Ningjun L. Inactivation of fatty acid amide hydrolase protects against ischemic reperfusion injury-induced renal fibrogenesis. Biochimica et biophysica acta. Molecular basis of disease vol issue 2022 35710061 although cannabinoid receptors (cb) are recognized as targets for renal fibrosis, the role of endogenous cannabinoid anandamide (aea) and its primary hydrolytic enzyme, fatty acid amide hydrolase (faah), in renal fibrogenesis remains unclear. 2022-06-16 2022-06-20 Not clear
Farinaz Ghaderi, Fattah Sotoodehnejadnematalahi, Zahra Hajebrahimi, Abolfazl Fateh, Seyed Davar Siada. Effects of active, inactive, and derivatives of Akkermansia muciniphila on the expression of the endocannabinoid system and PPARs genes. Scientific reports vol 12 issue 1 2022 35705595 this study aimed to investigate the effects of active and heat-inactivated forms of akkermansia muciniphila, bacterium-derived outer membrane vesicles (omvs), and cell-free supernatant on the transcription of endocannabinoid system (ecs) members, including cannabinoid receptors 1 and 2 (cb1 and cb2), fatty acid amide hydrolase (faah), and peroxisome proliferator-activated receptors (ppars) genes (i.e., \xce\xb1, \xce\xb2/\xce\xb4, and \xce\xb4) in caco-2 and hepg-2 cell lines. 2022-06-15 2022-06-20 Not clear
Veronica Lunerti, Hongwu Li, Federica Benvenuti, Qianwei Shen, Ana Domi, Laura Soverchia, Rita Maria Concetta Di Martino, Giovanni Bottegoni, Carolina L Haass-Koffler, Nazzareno Cannell. The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats. European journal of pharmacology vol issue 2022 35690082 inhibition of the fatty acid amide hydrolase (faah), the enzyme responsible for the degradation of the endocannabinoid anandamide (aea), palmitoylethanolamide (pea) and oleoylethanolamide (oea), reduces nicotine-enhanced dopamine transmission and acquisition of nicotine self-administration in rats. 2022-06-11 2022-06-13 Not clear
Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiole. Release of Endocannabinoids into the Cerebrospinal Fluid during the Induction of the Trigemino-Hypoglossal Reflex in Rats. Current issues in molecular biology vol 44 issue 5 2022 35678693 since the specific effects of endocannabinoids within the orofacial area are largely unknown, we aimed to determine whether an increase in the endocannabinoid concentration in the cerebrospinal fluid (csf) caused by the peripheral administration of the faah inhibitor urb597 and tooth pulp stimulation would affect the transmission of impulses between the sensory and motor centers localized in the vicinity of the third and fourth cerebral ventricles. 2022-06-09 2022-06-13 Not clear
Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiole. Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats. International journal of molecular sciences vol 23 issue 9 2022 35563056 the levels of the investigated mediators anandamide (aea), 2-arachidonyl glycerol (2-ag), substance p (sp), calcitonin-gene-related peptide (cgrp), endomorphin-2 (em-2) and fatty acid amide hydrolase (faah) inhibitor by urb597 and receptors cannabinoid type-1 receptors (cb1r), cannabinoid type-2 receptors (cb2r) and \xc2\xb5-opioid receptors (mor) were determined in the mesencephalon, thalamus and hypothalamus tissues. 2022-05-14 2022-06-13 Not clear
Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiole. Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats. International journal of molecular sciences vol 23 issue 9 2022 35563056 we have shown that increasing endocannabinoid aea levels by both central and peripheral inhibition of faah inhibitor by urb597 has an antinociceptive effect on the trigemino-hypoglossal reflex mediated by cb1r and influences the activation of the brain areas studied. 2022-05-14 2022-06-13 Not clear
Stacey Strandberg, K Brzozowski, M Daily, C Desjarlais, M Dougherty, K Hemsworth, K Mark, J Marsho, L Mora Gallegos, E Otten, C Schaefer, A Scheidt, S Strandberg, H Toth, K Vanderhoef, A Walesa, T Whit. Shut the F(AAH) Up: Inhibiting Fatty Acid Amide Hydrolase as a Novel Approach to Pain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 36 Suppl 1 issue 2022 35559559 faah is responsible for breaking down anandamide, which is an endogenous agonist of the cb1 cannabinoid receptor and analgesic neurotransmitter. 2022-05-13 2022-06-13 Not clear
Adriana Della Pietra, Juha Savinainen, Rashid Giniatulli. Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain. International journal of molecular sciences vol 23 issue 8 2022 35457225 we describe here: (i) migraine pain signaling pathways, which could serve as specific targets for antinociception; (ii) a divergent distribution of magl and faah activities in the key regions of the pns and cns implicated in migraine pain signaling; (iii) a complexity of anti-nociceptive effects of endocbs mediated by cannabinoid receptors and through a direct modulation of ion channels in nociceptive neurons; and (iv) the spectrum of emerging potent magl and faah inhibitors which efficiently increase endocbs levels. 2022-04-23 2022-04-25 Not clear
Lakhan S Khara, Md Ruhul Amin, Declan W Al. Inhibiting the endocannabinoid degrading enzymes FAAH and MAGL during zebrafish embryogenesis alters sensorimotor function. The Journal of experimental biology vol issue 2022 35438163 inhibiting the endocannabinoid degrading enzymes faah and magl during zebrafish embryogenesis alters sensorimotor function. 2022-04-19 2022-04-25 Not clear
Shivanshu Bajaj, Saima Zameer, Shreshta Jain, Vaishali Yadav, Divya Vohor. Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer's Disease-like Sporadic Dementia in Mice with an Emphasis on A\\xce\\xb2, HSP-70, Neuroinflammation, and Oxidative Stress. ACS chemical neuroscience vol issue 2022 35316021 recently, pharmacological inhibition of endocannabinoid (ecb)-degrading enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), is being investigated to modulate the pathology of alzheimer's disease. 2022-03-22 2022-04-14 Not clear
Sarah E Melford, Anthony H Taylor, Justin C Konj. Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLD Reproduction & fertility vol 2 issue 2 2022 35128447 nitric oxide positively affects endometrial receptivity via faah and nape-pld to determine if models of human 'receptive' and 'non-receptive endometrium' differ in their responses to nitric oxide (no) supplementation by measuring the levels of the enzymes of the endocannabinoid system (ecs) (fatty acid amide hydrolase (faah) and n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld)), which control the 'anandamide tone' essential for successful pregnancy. 2022-02-07 2022-02-10 Not clear
Shivani Jaiswal, Senthil Raja Ayyanna. Anticancer Potential of Small-Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase. ChemMedChem vol 16 issue 14 2021 33834617 both faah and magl are the endocannabinoid degrading enzymes that hydrolyze several endogenous ligands, mainly anandamide (aea) and 2-arachidonic glycerol (2-ag), which regulate various pathophysiological conditions in the body such as emotion, cognition, energy balance, pain sensation, neuroinflammation, and cancer cell proliferation. 2022-02-04 2022-01-14 Not clear
Shrouq I Farah, Samantha Hilston, Ngan Tran, Nikolai Zvonok, Alexandros Makriyanni. 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1. Biochemical and biophysical research communications vol 591 issue 2022 34995983 here, we present the interaction profiles of 2-ag and its isomerization products, 1- and 3-ag, with the endocannabinoid mgl, abhd6 and faah enzymes as well as the cb1 receptor. 2022-02-03 2022-01-13 Not clear
Navatha Alugubelly, Afzaal N Mohammed, Russell L Car. Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles. Neurotoxicology vol 85 issue 2021 34058248 exposure to cpf at these levels inhibits the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (faah) but it is not clear what the persistent effects of this inhibition are. 2022-01-28 2022-01-13 Not clear
Nathan J Kolla, Isabelle Boileau, R Michael Bagb. Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders. Scientific reports vol 12 issue 1 2022 35064143 fatty acid amide hydrolase (faah), an enzyme of the endocannabinoid system (ecs), has been linked to regulation of mood through modulation of anandamide, an endocannabinoid. 2022-01-28 2022-01-27 Not clear
Reshed Abohalaka, Turgut Emrah Bozkurt, Tuba Re\\xc3\\xa7ber, Sevgen Celik Onder, Emirhan Nemutlu, Sedef K\\xc4\\xb1r, Inci Sahin-Erdeml. The effects of systemic and local fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on the metabolomic profile of lungs. Biomedical chromatography : BMC vol issue 2021 34449902 previously, we have shown that increasing the tissue endocannabinoid levels by fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) inhibitors can prevent airway inflammation and hyperreactivity. 2022-01-26 2022-01-13 Not clear
Maximilian Barth, Stefan Rudolph, Jan Kampschulze, Imke Meyer Zu Vilsendorf, Walburga Hanekamp, Dennis Mulac, Klaus Langer, Matthias Leh. Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors:\\xc2\\xa0biochemical and physicochemical properties. ChemMedChem vol issue 2022 35072346 a series of\xc2\xa0hexafluoroisopropyl carbamates with indolyl-alkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). 2022-01-24 2022-01-27 Not clear
Nathan J Kolla, Isabelle Boileau, R Michael Bagb. Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders. Scientific reports vol 12 issue 1 2022 35064143 fatty acid amide hydrolase (faah), an enzyme of the endocannabinoid system (ecs), has been linked to regulation of mood through modulation of anandamide, an endocannabinoid. 2022-01-22 2022-01-27 Not clear
Shrouq I Farah, Samantha Hilston, Ngan Tran, Nikolai Zvonok, Alexandros Makriyanni. 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1. Biochemical and biophysical research communications vol 591 issue 2022 34995983 here, we present the interaction profiles of 2-ag and its isomerization products, 1- and 3-ag, with the endocannabinoid mgl, abhd6 and faah enzymes as well as the cb1 receptor. 2022-01-07 2022-01-13 Not clear
Subramaniam Jayanthi, Ritvik Peesapati, Michael T McCoy, Bruce Ladenheim, Jean Lud Cade. Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2). Molecular neurobiology vol issue 2022 34978045 animals were euthanized 2\xc2\xa0h after the last meth sa session and their hippocampi were used to measure mrna levels of cannabinoid receptors (cb/cnr), as well as those of synthesizing (dagl-a, dagl-b, napepld) and metabolizing (mgll, faah, ptgs2) enzymes of the endocannabinoid cascade. 2022-01-03 2022-01-13 Not clear
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