All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Shreya Desai, Clara G Zundel, Julia M Evanski, Leah C Gowatch, Amanpreet Bhogal, Samantha Ely, Carmen Carpenter, MacKenna Shampine, Emilie O'Mara, Christine A Rabinak, Hilary A Marusa. Genetic variation in endocannabinoid signaling: Anxiety, depression, and threat- and reward-related brain functioning during the transition into adolescence. Behavioural brain research. 2024-02-29. PMID:38423255. in adults, neuroimaging studies link a common genetic variant in fatty acid amide hydrolase (faah c385a)-an enzyme that regulates endocannabinoid signaling-to reduced risk of anxiety and depression, and altered threat- and reward-related neural activity. 2024-02-29 2024-03-03 Not clear
C Medina-Saldivar, G V E Pardo, L F Pacheco-Otalor. Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-02-21. PMID:38381881. mch1 is a synthetic macamide that has shown in vitro inhibitory activity on fatty acid amide hydrolase (faah), an enzyme responsible for endocannabinoid metabolism. 2024-02-21 2024-02-24 mouse
C Medina-Saldivar, G V E Pardo, L F Pacheco-Otalor. Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-02-21. PMID:38381881. the present study aimed to evaluate the effect of the in vivo administration of mch1 (3, 10, and 30 mg/kg, ip) in 2-month-old balb/c male mice (n=97) on forced swimming test (fst), light-dark box (ldb), and open field test (oft) and on early gene expression changes 2 h after drug injection related to the endocannabinoid system (cnr1 and faah) and dopaminergic signaling (drd1 and drd2) in the nac core. 2024-02-21 2024-02-24 mouse
Daniela Kovacs, Enrica Flori, Emanuela Bastonini, Sarah Mosca, Emilia Migliano, Carlo Cota, Marco Zaccarini, Stefania Briganti, Giorgia Cardinal. Targeting Fatty Acid Amide Hydrolase Counteracts the Epithelial-to-Mesenchymal Transition in Keratinocyte-Derived Tumors. International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139209. inhibiting faah (fatty acid amide hydrolase), the degradation enzyme of the endocannabinoid anandamide (aea) leads to the increase in aea levels, thus enhancing its biological effects. 2023-12-23 2023-12-25 human
b' A Pa\\xc5\\x99\\xc3\\xadzek, J Suchop\\xc3\\xa1r, Z La\\xc5\\xa1t\\xc5\\xafvka, M Alblov\\xc3\\xa1, M Hill, M Du\\xc5\\xa1kov\\xc3\\xa. The Endocannabinoid System and Its Relationship to Human Reproduction. Physiological research. vol 72. issue S4. 2023-12-20. PMID:38116770.' only an exceptional interplay of enzymes such as nape-pdl or faah, endogenous cannabinoids and cannabinoid receptors cb1 and cb2 can ensure the proper functioning of the reproductive organs and thus lead to delivery on time. 2023-12-20 2023-12-23 human
Chiara Demartini, Rosaria Greco, Anna Maria Zanaboni, Miriam Francavilla, Sara Facchetti, Cristina Tassorell. URB937 Prevents the Development of Mechanical Allodynia in Male Rats with Trigeminal Neuralgia. Pharmaceuticals (Basel, Switzerland). vol 16. issue 11. 2023-11-25. PMID:38004491. the inhibition of the fatty acid amide hydrolase (faah), the degrading enzyme of the endocannabinoid anandamide, has received attention as an alternative to cannabinoids in the treatment of neuropathic pain. 2023-11-25 2023-11-28 rat
Mallika Tripathy, Amy Bui, Jared Henderson, Jeffrey Sun, Christian Rutan Woods, Soumya Somani, Thao Doan, Anto Sam Crosslee Louis Sam Titus, Chandra Moha. FAAH inhibition ameliorates breast cancer in a murine model. Oncotarget. vol 14. 2023-11-03. PMID:37921652. faah inhibition was more effective than exogenous endocannabinoid treatment, and the combination of faah inhibitors and endocannabinoids was the most effective in inducing apoptosis of breast cancer cells 2023-11-03 2023-11-08 Not clear
K Taboada-Rosell, F A Castro-García, C Medina-Saldívar, S R Cruz-Visalaya, L F Pacheco-Otalor. The novel FAAH inhibitor, MCH1, reduces the infarction area in the motor cortex-related region but does not affect the sensorimotor function or memory and spatial learning in rats exposed to transient middle cerebral artery occlusion. Brain research. 2023-10-21. PMID:37865139. this deduction comes from its ability to inhibit the fatty acid amide hydrolase activity, an enzyme related to the endocannabinoid anandamide hydrolysis. 2023-10-21 2023-11-08 rat
Lisa Bornscheuer, Andreas Lundin, Yvonne Forsell, Catharina Lavebratt, Philippe A Mela. Functional Variation in the Genes. vol 14. issue 9. 2023-09-28. PMID:37761966. functional variation in the fatty acid amide hydrolase (faah) is an enzyme that degrades anandamide, an endocannabinoid that modulates mesolimbic dopamine release and, consequently, influences states of well-being. 2023-09-28 2023-10-07 Not clear
Alessandro Papa, Ilaria Cursaro, Luca Pozzetti, Chiara Contri, Martina Cappello, Silvia Pasquini, Gabriele Carullo, Anna Ramunno, Sandra Gemma, Katia Varani, Stefania Butini, Giuseppe Campiani, Fabrizio Vincenz. Pioneering first-in-class FAAH-HDAC inhibitors as potential multitarget neuroprotective agents. Archiv der Pharmazie. 2023-09-26. PMID:37750286. aiming to simultaneously modulate the endocannabinoid system (ecs) functions and the epigenetic machinery, we selected the fatty acid amide hydrolase (faah) and histone deacetylase (hdac) enzymes as desired targets to develop potential neuroprotective multitarget-directed ligands (mtdls), expecting to achieve an additive or synergistic therapeutic effect in oxidative stress-related conditions. 2023-09-26 2023-10-07 human
Anthony H Taylor, Panos Bachkangi, Justin C Konj. Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta. Histochemistry and cell biology. 2023-09-26. PMID:37750996. here we examined the expression of the n-acylethanolamine-modulating enzymes fatty acid amide hydrolase (faah) and n-acyl-phosphatidylethanolamine-specific phospholipase-d (nape-pld) and of the cannabinoid receptors (cb1 and cb2) in the placenta and their activation in an in vitro model of the third-trimester placenta to determine if those expressions change with labour and have functional significance. 2023-09-26 2023-10-07 human
Danielle M Gerhard, Nathaniel Tse, Francis S Lee, Heidi C Meye. Developmental age and fatty acid amide hydrolase genetic variation converge to mediate fear regulation in female mice. Developmental psychobiology. vol 65. issue 6. 2023-08-22. PMID:37607892. for this, we used knock-in mice containing a common human mutation in the gene for fatty acid amide hydrolase (faah), the primary catabolic enzyme for the endocannabinoid anandamide (faah-in). 2023-08-22 2023-09-07 mouse
Joao P De Aquin. Fatty Acid Amide Hydrolase, Neurodevelopment, and Alcohol: Illuminating the Intricacies of the Endocannabinoid System in Addiction Susceptibility. Biological psychiatry. vol 94. issue 5. 2023-08-09. PMID:37558315. fatty acid amide hydrolase, neurodevelopment, and alcohol: illuminating the intricacies of the endocannabinoid system in addiction susceptibility. 2023-08-09 2023-08-16 Not clear
Gina Granja-Galeano, Ana Paula Dominguez Rubio, C Daniel Zappia, Manuel Wolfson, Sara Sanz Blasco, Julieta Aisemberg, Maria Zorrilla Zubilete, Natalia Fernandez, Ana Franchi, Carlos P Fitzsimons, Federico Monczo. CB1 receptor expression and signaling are required for dexamethasone-induced aversive memory consolidation. Neuropharmacology. 2023-08-04. PMID:37541383. furthermore, we provide primary evidence for the mechanism responsible for this crosstalk between cannabinoid and glucocorticoid-mediated signaling pathways, showing that dexamethasone regulates endocannabinoid metabolism by inhibiting the activity of the fatty acid amide hydrolase (faah), an integral membrane enzyme that hydrolyzes endocannabinoids and related amidated signaling lipids. 2023-08-04 2023-08-14 Not clear
Marta Kruk-Slomka, Bartlomiej Adamski, Tomasz Slomka, Grazyna Bial. Inhibitors of Endocannabinoids' Enzymatic Degradation as a Potential Target of the Memory Disturbances in an Acute N-Methyl-D-Aspartate (NMDA) Receptor Hypofunction Model of Schizophrenia in Mice. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511157. the ecs is comprised of cannabinoid (cb) receptors, endocannabinoids and enzymes responsible for the metabolism of endocannabinoids (fatty acid hydrolase (faah) and monoacylglycerol lipase (magl)). 2023-07-29 2023-08-14 mouse
Takehito Terajima, Hirofumi Inoue, Kenji Shimomura, Fuki Iwasaki, Aya Sasaki, Yuki Ito, Michihiro Kamijima, Motohiro Tomizaw. Organophosphate agent action at the fatty acid amide hydrolase enhancing anandamide-induced apoptosis in NG108-15 cells. The Journal of toxicological sciences. vol 48. issue 7. 2023-07-02. PMID:37394655. op agent as an anticholinesterase also acts on the endocannabinoid (ec)-hydrolases, i.e., fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), to reveal unexpected adverse effects including adhd-like behaviors in adolescent male rats. 2023-07-02 2023-08-14 human
Takehito Terajima, Hirofumi Inoue, Kenji Shimomura, Fuki Iwasaki, Aya Sasaki, Yuki Ito, Michihiro Kamijima, Motohiro Tomizaw. Organophosphate agent action at the fatty acid amide hydrolase enhancing anandamide-induced apoptosis in NG108-15 cells. The Journal of toxicological sciences. vol 48. issue 7. 2023-07-02. PMID:37394655. accordingly, faah inhibition by eopf suppresses aea-metabolism, and accumulated excess aea overstimulates both the cannabinoid receptor- and mitochondria-mediated apoptotic pathways. 2023-07-02 2023-08-14 human
Tiziana Genovese, Andrea Duranti, Francesco Monaco, Rosalba Siracusa, Roberta Fusco, Daniela Impellizzeri, Ramona D'Amico, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paol. Inhibition of Fatty Acid Amide Hydrolase (FAAH) Regulates NF-kb Pathways Reducing Bleomycin-Induced Chronic Lung Inflammation and Pulmonary Fibrosis. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373275. increasing endogenous levels of endocannabinoid by pharmacologically inhibiting faah results in numerous analgesic advantages in a variety of experimental models for pre-clinical pain and inflammation. 2023-06-28 2023-08-14 Not clear
Hajar Mikaeili, Abdella M Habib, Charlix Wai-Lok Yeung, Sonia Santana-Varela, Ana P Luiz, Kseniia Panteleeva, Sana Zuberi, Alkyoni Athanasiou-Fragkouli, Henry Houlden, John N Wood, Andrei L Okorokov, James J Co. Molecular basis of FAAH-OUT-associated human pain insensitivity. Brain : a journal of neurology. 2023-05-24. PMID:37222214. here we report how the recently discovered brain and dorsal root ganglia-expressed faah-out long non-coding rna (lncrna) gene, which was found from studying a pain-insensitive patient with reduced anxiety and fast wound healing, regulates the adjacent key endocannabinoid system gene faah, which encodes the anandamide-degrading fatty acid amide hydrolase enzyme. 2023-05-24 2023-08-14 human
Hernan Bazan, Surjyadipta Bhattacharjee, Madigan Reid, Bokkyoo Jun, Connor Polk, Madeleine Strain, Linsey St Pierre, Neehar Desai, Patrick Daly, Jessica Cucinello-Ragland, Scott Edwards, Julio Alvarez-Builla, James Cai, Nicolas Baza. Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG region. Research square. 2023-05-19. PMID:37205420. single-cell transcriptomics of pag uncovered that srp-001 and apap also share modulation of pain-related gene expression and cell signaling pathways, including the endocannabinoid, mechanical nociception, and fatty acid amide hydrolase (faah) pathways. 2023-05-19 2023-08-14 Not clear