| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Neda Lotfi Yagin, Fereshteh Aliasgari, Soghra Aliasgharzadeh, Reza Mahdavi, Maryam Akbarzade. The influence of the fatty acid amide hydrolase 385C>A single nucleotide polymorphisms on obesity susceptibility. Molecular biology reports. vol 46. issue 5. 2020-03-09. PMID:31286394. |
a common 385c>a single nucleotide polymorphism of the fatty acid amide hydrolase, one the most important inactivating enzymes of endogenous cannabinoids, has been shown to be associated with obese phenotype. |
2020-03-09 |
2023-08-13 |
human |
| Alessia Ligresti, Cristoforo Silvestri, Rosa Maria Vitale, Jose L Martos, Fabiana Piscitelli, Jenny W Wang, Marco Allarà, Robert W Carling, Livio Luongo, Francesca Guida, Anna Illiano, Angela Amoresano, Sabatino Maione, Pietro Amodeo, David F Woodward, Vincenzo Di Marzo, Gennaro Marin. FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30226747. |
fatty acid amide hydrolase (faah) belongs to the amidase signature superfamily and is a major endocannabinoid inactivating enzyme using an atypical catalytic mechanism involving hydrolysis of amide and occasionally ester bonds. |
2020-02-18 |
2023-08-13 |
Not clear |
| Alessia Ligresti, Cristoforo Silvestri, Rosa Maria Vitale, Jose L Martos, Fabiana Piscitelli, Jenny W Wang, Marco Allarà, Robert W Carling, Livio Luongo, Francesca Guida, Anna Illiano, Angela Amoresano, Sabatino Maione, Pietro Amodeo, David F Woodward, Vincenzo Di Marzo, Gennaro Marin. FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30226747. |
we report a new multitarget drug, agn220653, containing a carboxyamide-4-oxazole moiety and endowed with efficacious analgesic and anti-inflammatory activities, which are partly due to its capability of achieving inhibition of faah, and subsequently increasing the tissue concentrations of the endocannabinoid anandamide. |
2020-02-18 |
2023-08-13 |
Not clear |
| Hong Yin, Xuehan Li, Rui Xia, Mingliang Yi, Yan Cheng, Yu Wu, Bowen Ke, Rurong Wan. Posttreatment With the Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates One-Lung Ventilation-Induced Lung Injury in a Rabbit Model. The Journal of surgical research. vol 239. 2020-01-24. PMID:30822695. |
fatty acid amide hydrolase (faah) is the major enzyme that degrades the endocannabinoid arachidonoylethanolamine (aea), an important regulator of inflammation, and its downstream metabolites such as arachidonic acid (aa) are also involved in inflammation. |
2020-01-24 |
2023-08-13 |
rabbit |
| Mariangela Pucci, Maria Vittoria Micioni Di Bonaventura, Elizabeta Zaplatic, Fabio Bellia, Mauro Maccarrone, Carlo Cifani, Claudio D'Addari. Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene. The International journal of eating disorders. vol 52. issue 1. 2020-01-06. PMID:30578649. |
transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene. |
2020-01-06 |
2023-08-13 |
rat |
| Sara K Dempsey, Ashley M Gesseck, Ashfaq Ahmad, Zdravka Daneva, Joseph K Ritter, Justin L Pokli. Formation of HETE-EAs and dihydroxy derivatives in mouse kidney tissue and analysis by high-performance liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1126-1127. 2019-12-30. PMID:31437772. |
the endocannabinoid system consists of the two major cannabinoid receptor agonists, anandamide (aea) and 2-arachidonylglycerol (2-ag), their hydrolyzing enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), and the cannabinoid receptors, cb |
2019-12-30 |
2023-08-13 |
mouse |
| Marcos Lorca, Yudisladys Valdes, Hery Chung, Javier Romero-Parra, C David Pessoa-Mahana, Jaime Mell. Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117309. |
three-dimensional quantitative structure-activity relationships (3d-qsar) on a series of piperazine-carboxamides fatty acid amide hydrolase (faah) inhibitors as a useful tool for the design of new cannabinoid ligands. |
2019-12-03 |
2023-08-13 |
Not clear |
| Marcos Lorca, Yudisladys Valdes, Hery Chung, Javier Romero-Parra, C David Pessoa-Mahana, Jaime Mell. Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117309. |
fatty acid amide hydrolase (faah) is one of the main enzymes responsible for endocannabinoid metabolism. |
2019-12-03 |
2023-08-13 |
Not clear |
| Marcos Lorca, Yudisladys Valdes, Hery Chung, Javier Romero-Parra, C David Pessoa-Mahana, Jaime Mell. Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117309. |
inhibition of faah increases endogenous levels of fatty acid ethanolamides such as anandamide (aea) and thus consitutes an indirect strategy that can be used to modulate endocannabinoid tone. |
2019-12-03 |
2023-08-13 |
Not clear |
| Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Elżbieta Skrzydlewsk. Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism. Advances in medical sciences. vol 64. issue 1. 2019-11-20. PMID:30243113. |
the effect of chronic administration of [3-(3-carbamoylphenyl)phenyl] n-cyclohexylcarbamate (urb597), inhibitor of fatty acid amide hydrolase (faah) that hydrolyzes anandamide, on cross-talk between endocannabinoid system, oxidative status and pro-inflammatory factors in the liver of spontaneously hypertensive rats (shrs) was investigated. |
2019-11-20 |
2023-08-13 |
rat |
| Zdravka Daneva, Sara K Dempsey, Ashfaq Ahmad, Ningjun Li, Pin-Lan Li, Joseph K Ritte. Diuretic, Natriuretic, and Vasodepressor Activity of a Lipid Fraction Enhanced in Medium of Cultured Mouse Medullary Interstitial Cells by a Selective Fatty Acid Amide Hydrolase Inhibitor. The Journal of pharmacology and experimental therapeutics. vol 368. issue 2. 2019-11-04. PMID:30530623. |
to investigate the possible role of the endocannabinoid system in renomedullary interstitial cells, mouse medullary interstitial cells (mmics) were obtained, cultured, and characterized for their responses to treatment with a selective inhibitor of fatty acid amide hydrolase, pf-3845 ( |
2019-11-04 |
2023-08-13 |
mouse |
| Shakiru O Alapafuja, Michael S Malamas, Vidyanand Shukla, Alexander Zvonok, Sally Miller, Laura Daily, Girija Rajarshi, Christina Yume Miyabe, Honrao Chandrashekhar, JodiAnne Wood, Sergiy Tyukhtenko, Alex Straiker, Alexandros Makriyanni. Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. Bioorganic & medicinal chemistry. vol 27. issue 1. 2019-10-17. PMID:30446439. |
the new inhibitors showed potent nanomolar inhibitory activity against recombinant human and purified rat mgl, were selective (>1000-fold) against serine hydrolases faah and abhd6 and lacked any affinity for the cannabinoid receptors cb1 and cb2. |
2019-10-17 |
2023-08-13 |
human |
| Serena Stopponi, Yannick Fotio, Ana Domi, Anna Maria Borruto, Luis Natividad, Marisa Roberto, Roberto Ciccocioppo, Nazzareno Cannell. Inhibition of fatty acid amide hydrolase in the central amygdala alleviates co-morbid expression of innate anxiety and excessive alcohol intake. Addiction biology. vol 23. issue 6. 2019-10-07. PMID:29071769. |
fatty acid amide hydrolase (faah) is an enzyme that prominently degrades the major endocannabinoid n-arachidonoylethanolamine (anandamide). |
2019-10-07 |
2023-08-13 |
rat |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
fatty acid amide hydrolase (faah) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cannabinoid n-acylethanolamines. |
2019-09-17 |
2023-08-13 |
mouse |
| Margherita Brindisi, Giuseppe Borrelli, Simone Brogi, Alessandro Grillo, Samuele Maramai, Marco Paolino, Mascia Benedusi, Alessandra Pecorelli, Giuseppe Valacchi, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Marco Allarà, Alessia Ligresti, Patrizia Minetti, Giuseppe Campiani, Vincenzo di Marzo, Stefania Butini, Sandra Gemm. Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain. ChemMedChem. vol 13. issue 19. 2019-09-16. PMID:30085402. |
the unique role of fatty acid amide hydrolase (faah) in terminating endocannabinoid (ec) signaling supports its relevance as a therapeutic target. |
2019-09-16 |
2023-08-13 |
Not clear |
| Bruna Cuccurazzu, Erica Zamberletti, Cristiano Nazzaro, Pamela Prini, Massimo Trusel, Mariagrazia Grilli, Daniela Parolaro, Raffaella Tonini, Tiziana Rubin. Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling. The international journal of neuropsychopharmacology. vol 21. issue 11. 2019-08-29. PMID:29982505. |
we recently reported that most depressive-like behaviors triggered by adolescent Δ9-tetrahydrocannabinol exposure can be rescued by manipulating endocannabinoid signaling in adulthood with the anandamide-inactivating enzyme faah inhibitor, urb597. |
2019-08-29 |
2023-08-13 |
rat |
| Matthew E Sloan, Joshua L Gowin, Jia Yan, Melanie L Schwandt, Primavera A Spagnolo, Hui Sun, Colin A Hodgkinson, David Goldman, Vijay A Ramchandan. Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. Addiction biology. vol 23. issue 1. 2019-08-27. PMID:28150397. |
one of the two main endocannabinoid neurotransmitters, anandamide, is metabolized by fatty acid amide hydrolase, an enzyme with a functional genetic polymorphism (faah pro129thr, rs324420). |
2019-08-27 |
2023-08-13 |
human |
| Elaine de Oliveira, Fernanda T Quitete, Dayse N Bernardino, Deysla S Guarda, Fabiele A H Caramez, Patrícia N Soares, Thamara C Peixoto, Vanessa S T Rodrigues, Isis H Trevenzoli, Egberto G Moura, Patrícia C Lisbo. Maternal coconut oil intake on lactation programs for endocannabinoid system dysfunction in adult offspring. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 130. 2019-07-29. PMID:31059745. |
the co group showed higher daglα (endocannabinoid synthesis) but no alteration of faah (endocannabinoid degradation) or cb1r. |
2019-07-29 |
2023-08-13 |
Not clear |
| Deepak Cyril D'Souza, Jose Cortes-Briones, Gina Creatura, Grai Bluez, Halle Thurnauer, Emma Deaso, Kim Bielen, Toral Surti, Rajiv Radhakrishnan, Aarti Gupta, Swapnil Gupta, John Cahill, Mohamed A Sherif, Alexandros Makriyannis, Peter T Morgan, Mohini Ranganathan, Patrick D Skosni. Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. The lancet. Psychiatry. vol 6. issue 1. 2019-07-26. PMID:30528676. |
one approach is to potentiate endocannabinoid signalling by inhibiting fatty acid amide hydrolase (faah), the enzyme that degrades the endocannabinoid anandamide. |
2019-07-26 |
2023-08-13 |
Not clear |
| M Alasmari, M Bӧhlke, C Kelley, T Maher, A Pino-Figuero. Inhibition of Fatty Acid Amide Hydrolase (FAAH) by Macamides. Molecular neurobiology. vol 56. issue 3. 2019-07-17. PMID:29926378. |
the aim of this study was to characterize the inhibitory activity of four of these maccamides (n-benzylstearamide, n-benzyloleamide, n-benzyloctadeca-9z,12z-dienamide, and n-benzyloctadeca-9z,12z,15z-trienamide) on fatty acid amide hydrolase (faah), an enzyme that is responsible for endocannabinoid degradation in the nervous system (kumar et al. |
2019-07-17 |
2023-08-13 |
Not clear |